Medical Emergencies in Pediatric Dentistry: A Clinical Guide

Medical emergencies in pediatric dentistry require immediate recognition, structured assessment, and prompt intervention to prevent serious complications.

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Although uncommon, emergencies can occur during routine dental procedures, particularly in children with underlying medical conditions, anxiety, or physiological responses to dental treatment.

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Pediatric patients present specific challenges because their physiological responses, medication requirements, and emergency management differ from those of adults. Consequently, every dental professional should be prepared to recognize early warning signs, initiate basic life support, and activate emergency medical services when necessary.
This guide reviews the most relevant medical emergencies in pediatric dental practice, their clinical manifestations, and essential management principles.

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✅ Most Common Medical Emergencies in Pediatric Dentistry
The most clinically relevant emergencies include vasovagal syncope, hypoglycemia, asthma exacerbations, allergic reactions, anaphylaxis, seizures, and airway obstruction.

Emergency	Clinical Manifestations	Initial Management
Vasovagal syncope	Pallor, sweating, nausea, dizziness, transient loss of consciousness.	Stop treatment, place supine, elevate legs, assess airway and breathing.
Hypoglycemia	Sweating, tremors, irritability, confusion, weakness.	Check blood glucose if possible. If conscious and able to swallow, administer oral glucose.
Asthma attack	Wheezing, coughing, dyspnea, chest tightness.	Stop treatment, sit upright, administer prescribed inhaled salbutamol (albuterol).
Allergic reaction	Urticaria, itching, localized swelling.	Discontinue exposure and assess for respiratory or cardiovascular involvement.
Anaphylaxis	Airway swelling, stridor, wheezing, hypotension, or collapse.	Administer intramuscular epinephrine immediately and activate emergency medical services.
Seizure	Uncontrolled movements, altered consciousness, muscle rigidity.	Protect the child from injury, remove dental instruments, maintain airway safety, and time the seizure.
Airway obstruction	Sudden coughing, choking, inability to speak or breathe.	Apply age-appropriate foreign-body airway obstruction maneuvers.

✅ Essential Emergency Management Protocols

A. Anaphylaxis
Anaphylaxis is a life-threatening systemic allergic reaction that may develop rapidly following exposure to medications, latex, or other allergens.
Key management steps:
1. Stop dental treatment and remove the suspected allergen if possible.
2. Activate emergency medical services immediately.
3. Administer intramuscular epinephrine (1 mg/mL) into the anterolateral thigh.
4. Position the child supine with legs elevated, unless breathing difficulty requires a more comfortable position.
5. Provide oxygen and monitor respiratory and cardiovascular function.
6. Repeat epinephrine after 5 minutes if symptoms persist, following the applicable emergency protocol.

Important: Antihistamines are not a substitute for epinephrine and must not delay its administration.

B. Asthma Exacerbation
Asthma attacks may be triggered by anxiety, respiratory infections, or exposure to irritants.
▪️ Stop dental treatment and remove instruments from the mouth.
▪️ Position the child comfortably, preferably upright.
▪️ Administer the child's prescribed short-acting beta-2 agonist, such as salbutamol, using a metered-dose inhaler with a spacer.
▪️ Administer oxygen if hypoxemia or significant respiratory distress is present.
▪️ Activate emergency services if symptoms are severe or fail to improve promptly.

C. Hypoglycemia
Hypoglycemia is particularly relevant in children with diabetes, especially when meals are missed or insulin and food intake are mismatched.
▪️ Recognize early manifestations, including sweating, tremors, irritability, and altered behavior.
▪️ Check blood glucose when equipment is available.
▪️ If the child is conscious and can swallow safely, administer approximately 0.3 g/kg of oral glucose, according to the applicable pediatric protocol.
▪️ Reassess glucose and clinical status.
▪️ If consciousness is impaired or swallowing is unsafe, do not administer anything orally. Activate emergency services and follow the appropriate protocol for glucagon or intravenous glucose.

D. Seizures
Seizures may occur in children with epilepsy, fever-related disorders, or other neurological conditions.
▪️ Stop dental treatment and remove instruments from the oral cavity.
▪️ Protect the child from nearby objects and prevent falls.
▪️ Do not restrain movements or place objects inside the mouth.
▪️ Monitor breathing and record seizure duration.
▪️ After convulsive activity stops, assess the airway and place the child in the recovery position if appropriate.

Emergency referral is essential for a first seizure, prolonged seizure lasting 5 minutes or more, repeated seizures without recovery, respiratory compromise, or significant injury.

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✅ Additional Emergencies Relevant to Dental Procedures

A. Vasovagal Syncope
Syncope is one of the most frequently recognized emergencies in dental settings. It may be associated with fear, pain, emotional stress, or prolonged upright positioning.
Management consists of:
▪️ Discontinuing treatment immediately.
▪️ Placing the child in a supine position with the legs elevated.
▪️ Ensuring airway patency.
▪️ Monitoring pulse, blood pressure, and respiratory status.
▪️ Assessing recovery before considering further treatment.

Persistent unconsciousness, abnormal breathing, or failure to recover promptly requires emergency medical assessment.

B. Local Anesthetic Toxicity
Local anesthetic systemic toxicity (LAST) may result from accidental intravascular injection or excessive dosage relative to body weight.
Early manifestations include:
▪️ Dizziness and lightheadedness.
▪️ Metallic taste or tinnitus.
▪️ Visual disturbances.
▪️ Agitation, confusion, or tremors.
Severe toxicity may progress to seizures, respiratory depression, and cardiovascular instability.
Management requires immediate discontinuation of the anesthetic, airway and breathing support, oxygen administration, and emergency medical activation. Advanced treatment, including lipid emulsion therapy when indicated, should follow an established LAST protocol.

C. Foreign-Body Airway Obstruction
Dental materials and small instruments can become airway hazards, particularly in young children.
Clinical signs include coughing, choking, stridor, inability to speak, and cyanosis.
According to the 2025 AHA/AAP pediatric basic life support guidelines:
▪️ Mild obstruction: encourage coughing and observe closely.
▪️ Infants with severe obstruction: alternate five back blows with five chest thrusts.
▪️ Children with severe obstruction: alternate five back blows with five abdominal thrusts.
▪️ If the child becomes unresponsive, initiate CPR and remove only visible foreign objects.

Blind finger sweeps should never be performed.


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✅ General Emergency Response Protocol
A standardized response helps reduce delays and improves coordination among dental personnel.

