Mostrando entradas con la etiqueta Odontobebe. Mostrar todas las entradas
Mostrando entradas con la etiqueta Odontobebe. Mostrar todas las entradas

martes, 15 de julio de 2025

Antibiotic Selection in Pediatric Dental Infections: Updated Clinical Criteria for U.S. Dentists

Pediatric Dental Infections

Pediatric dental infections are common in clinical practice and can progress rapidly due to anatomical and immunological factors specific to children. When systemic signs or soft tissue involvement are present, selecting the right antibiotic becomes critical.

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However, antibiotic prescription in pediatric patients requires careful consideration of the likely pathogens, the child’s age and weight, medical history, drug allergies, and antibiotic pharmacokinetics.

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This article outlines the evidence-based criteria for selecting safe and effective antibiotics for pediatric odontogenic infections, in accordance with U.S. clinical guidelines.

When Are Antibiotics Indicated in Pediatric Dentistry?
According to the American Academy of Pediatric Dentistry (AAPD, 2022) and current literature, systemic antibiotics in children should be adjunctive, not primary, to dental treatment (e.g., extraction, pulpectomy, or drainage). Antibiotics are indicated in the following situations:

° Infections with systemic involvement (fever, lymphadenopathy, malaise).
° Spread to soft tissues or fascial spaces (e.g., cellulitis).
° Delayed access to dental treatment.
° Medically compromised or immunosuppressed children.

For localized infections without systemic signs, antibiotics are not recommended (Robertson et al., 2020).

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Key Criteria for Antibiotic Selection

1. Bacterial Spectrum and Common Pathogens
Most odontogenic infections in children are caused by facultative and anaerobic Gram-positive bacteria, including Streptococcus viridans, Prevotella, and Fusobacterium species. Therefore, antibiotics must provide coverage for both aerobic and anaerobic oral flora.
° First-line therapy: Amoxicillin or Amoxicillin-clavulanate.
° Penicillin allergy: Clindamycin or Azithromycin (with caution).

2. Age and Weight-Based Dosing
Pediatric dosing is weight-dependent and must be calculated accurately to ensure therapeutic efficacy and safety. Liquid oral formulations are preferred in most outpatient scenarios.



3. Safety Profile and Contraindications
Certain antibiotics such as tetracyclines are contraindicated in children under 8 years due to the risk of permanent tooth discoloration. Fluoroquinolones are generally avoided in pediatric patients due to concerns about cartilage and tendon development.

4. Route of Administration and Adherence
The oral route is the first choice for mild to moderate infections. Short treatment durations (5–7 days), pleasant-tasting liquid preparations, and fewer daily doses improve adherence in children. For severe infections with fever or poor oral intake, intravenous antibiotics may be required in a hospital setting.

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PDF🔽 Antimicrobial therapies for odontogenic infections in children and adolescents ... We share a literature review that establishes guidelines for antimicrobial therapy in infections of odontogenic origin and clinical recommendations.
💬 Discussion
While antibiotics are essential in managing pediatric dental infections with systemic signs, inappropriate use contributes to antimicrobial resistance, a major global and national health concern. In pediatric dentistry, prescribers must balance effectiveness with safety, keeping in mind the developmental sensitivity of the patient and the limited options available.
The cornerstone of management remains the removal of the infection source through local treatment. When antibiotics are necessary, they must be selected using evidence-based guidelines, adjusted for age and body weight, and monitored for adverse effects. Parental education on dosage compliance is also essential.

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💡 Conclusion Antibiotic selection in pediatric dental infections must be grounded in clear clinical indications and guided by updated U.S. pediatric dental protocols. Amoxicillin remains the first-line antibiotic for most cases. Alternatives such as clindamycin or azithromycin should only be used in specific situations. Rational antibiotic use, combined with timely dental intervention and follow-up, ensures optimal outcomes and minimizes complications.

📚 References

✔ American Academy of Pediatric Dentistry. (2022). Guideline on Use of Antibiotic Therapy for Pediatric Dental Patients. AAPD Reference Manual. https://www.aapd.org/research/oral-health-policies--recommendations/

✔ Robertson, D., Smith, A. J., & Garton, M. (2020). The role of systemic antibiotics in the treatment of acute dental infections. British Dental Journal, 228(9), 657–662. https://doi.org/10.1038/s41415-020-1464-x

✔ Pichichero, M. E. (2018). Understanding antibiotic pharmacokinetics in children. Pediatrics in Review, 39(1), 5–17. https://doi.org/10.1542/pir.2016-0165

✔ Wilson, W., Taubert, K. A., Gewitz, M., et al. (2007). Prevention of infective endocarditis: Guidelines from the American Heart Association. Circulation, 116(15), 1736–1754. https://doi.org/10.1161/CIRCULATIONAHA.106.183095

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Antibióticos en Infecciones Odontogénicas Pediátricas: Criterios de Selección Actualizados

Infecciones Odontogénicas

Las infecciones odontogénicas en niños son frecuentes y pueden progresar rápidamente debido a factores anatómicos e inmunológicos propios de la infancia. El tratamiento antibiótico adecuado es crucial cuando existe evidencia de diseminación sistémica o compromiso de tejidos blandos.

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Sin embargo, la selección del antibiótico en pacientes pediátricos requiere considerar aspectos como el agente etiológico probable, edad del niño, peso corporal, historial médico, alergias, y la farmacocinética de los medicamentos. Este artículo analiza los criterios clínicos actualizados para una prescripción segura y eficaz de antibióticos en infecciones odontogénicas infantiles.

Enlaces Patrocinados

Indicaciones de Antibióticos en Odontopediatría
Según la American Academy of Pediatric Dentistry (AAPD, 2022) y estudios recientes, el uso de antibióticos en odontología pediátrica debe ser complementario al tratamiento de la causa odontogénica (p. ej., exodoncia, endodoncia o drenaje), y está indicado en los siguientes casos:

° Infección con compromiso sistémico (fiebre, linfadenopatías, malestar general).
° Diseminación a tejidos blandos o espacios fasciales.
° Imposibilidad de realizar tratamiento quirúrgico inmediato.
° Pacientes inmunocomprometidos o con comorbilidades de riesgo.

En casos de infecciones localizadas sin signos sistémicos, no está indicada la prescripción empírica de antibióticos (Robertson et al., 2020).

