Herpangina in Children: Causes, Symptoms, and Treatment of This Viral Infection

Herpangina is a common viral illness that primarily affects children under the age of five. It is marked by a sudden onset of fever, sore throat, and small ulcers or blisters in the back of the mouth—typically on the soft palate, uvula, and tonsils.

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Although self-limiting, early recognition is crucial to manage symptoms and prevent complications such as dehydration.

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✅ What Is Herpangina?
Herpangina is an acute viral infection characterized by painful mouth ulcers and systemic symptoms such as fever and malaise. It typically affects the posterior region of the oral cavity and is most prevalent during summer and early fall in the United States.

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✅ Causes (Etiology)
Herpangina is caused primarily by Coxsackievirus A, though other enteroviruses like Coxsackie B and echoviruses may also be responsible. These viruses spread easily through:

° Fecal-oral route
° Respiratory droplets
° Contaminated surfaces (e.g., toys, utensils)

Outbreaks are common in daycare centers and preschools (Khetsuriani et al., 2006).

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✅ Symptoms and Clinical Features
The condition develops rapidly and typically includes:

° High fever (101–104°F / 38.5–40°C)
° Sore throat and painful swallowing
° Loss of appetite
° Irritability
° Abdominal pain (occasionally)

➤ Oral findings appear within 24–48 hours:

° Small, fluid-filled blisters (1–2 mm) on the soft palate, uvula, and tonsils
° Blisters rupture into shallow ulcers with red halos
° Symptoms usually resolve in 5 to 7 days

Unlike hand, foot, and mouth disease, herpangina typically does not involve skin rashes or lesions on the hands and feet (Puenpa et al., 2019).

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✅ Differential Diagnosis
Conditions that may resemble herpangina include:

° Primary herpetic gingivostomatitis
° Strep throat (streptococcal pharyngitis)
° Infectious mononucleosis
° Hand-foot-and-mouth disease

Diagnosis is clinical and based on the child’s age, symptom pattern, and the appearance of the lesions. Lab tests are rarely needed.

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✅ Treatment
There is no specific antiviral medication for herpangina. Treatment focuses on supportive care:

➤ Hydration: Encourage frequent sips of water or electrolyte solutions
➤ Pain relief: Acetaminophen or ibuprofen for fever and sore throat
➤ Soft, cold foods: Popsicles, smoothies, and yogurt to reduce discomfort
➤ Avoid acidic or spicy foods: These may worsen oral pain

Antibiotics are not effective and should not be used unless there is a confirmed secondary bacterial infection.

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✅ Prevention
Key preventive strategies include:

° Frequent handwashing with soap and water
° Avoiding the sharing of utensils or cups
° Disinfecting surfaces and toys
° Keeping infected children home during the contagious period

There is no vaccine specifically for herpangina, though vaccine research targeting certain enteroviruses is ongoing in high-incidence regions.

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💬 Discussion
While herpangina is generally mild, it can be distressing for both children and parents due to painful symptoms and feeding difficulties. In some cases—especially in younger children—dehydration may require medical attention. Additionally, misdiagnosis can lead to inappropriate use of antibiotics, contributing to antibiotic resistance.
Public health education for caregivers and accurate clinical guidance are essential to avoid unnecessary treatments and improve patient outcomes. Healthcare providers should offer clear instructions for at-home care and signs that warrant medical evaluation.

💡 Conclusion
Herpangina is a self-limiting viral illness in children caused by enteroviruses such as Coxsackievirus A. It presents with fever, sore throat, and ulcers in the back of the mouth. Management is supportive, focusing on hydration and pain relief. Understanding its symptoms, transmission, and proper care helps reduce complications and prevents unnecessary medical interventions.