Emergency Step	Clinical Actions
1. Recognize the Emergency	Identify abnormal clinical signs and stop dental treatment immediately.
2. Initial Assessment	Assess airway, breathing, circulation, consciousness, and vital signs.
3. Activate the Emergency Team	Assign staff responsibilities and call emergency medical services when indicated.
4. Provide Condition-Specific Care	Administer appropriate emergency medication, oxygen, or basic life support according to the clinical condition.
5. Monitor and Transfer	Continue monitoring and arrange emergency department evaluation when required.

✅ Emergency Equipment and Preparedness
Every pediatric dental office should maintain an age-appropriate emergency kit and equipment suitable for the patient population.
Essential resources include:
▪️ Oxygen delivery system with appropriate masks.
▪️ Bag-valve-mask ventilation equipment.
▪️ Automated external defibrillator (AED), preferably with pediatric pads or attenuator.
▪️ Pulse oximeter and blood pressure monitor.
▪️ Suction equipment and age-appropriate airway adjuncts.
▪️ Epinephrine for anaphylaxis.
▪️ Salbutamol (albuterol) inhaler and spacer.
▪️ Glucose and appropriate hypoglycemia treatment supplies.
▪️ Emergency medications selected according to the office's clinical scope and protocols.

Emergency medications should be clearly labeled, weight-based dosing charts should be readily accessible, and expiration dates should be checked regularly.
Staff training is equally important. Regular simulation exercises and current pediatric basic life support certification help ensure that each team member understands their responsibilities during an emergency.

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💬 Discussion
The management of medical emergencies in pediatric dentistry requires a combination of clinical knowledge, preparation, and coordinated teamwork. Although some events, such as vasovagal syncope, are generally self-limiting, others, including anaphylaxis, severe asthma exacerbations, seizures, and airway obstruction, can rapidly become life-threatening.
An important consideration is the physiological vulnerability of pediatric patients. Respiratory compromise can progress rapidly to cardiovascular deterioration and cardiac arrest. Therefore, early recognition of respiratory distress and prompt intervention are essential.
The 2025 AHA/AAP resuscitation guidelines reinforce the importance of high-quality pediatric CPR, effective ventilation, and early defibrillation when indicated. These recommendations highlight the need for dental professionals to maintain practical resuscitation skills rather than relying exclusively on written emergency protocols.

✍️ Conclusion
Medical emergencies in pediatric dentistry require immediate recognition and an organized clinical response. Anaphylaxis, asthma attacks, hypoglycemia, seizures, syncope, local anesthetic toxicity, and airway obstruction represent important situations that dental professionals must be prepared to manage.
A well-equipped dental office, appropriate emergency medications, regular staff training, and familiarity with pediatric basic life support guidelines are essential components of patient safety. Ultimately, emergency preparedness is a fundamental responsibility of pediatric dental practice.

🎯 Clinical Recommendations
▪️ Establish weight-based emergency medication charts for commonly used pediatric drugs, including epinephrine and rescue medications.
▪️ Conduct periodic emergency simulations involving the entire dental team, including role assignment and communication with emergency services.
▪️ Review each child's medical history before treatment, identifying allergies, asthma, diabetes, seizure disorders, and previous emergency episodes.
▪️ Establish clear criteria for suspending dental treatment and transferring patients to emergency medical facilities.
▪️ Maintain an updated emergency kit and document equipment checks, medication expiration dates, and training activities.

📚 References
✔ American Academy of Pediatric Dentistry. (2025). Management of medical emergencies. In The reference manual of pediatric dentistry (2025–2026 ed., pp. 682–683). American Academy of Pediatric Dentistry. Official AAPD guideline.
✔ Joyner, B. L., Jr., Dewan, M., Bavare, A., de Caen, A., DiMaria, K., Donofrio-Odmann, J., Fosse, G., Haskell, S., Mahgoub, M., Meckler, G., Requist, J., Schexnayder, S. M., Olech Smith, M., Werho, D., & Raymond, T. T. (2025). Part 6: Pediatric basic life support: 2025 American Heart Association and American Academy of Pediatrics guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation, 152(Suppl. 2), S424–S447. https://doi.org/10.1161/CIR.0000000000001370
✔ Resuscitation Council UK. (2021). Emergency treatment of anaphylactic reactions: Guidelines for healthcare providers. Official clinical guideline.
✔ American Academy of Pediatric Dentistry. (n.d.). Medical emergencies in the dental office. AAPD emergency preparedness resources.

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Dentinogenesis Imperfecta: Current Treatment Options

Dentinogenesis imperfecta (DI) is a hereditary developmental disorder characterized by abnormal dentin formation, resulting in discolored teeth, reduced structural integrity, and increased susceptibility to dental wear and fractures. It can affect both primary and permanent dentitions, with clinical severity varying according to the genetic subtype.

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The condition is most frequently associated with pathogenic variants in the DSPP gene and may occur independently or in association with osteogenesis imperfecta, particularly in patients with variants affecting the COL1A1 or COL1A2 genes.

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The primary objectives of dentinogenesis imperfecta treatment are to preserve tooth structure, prevent premature tooth loss, restore masticatory function, improve esthetics, and maintain oral health throughout growth and development.
Management requires an individualized, multidisciplinary approach involving pediatric dentists, restorative dentists, orthodontists, and prosthodontists when necessary.

✅ Treatment Planning According to Dentition Stage
The treatment of dentinogenesis imperfecta should be initiated as early as possible to minimize progressive tooth destruction. Current recommendations emphasize age-specific restorative strategies rather than premature definitive prosthetic rehabilitation.

1. Primary Dentition
The main objectives are to preserve primary teeth, prevent excessive attrition, restore occlusal vertical dimension, and maintain masticatory function.
Recommended approaches include:
▪️ Prefabricated stainless steel crowns: Particularly useful for primary molars with extensive structural damage or significant occlusal wear.
▪️ Direct composite restorations: Indicated for localized defects and anterior teeth when adequate retention and isolation can be achieved.
▪️ Glass ionomer cement: May be used as an interim restorative material when moisture control is limited or as part of a staged treatment approach.
▪️ Preventive care: Regular fluoride application, dietary counseling, and plaque control.
Early full-coverage restoration of severely affected primary molars can help prevent further loss of tooth structure and preserve occlusal relationships.