Criterios para la Selección del Antibiótico

1. Espectro de acción y bacterias predominantes
La mayoría de infecciones odontogénicas en niños son causadas por bacterias anaerobias y facultativas Gram positivas, como Streptococcus viridans, Prevotella spp., y Fusobacterium spp. Por ello, los antibióticos elegidos deben tener cobertura contra estas bacterias.
° Primera elección: Amoxicilina o Amoxicilina con ácido clavulánico.
° Alergia a penicilinas: Clindamicina o Azitromicina (de forma cautelosa).

2. Edad y peso del paciente
La dosificación debe ajustarse con precisión en función del peso del niño (mg/kg/día), utilizando fórmulas líquidas pediátricas y respetando la frecuencia y duración indicadas.



3. Perfil de seguridad
Debe evitarse el uso de antibióticos como tetraciclinas, ya que pueden causar coloración permanente en dientes en formación. También se evita el uso de fluoroquinolonas en niños por riesgo de alteraciones osteoarticulares.

4. Adherencia y vía de administración
Se prefiere la vía oral en infecciones no complicadas. La forma farmacéutica líquida y una pauta corta (5–7 días) mejoran la adherencia en población pediátrica. En casos severos o con vómitos/fiebre alta, puede considerarse la vía parenteral (hospitalaria).

💬 Discusión Aunque los antibióticos siguen siendo herramientas esenciales frente a infecciones odontogénicas con afectación sistémica, su uso inadecuado contribuye al desarrollo de resistencias antimicrobianas, un problema de salud global. En odontopediatría, la responsabilidad en la indicación y selección del antibiótico es aún mayor, debido a la sensibilidad fisiológica del paciente en crecimiento y a las limitadas opciones terapéuticas disponibles.
La combinación de diagnóstico clínico acertado, tratamiento local de la infección y antibioticoterapia bien justificada garantiza mejores resultados y reduce complicaciones. Las guías clínicas, como las de la AAPD y la ADA, proporcionan una base sólida para la toma de decisiones, pero siempre deben contextualizarse con el cuadro clínico individual.

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💡 Conclusión La selección de antibióticos en infecciones odontogénicas pediátricas debe basarse en criterios clínicos estrictos, priorizando el tratamiento local de la infección y el uso racional del fármaco más eficaz y seguro. Amoxicilina, sola o combinada, continúa siendo la primera línea en la mayoría de los casos. En niños con alergias o condiciones especiales, se requieren alternativas cuidadosamente seleccionadas. El seguimiento clínico y la educación a los cuidadores son también piezas clave del éxito terapéutico.

📚 Referencias

✔ American Academy of Pediatric Dentistry. (2022). Guideline on Use of Antibiotic Therapy for Pediatric Dental Patients. AAPD Reference Manual. https://www.aapd.org/research/oral-health-policies--recommendations/

✔ Robertson, D., Smith, A. J., & Garton, M. (2020). The role of systemic antibiotics in the treatment of acute dental infections. British Dental Journal, 228(9), 657–662. https://doi.org/10.1038/s41415-020-1464-x

✔ Pichichero, M. E. (2018). Understanding antibiotic pharmacokinetics in children. Pediatrics in Review, 39(1), 5–17. https://doi.org/10.1542/pir.2016-0165

✔ Wilson, W., Taubert, K. A., Gewitz, M., et al. (2007). Prevention of infective endocarditis: guidelines from the American Heart Association. Circulation, 116(15), 1736–1754. https://doi.org/10.1161/CIRCULATIONAHA.106.183095

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lunes, 14 de julio de 2025

Diferencias entre Infecciones Odontogénicas en Adultos y Niños: Diagnóstico y Manejo Actualizado

Infecciones Odontogénicas

Las infecciones odontogénicas constituyen una causa frecuente de consulta en odontología y medicina general, afectando tanto a niños como a adultos. Sin embargo, su presentación clínica, diseminación, complicaciones y abordaje terapéutico varían significativamente según la edad del paciente.

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Esta revisión analiza las principales diferencias entre las infecciones odontogénicas en adultos y niños, a partir de la evidencia científica reciente.

Enlaces Patrocinados

Diferencias Anatómicas y Fisiológicas
Las diferencias anatómicas entre adultos y niños juegan un papel crucial en la forma en que se desarrollan y diseminan las infecciones odontogénicas:

° En los niños, los huesos maxilares son más porosos y menos mineralizados, lo que permite una diseminación más rápida de la infección a los tejidos blandos adyacentes (Borkar et al., 2020).
° En los adultos, la mayor densidad ósea tiende a confinar la infección, favoreciendo la formación de abscesos localizados.

Asimismo, en pacientes pediátricos, la proximidad de los ápices radiculares de los dientes temporales a los gérmenes de los dientes permanentes representa un riesgo para el desarrollo dentario futuro en caso de infección no tratada (Andreadis et al., 2021).

Etiología y Factores de Riesgo
Las causas más comunes también difieren según el grupo etario:

° En niños, las infecciones están mayormente asociadas a caries profundas no tratadas en dentición temporal, traumatismos
° En adultos, predominan las infecciones periapicales crónicas, complicaciones postoperatorias (como las infecciones tras exodoncias o cirugías), y la enfermedad periodontal avanzada (Flynn, 2011).
° Los adultos con enfermedades sistémicas como diabetes, inmunosupresión o cáncer presentan mayor riesgo de infecciones odontogénicas severas o complicadas (Kuriyama et al., 2019).

Presentación Clínica y Diseminación
Las manifestaciones clínicas también muestran contrastes importantes:

° En niños, la infección tiende a diseminarse más rápidamente a espacios fasciales, favoreciendo cuadros de celulitis facial, submandibular o periorbitaria, incluso con síntomas sistémicos como fiebre, irritabilidad o anorexia (Auluck et al., 2020).
° En adultos, es más frecuente encontrar abscesos localizados, con menor compromiso sistémico inicial, pero con potencial para diseminarse si no se trata adecuadamente, especialmente hacia espacios cervicales profundos o el mediastino.

El compromiso de la vía aérea, aunque raro, puede ser más grave en adultos por el desarrollo completo de los espacios anatómicos profundos.

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Diagnóstico y Abordaje Terapéutico

➤ Diagnóstico
El diagnóstico clínico se basa en la anamnesis, exploración intra y extraoral, y estudios por imágenes (radiografías periapicales o panorámicas). En casos severos, puede requerirse tomografía computarizada (CT).
° En niños, el diagnóstico debe considerar el estadio de erupción dentaria y la posible afectación de dientes permanentes no erupcionados.
° En adultos, se valora además la historia de tratamientos endodónticos previos o enfermedad periodontal.