📚 References

✔ Khetsuriani, N., Lamonte-Fowlkes, A., Oberst, S., & Pallansch, M. A. (2006). Enterovirus surveillance—United States, 1970–2005. MMWR Surveillance Summaries, 55(8), 1–20. https://www.cdc.gov/mmwr/preview/mmwrhtml/ss5508a1.htm

✔ Puenpa, J., Vongpunsawad, S., & Poovorawan, Y. (2019). Enterovirus infections in children with herpangina and hand, foot, and mouth disease in Thailand, 2012–2018. Virology Journal, 16(1), 1–10. https://doi.org/10.1186/s12985-019-1202-0

✔ National Institutes of Health. (2022). Herpangina. MedlinePlus Medical Encyclopedia. https://medlineplus.gov/ency/article/001366.htm

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How to Correct Harmful Oral Habits in Children That Affect Facial and Dental Development

Early childhood is a critical period for craniofacial and dental development. Certain harmful oral habits, such as thumb sucking, mouth breathing, or nail biting, can interfere with proper facial growth and tooth alignment.

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If not addressed early, these habits may lead to malocclusion, facial asymmetry, and the need for complex orthodontic treatment later in life. This article outlines the most common harmful oral habits in children, their effects on dental and facial development, and effective evidence-based treatment strategies.

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✅ Common Harmful Oral Habits in Children: Definitions and Treatments

1. Thumb Sucking
➤ Definition:
° A repetitive behavior in which the child inserts one or more fingers into the mouth, usually for comfort or stress relief.
➤ Potential Effects:
° Anterior open bite
° Protrusion of upper front teeth
° Underdeveloped lower jaw
° Improper lip seal
➤ Treatment Options:
° Positive reinforcement techniques (e.g., reward charts)
° Behavior tracking with family support
° Intraoral appliances (e.g., palatal crib or tongue rake) in persistent cases
° Psychological support for anxiety-linked cases (Barbería et al., 2021)

2. Prolonged Pacifier or Bottle Use
➤ Definition:
° Using a pacifier or bottle beyond age 2–3, leading to non-nutritive sucking behavior.
➤ Potential Effects:
° Anterior open bite
° Posterior crossbite
° High, narrow palate
➤ Treatment Options:
° Parent education on weaning by age 2
° Gradual transition to cups and comfort objects
° Orthodontic intervention if malocclusion persists
° Oral muscle training to improve lip seal and tongue posture

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3. Tongue Thrust (Atypical Swallowing)
➤ Definition:
° Pushing the tongue against or between the teeth when swallowing or speaking, instead of placing it against the palate.
➤ Potential Effects:
° Anterior open bite
° Gaps between front teeth
° Weak orofacial muscles
➤ Treatment Options:
° Orofacial myofunctional therapy (OMT)
° Palatal cribs or tongue spurs if habit continues past age 6
° Collaboration with a speech-language pathologist
° Long-term monitoring by pediatric dentist or orthodontist

4. Mouth Breathing
➤ Definition:
° Breathing through the mouth instead of the nose, often due to nasal obstruction or habit.
➤ Potential Effects:
° Long face syndrome
° Incompetent lips (open mouth posture)
° Narrow upper jaw and posterior crossbite
° High-arched palate
➤ Treatment Options:
° ENT evaluation for nasal or adenoid obstruction
° Palatal expansion in cases of narrow maxilla
° Orofacial therapy to re-establish nasal breathing
° Nasal hygiene and breathing retraining exercises

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5. Nail Biting (Onychophagia)
➤ Definition:
° A compulsive habit of biting or chewing nails, often triggered by stress or anxiety.
➤ Potential Effects:
° Tooth wear or misalignment
° Microfractures in front teeth
° Risk of infections around the mouth
° Jaw tension or muscle strain
➤ Treatment Options:
° Behavioral strategies (e.g., bitter nail polish, habit reversal training)
° Psychological support if anxiety-related
° Orofacial therapy to manage perioral muscle tension
° Parental coaching and support at home and school (Maia et al., 2019)