2. Mixed Dentition and Early Permanent Dentition
During this stage, treatment focuses on protecting erupting permanent teeth and preventing progressive loss of dentin.
Recommended restorative options:
- Direct composite restorations for localized defects.
- Prefabricated stainless steel crowns for affected permanent molars when indicated.
- Individually fabricated indirect restorations for teeth with extensive structural compromise.
- Interim prosthetic or space-maintaining measures when premature extraction of primary teeth becomes necessary.
The 2026 German S3 guideline recommends initiating definitive rehabilitation during the early permanent dentition using a full-mouth rehabilitation approach, adapted to the patient's growth and clinical condition.

3. Adult Permanent Dentition
Once craniofacial growth has been completed, more definitive restorative and prosthodontic procedures can be considered.
Treatment options include:
▪️ Indirect crowns: For posterior teeth with extensive structural damage and progressive wear.
▪️ Direct composite restorations: For selected anterior defects and localized restorative needs.
▪️ Ceramic or other indirect restorations: When appropriate for the remaining tooth structure and occlusal requirements.
▪️ Fixed or removable prostheses: To replace missing teeth and restore occlusal function.
▪️ Implant-supported prostheses: In selected patients after growth completion and comprehensive evaluation.
Posterior rehabilitation should generally be prioritized to stabilize or restore the occlusal vertical dimension before definitive anterior reconstruction.

✅ Current Restorative Treatment Options
The selection of restorative materials depends on tooth structure, dentition stage, occlusal loading, esthetic requirements, and the feasibility of adhesive procedures.

Restorative Option	Main Indication
Stainless Steel Crowns	Extensive damage to primary molars and selected permanent molars.
Direct Composite Resin	Localized defects, anterior restorations, and conservative rehabilitation.
Glass Ionomer Cement	Interim restorations and situations with limited moisture control.
Indirect Resin Crowns	Conservative full-coverage rehabilitation in selected young patients.
Ceramic Crowns	Definitive rehabilitation of structurally compromised permanent teeth.
Fixed or Removable Prostheses	Replacement of missing teeth and restoration of function.

A clinical case published in 2024 demonstrated successful rehabilitation of a 12-year-old patient with DI type II using CAD/CAM nanoceramic resin crowns, with an eight-year follow-up reporting favorable functional and esthetic outcomes. However, this represents case-report evidence rather than proof of superiority over other restorative materials.

✅ Preventive and Supportive Management
Preventive dentistry is essential because patients with dentinogenesis imperfecta may experience extensive tooth wear, structural breakdown, and difficulties maintaining oral health.

Important measures include:
▪️ Regular clinical examinations and individualized recall intervals.
▪️ Professional fluoride application according to caries risk.
▪️ Appropriate home fluoride toothpaste.
▪️ Dietary counseling to reduce frequent exposure to fermentable carbohydrates and acidic beverages.
▪️ Early restoration of structurally compromised teeth.
▪️ Monitoring of occlusal changes and tooth wear.

Long-term preventive care should continue throughout life, even after comprehensive restorative rehabilitation.

✅ Diagnostic and Interdisciplinary Considerations
Before initiating treatment, clinicians should establish the clinical subtype and evaluate possible systemic associations.

Important considerations include:
▪️ Family history and possible autosomal dominant inheritance.
▪️ Genetic evaluation when indicated, particularly involving DSPP, COL1A1, and COL1A2.
▪️ Assessment for associated osteogenesis imperfecta, including skeletal manifestations and relevant medical history.
▪️ Radiographic evaluation of pulp chambers, root morphology, and periapical tissues.
▪️ Assessment of occlusal vertical dimension and the extent of dentin loss.

Genetic testing can help clarify the underlying etiology and distinguish isolated dentinogenesis imperfecta from syndromic presentations.

💬 Discussion
The current management of dentinogenesis imperfecta has shifted toward early intervention, preservation of tooth structure, and staged full-mouth rehabilitation. The objective is not simply to restore tooth appearance but to prevent progressive dentin loss, maintain occlusal stability, and preserve the dentition throughout development.
The 2026 German S3 clinical guideline represents an important development because it provides specific recommendations for DI across different stages of dentition. It supports direct restorations and prefabricated crowns during primary and mixed dentition, followed by individualized indirect restorations and comprehensive prosthodontic rehabilitation during permanent dentition.
An important limitation is that several DI-specific recommendations are supported by very low-certainty evidence despite strong guideline recommendations. Therefore, treatment decisions should consider individual clinical circumstances, long-term prognosis, and the preservation of remaining tooth structure.

✍️ Conclusion
Dentinogenesis imperfecta treatment requires an individualized and long-term restorative strategy. Early intervention with protective restorations, particularly stainless steel crowns in severely affected primary molars, can help prevent further structural deterioration.
During permanent dentition, indirect restorations and comprehensive rehabilitation become increasingly important. The integration of preventive dentistry, genetic evaluation, and multidisciplinary care is essential to maintain oral function, esthetics, and quality of life.

🎯 Clinical Recommendations
1. Prioritize early protection: Restore severely affected primary and permanent molars before extensive occlusal breakdown develops.
2. Preserve tooth structure: Favor minimally invasive restorative procedures whenever clinically feasible.
3. Plan rehabilitation sequentially: Stabilize posterior occlusion and vertical dimension before definitive anterior reconstruction.
4. Consider growth: Avoid definitive prosthodontic solutions that may compromise future dental and craniofacial development.
5. Maintain lifelong surveillance: Monitor restorative integrity, occlusal changes, tooth wear, and periodontal health.

📚 References
✔ Dujic, H., Bücher, K., Schüler, I. M., Schmidt, P., Hertel, S., Timpel, J., Jablonski-Momeni, A., Schilke, R., Kapferer-Seebacher, I., Zschocke, J., Liebermann, A., Güth, J. F., Edelhoff, D., Heinrich-Weltzien, R., & Kühnisch, J. (2026). The German S3-level guideline for the diagnosis and management of rare dental disorders. Clinical Oral Investigations, 30, Article 459. https://doi.org/10.1007/s00784-026-07142-w
✔ Gilani, M., Saikia, A., & Anthonappa, R. (2025). The genetics of non-syndromic dentinogenesis imperfecta: A systematic review. European Archives of Paediatric Dentistry, 26(1), 3–16. https://doi.org/10.1007/s40368-024-00992-6
✔ Casaña-Ruiz, M. D., Frechina, N., Estrela, F., & Catalá-Pizarro, M. (2024). Dentinogenesis imperfecta: Case report with nanoceramic resin crowns restorative treatment. The Journal of Clinical Pediatric Dentistry, 48(2), 189–195. https://doi.org/10.22514/jocpd.2024.047
✔ MedlinePlus Genetics. (n.d.). Dentinogenesis imperfecta. U.S. National Library of Medicine. https://medlineplus.gov/genetics/condition/dentinogenesis-imperfecta/ 020-00333-5

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Pediatric Salivary Gland Disorders: Diagnosis and Management

Salivary gland disorders in children encompass a diverse group of inflammatory, infectious, obstructive, developmental, autoimmune, and neoplastic conditions.