➤ Tratamiento
El tratamiento incluye control del foco infeccioso (exodoncia, endodoncia o drenaje quirúrgico), soporte sistémico y antibióticoterapia.
° En niños, se prefiere el uso de antibióticos como la amoxicilina o amoxicilina-clavulánico. Las tetraciclinas están contraindicadas por riesgo de alteraciones en la dentición permanente (AAPD, 2022).
° En adultos, se puede usar una gama más amplia de antibióticos, incluyendo metronidazol en casos anaeróbicos o clindamicina en pacientes alérgicos a penicilina.
En ambos casos, la intervención oportuna es esencial para prevenir complicaciones locales o sistémicas.

💬 Discusión
Las diferencias en la respuesta inmunológica, anatomía ósea y etiología explican por qué las infecciones odontogénicas deben manejarse de forma diferenciada según la edad. En pediatría, el riesgo de afectación al desarrollo maxilofacial y dentario exige un enfoque más conservador y preventivo. En adultos, el control de comorbilidades y hábitos (como el tabaquismo) también forma parte del tratamiento integral.
Además, las infecciones odontogénicas pueden representar un riesgo de hospitalización, especialmente en grupos vulnerables. Una atención odontológica temprana, programas de prevención, y educación sobre higiene oral siguen siendo fundamentales para evitar la aparición de estas patologías.

💡 Conclusión Las infecciones odontogénicas en adultos y niños comparten un origen bacteriano, pero presentan diferencias clínicas y terapéuticas relevantes. Comprender estas diferencias es esencial para un diagnóstico preciso y una intervención eficaz, minimizando complicaciones a corto y largo plazo. La individualización del tratamiento, basada en la edad y condiciones del paciente, debe ser una prioridad en la atención odontológica actual.

📚 Referencias

✔ American Academy of Pediatric Dentistry. (2022). Guideline on Antibiotic Prophylaxis for Dental Patients at Risk for Infection. AAPD Reference Manual. https://www.aapd.org

✔ Andreadis, D., Epivatianos, A., Papanayotou, P., & Antoniades, D. (2021). Odontogenic infections in children: A retrospective analysis over a 7-year period. Journal of Clinical Pediatric Dentistry, 45(2), 92–96. https://doi.org/10.17796/1053-4625-45.2.7

✔ Auluck, A., Pai, K. M., & Mupparapu, M. (2020). Maxillofacial space infections in children: diagnostic challenges and case-based approach. Dentistry Journal, 8(2), 35. https://doi.org/10.3390/dj8020035

✔ Borkar, S. A., Joshi, P., & Sapate, R. B. (2020). Odontogenic infections in pediatric patients: A review. Journal of International Oral Health, 12(3), 177–182. https://doi.org/10.4103/jioh.jioh_242_19

✔ Flynn, T. R. (2011). Principles and surgical management of head and neck infections. Oral and Maxillofacial Surgery Clinics of North America, 23(3), 331–349. https://doi.org/10.1016/j.coms.2011.03.006

✔ Kuriyama, T., Karasawa, T., Nakagawa, K., & Yamamoto, E. (2019). Past medical history and clinical findings in patients with odontogenic infection. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 127(5), 407–412. https://doi.org/10.1016/j.oooo.2018.12.013

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Key Differences Between Pediatric and Adult Odontogenic Infections: Updated Clinical Guidelines

Odontogenic Infections

Odontogenic infections are a common reason for dental and emergency visits across all age groups. However, there are critical differences in how these infections manifest, spread, and are managed in children versus adults.

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This article outlines the major anatomical, clinical, and therapeutic distinctions between pediatric and adult odontogenic infections, highlighting the need for age-specific diagnosis and treatment approaches.

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Anatomical and Physiological Differences
The anatomical structure of the maxillofacial region changes significantly from childhood to adulthood:

° In children, the jawbones are more porous and less mineralized, allowing for faster spread of infections into adjacent soft tissues (Borkar et al., 2020).
° In adults, denser bone structure typically leads to more localized infections, often presenting as periapical abscesses.

Additionally, primary teeth in children are closely associated with the developing permanent tooth buds, making untreated infections a potential threat to future dental development (Andreadis et al., 2021).

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Etiology and Risk Factors
The root causes of odontogenic infections vary by age group:

° In children, the most common causes include deep caries in primary teeth, dental trauma, and issues related to tooth eruption.
° In adults, infections are often linked to chronic periapical disease, periodontal conditions, or post-extraction complications (Flynn, 2011).
° Systemic risk factors such as diabetes, cancer therapy, or immunosuppression increase susceptibility to severe odontogenic infections, especially in adults (Kuriyama et al., 2019).

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Clinical Presentation and Spread
The way odontogenic infections present and evolve differs significantly between children and adults:

° Pediatric patients often show rapid infection spread, leading to facial cellulitis, periorbital involvement, or submandibular swelling, frequently accompanied by fever and irritability (Auluck et al., 2020).
° Adults are more likely to present with localized abscesses, although delayed treatment can result in deep neck space infections or even mediastinitis.

Airway compromise is rare but poses a greater threat in adults due to fully developed fascial planes and deeper anatomical spaces.

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Diagnosis and Treatment

➤ Diagnosis
Diagnostic evaluation includes detailed history, clinical examination, and imaging such as periapical or panoramic X-rays. CT scans are warranted in advanced or deep space infections.
° In children, clinicians must assess tooth eruption stage and the proximity of infection to permanent tooth buds.
° In adults, factors such as past root canal treatments or the presence of periodontal disease are important in diagnosis.

➤ Treatment Approach
Treatment focuses on eliminating the source of infection (via extraction, root canal, or incision and drainage), systemic support, and appropriate antibiotic therapy.
° For pediatric patients, first-line antibiotics include amoxicillin or amoxicillin-clavulanate. Tetracyclines are contraindicated due to their adverse effects on tooth development (AAPD, 2022).
° In adults, a wider range of antibiotics can be used, including clindamycin for penicillin-allergic patients or metronidazole for anaerobic coverage.
Timely intervention in both groups is crucial to avoid systemic complications and long-term morbidity.