✅ Diagnosis
A thorough diagnosis involves both physical and behavioral evaluation:
Comprehensive dental and facial exam
History of the habit (age of onset, frequency, triggers)
Functional assessment of breathing, swallowing, and oral posture
Referral to ENT, speech therapist, or child psychologist if needed

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💬 Discussion
Persistent oral habits beyond ages 3–4 can significantly impact a child's bite, facial symmetry, and speech development. Studies have shown that early intervention is key, ideally before age 6, when craniofacial structures are still adaptable (Grippaudo et al., 2020; Souki et al., 2019).
Most habits can be addressed successfully through behavioral therapy and parent involvement. In more severe cases, interceptive orthodontics or interdisciplinary care may be required. Educating caregivers is essential for consistent support at home.

💡 Conclusion
Harmful oral habits can disrupt normal facial and dental development if not treated in time. Each habit presents specific risks and requires a tailored treatment approach. Early identification, behavioral guidance, and, when necessary, interdisciplinary therapy, offer the best outcomes. Prevention and early parental education remain the most effective tools in managing these behaviors.

📚 References

✔ Barbería, E., Lucavechi, T., & Suárez-Clúa, M. C. (2021). Clinical Pediatric Dentistry. Elsevier España.

✔ Grippaudo, C., Paolantonio, E. G., Antonini, G., Saulle, R., La Torre, G., & Deli, R. (2020). Association between oral habits, mouth breathing and malocclusion. Acta Otorhinolaryngologica Italica, 40(5), 282–289. https://doi.org/10.14639/0392-100X-N0616

✔ Souki, B. Q., Pimenta, G. B., Souki, M. Q., Franco, L. P., Becker, H. M. G., & Pinto, J. A. (2019). Prevalence of malocclusion among mouth breathing children: do expectations meet reality? International Journal of Pediatric Otorhinolaryngology, 119, 146–150. https://doi.org/10.1016/j.ijporl.2019.01.032

✔ Viggiano, D., Fasano, D., Monaco, G., & Strohmenger, L. (2020). Oral habits and orthodontic anomalies in preschool children. International Journal of Paediatric Dentistry, 30(3), 326–333. https://doi.org/10.1111/ipd.12594

✔ Maia, B. R., Marques, D. R., & Barbosa, F. (2019). Nail biting in children: an integrative review. Psicologia: Reflexão e Crítica, 32(1), 1–9. https://doi.org/10.1186/s41155-019-0116-1

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Acetaminophen for Kids: Safe Pain Relief in Pediatric Dental Patients

Effective pain control is essential in pediatric dentistry to promote positive dental experiences and reduce anxiety.

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Among over-the-counter analgesics, acetaminophen (paracetamol) is widely regarded as a safe and effective option for managing mild to moderate dental pain in children. Its favorable safety profile and accessibility make it a cornerstone in everyday pediatric dental care in the United States.

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✅ Mechanism of Action
Acetaminophen primarily works by inhibiting the cyclooxygenase (COX) enzymes in the central nervous system, particularly COX-3. This reduces the production of prostaglandins, resulting in analgesic and antipyretic effects. Unlike nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen has minimal anti-inflammatory activity, making it suitable when pain relief is needed without gastrointestinal side effects.

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✅ Recommended Pediatric Dosage
According to the American Academy of Pediatrics (AAP) and the U.S. Food and Drug Administration (FDA), the following pediatric dosage guidelines apply:

➤ Oral Dosage for Children:
° 10–15 mg/kg per dose every 4 to 6 hours as needed.
° Maximum Daily Dose: 75 mg/kg/day or no more than 4,000 mg/day (whichever is lower).
➤ Common Forms in the U.S.:
° Infant drops (160 mg/5 mL)
° Children's syrup (160 mg/5 mL)
° Chewable tablets (usually 80 mg or 160 mg)
° Suppositories (vary by age and weight)
Example: A child weighing 44 lbs (20 kg) can receive 200–300 mg per dose every 6 hours, with a maximum of 1,200 mg in 24 hours.