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Although less common than many other oral diseases, they represent an important diagnostic challenge in pediatric dentistry because their clinical manifestations may overlap with lymphadenopathy, odontogenic infections, and other soft tissue lesions.

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The major salivary glands affected include the parotid, submandibular, and sublingual glands, while minor salivary glands may develop localized lesions such as mucoceles.
Early recognition is essential to establish an appropriate differential diagnosis, avoid unnecessary interventions, and identify conditions requiring specialist assessment.
Recent literature emphasizes clinical examination, ultrasonography, and individualized management according to the underlying pathology.

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✅ Classification of Pediatric Salivary Gland Disorders
Pediatric salivary gland pathology can be classified according to its underlying mechanism and clinical presentation.

Category	Main Conditions
Inflammatory	Juvenile recurrent parotitis, chronic sialadenitis
Infectious	Viral parotitis (mumps), acute bacterial sialadenitis
Obstructive	Sialolithiasis, ductal stenosis
Cystic and Traumatic	Mucocele, ranula, salivary duct cyst
Autoimmune	Sjögren syndrome, autoimmune sialadenitis
Neoplastic	Pleomorphic adenoma, mucoepidermoid carcinoma, acinic cell carcinoma

These disorders differ in frequency, clinical behavior, and treatment requirements. In children, non-neoplastic conditions predominate, although neoplastic lesions must remain part of the differential diagnosis.

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✅ Most Common Salivary Gland Disorders in Children

1. Juvenile Recurrent Parotitis (JRP)
Juvenile recurrent parotitis is a recurrent, non-obstructive inflammatory condition affecting primarily the parotid glands. It commonly develops during childhood, particularly in preschool and school-aged patients.

Clinical characteristics:
▪️ Recurrent unilateral or bilateral parotid swelling.
▪️ Pain and tenderness during acute episodes.
▪️ Occasional fever and malaise.
▪️ Episodes may last several days and recur at variable intervals.
Its etiology remains incompletely understood. Immunological factors, developmental abnormalities, and ductal changes have been proposed.

Diagnosis and management:
Ultrasonography is the preferred initial imaging examination and may reveal heterogeneous glandular tissue with multiple small hypoechoic areas.
Treatment is generally conservative, including hydration, analgesics, warm compresses, and gland massage. Antibiotics should be reserved for suspected bacterial superinfection. In patients with frequent or severe recurrences, sialendoscopy and duct irrigation may reduce episode frequency and severity. Many cases improve spontaneously around puberty.

2. Acute Bacterial and Viral Sialadenitis
Sialadenitis refers to inflammation of the salivary gland and may result from infectious or noninfectious causes.
Bacterial sialadenitis is commonly associated with reduced salivary flow, dehydration, or ductal obstruction. Staphylococcus aureus is an important causative organism.

Clinical manifestations include:
▪️ Painful gland enlargement.
▪️ Localized erythema and tenderness.
▪️ Fever and systemic symptoms.
▪️ Purulent discharge from the affected duct in some cases.
Management includes hydration, analgesia, gland massage, and appropriate antibiotic therapy when bacterial infection is suspected. Abscess formation requires specialist assessment and possible drainage.
Viral sialadenitis is frequently associated with mumps virus, although other viral infections may also affect the salivary glands. Mumps typically produces painful parotid enlargement, sometimes bilaterally, accompanied by fever and malaise.
Management is supportive, with hydration, analgesics, and infection-control measures. Antibiotics are not indicated for uncomplicated viral infections.

3. Mucocele
Mucocele is a common benign lesion resulting from trauma or rupture of a minor salivary gland duct, causing mucus accumulation in surrounding connective tissue.
It most frequently affects the lower lip and is characterized by a soft, fluctuant, translucent or bluish swelling.

Management:
Small, superficial mucoceles may resolve spontaneously. Persistent, recurrent, or symptomatic lesions may require surgical excision, generally including the associated minor salivary glands to reduce recurrence.
Histopathological examination is recommended for excised tissue.

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4. Ranula
A ranula is a mucus extravasation lesion originating predominantly from the sublingual gland and presenting as a soft, bluish or translucent swelling in the floor of the mouth.
Larger lesions may interfere with speech, swallowing, and feeding.

Management:
Treatment depends on lesion size, recurrence, and anatomical extension. Surgical management frequently involves removal of the involved sublingual gland, particularly in recurrent or plunging ranulas.
Marsupialization alone may have a higher recurrence rate than procedures addressing the source gland.

5. Sialolithiasis
Sialolithiasis is characterized by the formation of calcified deposits within salivary ducts, producing partial or complete obstruction of salivary flow.
Although less common in children than adults, it can affect the submandibular gland and occasionally the parotid gland.

Typical findings include:
▪️ Recurrent gland swelling during meals.
▪️ Pain associated with salivary stimulation.
▪️ Reduced salivary flow.
▪️ Occasionally, secondary infection.

Management: Initial treatment may include hydration, warm compresses, massage, and sialogogues. Persistent obstruction may require sialendoscopy or minimally invasive stone removal.

6. Autoimmune Salivary Gland Disorders
Autoimmune conditions, particularly Sjögren syndrome, can affect salivary gland function in children.
Although uncommon, pediatric Sjögren syndrome may present with recurrent parotid enlargement, xerostomia, dry eyes, and systemic manifestations.

Clinical assessment may include:
▪️ Evaluation of salivary and lacrimal function.
▪️ Autoantibodies, including anti-SSA/Ro and anti-SSB/La.
▪️ Assessment by pediatric rheumatology when indicated.

Early recognition is important because chronic salivary dysfunction may increase the risk of dental caries, oral discomfort, and difficulties with swallowing.