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💬 Discussion
Anatomical, immunological, and developmental factors necessitate different clinical strategies when managing odontogenic infections in children and adults. In children, protecting the integrity of developing permanent teeth and facial structures is critical, requiring more conservative and preventive approaches. In adults, the presence of comorbidities and a higher likelihood of chronic infections demand comprehensive evaluation and individualized care.
Additionally, odontogenic infections continue to be a significant public health concern, especially when early dental care is neglected. Preventive dentistry, public education, and timely treatment are key to reducing the prevalence and severity of these infections across all age groups.

💡 Conclusion
While pediatric and adult odontogenic infections share a bacterial origin, they differ markedly in presentation, progression, and treatment needs. Dental professionals must understand these distinctions to provide safe, effective, and age-appropriate care. A tailored treatment approach not only improves clinical outcomes but also minimizes complications, especially in growing children and medically compromised adults.

📚 References

✔ American Academy of Pediatric Dentistry. (2022). Guideline on Antibiotic Prophylaxis for Dental Patients at Risk for Infection. AAPD Reference Manual. https://www.aapd.org

✔ Andreadis, D., Epivatianos, A., Papanayotou, P., & Antoniades, D. (2021). Odontogenic infections in children: A retrospective analysis over a 7-year period. Journal of Clinical Pediatric Dentistry, 45(2), 92–96. https://doi.org/10.17796/1053-4625-45.2.7

✔ Auluck, A., Pai, K. M., & Mupparapu, M. (2020). Maxillofacial space infections in children: diagnostic challenges and case-based approach. Dentistry Journal, 8(2), 35. https://doi.org/10.3390/dj8020035

✔ Borkar, S. A., Joshi, P., & Sapate, R. B. (2020). Odontogenic infections in pediatric patients: A review. Journal of International Oral Health, 12(3), 177–182. https://doi.org/10.4103/jioh.jioh_242_19

✔ Flynn, T. R. (2011). Principles and surgical management of head and neck infections. Oral and Maxillofacial Surgery Clinics of North America, 23(3), 331–349. https://doi.org/10.1016/j.coms.2011.03.006

✔ Kuriyama, T., Karasawa, T., Nakagawa, K., & Yamamoto, E. (2019). Past medical history and clinical findings in patients with odontogenic infection. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 127(5), 407–412. https://doi.org/10.1016/j.oooo.2018.12.013

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domingo, 13 de julio de 2025

Indications and Contraindications of Serial Extractions in Pediatric Dentistry: Updated Clinical Guide

Serial Extractions

Serial extractions are a preventive orthodontic procedure used to manage severe crowding by sequentially removing selected primary and permanent teeth. Correct case selection is essential to ensure long-term success and avoid complications.

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Clinical Importance of Serial Extractions
Serial extractions help manage space deficiencies during mixed dentition, guiding permanent teeth into more favorable positions. When indicated appropriately, they can:

° Reduce the need for complex orthodontic treatments in adolescence.
° Minimize treatment duration and need for permanent extractions later.
° Maintain balanced facial growth and dental function.

As Proffit et al. (2019) highlight, interceptive orthodontics, including serial extractions, plays a crucial role in guiding proper occlusal development in growing patients.

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Indications for Serial Extractions
Serial extractions are recommended when the following conditions are met:

1. Severe Crowding (>4–5 mm per quadrant)
The primary indication is significant space deficiency that prevents proper eruption of permanent teeth.

2. Negative Tooth–Arch Size Discrepancy
When the total mesiodistal width of permanent teeth exceeds the basal arch length, serial extractions help achieve alignment.

3. Altered or Asynchronous Eruption Patterns
When the eruption sequence is delayed or misaligned, especially in anterior segments, creating space can improve outcomes.

4. Skeletal Class I Pattern
Serial extractions are most effective in patients with normal skeletal growth and no vertical or sagittal disharmonies.

5. Ideal Age: 8–11 Years (Early Mixed Dentition)
The ideal timing is when the first permanent molars and incisors are present, and canines and premolars are developing.

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Contraindications for Serial Extractions
This procedure is not recommended in the following situations:

1. Skeletal Malocclusions (Class II or III)
Patients with significant jaw discrepancies, open bites, deep bites, or crossbites may require orthopedic intervention instead.

2. Presence of Harmful Oral Habits
Thumb sucking, tongue thrust, or mouth breathing must be addressed first, as they can compromise treatment outcomes.

3. Hypodontia or Congenitally Missing Teeth
Teeth should not be extracted if others are absent, as this may worsen spacing or occlusal issues.

4. Mild Crowding or Adequate Arch Space
Unnecessary extractions may cause undesirable gaps or misalignment in otherwise manageable dentitions.

5. Eruption Anomalies or Tooth Impactions
Ectopic eruptions or impacted teeth may require surgical exposure or space creation through other orthodontic means.

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Updated Clinical Recommendations

° Comprehensive diagnostic workup is essential: panoramic and cephalometric X-rays, dental cast analysis, and space evaluation.
° Collaborate with an orthodontist early in treatment planning.
° Educate parents and caregivers about the rationale, timeline, and phases of serial extraction.
° Ensure long-term follow-up to monitor permanent tooth eruption and intervene if deviations occur.

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💬 Discussion
When applied correctly, serial extractions can greatly reduce future treatment complexity. However, inappropriate indication—such as in skeletal malocclusion cases—may lead to unwanted effects, such as arch collapse or residual spacing. The procedure does not replace orthodontic treatment but is rather a preventive adjunct to simplify it (Jarjoura et al., 2020).
Current research supports the effectiveness of serial extractions in well-selected Class I cases. Multidisciplinary coordination and long-term monitoring are key to avoiding complications and ensuring occlusal harmony.

💡 Conclusion
Serial extractions remain a valuable strategy in pediatric orthodontics, but only when properly indicated. Understanding both indications and contraindications allows clinicians to plan treatment safely and predictably. When combined with accurate diagnosis and follow-up, this preventive approach can optimize dental development and reduce the need for future interventions.

📚 References

✔ Jarjoura, K., Goonewardene, M., & Fleming, P. S. (2020). Serial extraction in orthodontics: A systematic review of effectiveness and efficiency. Orthodontics & Craniofacial Research, 23(2), 122–131. https://doi.org/10.1111/ocr.12338

✔ Proffit, W. R., Fields, H. W., Larson, B., & Sarver, D. M. (2019). Contemporary Orthodontics (6th ed.). Elsevier.

