Cold sores, canker sores, and oral thrush are among the most frequent oral lesions, often mistaken for one another.
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✅ Introduction
Oral lesions are common in dentistry and general practice. Cold sores (herpes labialis), canker sores (recurrent aphthous stomatitis), and oral thrush (candidiasis) are frequent conditions, but they differ in etiology: viral, inflammatory, and fungal, respectively. Correct identification is essential for adequate management, prevention, and recurrence control.
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➤ Etiology
Caused by herpes simplex virus type 1 (HSV-1).
➤ Signs and Symptoms
° Prodromal stage: tingling, itching, or burning on the lip.
° Lesion: grouped vesicles on the vermilion border that ulcerate and form crusts.
➤ Diagnosis
Mainly clinical; PCR or serology can be used in atypical cases.
➤ Treatment
° Adults: oral or topical antivirals (acyclovir, valacyclovir).
° Children: symptomatic management; antivirals in severe cases.
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➤ Etiology
Multifactorial: genetic predisposition, nutritional deficiencies (iron, folic acid, vitamin B12), trauma, or stress.
➤ Signs and Symptoms
° Round, painful ulcers with a white-yellow base and red halo.
° Pain can impair eating and speaking.
➤ Diagnosis
Clinical, based on ulcer morphology and absence of vesicular stage.
➤ Treatment
° Adults and children: antiseptic rinses (chlorhexidine), topical anesthetics (lidocaine), and topical corticosteroids for severe episodes.
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➤ Etiology
Fungal infection caused by Candida albicans. Risk factors: immunosuppression, antibiotic use, inhaled corticosteroids, dentures.
➤ Signs and Symptoms
° Forms:
- Pseudomembranous: removable white plaques with red underlying mucosa.
- Atrophic: painful red mucosa.
- Hyperplastic: non-removable white lesions.
➤ Diagnosis
Mainly clinical; confirmed with exfoliative cytology or fungal culture.
➤ Treatment
° Adults: topical antifungals (nystatin, miconazole) or systemic antifungals (fluconazole) in resistant cases.
° Children: oral suspension of nystatin.
📊 Comparative Table: Cold Sore, Canker Sore, and Oral Thrush
💬 Discussion
Although similar in appearance, these conditions can be clearly distinguished through careful clinical evaluation. Cold sores show a vesicular stage and recurrence, canker sores are isolated painful ulcers without vesicles, and oral thrush presents as persistent plaques or erythematous mucosa. Treatment differs according to etiology, highlighting the need for precise diagnosis and tailored therapy in both children and adults.
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Recognizing the differences between cold sores, canker sores, and oral thrush ensures appropriate treatment and reduces recurrence or complications. Patient education, preventive measures, and early evaluation remain key in managing these frequent oral conditions.
📚 References
✔ Arduino, P. G., & Porter, S. R. (2008). Herpes Simplex Virus Type 1 infection: overview on relevant clinico-pathological features. Journal of Oral Pathology & Medicine, 37(2), 107-121. https://doi.org/10.1111/j.1600-0714.2007.00586.x
✔ Belenguer-Guallar, I., Jiménez-Soriano, Y., & Claramunt-Lozano, A. (2014). Treatment of recurrent aphthous stomatitis. A literature review. Journal of Clinical and Experimental Dentistry, 6(2), e168–e174. https://doi.org/10.4317/jced.51402
✔ Scully, C., & Porter, S. (2008). Oral candidosis: current concepts in pathogenesis and therapy. Dental Update, 35(9), 606-612. https://doi.org/10.12968/denu.2008.35.9.606
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