7. Salivary Gland Neoplasms
Salivary gland tumors are uncommon in children but require particular attention because both benign and malignant lesions occur.

Common benign tumors:
▪️ Pleomorphic adenoma.
▪️ Other benign epithelial neoplasms.

Important malignant tumors:
▪️ Mucoepidermoid carcinoma.
▪️ Acinic cell carcinoma.
▪️ Adenoid cystic carcinoma.

The parotid gland is the most frequently affected major salivary gland. Mucoepidermoid carcinoma is the most common malignant salivary gland tumor in children.
A persistent, painless or progressively enlarging mass should not be assumed to be inflammatory. Facial weakness, numbness, persistent pain, fixation, or associated lymphadenopathy increases concern and warrants prompt specialist evaluation.

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✅ Clinical Diagnosis and Imaging
The diagnostic approach should integrate medical history, physical examination, lesion characteristics, and appropriate imaging.

Clinical examination should assess:
▪️ Location and laterality of gland enlargement.
▪️ Pain, tenderness, and consistency.
▪️ Duration and recurrence of symptoms.
▪️ Salivary flow and ductal discharge.
▪️ Presence of fever or systemic manifestations.
▪️ Oral mucosal changes and associated dental findings.

Imaging considerations:

Diagnostic Method	Main Clinical Application
Ultrasonography	First-line assessment of gland enlargement, cystic lesions, inflammation, and suspected stones.
MRI	Evaluation of deep lesions, tumor extension, and complex soft tissue abnormalities.
CT	Selected cases involving calcifications, suspected complications, or complex anatomy.
Biopsy	Histopathological diagnosis of suspicious or persistent solid lesions.

Ultrasonography is particularly valuable in pediatric patients because it avoids ionizing radiation. MRI provides additional soft tissue characterization when necessary.

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💬 Discussion
Pediatric salivary gland pathology requires a diagnostic approach that considers the patient's age, clinical presentation, anatomical location, and recurrence pattern. Although inflammatory and non-neoplastic disorders represent a substantial proportion of pediatric cases, persistent glandular enlargement should always prompt investigation for structural or neoplastic abnormalities.
Recent evidence supports ultrasonography as the initial imaging modality for most glandular abnormalities. Furthermore, minimally invasive techniques, particularly sialendoscopy, have expanded treatment options for recurrent inflammatory and obstructive conditions.
An important consideration in pediatric dentistry is the distinction between lesions originating from minor salivary glands, such as mucoceles, and diseases affecting major glands, such as juvenile recurrent parotitis. This distinction influences referral decisions, diagnostic procedures, and treatment selection.

✍️ Conclusion
Salivary gland disorders in children encompass a broad spectrum of inflammatory, infectious, obstructive, cystic, autoimmune, and neoplastic conditions. Accurate clinical assessment and appropriate imaging are essential for establishing a differential diagnosis and selecting effective treatment.
Pediatric dentists play an important role in recognizing early manifestations, identifying potentially serious lesions, and coordinating care with pediatricians, oral and maxillofacial surgeons, and otolaryngologists. Persistent or progressive glandular abnormalities require further investigation to exclude significant underlying disease.

🎯 Clinical Recommendations
1. Prioritize anatomical localization: Determine whether the lesion originates from a major or minor salivary gland before establishing a diagnostic approach.
2. Avoid empirical antibiotics without clinical justification: Differentiate bacterial infections from viral and noninfectious inflammatory conditions.
3. Establish follow-up for conservative management: Document lesion dimensions and clinical changes to assess spontaneous resolution or progression.
4. Refer persistent or suspicious masses promptly: Particularly those associated with facial nerve dysfunction, progressive enlargement, fixation, or unexplained pain.
5. Request histopathological examination: Ensure that surgically removed suspicious salivary gland tissue is submitted for definitive diagnosis.

📚 References
✔ Amin, S. N., Patterson, K. T., Cvancara, D. J., & Dahl, J. P. (2024). Pediatric salivary gland pathology. Oral and Maxillofacial Surgery Clinics of North America, 36(3), 317–332. https://doi.org/10.1016/j.coms.2024.02.001
✔ American Academy of Pediatric Dentistry. (2025). Management considerations for pediatric oral pathology. In The Reference Manual of Pediatric Dentistry (pp. 545–550). American Academy of Pediatric Dentistry. https://www.aapd.org/globalassets/media/policies_guidelines/bp_oralpathology25.pdf
✔ Chafin, J. B., & Bayazid, L. (2022). Pediatric salivary gland disease. Pediatric Clinics of North America, 69(2), 363–380. https://doi.org/10.1016/j.pcl.2022.01.004
✔ Kim, M. J., Milliren, A., & Gerold, D. J. (2024). Salivary gland disorders: Rapid evidence review. American Family Physician, 109(6), 550–559. https://www.aafp.org/afp/2024/0600/salivary-gland-disorders
✔ National Cancer Institute. (2024). Childhood salivary gland tumors treatment (PDQ®): Health professional version. https://www.cancer.gov/types/head-and-neck/hp/child/salivary-gland-treatment-pdq
✔ Pereira Martins, M. S., Barros Pereira, L. P. de S., Pereira da Costa, E. M., & Amaral de Vasconcelos Pinheiro Malheiro, A. T. (2026). Juvenile recurrent parotitis: A systematic review of diagnosis and treatment. Birth and Growth Medical Journal, 35(2), 72–83. https://doi.org/10.25753/BirthGrowthMJ.v35.i2.43060

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Bednar's Aphthae: Causes, Diagnosis, and Management

Bednar's aphthae are traumatic oral ulcers that occur primarily in newborns and young infants. They typically develop on the posterior region of the hard palate, near the junction with the soft palate, as a result of repetitive mechanical irritation.

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Although these lesions are generally benign and self-limiting, they may cause discomfort during feeding and require differentiation from other neonatal oral lesions, particularly infectious and congenital conditions.

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Understanding their characteristic location, clinical presentation, and underlying mechanism is essential for establishing an accurate diagnosis and avoiding unnecessary treatment.

✅ Etiology and Pathophysiology
The exact pathogenesis of Bednar's aphthae remains incompletely understood. However, mechanical trauma and repetitive pressure on the palatal mucosa are considered the principal contributing factors.