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✅ Contraindications and Warnings
While acetaminophen is generally safe, there are important situations where its use must be carefully considered:

➤ Absolute Contraindications:
° Known allergy or hypersensitivity to acetaminophen
° Severe liver disease or hepatic failure
➤ Caution in the Following Cases:
° Chronic malnutrition or dehydration
° Use in neonates (requires adjusted dosing and close monitoring)
° Accidental overdose due to combination with other OTC medications containing acetaminophen
Important: Caregivers should be educated to avoid combining multiple products (e.g., cold medications) that may contain acetaminophen.

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✅ Clinical Evidence in Pediatric Dentistry
Recent studies support acetaminophen’s effectiveness in managing dental pain in children, especially following common procedures such as extractions, pulp therapy, or trauma management.
A clinical trial by Coelho et al. (2021) found that acetaminophen provided pain relief equivalent to ibuprofen after dental procedures in children, with fewer gastrointestinal side effects. The American Academy of Pediatric Dentistry (AAPD, 2023) also endorses acetaminophen as the first-line analgesic for young children or those who cannot take NSAIDs.

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💬 Discussion Acetaminophen remains a go-to option in pediatric dental care due to its strong safety profile and efficacy. Weight-based dosing is essential, and dental professionals must provide clear instructions to caregivers to prevent misuse or overdose. In some cases of moderate to severe inflammation, NSAIDs may offer superior pain control, but acetaminophen is often preferred in children due to fewer side effects.
Combination therapy (e.g., acetaminophen plus ibuprofen) may be considered in select cases under dental supervision.

💡 Conclusion
Acetaminophen is a safe and effective pain reliever for pediatric dental patients when used at the correct dosage and with proper caregiver guidance. Understanding its mechanism, indications, and safety limits ensures optimal pain management and prevents complications related to improper use.

📚 References

✔ American Academy of Pediatrics. (2023). Pain Management Guidelines for Pediatric Patients. Retrieved from https://www.aap.org

✔ American Academy of Pediatric Dentistry. (2023). Use of Analgesics in Pediatric Dental Care. Retrieved from https://www.aapd.org

✔ U.S. Food and Drug Administration (FDA). (2023). Acetaminophen and Safe Use in Children. Retrieved from https://www.fda.gov

✔ Coelho, M. S., Oliveira, D., & Silva, A. C. (2021). Comparative effectiveness of paracetamol and ibuprofen for post-operative pain in pediatric dental patients. Pediatric Dentistry, 43(1), 45–50.

✔ World Health Organization. (2023). WHO Model List of Essential Medicines for Children – 8th Edition. Retrieved from https://www.who.int

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Effective Pediatric Oral Surgery Management: Proven Strategies for a Positive Experience

Oral surgery in children—such as extractions, frenectomies, and removal of supernumerary teeth—presents unique challenges. These include dental anxiety, limited communication abilities, and emotional sensitivity.

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A successful surgical experience depends on more than clinical technique; it also relies on emotional support, behavior management, and a child-friendly environment. Dental providers must apply comprehensive strategies that meet the developmental, emotional, and psychological needs of young patients.

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✅ Pediatric Patient Characteristics in Oral Surgery
Children differ significantly from adults in their response to clinical settings:

° Cognitive development affects their understanding of dental procedures.
° Emotional response includes fear of pain, separation anxiety, and past traumatic experiences.
° Communication skills are often limited, especially in younger children.
° Recognizing these traits is critical in developing patient-centered care strategies.

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✅ Strategies for a Positive Pediatric Oral Surgery Experience

1. Comprehensive Preoperative Assessment
Key steps include:

° Assessing dental anxiety using tools like the Venham Picture Test or FLACC scale.
° Reviewing prior dental experiences and behavior patterns.
° Providing child-friendly explanations with visual aids and interactive models.

