Molar–Incisor Hypomineralization (MIH) is a developmental enamel defect affecting one to four permanent first molars and often the permanent incisors.
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✅ Definition and Clinical Features
MIH is defined as a qualitative defect of enamel mineralization with normal enamel thickness but reduced hardness and increased porosity. Typical clinical findings include:
▪️ Demarcated opacities (white, yellow, or brown).
▪️ Post-eruptive enamel breakdown (PEB) shortly after eruption.
▪️ Severe dentin hypersensitivity, often disproportionate to clinical appearance.
▪️ High caries susceptibility due to compromised enamel structure.
▪️ Rapid restoration failure, especially in molars affected by PEB.
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Although MIH’s exact cause remains multifactorial, current evidence highlights:
▪️ Prenatal and perinatal complications
▪️ Childhood respiratory diseases
▪️ Fever of early childhood
▪️ Environmental toxins (e.g., dioxins)
▪️ Genetic predisposition affecting amelogenesis
These factors disrupt ameloblast activity during mineralization of first permanent molars and incisors.
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Diagnosis is clinical and based on:
▪️ Demarcated opacities with clear boundaries
▪️ Opacity color indicating severity (white less than yellow-brown)
▪️ Post-eruptive breakdown
▪️ Hypersensitivity not explained by caries
▪️ Atypical restorations on newly erupted permanent molars
Early diagnosis allows prompt preventive reinforcement and staged treatment planning.
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1. Prevention and Sensitivity Control
▪️ Use 5% sodium fluoride varnish to enhance remineralization.
▪️ CPP-ACP creams reduce hypersensitivity and improve enamel integrity.
▪️ Desensitizing dentifrices with arginine or stannous fluoride may help.
2. Minimally Invasive Restorative Approaches
▪️ Resin infiltration for mild opacities on incisors.
▪️ Glass ionomer cement (GIC) as a temporary restoration in hypersensitive molars.
▪️ Fissure sealants for mild MIH without structural loss.
3. Definitive Restorative Treatment
▪️ Resin composite for moderate breakdown, though longevity is limited.
▪️ Stainless steel crowns (SSC) are the gold standard for severely affected molars, reducing sensitivity and restoring function.
▪️ Indirect restorations (e.g., onlays) in permanent dentition.
4. Extraction Planning
Early extraction of first permanent molars may be indicated in severe cases where long-term prognosis is poor, ideally between 8–10 years, considering orthodontic outcomes.
📊 Comparative Table: Differential Diagnosis of MIH
| Aspect | Advantages | Limitations |
|---|---|---|
| Fluorosis | Symmetrical; diffuse opacities; usually no PEB | May resemble white MIH lesions; requires careful history |
| Amelogenesis Imperfecta | Generalized involvement; clear genetic pattern | Severe enamel defects may mimic MIH; affects all teeth |
💬 Discussion
MIH requires individualized care due to its wide variability in severity and patient discomfort. Restorations tend to fail more often compared to sound enamel, particularly when moisture control is compromised or hypersensitivity impedes cooperation. The use of bioactive materials, SSCs, and minimal intervention approaches has significantly improved outcomes. Long-term follow-up is essential, as MIH is a chronic condition requiring ongoing preventive support.
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Effective management of Molar–Incisor Hypomineralization depends on early diagnosis, prevention, and appropriate restorative strategies based on severity. The integration of bioactive materials, fluoride therapies, and SSCs enhances prognosis. Clinicians must provide continuous monitoring and individualized care to reduce pain, prevent caries progression, and maintain long-term function.
🔎 Recommendations
▪️ Prioritize early diagnosis during the eruption period.
▪️ Apply high-fluoride varnish and desensitizing protocols regularly.
▪️ Use SSCs in cases of severe PEB for long-term stability.
▪️ Consider resin infiltration for aesthetic management of incisor opacities.
▪️ Evaluate orthodontic implications before extracting compromised molars.
▪️ Schedule frequent recall visits (every 3–6 months).
📚 References
✔ Alaluusua, S. (2010). Aetiology of molar–incisor hypomineralisation: A systematic review. European Archives of Paediatric Dentistry, 11(2), 53–58. https://doi.org/10.1007/BF03262713
✔ Elhennawy, K., & Schwendicke, F. (2016). Managing molar–incisor hypomineralization: A systematic review. Journal of Dentistry, 55, 1–9. https://doi.org/10.1016/j.jdent.2016.09.012
✔ Fagrell, T. G., Ludvigsson, J., & Lundin, S. A. (2011). Childhood illnesses and molar incisor hypomineralization. Acta Odontologica Scandinavica, 69(4), 234–244. https://doi.org/10.3109/00016357.2010.549502
✔ Weerheijm, K. L. (2003). Molar incisor hypomineralisation (MIH): Clinical presentation and management. Dental Update, 30(1), 9–12. https://doi.org/10.12968/denu.2003.30.1.9
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