Commonly associated factors include:
▪️ Bottle-feeding: Repeated contact between the nipple and posterior palate.
▪️ Breastfeeding: Mechanical pressure during sucking.
▪️ Incorrect feeding position: Feeding the infant in a horizontal position may increase palatal pressure.
▪️ Pacifier use: Repetitive friction or pressure against the palatal tissues.
▪️ Nipple characteristics: Inappropriate nipple design or flow may contribute to feeding-related trauma.

The neonatal oral mucosa is particularly susceptible to mechanical injury. Repetitive irritation can result in localized epithelial damage and ulcer formation.

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✅ Clinical Features
Bednar's aphthae have characteristic clinical features that facilitate diagnosis.

▪️ Location: Posterior hard palate, particularly near the junction with the soft palate.
▪️ Appearance: Superficial, shallow ulcerations with whitish or yellowish surfaces.
▪️ Shape: Typically oval or round, sometimes linear.
▪️ Distribution: Frequently bilateral and symmetrical, although unilateral presentations may occur.
▪️ Surrounding tissue: May exhibit a slightly erythematous margin.
▪️ Symptoms: Often asymptomatic, but some infants experience irritability, prolonged feeding time, or reduced milk intake.

Clinical observations reported by Nam et al. (2016) demonstrated that feeding difficulties were common, although some lesions were discovered incidentally during routine examinations.

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✅ Diagnosis
The diagnosis of Bednar's aphthae is primarily clinical, based on the infant's age, characteristic ulcer location, lesion morphology, and feeding history.

A comprehensive oral examination should evaluate:
▪️ Location, number, symmetry, and appearance of the ulcers.
▪️ Presence of erythema, bleeding, or additional oral lesions.
▪️ Feeding techniques, bottle nipple characteristics, and pacifier use.
▪️ Associated symptoms, including fever and feeding intolerance.

Laboratory investigations and biopsies are not routinely indicated when the clinical presentation is characteristic and the infant is otherwise healthy.
However, atypical lesions or systemic symptoms require further evaluation to exclude infectious or other pathological conditions.

✅ Differential Diagnosis
Several neonatal oral conditions may resemble Bednar's aphthae. Accurate differentiation is essential to prevent unnecessary treatment.

Condition	Characteristic Clinical Findings
Bednar's aphthae	Superficial, frequently symmetrical ulcers at the posterior hard palate.
Oral candidiasis	White plaques on the tongue, buccal mucosa, or palate that are not easily removed.
Neonatal herpes simplex	Vesicles progressing to multiple ulcers, often accompanied by systemic symptoms.
Traumatic oral ulcer	Localized ulceration associated with identifiable mechanical injury.
Epstein pearls	Small, white or yellow keratin-filled cysts along the palatal midline; non-ulcerative.
Herpangina	Vesicular and ulcerative lesions predominantly involving the soft palate and posterior oropharynx, often with fever.

Clinical distinction: Bednar's aphthae are generally localized, mechanically associated lesions without systemic manifestations. Fever, widespread oral ulceration, or vesicular lesions should raise suspicion of an alternative diagnosis.

✅ Management and Treatment Bednar's aphthae are benign and generally resolve spontaneously. Treatment focuses on eliminating mechanical irritation rather than prescribing medication.

The following measures are recommended:
1. Correct feeding position: Encourage a semi-upright feeding position to reduce repetitive pressure on the posterior palate.
2. Evaluate bottle-feeding technique: Assess nipple flow, design, and positioning. Correct any feeding difficulties without arbitrarily enlarging the nipple opening.
3. Assess pacifier use: Identify whether the pacifier contributes to repetitive palatal irritation and modify its use when necessary.
4. Monitor oral healing: Reassess the lesions and feeding behavior to ensure progressive improvement.
5. Maintain adequate nutrition: Monitor milk intake, hydration, and weight gain when feeding difficulties are present.

Pharmacological treatment is generally unnecessary. Antibiotics, antifungals, and topical corticosteroids are not indicated for uncomplicated Bednar's aphthae.
Topical anesthetics should not be routinely applied to neonatal oral ulcers because of potential adverse effects.

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✅ Prognosis and Healing
The prognosis of Bednar's aphthae is excellent. Most lesions resolve spontaneously after eliminating the contributing mechanical factors.
Clinical observations indicate that healing generally occurs within one to four weeks, although the recovery period varies according to lesion severity and continued irritation.
Persistent, enlarging, recurrent, or atypical ulcers require reassessment to exclude other conditions.

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💬 Discussion
Bednar's aphthae represent an important diagnostic consideration in neonatal and infant oral pathology. Despite their benign nature, these lesions may be overlooked or mistaken for infectious ulcerative conditions.
The study by Nebgen et al. (2010), involving 1,494 neonates, identified Bednar's aphthae in 15.8% of examined infants whose entire palate could be visualized. This finding suggests that the condition may be more frequent than commonly recognized.
Furthermore, Nam et al. (2016) demonstrated that correcting feeding position and technique was associated with lesion resolution in their retrospective series of 16 infants.
Although the available evidence is limited by relatively small clinical studies and observational designs, findings consistently support mechanical irritation as an important contributing factor.
Early recognition and appropriate parental education are therefore central to conservative management, reducing unnecessary diagnostic procedures and medication use.

✍️ Conclusion
Bednar's aphthae are benign traumatic ulcers affecting the posterior palatal mucosa of newborns and infants. Their characteristic clinical distribution, association with feeding-related mechanical pressure, and spontaneous healing facilitate clinical recognition.
Management should prioritize identifying and eliminating the source of irritation, supporting adequate feeding, and monitoring healing. Recognition of these lesions is essential for avoiding unnecessary pharmacological interventions and ensuring appropriate neonatal oral care.

🎯 Clinical Recommendations
For pediatric dentists and healthcare professionals, the following recommendations support practical clinical management:

▪️ Prioritize clinical diagnosis: Consider Bednar's aphthae when symmetrical posterior palatal ulcers are identified in an otherwise healthy infant.
▪️ Evaluate feeding mechanics: Examine feeding position and the interaction between the nipple or pacifier and palatal tissues.
▪️ Avoid unnecessary medication: Do not prescribe antimicrobial agents for uncomplicated traumatic lesions.
▪️ Establish follow-up: Confirm lesion regression and adequate feeding. Investigate promptly if systemic symptoms, dehydration, or atypical progression occurs.