2. Behavior Management Techniques
Recommended by the American Academy of Pediatric Dentistry (AAPD):

° Tell-Show-Do: Builds trust and predictability.
° Positive reinforcement: Verbal praise, stickers, or small rewards.
° Voice control: Calm but firm tone to guide behavior.
° Distraction: Videos, music, or storytelling to divert attention.
° Parental presence: Used selectively based on the child's needs and behavior.

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3. Pharmacologic Management
Used when non-pharmacological techniques are insufficient:

° Nitrous oxide sedation: Safe and widely used for mild to moderate anxiety.
° Oral sedation: Midazolam and similar agents for more significant anxiety.
° General anesthesia: Reserved for extensive procedures or severe dental phobia, typically in a hospital setting.

4. Child-Friendly Dental Environment
Environmental modifications include:

° Soft colors and playful decor in the operatory.
° Dental tools with friendly designs or names.
° Friendly, trained staff skilled in pediatric communication.

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5. Effective Communication with Children and Parents
Strong communication builds trust and improves cooperation:

° Clear and simple explanations tailored to the child’s developmental level.
° Transparent discussion of surgical procedures and aftercare with parents.
° Giving the child limited choices (e.g., music selection) to increase their sense of control.

💬 Discussion
Research shows that untreated dental fear in childhood often continues into adulthood, negatively affecting oral health outcomes (Klingberg & Broberg, 2022). Combining behavior management with appropriate sedation techniques significantly reduces anxiety and improves surgical cooperation (Olumide et al., 2021). A child-focused, holistic approach is increasingly recognized as the gold standard in pediatric oral surgery, emphasizing both technical excellence and emotional support.

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💡 Conclusions
Successful pediatric oral surgery involves more than technical skill. It requires tailored strategies that consider each child’s emotional, psychological, and developmental needs. The integration of behavior management, pharmacological tools, environmental modifications, and effective communication fosters a positive experience that encourages lifelong oral health habits.

📚 References

✔ American Academy of Pediatric Dentistry. (2023). Behavior Guidance for the Pediatric Dental Patient. The Reference Manual of Pediatric Dentistry. https://www.aapd.org/globalassets/media/policies_guidelines/bp_behavior.pdf

✔ Klingberg, G., & Broberg, A. G. (2022). Dental fear/anxiety and dental behaviour management problems in children and adolescents: A review of prevalence and concomitant psychological factors. International Journal of Paediatric Dentistry, 32(1), 3–9. https://doi.org/10.1111/ipd.12898

✔ Olumide, F., Costa, L. R., & Almeida, E. S. (2021). Behavioral techniques versus pharmacological management in pediatric dental sedation: A systematic review. Pediatric Dentistry, 43(2), 97–105. https://www.aapd.org/research/oral-health-policies--recommendations/behavior-guidance/

✔ Versloot, J., Veerkamp, J. S. J., & Hoogstraten, J. (2020). Children’s coping with pain during dental care. Community Dentistry and Oral Epidemiology, 48(4), 272–278. https://doi.org/10.1111/cdoe.12534

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Pulp Polyps in Children: Causes, Diagnosis, and Treatment Options in Pediatric Dentistry

Chronic hyperplastic pulpitis, commonly referred to as a pulp polyp, is a non-neoplastic, benign proliferation of pulpal tissue. It is often observed in children and adolescents, attributed to their rich pulpal vascularity and strong immune response.

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While it is a protective response to chronic inflammation, it reflects significant pulpal exposure, often requiring endodontic or surgical management.

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✅ Etiology
Pulp polyps arise primarily due to:

➤ Advanced Dental Caries: The most common cause, where prolonged exposure leads to bacterial infiltration and chronic inflammation (Seltzer & Bender, 2002).
➤ Dental Trauma: Fractured teeth or open pulp chambers expose the tissue to irritation.
➤ Open Apex or Immature Roots: In children, an open apex allows for vascular proliferation and granulation tissue growth (Brito et al., 2018).
➤ Poor Oral Hygiene: Facilitates microbial colonization and chronic irritation.