✔ Singh, G., & Clark, W. (2018). Interceptive orthodontics: Key concepts and clinical applications. Dental Clinics of North America, 62(3), 457–471. https://doi.org/10.1016/j.cden.2018.03.002

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viernes, 11 de julio de 2025

Fases de las Extracciones Seriadas: Protocolo Clínico, Beneficios y Recomendaciones

Extracciones Seriadas

Las extracciones seriadas constituyen un procedimiento preventivo dentro de la ortodoncia interceptiva, cuya finalidad es guiar el desarrollo armónico de la dentición permanente en pacientes con discrepancia óseo-dentaria significativa.

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Este artículo describe en detalle las fases del protocolo clínico, su justificación, beneficios y recomendaciones prácticas, con respaldo en la literatura científica más reciente.

Enlaces Patrocinados

Definición de Extracciones Seriadas
Las extracciones seriadas son la remoción secuencial y planificada de dientes temporales y, en ciertos casos, de dientes permanentes (generalmente primeros premolares), con el objetivo de aliviar el apiñamiento dental severo y permitir la correcta erupción y alineación de los dientes permanentes (Proffit et al., 2019).
Este procedimiento forma parte de la ortodoncia interceptiva y se realiza principalmente en pacientes en etapa de dentición mixta, generalmente entre los 8 y 11 años de edad, cuando aún es posible guiar el desarrollo de los maxilares y el patrón de erupción dental.

Importancia Clínica del Procedimiento
Las extracciones seriadas ofrecen varias ventajas clínicas si se indican correctamente:

° Previenen maloclusiones severas en la adolescencia.
° Disminuyen la necesidad de tratamientos ortodóncicos prolongados y complejos.
° Ayudan a mantener la estética facial y la simetría del perfil.
° Contribuyen al desarrollo saludable de la oclusión funcional.

Según estudios longitudinales, los pacientes tratados con extracciones seriadas presentan resultados más estables a largo plazo en comparación con aquellos tratados con ortodoncia únicamente correctiva (Valentine & Howitt, 2019).

Fases del Protocolo de Extracciones Seriadas

1. Fase Diagnóstica
Antes de iniciar el tratamiento, se debe realizar una evaluación completa:
° Historia clínica y dental.
° Radiografías panorámicas y cefalométricas.
° Análisis de modelos de estudio.
° Medición de la discrepancia óseo-dentaria.
Se considera candidata o candidato a extracciones seriadas aquel paciente con apiñamiento de más de 4 mm por cuadrante y sin alteraciones esqueléticas severas (Jarjoura et al., 2020).

2. Fase I: Extracción de Dientes Temporales
° Piezas usuales: Caninos temporales, seguidos por primeros molares temporales.
° Objetivo: Facilitar la erupción ordenada de los incisivos y caninos permanentes.
° Momento ideal: Entre los 8 y 9 años, con evaluación radiográfica previa.

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3. Fase II: Extracción de Primeros Premolares Permanentes (Si es necesario)
° Indicada cuando, tras la erupción de incisivos y caninos, persiste un apiñamiento significativo.
° Se realiza generalmente entre los 10 y 11 años, cuando los premolares han completado al menos dos tercios de su formación radicular.
° Es fundamental considerar el pronóstico periodontal y la salud de los dientes a conservar.

4. Fase III: Seguimiento y Corrección Ortodóncica
° Uso de aparatos ortodóncicos fijos o removibles para guiar la alineación final.
° Controles clínicos y radiográficos cada 4-6 meses.
° Evaluación de la estabilidad oclusal y estética facial.

Recomendaciones Clínicas Actualizadas

° Las extracciones deben realizarse únicamente con planificación ortodóncica detallada.
° Involucrar a ortodoncistas desde la fase diagnóstica.
° Informar adecuadamente a padres o tutores sobre el procedimiento y sus beneficios a largo plazo.
° Realizar seguimiento ortodóncico hasta el final de la erupción permanente.

📌 Artículo Recomendado:
PDF 🔽 Manual de Ortodoncia Interceptiva. Guía de Práctica ... La ortodoncia interceptiva tiene como función eliminar todo tipo de interferencia durante el desarrollo de la oclusión y del crecimiento maxilofacial.
💬 Discusión
Las extracciones seriadas no son un tratamiento universal, y su aplicación debe individualizarse. Su principal limitación es que no corrige discrepancias esqueléticas, por lo que no es recomendable en pacientes con maloclusiones clase II o III severas, mordidas abiertas o problemas funcionales asociados.
Por otro lado, cuando se aplican correctamente, los beneficios incluyen una mejor alineación dental, menor necesidad de extracciones en la adolescencia, y mayor estabilidad post-tratamiento. La literatura científica respalda su efectividad en casos bien seleccionados, y sugiere que pueden disminuir la duración y complejidad del tratamiento ortodóncico posterior (Proffit et al., 2019; Jarjoura et al., 2020).

💡 Conclusión Las extracciones seriadas representan una estrategia preventiva eficaz dentro de la ortodoncia pediátrica. Su implementación debe seguir un protocolo bien definido, con diagnóstico preciso, planificación individualizada y seguimiento constante. Aplicadas correctamente, ofrecen importantes beneficios clínicos, estéticos y funcionales que pueden mejorar significativamente la calidad de vida de los pacientes en desarrollo.

📚 Referencias Bibliográficas

✔ Jarjoura, K., Goonewardene, M., & Fleming, P. S. (2020). Serial extraction in orthodontics: A systematic review of effectiveness and efficiency. Orthodontics & Craniofacial Research, 23(2), 122–131. https://doi.org/10.1111/ocr.12338

✔ Proffit, W. R., Fields, H. W., Larson, B., & Sarver, D. M. (2019). Contemporary Orthodontics (6th ed.). Elsevier.

✔ Valentine, F., & Howitt, J. W. (2019). Long-term outcomes of serial extraction: A 20-year follow-up. American Journal of Orthodontics and Dentofacial Orthopedics, 155(3), 411–419. https://doi.org/10.1016/j.ajodo.2018.06.015

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domingo, 6 de julio de 2025

Herpangina in Children: Causes, Symptoms, and Treatment of This Viral Infection

Herpangina

Herpangina is a common viral illness that primarily affects children under the age of five. It is marked by a sudden onset of fever, sore throat, and small ulcers or blisters in the back of the mouth—typically on the soft palate, uvula, and tonsils.

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Although self-limiting, early recognition is crucial to manage symptoms and prevent complications such as dehydration.