📚 References
✔ Nam, S. W., Ahn, S. H., Shin, S. M., & Jeong, G. (2016). Clinical features of Bednar's aphthae in infants. Korean Journal of Pediatrics, 59(1), 30–34. https://doi.org/10.3345/kjp.2016.59.1.30
✔ Nebgen, S., Kasper, H. U., Schäfer, D., Christ, H., & Roth, B. (2010). Bednar's aphthae in neonates: Incidence and associated factors. Neonatology, 98(2), 208–211. https://doi.org/10.1159/000285523
✔ Pedra, C., Terra, C. M., Ejzenberg, B., Baldacci, E. R., & Okay, Y. (1996). Oral palatine ulcers of a traumatic nature in infants: Bednar's aphthae. International Journal of Pediatric Otorhinolaryngology, 35(1), 39–49. https://doi.org/10.1016/0165-5876(95)01282-6
✔ Chaudhry, A. (2021). Infantile Bednar's aphthae. Journal of Paediatrics and Child Health, 57(10), 1717. https://doi.org/10.1111/jpc.1_15383

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Oral Cavity Embryology: Key Stages and Clinical Facts

The embryological development of the oral cavity is a coordinated process involving the ectoderm, endoderm, mesoderm, and cranial neural crest cells.

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These tissues contribute to the formation of the oral mucosa, tongue, palate, jaws, and teeth. Understanding these developmental stages is essential for recognizing congenital abnormalities and interpreting their clinical implications in dentistry.

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✅ Formation of the Primitive Oral Cavity
The primitive mouth, known as the stomodeum, appears during early embryonic development, around the third week after fertilization. It is initially separated from the primitive pharynx by the oropharyngeal membrane, which subsequently breaks down, establishing communication between the two spaces.
During weeks 4–8, the facial prominences surrounding the stomodeum grow and merge through coordinated tissue growth and fusion. These structures contribute to the formation of the upper and lower lips, jaws, and other components of the developing oral region.

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✅ Development of the Main Oral Structures

1. Palate
The palate develops through the formation of two embryologically distinct components:

a. Primary palate: Derived from the intermaxillary segment formed by the fusion of the medial nasal prominences. It contributes to the anterior portion of the maxilla, including the region of the upper incisors.
b. Secondary palate: Develops from paired palatal shelves arising from the maxillary prominences. These shelves elevate, approach one another, and fuse at the midline, separating the oral and nasal cavities.

Palatal development occurs primarily during weeks 6–12. Disruption of growth or fusion can result in cleft palate (Hammond & Dixon, 2022).

2. Tongue
Tongue development begins around the fourth week and involves contributions from several pharyngeal arches.

a. Anterior two-thirds: Develop primarily from the first pharyngeal arch.
b. Posterior one-third: Develops mainly from the third pharyngeal arch, with contributions from the second and fourth arches to specific regions.
c. Muscles: Originate predominantly from migrating occipital myoblasts.

The complex embryological origin of the tongue explains its distinct sensory, motor, and gustatory innervation patterns (Jain & Rathee, 2023).

3. Jaws and Teeth
The maxilla and mandible develop largely from neural crest-derived mesenchyme associated with the first pharyngeal arch. The mandible forms primarily through intramembranous ossification, while the maxilla also develops predominantly through intramembranous ossification.
Tooth development begins around the sixth week of embryonic development with the formation of the dental lamina, an epithelial thickening that initiates odontogenesis. Tooth germs subsequently progress through the bud, cap, and bell stages.
Interactions between oral epithelium and neural crest-derived ectomesenchyme regulate tooth morphology and the differentiation of ameloblasts and odontoblasts, which produce enamel and dentin, respectively (Jussila & Thesleff, 2012; Peterková et al., 2018).

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✅ Summary of Embryological Development

Structure	Developmental Origin or Process	Clinical Relevance
Stomodeum	Primitive oral depression	Establishes the initial oral region
Palate	Growth and fusion of primary and secondary components	Cleft lip and palate
Tongue	Contributions from pharyngeal arches and occipital myoblasts	Congenital tongue abnormalities
Jaws	Neural crest-derived mesenchyme and ossification	Craniofacial skeletal anomalies
Teeth	Dental lamina and epithelial–mesenchymal interactions	Agenesis, supernumerary teeth, and structural anomalies

💬 Clinical Discussion
The embryology of the oral cavity provides a foundation for understanding congenital craniofacial anomalies. Cleft lip and palate are associated with disturbances in facial development and tissue fusion, whereas abnormalities in odontogenesis can affect tooth number, shape, and structure.
Current research emphasizes the role of genetic regulation and signaling pathways, including SHH, BMP, FGF, and WNT, in coordinating craniofacial development. These mechanisms help explain why developmental disturbances may affect several related anatomical structures rather than a single tissue (Hammond & Dixon, 2022).

✍️ Conclusion
The oral cavity develops through coordinated interactions between embryonic tissues, facial prominences, and pharyngeal arches. Palatogenesis, tongue formation, jaw development, and odontogenesis are particularly important processes in dental embryology. Knowledge of these mechanisms supports the identification and understanding of congenital abnormalities and strengthens the scientific basis of clinical dental practice.

💡 Clinical Pearls
▪️ Cleft lip and cleft palate are developmentally distinct conditions: they involve different anatomical processes, although they can occur together.
▪️ Tooth agenesis and morphological anomalies may reflect disturbances in early odontogenesis, particularly in regions associated with facial prominence fusion.
▪️ Developmental timing matters: identifying the embryological process affected can help explain the anatomical pattern of a congenital anomaly.

📚 References
✔ Hammond, N. L., & Dixon, M. J. (2022). Revisiting the embryogenesis of lip and palate development. Oral Diseases, 28(5), 1306–1326. https://doi.org/10.1111/odi.14174
✔ Jain, P., & Rathee, M. (2023). Embryology, tongue. In StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK547697/
✔ Jussila, M., & Thesleff, I. (2012). Signaling networks regulating tooth organogenesis and regeneration, and the specification of dental mesenchymal and epithelial cell lineages. Cold Spring Harbor Perspectives in Biology, 4(4), Article a008425. https://doi.org/10.1101/cshperspect.a008425
✔ Peterková, R., Lesot, H., Peterka, M., & Hovorakova, M. (2018). Early development of the human dentition revisited. Journal of Anatomy, 233(2), 135–145. https://doi.org/10.1111/joa.12825

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Most Common Oral Mucosal Lesions in Children: A Clinical Guide

Oral mucosal lesions in children include inflammatory, infectious, traumatic, and developmental conditions that may affect the tongue, lips, gingiva, palate, and buccal mucosa.