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✅ Clinical Features

° Appears as a red or pink soft tissue mass arising from a large carious lesion or a fractured tooth.
° Painless in most cases due to lack of nerve innervation in the granulation tissue.
° No bleeding on manipulation or mild bleeding only.
° Most commonly seen in molars of children and adolescents.
° May interfere with occlusion or become traumatized during chewing.

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✅ Diagnosis
Diagnosis is primarily clinical, but may be supported by:

➤ Radiographs: To evaluate the extent of decay and assess root development or periapical pathology.
➤ Pulp Vitality Testing: Usually not necessary, but may help in borderline cases.
➤ Histopathology: Shows fibrovascular granulation tissue with chronic inflammatory cells (Ricucci & Siqueira, 2010).

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✅ Differential Diagnosis

° Gingival polyps
° Papillary hyperplasia
° Peripheral giant cell granuloma
° Inflammatory fibrous hyperplasia

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✅ Treatment Options
Treatment depends on the tooth’s vitality, restorability, and root development stage:

1. Pulpotomy
Indicated in vital teeth with no periapical pathology. The coronal pulp is removed and the radicular pulp preserved, often using materials like MTA or Biodentine (El Meligy et al., 2019).
2. Pulpectomy
Complete removal of pulp tissue, ideal for non-vital primary teeth. Root canals are filled with resorbable materials like ZOE or iodoform-based pastes.
3. Extraction
Indicated in non-restorable teeth, teeth with excessive root resorption, or when endodontic treatment is contraindicated. Placement of a space maintainer may be necessary.

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✅ Prognosis and Follow-Up
With appropriate intervention, the prognosis is excellent. Follow-up is essential to monitor eruption of permanent teeth and prevent space loss.

💬 Discussion
Pulp polyps are often misunderstood as aggressive lesions, but they are a benign response to chronic irritation in young, healthy pulp tissue. Pediatric patients’ immune and reparative capacities allow this type of response, unlike in adults. Early detection through routine exams can prevent complications. Advances in biocompatible materials and minimally invasive dentistry have improved outcomes for pulp therapy in children.

💡 Conclusion
Pulp polyps in children are a clear indicator of neglected dental caries or trauma. Prompt recognition and appropriate treatment—whether pulp therapy or extraction—are critical for preserving oral health and preventing long-term complications in developing dentition.

📚 References

✔ Brito, F. C., de Sousa, C. M., & Maia, L. C. (2018). Pediatric endodontic treatment: A systematic review. International Journal of Paediatric Dentistry, 28(6), 525–539. https://doi.org/10.1111/ipd.12406

✔ El Meligy, O. A., Allazzam, S. M., & Alamoudi, N. M. (2019). Clinical and radiographic success of MTA pulpotomy in primary molars: A 24-month follow-up. European Archives of Paediatric Dentistry, 20(3), 225–230. https://doi.org/10.1007/s40368-019-00414-3

✔ Ricucci, D., & Siqueira, J. F. (2010). Biofilms and apical periodontitis: Study of prevalence and association with clinical and histopathologic findings. Journal of Endodontics, 36(8), 1277–1288. https://doi.org/10.1016/j.joen.2010.04.007

✔ Seltzer, S., & Bender, I. B. (2002). The dental pulp: Biology, pathology, and regenerative therapies. Quintessence Publishing.

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Top Benefits of Chemical Caries Removal in Children and Patients with Dental Anxiety

Modern dentistry increasingly embraces minimally invasive approaches that prioritize preserving healthy tooth structure and enhancing the patient experience.

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In this context, chemical caries removal (CCR) has emerged as a safe, effective alternative to traditional drilling—especially valuable in pediatric dentistry and for patients with dental anxiety or phobia. This technique allows clinicians to eliminate decayed dentin without rotary tools, reducing discomfort, fear, and the need for local anesthesia.