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What Is Herpangina?
Herpangina is an acute viral infection characterized by painful mouth ulcers and systemic symptoms such as fever and malaise. It typically affects the posterior region of the oral cavity and is most prevalent during summer and early fall in the United States.

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Causes (Etiology)
Herpangina is caused primarily by Coxsackievirus A, though other enteroviruses like Coxsackie B and echoviruses may also be responsible. These viruses spread easily through:

° Fecal-oral route
° Respiratory droplets
° Contaminated surfaces (e.g., toys, utensils)

Outbreaks are common in daycare centers and preschools (Khetsuriani et al., 2006).

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Symptoms and Clinical Features
The condition develops rapidly and typically includes:

° High fever (101–104°F / 38.5–40°C)
° Sore throat and painful swallowing
° Loss of appetite
° Irritability
° Abdominal pain (occasionally)

➤ Oral findings appear within 24–48 hours:

° Small, fluid-filled blisters (1–2 mm) on the soft palate, uvula, and tonsils
° Blisters rupture into shallow ulcers with red halos
° Symptoms usually resolve in 5 to 7 days

Unlike hand, foot, and mouth disease, herpangina typically does not involve skin rashes or lesions on the hands and feet (Puenpa et al., 2019).

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Differential Diagnosis
Conditions that may resemble herpangina include:

° Primary herpetic gingivostomatitis
° Strep throat (streptococcal pharyngitis)
° Infectious mononucleosis
° Hand-foot-and-mouth disease

Diagnosis is clinical and based on the child’s age, symptom pattern, and the appearance of the lesions. Lab tests are rarely needed.

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Treatment
There is no specific antiviral medication for herpangina. Treatment focuses on supportive care:

➤ Hydration: Encourage frequent sips of water or electrolyte solutions
➤ Pain relief: Acetaminophen or ibuprofen for fever and sore throat
➤ Soft, cold foods: Popsicles, smoothies, and yogurt to reduce discomfort
➤ Avoid acidic or spicy foods: These may worsen oral pain

Antibiotics are not effective and should not be used unless there is a confirmed secondary bacterial infection.

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Prevention
Key preventive strategies include:

° Frequent handwashing with soap and water
° Avoiding the sharing of utensils or cups
° Disinfecting surfaces and toys
° Keeping infected children home during the contagious period

There is no vaccine specifically for herpangina, though vaccine research targeting certain enteroviruses is ongoing in high-incidence regions.

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💬 Discussion
While herpangina is generally mild, it can be distressing for both children and parents due to painful symptoms and feeding difficulties. In some cases—especially in younger children—dehydration may require medical attention. Additionally, misdiagnosis can lead to inappropriate use of antibiotics, contributing to antibiotic resistance.
Public health education for caregivers and accurate clinical guidance are essential to avoid unnecessary treatments and improve patient outcomes. Healthcare providers should offer clear instructions for at-home care and signs that warrant medical evaluation.

💡 Conclusion
Herpangina is a self-limiting viral illness in children caused by enteroviruses such as Coxsackievirus A. It presents with fever, sore throat, and ulcers in the back of the mouth. Management is supportive, focusing on hydration and pain relief. Understanding its symptoms, transmission, and proper care helps reduce complications and prevents unnecessary medical interventions.

📚 References

✔ Khetsuriani, N., Lamonte-Fowlkes, A., Oberst, S., & Pallansch, M. A. (2006). Enterovirus surveillance—United States, 1970–2005. MMWR Surveillance Summaries, 55(8), 1–20. https://www.cdc.gov/mmwr/preview/mmwrhtml/ss5508a1.htm

✔ Puenpa, J., Vongpunsawad, S., & Poovorawan, Y. (2019). Enterovirus infections in children with herpangina and hand, foot, and mouth disease in Thailand, 2012–2018. Virology Journal, 16(1), 1–10. https://doi.org/10.1186/s12985-019-1202-0

✔ National Institutes of Health. (2022). Herpangina. MedlinePlus Medical Encyclopedia. https://medlineplus.gov/ency/article/001366.htm

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sábado, 5 de julio de 2025

Medications and Developing Teeth: Dental Risks, Mechanisms, and Prevention in Children

Oral Medicine

Tooth development is a complex process influenced by genetic and environmental factors, including exposure to certain medications. During critical stages—from pregnancy through early childhood—various drugs can interfere with odontogenesis, leading to permanent changes in tooth color, structure, and eruption patterns.

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Understanding how specific medications affect dental development is crucial for pediatricians, dentists, and caregivers to make informed decisions and prevent long-term oral health issues.

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Dental Development and Critical Windows
Odontogenesis begins around the 6th to 8th week of gestation and continues into adolescence. The most vulnerable phases include:

➤ Amelogenesis: enamel formation.
➤ Dentinogenesis: dentin formation.
➤ Calcification and eruption: mineralization and emergence of the tooth into the oral cavity.

Cells like ameloblasts and odontoblasts are especially sensitive to systemic disturbances during these stages.

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Medications Commonly Linked to Dental Effects

1. Tetracyclines
Tetracyclines (e.g., doxycycline, tetracycline) bind to calcium ions and become incorporated into developing dentin and enamel, causing yellow to brown tooth discoloration and enamel hypoplasia. These antibiotics are contraindicated in children under age 8 and during pregnancy (Chopra & Roberts, 2020).

2. Excessive Fluoride
Prolonged intake of fluoride above recommended levels—whether from supplements, toothpaste, or water—can lead to dental fluorosis. This enamel defect ranges from mild white streaks to severe brown staining and surface irregularities (Wong et al., 2011).

3. Sugary Syrups, Antihistamines, and Asthma Medications
Pediatric medications often come in syrup forms with high sugar content. Chronic use increases the risk of early childhood caries. Additionally, some antihistamines and bronchodilators reduce salivary flow, contributing to enamel demineralization and increased caries risk (Daly et al., 2021).

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4. Chemotherapy and Radiation Therapy in Pediatric Patients
Cancer treatments during childhood can disrupt tooth development, leading to enamel hypoplasia, microdontia, delayed eruption, or root malformations. The younger the child at the time of therapy, the greater the impact (Pérez et al., 2019).

5. Teratogenic Drugs: Thalidomide and Anticonvulsants
Drugs like thalidomide, known for causing congenital abnormalities, may result in craniofacial defects and missing teeth. Phenytoin, an anticonvulsant, is associated with gingival overgrowth and abnormal tooth eruption patterns (Naziri et al., 2022).