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Although most are benign and self-limiting, accurate diagnosis is essential to distinguish common conditions from manifestations of systemic disease or lesions requiring further investigation.

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A scoping review of pediatric oral mucosal disorders identified aphthous ulcers, traumatic lesions, and herpes simplex virus–associated lesions among the most frequently observed conditions in clinical studies. However, prevalence varies according to age, population, and diagnostic criteria.

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✅ Most Common Oral Mucosal Lesions in Children
The following table summarizes the principal conditions, their characteristic clinical findings, and key management considerations.

Condition	Clinical features	Management considerations
Recurrent aphthous stomatitis	Painful, round or oval ulcers with a whitish-yellow base and erythematous halo, usually on non-keratinized mucosa.	Symptomatic relief; investigate frequent, severe, or persistent episodes for possible underlying factors.
Traumatic ulcers	Localized ulcers or erosions associated with biting, sharp teeth, appliances, or thermal injury.	Remove the source of trauma and monitor healing.
Primary herpetic gingivostomatitis	Multiple vesicles and ulcers, diffuse gingival inflammation, fever, malaise, and possible difficulty drinking.	Hydration and pain control; consider early systemic antiviral therapy in selected cases according to clinical assessment.
Oral candidiasis	White plaques that can be wiped away, typically leaving an erythematous surface underneath.	Assess predisposing factors; use antifungal treatment when indicated.
Geographic tongue	Migrating, irregular erythematous areas with pale borders on the dorsal tongue.	Usually reassurance; manage sensitivity if symptomatic.
Mucocele	Soft, dome-shaped, often bluish or translucent swelling, commonly on the lower lip.	Assess persistence and recurrence; consider referral for definitive diagnosis and treatment.
Hand-foot-and-mouth disease and herpangina	Oral vesicles or ulcers, often accompanied by fever; hand-foot-and-mouth disease may also cause skin lesions on the hands and feet.	Supportive care, fluids, and age-appropriate analgesia.

Sources: American Academy of Pediatric Dentistry (AAPD, 2025) and peer-reviewed reviews of childhood oral mucosal lesions.

✅ Clinical Assessment and Differential Diagnosis
The diagnosis of oral mucosal lesions in children should be based on medical and dental history, lesion morphology, anatomical location, duration, recurrence, and associated systemic symptoms. Important diagnostic considerations include:

▪️ Ulcers: Differentiate recurrent aphthous stomatitis from traumatic ulcers, primary herpes infection, and enteroviral disease.
▪️ White lesions: Determine whether plaques can be removed and whether the underlying mucosa is erythematous. Consider candidiasis and other white mucosal conditions.
▪️ Tongue changes: Geographic tongue is usually benign, whereas persistent or unexplained changes require further evaluation.
▪️ Soft-tissue swellings: Consider mucoceles, reactive lesions, and other benign or, rarely, neoplastic conditions.

A lesion that does not resolve after its suspected cause has been eliminated, particularly one persisting for approximately two weeks or longer, warrants reassessment and consideration of referral or biopsy, depending on its clinical features. Fever, dehydration, rapidly progressive swelling, immunocompromise, or difficulty swallowing requires prompt evaluation.

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💬 Discussion
The clinical importance of pediatric oral mucosal lesions lies in their diverse etiologies and overlapping presentations. Recurrent aphthous stomatitis and traumatic lesions are common findings, but infections such as primary herpetic gingivostomatitis and enteroviral disease may require additional assessment because of systemic symptoms and the risk of dehydration.
Epidemiological findings should be interpreted cautiously. In a scoping review encompassing 85,976 children in clinical studies, aphthous ulcerations had a pooled relative frequency of 1.82%, while trauma-associated and herpes simplex virus–associated lesions each accounted for 1.33%. These estimates describe the included study populations and should not be interpreted as universal prevalence figures.
The American Academy of Pediatric Dentistry (AAPD) emphasizes systematic examination, documentation, differential diagnosis, and appropriate referral. Although most pediatric oral lesions are benign, persistent, atypical, or progressive lesions should not be assumed to be harmless without adequate assessment.

🎯 Clinical Recommendations
▪️ Perform a systematic examination of all oral mucosal surfaces during pediatric dental visits.
▪️ Document lesion size, location, appearance, duration, symptoms, and recurrence to support clinical monitoring.
▪️ Select treatment according to the suspected etiology; avoid unnecessary antibiotics for viral or noninfectious lesions.
▪️ Prioritize hydration and pain control in children with extensive painful ulcerations.
▪️ Arrange timely referral when the diagnosis remains uncertain or the lesion is persistent, indurated, bleeding, enlarging, or otherwise atypical.

✍️ Conclusion
Oral mucosal lesions in children are frequently benign, but their clinical presentation can overlap with infectious, traumatic, inflammatory, and systemic conditions. Recurrent aphthous stomatitis, traumatic ulcers, and herpes-associated lesions are among the most frequently reported disorders. Accurate diagnosis, appropriate symptom management, and timely referral of suspicious lesions are essential components of pediatric dental care.

📚 References
✔ American Academy of Pediatric Dentistry. (2025). Management considerations for pediatric oral pathology. In The Reference Manual of Pediatric Dentistry. https://www.aapd.org/research/oral-health-policies--recommendations/management-considerations-for-pediatric-oral-surgery-and-oral-pathology2/
✔ Hong, C. H. L., Dean, D. R., Hull, K., Hu, S. J., Sim, Y. F., Nadeau, C., Gonçalves, S., Lodi, G., & Hodgson, T. A. (2019). World Workshop on Oral Medicine VII: Relative frequency of oral mucosal lesions in children, a scoping review. Oral Diseases, 25(Suppl. 1), 193–203. https://doi.org/10.1111/odi.13112
✔ Owczarek-Drabińska, J. E., Nowak, P., Zimoląg-Dydak, M., & Radwan-Oczko, M. (2022). The prevalence of oral mucosa lesions in pediatric patients. International Journal of Environmental Research and Public Health, 19(18), Article 11277. https://doi.org/10.3390/ijerph191811277
✔ Yuhan, B. T., Svider, P. F., Mutchnick, S., & Sheyn, A. (2018). Benign and malignant oral lesions in children and adolescents: An organized approach to diagnosis and management. Pediatric Clinics of North America, 65(5), 1033–1050. https://doi.org/10.1016/j.pcl.2018.05.013

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