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✅ What Is Chemical Caries Removal?
CCR is a conservative, non-invasive technique that uses enzymatic or oxidizing agents to soften infected dentin, allowing its manual removal without mechanical drilling. Common products include Carisolv®, Papacárie Duo®, Brix3000®, and Carie-Care™, which have proven effective in clinical studies.

✅ Why Is CCR Ideal for Children and Anxious Patients?

1. Avoids the dental drill
The sound and vibration of a dental drill often trigger anxiety in children and phobic adults. CCR eliminates the need for rotary instruments.
2. Often requires no local anesthesia
Recent studies show that chemical agents can remove caries painlessly, making injections unnecessary in many cases (Elgalaid et al., 2022).
3. Increases treatment acceptance
Minimally invasive techniques result in a more relaxed experience, improving cooperation in young children and anxious patients (Ghasempour et al., 2020).
4. Preserves healthy tooth structure
Most CCR products act selectively on infected dentin, aligning with the principles of minimally invasive dentistry.
5. Creates a calm clinical environment
Less noise and vibration help maintain a soothing atmosphere, reducing stress for both patient and provider.

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✅ Latest Scientific Evidence
Recent clinical research highlights CCR’s effectiveness and patient acceptance:

° Elgalaid et al. (2022) found that Carisolv® significantly lowered anxiety and pain perception in children compared to conventional methods.
° Ghasempour et al. (2020) reported high satisfaction rates using Brix3000® among children aged 4–7 years.
° Santos et al. (2021) confirmed the safety and effectiveness of Papacárie Duo® in patients with mild to moderate dental anxiety.

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✅ Clinical Guidelines

° Indications: Ideal for shallow to moderate dentin caries without pulpal involvement.
° Contraindications: Avoid in deep lesions near the pulp or sclerotic dentin.
° Chair time: Slightly longer than conventional drilling, but often compensated by improved cooperation.
° Restoration options: Compatible with adhesive and bioactive restorative materials.

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💬 Discussion
Chemical caries removal represents a paradigm shift in managing caries in vulnerable populations. Its patient-friendly and drill-free nature allows for a less traumatic and more empathetic experience. The ability to reduce fear and discomfort during treatment makes CCR especially valuable in pediatric and behavioral dentistry. It also fosters better long-term dental relationships by building trust from an early age.

💡 Conclusion
Chemical caries removal is a powerful tool for modern dentistry, particularly when treating children and patients with dental phobia. Backed by recent evidence, its use promotes a more comfortable, conservative, and effective dental care experience. CCR should be considered a standard part of the clinical toolkit when aiming for anxiety-free dental visits.

📚 References

✔ Elgalaid, M. A., Alshoraim, M. A., Alhazmi, Y. F., & Alahmari, R. A. (2022). A randomized clinical trial comparing Carisolv and rotary instruments in caries removal: anxiety and pain perception in pediatric patients. BMC Oral Health, 22, 333. https://doi.org/10.1186/s12903-022-02458-4

✔ Ghasempour, M., Yeganeh, P., & Golkari, A. (2020). Comparison of the effectiveness of Brix3000 and conventional methods in caries removal in children. Journal of Dentistry for Children, 87(3), 151–156.

✔ Santos, A. P., Freire, M. C. M., Oliveira, B. H., & Paiva, S. M. (2021). Effectiveness of Papacárie Duo in minimally invasive treatment of dental caries in anxious children: a randomized clinical trial. Pediatric Dentistry, 43(4), 259–265.

✔ Lussi, A., & Schaffner, M. (2019). Advances in minimally invasive caries removal: Chemo-mechanical agents. In Mount, G. J. & Hume, W. R. (Eds.), Preservation and Restoration of Tooth Structure (3rd ed., pp. 97–104). Wiley-Blackwell.

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Antibiotic Prophylaxis in Pediatric Dentistry: When and How to Use It Safely in 2025

Antibiotic prophylaxis in pediatric dentistry is a preventive measure used to avoid serious systemic infections, such as infective endocarditis, in children undergoing dental procedures.