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💬 Discussion
Tooth development is highly sensitive to pharmacological interference. The consequences of early exposure to certain drugs are not only cosmetic but also functional—affecting chewing, speech, and a child’s self-esteem. Preventive efforts must prioritize careful medication prescribing during pregnancy and childhood, use of sugar-free formulations, and regular dental monitoring.
Healthcare providers should work collaboratively across disciplines—medical, dental, and pharmaceutical—to reduce the risks. Early oral health education for caregivers is equally important to ensure safe medication practices and early detection of developmental dental problems.

💡 Conclusion
Several medications can cause permanent changes in tooth development when administered during critical periods. Avoiding high-risk drugs in pregnancy and early childhood, choosing sugar-free options, and ensuring regular dental follow-up are key strategies for prevention. Coordinated care and caregiver awareness play essential roles in protecting pediatric oral health.

📚 References

✔ Chopra, I., & Roberts, M. (2020). Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiology and Molecular Biology Reviews, 65(2), 232–260. https://doi.org/10.1128/MMBR.65.2.232-260.2001

✔ Daly, B., Thompsell, A., Rooney, Y. M., & White, D. A. (2021). Oral health and drug therapy in children: a review. British Dental Journal, 231(4), 225–230. https://doi.org/10.1038/s41415-021-2913-7

✔ Naziri, E., Karami, E., & Torabzadeh, H. (2022). The effect of antiepileptic drugs on oral health in pediatric patients. Journal of Pediatric Dentistry, 10(1), 45–50. https://doi.org/10.1055/s-0042-1742451

✔ Pérez, J. R., Luján, A., & Moraes, A. (2019). Dental abnormalities after pediatric cancer therapy: clinical considerations. Pediatric Dentistry Journal, 44(2), 89–96. https://doi.org/10.1016/j.pdj.2018.09.003

✔ Wong, M. C. M., Glenny, A. M., Tsang, B. W. Y., Lo, E. C. M., Worthington, H. V., & Marinho, V. C. C. (2011). Topical fluoride for caries prevention in children and adolescents. Cochrane Database of Systematic Reviews, (1). https://doi.org/10.1002/14651858.CD007693.pub2

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jueves, 3 de julio de 2025

Cómo corregir hábitos orales nocivos en niños que afectan su desarrollo facial y dental

hábitos orales

Durante los primeros años de vida, el sistema estomatognático del niño está en pleno desarrollo. La persistencia de ciertos hábitos orales nocivos, como la succión digital, la respiración bucal o la onicofagia, puede interferir con este desarrollo, produciendo maloclusiones y alteraciones morfofuncionales craneofaciales.

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Esta revisión ofrece un enfoque actualizado sobre cómo identificar y tratar dichos hábitos de manera efectiva y basada en evidencia.

Enlaces Patrocinados

Principales hábitos orales nocivos: definición y tratamiento

1. Succión digital (chuparse el dedo)
➤ Definición:
° Conducta repetitiva en la que el niño introduce uno o más dedos en la boca, generando presiones continuas sobre los dientes y estructuras orales.
➤ Consecuencias:
° Mordida abierta anterior
° Protrusión de incisivos superiores
° Retrognatia mandibular
° Alteración del sello labial
➤ Tratamiento:
° Educación y refuerzo positivo (sistema de premios)
° Calendarios de seguimiento y motivación
° Dispositivos intraorales como rejillas o topes palatinos en casos persistentes
° Apoyo psicológico si existe ansiedad asociada (Barbería et al., 2021)

2. Uso prolongado de chupón o biberón
➤ Definición:
° Uso de chupete o biberón más allá de los 2–3 años, con succión no nutritiva que condiciona estructuras orales.
➤ Consecuencias:
° Mordida abierta anterior
° Mordida cruzada posterior
° Paladar ojival
➤ Tratamiento:
° Intervención educativa temprana con padres
° Retiro progresivo del objeto con técnicas de sustitución
° Apoyo ortodóntico en caso de deformaciones persistentes
° Entrenamiento del sellado labial y postura lingual

3. Interposición lingual (deglución atípica)
➤ Definición:
° Empuje de la lengua contra los dientes al tragar o hablar, en lugar de apoyarla contra el paladar.
➤ Consecuencias:
° Mordida abierta anterior
° Diastemas
° Hipotonía muscular orofacial
➤ Tratamiento:
° Terapia miofuncional orofacial (TMO) con ejercicios dirigidos
° Uso de rejillas linguales o pistas palatinas
° Coordinación con fonoaudiólogo para rehabilitación funcional
° Control periódico por ortodoncista

4. Respiración bucal
➤ Definición:
° Patrón respiratorio predominante por la boca, ya sea por obstrucción nasal o hábito adquirido.
➤ Consecuencias:
° Cara alargada (síndrome de cara larga)
° Labios incompetentes
° Mordida cruzada posterior
° Paladar alto y estrecho
➤ Tratamiento:
° Evaluación con otorrinolaringólogo para causas obstructivas
° Expansión maxilar en caso de paladar estrecho
° Reeducación de respiración nasal con TMO
° Higiene nasal, ejercicios posturales y seguimiento pediátrico

5. Onicofagia (morderse las uñas)
➤ Definición:
° Hábito compulsivo de morderse las uñas, común en niños ansiosos o con dificultades emocionales.
➤ Consecuencias:
° Migración o inclinación dental
° Fracturas o microtraumatismos en incisivos
° Infecciones periorales
° Trastornos temporomandibulares (en casos crónicos)
➤ Tratamiento:
° Estrategias conductuales (uso de esmaltes amargos, refuerzo positivo)
° Intervención psicológica si hay estrés o ansiedad
° Terapia miofuncional para controlar tensión en labios y mandíbula
° Educación familiar y entorno escolar

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Diagnóstico
El diagnóstico debe integrar componentes clínicos, funcionales y emocionales:

° Examen bucodental completo
° Historia clínica detallada (edad de inicio, frecuencia del hábito, contexto emocional)
° Evaluación funcional de la deglución, respiración y postura oral
° Interconsulta con pediatría, fonoaudiología u otorrinolaringología si es necesario

💬 Discusión
Los hábitos orales nocivos son comunes en la infancia, pero cuando se extienden más allá de los 3 a 4 años pueden alterar significativamente el desarrollo del sistema estomatognático. La literatura actual respalda la eficacia de la intervención temprana, preferiblemente antes de los 6 años, cuando aún es posible guiar el crecimiento óseo y funcional de manera favorable (Grippaudo et al., 2020; Souki et al., 2019).
Las intervenciones más exitosas combinan un enfoque conductual con la aparatología interceptiva si el hábito ha generado alteraciones estructurales. La educación a padres y cuidadores es clave para lograr una colaboración efectiva y sostenible.