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The practice is guided by evidence-based protocols from organizations such as the American Heart Association (AHA) and the American Academy of Pediatric Dentistry (AAPD). Its use must be justified, as improper administration increases the risk of adverse effects and antibiotic resistance.

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✅ What Is Antibiotic Prophylaxis in Pediatric Dentistry?
This involves the preventive administration of antibiotics before invasive dental procedures in children who are at high risk for systemic infections. The aim is to minimize transient bacteremia that could colonize vulnerable tissues, such as the heart valves, particularly in immunocompromised or medically complex pediatric patients.

✅ Mechanism of Action
Antibiotics used for prophylaxis work by eliminating or reducing oral bacteria that can enter the bloodstream during dental procedures. The antibiotic is given 30–60 minutes before treatment to achieve optimal blood levels.

° Amoxicillin inhibits bacterial cell wall synthesis (bactericidal).
° Clindamycin inhibits bacterial protein synthesis (bacteriostatic or bactericidal depending on concentration).
° Macrolides (azithromycin, clarithromycin) also inhibit protein synthesis and are used in penicillin-allergic patients.

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✅ Clinical Indications

1. High-Risk Cardiac Conditions (Per AHA Guidelines)
Antibiotic prophylaxis is recommended for children with:
° Prosthetic heart valves or materials
° History of infective endocarditis
° Certain congenital heart defects (unrepaired, recently repaired with residual defects, or cyanotic CHD)
° Cardiac transplant recipients with valve disease

2. Immunocompromised Patients
Including those with:
° Cancer undergoing chemotherapy
° Neutropenia
° Organ transplants
° Long-term corticosteroid therapy
° IV bisphosphonate therapy

3. High-Risk Dental Procedures
Prophylaxis is recommended only for invasive procedures such as:
° Tooth extractions
° Periodontal surgery
° Deep scaling and root planing
° Any procedure causing mucosal or gingival bleeding

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✅ Recommended Antibiotics and Pediatric Dosing

💬 Discussion
Current research and AHA/AAPD guidelines stress that antibiotic prophylaxis should only be used when clinically indicated. Studies have shown that eliminating routine prophylaxis in low-risk patients did not increase the incidence of infective endocarditis. Misuse or overuse contributes to antibiotic resistance, Clostridioides difficile infection, and other complications.
Dentists must evaluate each child’s medical history and assess whether the risk justifies prophylactic use. Furthermore, educating caregivers on the responsible use of antibiotics is essential to support safe dental practices.

💡 Conclusion
Antibiotic prophylaxis in pediatric dentistry is a valuable tool for preventing severe infections but should be limited to patients with specific high-risk conditions. Updated guidelines from the AHA and AAPD emphasize evidence-based decision-making and individual risk assessment. Dental professionals must stay informed and adhere to standardized protocols to ensure the best outcomes for pediatric patients.

📚 References

✔ American Academy of Pediatric Dentistry. (2024). Use of antibiotic therapy for pediatric dental patients. The Reference Manual of Pediatric Dentistry, 533–537.

✔ Wilson, W. R., Gewitz, M., Lockhart, P. B., et al. (2021). Prevention of viridans group streptococcal infective endocarditis: A scientific statement from the American Heart Association. Circulation, 143(20), e963–e978. https://doi.org/10.1161/CIR.0000000000000969

✔ Suda, K. J., Calip, G. S., Zhou, J., et al. (2019). Assessment of the appropriateness of antibiotic prescriptions before dental procedures. JAMA Network Open, 2(5), e193909. https://doi.org/10.1001/jamanetworkopen.2019.3909

✔ Hollingshead, C. M., & Brizuela, M. (2023). Antibiotic prophylaxis in dental and oral surgery practice. In StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK470357/

✔ Zovko Končić, M., & Ivanušić, I. (2024). Antibiotic prophylaxis in dentistry: Recommendations and guidelines. Dentistry Journal, 12(11), 364. https://doi.org/10.3390/dj12110364

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