💡 Conclusión
Los hábitos orales nocivos pueden afectar de forma considerable el desarrollo craneofacial y dental del niño si no se detectan y tratan oportunamente. Cada hábito tiene sus particularidades clínicas y terapéuticas, por lo que el abordaje debe ser personalizado, multidisciplinario y centrado en el niño y su entorno. La prevención y la intervención temprana continúan siendo las estrategias más efectivas.

📚 Referencias

✔ Barbería, E., Lucavechi, T., & Suárez-Clúa, M. C. (2021). Odontopediatría Clínica. Elsevier España.

✔ Grippaudo, C., Paolantonio, E. G., Antonini, G., Saulle, R., La Torre, G., & Deli, R. (2020). Association between oral habits, mouth breathing and malocclusion. Acta Otorhinolaryngologica Italica, 40(5), 282–289. https://doi.org/10.14639/0392-100X-N0616

✔ Souki, B. Q., Pimenta, G. B., Souki, M. Q., Franco, L. P., Becker, H. M. G., & Pinto, J. A. (2019). Prevalence of malocclusion among mouth breathing children: do expectations meet reality? International Journal of Pediatric Otorhinolaryngology, 119, 146–150. https://doi.org/10.1016/j.ijporl.2019.01.032

✔ Viggiano, D., Fasano, D., Monaco, G., & Strohmenger, L. (2020). Oral habits and orthodontic anomalies in preschool children. International Journal of Paediatric Dentistry, 30(3), 326–333. https://doi.org/10.1111/ipd.12594

✔ Maia, B. R., Marques, D. R., & Barbosa, F. (2019). Nail biting in children: an integrative review. Psicologia: Reflexão e Crítica, 32(1), 1–9. https://doi.org/10.1186/s41155-019-0116-1

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miércoles, 2 de julio de 2025

Acetaminophen for Kids: Safe Pain Relief in Pediatric Dental Patients

Acetaminophen

Effective pain control is essential in pediatric dentistry to promote positive dental experiences and reduce anxiety.

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Among over-the-counter analgesics, acetaminophen (paracetamol) is widely regarded as a safe and effective option for managing mild to moderate dental pain in children. Its favorable safety profile and accessibility make it a cornerstone in everyday pediatric dental care in the United States.

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Mechanism of Action
Acetaminophen primarily works by inhibiting the cyclooxygenase (COX) enzymes in the central nervous system, particularly COX-3. This reduces the production of prostaglandins, resulting in analgesic and antipyretic effects. Unlike nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen has minimal anti-inflammatory activity, making it suitable when pain relief is needed without gastrointestinal side effects.

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Recommended Pediatric Dosage
According to the American Academy of Pediatrics (AAP) and the U.S. Food and Drug Administration (FDA), the following pediatric dosage guidelines apply:

➤ Oral Dosage for Children:
° 10–15 mg/kg per dose every 4 to 6 hours as needed.
° Maximum Daily Dose: 75 mg/kg/day or no more than 4,000 mg/day (whichever is lower).
➤ Common Forms in the U.S.:
° Infant drops (160 mg/5 mL)
° Children's syrup (160 mg/5 mL)
° Chewable tablets (usually 80 mg or 160 mg)
° Suppositories (vary by age and weight)
Example: A child weighing 44 lbs (20 kg) can receive 200–300 mg per dose every 6 hours, with a maximum of 1,200 mg in 24 hours.

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Contraindications and Warnings
While acetaminophen is generally safe, there are important situations where its use must be carefully considered:

➤ Absolute Contraindications:
° Known allergy or hypersensitivity to acetaminophen
° Severe liver disease or hepatic failure
➤ Caution in the Following Cases:
° Chronic malnutrition or dehydration
° Use in neonates (requires adjusted dosing and close monitoring)
° Accidental overdose due to combination with other OTC medications containing acetaminophen
Important: Caregivers should be educated to avoid combining multiple products (e.g., cold medications) that may contain acetaminophen.

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Clinical Evidence in Pediatric Dentistry
Recent studies support acetaminophen’s effectiveness in managing dental pain in children, especially following common procedures such as extractions, pulp therapy, or trauma management.
A clinical trial by Coelho et al. (2021) found that acetaminophen provided pain relief equivalent to ibuprofen after dental procedures in children, with fewer gastrointestinal side effects. The American Academy of Pediatric Dentistry (AAPD, 2023) also endorses acetaminophen as the first-line analgesic for young children or those who cannot take NSAIDs.

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💬 Discussion Acetaminophen remains a go-to option in pediatric dental care due to its strong safety profile and efficacy. Weight-based dosing is essential, and dental professionals must provide clear instructions to caregivers to prevent misuse or overdose. In some cases of moderate to severe inflammation, NSAIDs may offer superior pain control, but acetaminophen is often preferred in children due to fewer side effects.
Combination therapy (e.g., acetaminophen plus ibuprofen) may be considered in select cases under dental supervision.

💡 Conclusion
Acetaminophen is a safe and effective pain reliever for pediatric dental patients when used at the correct dosage and with proper caregiver guidance. Understanding its mechanism, indications, and safety limits ensures optimal pain management and prevents complications related to improper use.

📚 References

✔ American Academy of Pediatrics. (2023). Pain Management Guidelines for Pediatric Patients. Retrieved from https://www.aap.org

✔ American Academy of Pediatric Dentistry. (2023). Use of Analgesics in Pediatric Dental Care. Retrieved from https://www.aapd.org

✔ U.S. Food and Drug Administration (FDA). (2023). Acetaminophen and Safe Use in Children. Retrieved from https://www.fda.gov

✔ Coelho, M. S., Oliveira, D., & Silva, A. C. (2021). Comparative effectiveness of paracetamol and ibuprofen for post-operative pain in pediatric dental patients. Pediatric Dentistry, 43(1), 45–50.

✔ World Health Organization. (2023). WHO Model List of Essential Medicines for Children – 8th Edition. Retrieved from https://www.who.int

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