Perioral dermatitis (POD) is a chronic inflammatory skin disorder characterized by papulopustular eruptions primarily affecting the perioral, perinasal, and periorbital regions. It is commonly observed in young women but can occur across all ages and genders (Lipozenčić et al., 2020).
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✅ Differential Diagnosis of Perioral Dermatitis
➤ Acne Vulgaris
Acne typically presents with comedones, nodules, and cysts, which are absent in POD. The involvement is more generalized across sebaceous areas (face, chest, back).
➤ Rosacea
Rosacea commonly affects the central face with telangiectasia, erythema, and ocular involvement, features not typical in POD.
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Seborrheic dermatitis presents with greasy scales and erythema on seborrheic areas (scalp, eyebrows, nasolabial folds). POD lacks the greasy scale distribution pattern.
➤ Allergic or Irritant Contact Dermatitis
This condition often has well-demarcated erythematous patches with pruritus and a direct correlation to allergen exposure. POD is more chronic, papular, and less pruritic.
📊 Comparative Table: Differential Diagnosis of Perioral Dermatitis
Condition | Key Features | Differences from Perioral Dermatitis |
---|---|---|
Acne Vulgaris | Comedones, nodules, cysts in sebaceous areas | POD lacks comedones; distribution limited to perioral region |
Rosacea | Central facial erythema, telangiectasia, ocular involvement | POD spares central face and vermilion border; no ocular signs |
Seborrheic Dermatitis | Greasy yellowish scales on scalp, eyebrows, nasolabial folds | POD presents with papules and pustules, not greasy scales |
Contact Dermatitis | Well-demarcated erythema, itching, acute or chronic reaction | POD less pruritic, more chronic, with papules instead of plaques |
💬 Discussion
The overlap of symptoms between POD and other facial dermatoses often leads to misdiagnosis. The absence of comedones distinguishes it from acne, while sparing of central facial zones separates it from rosacea. Seborrheic dermatitis and contact dermatitis present with different morphological characteristics. Recognizing these subtle differences is essential for clinicians to prevent corticosteroid misuse, which can aggravate POD (Tan et al., 2022).
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Perioral dermatitis requires a careful differential diagnosis to avoid unnecessary or harmful treatments. Differentiating POD from acne, rosacea, seborrheic dermatitis, and contact dermatitis involves clinical evaluation of lesion morphology, distribution, and symptomatology. Early recognition and proper management improve patient outcomes and reduce recurrences.
📚 References
✔ Lipozenčić, J., Pustišek, N., & Ljubojević Hadžavdić, S. (2020). Perioral dermatitis: An update. Clinics in Dermatology, 38(2), 193–198. https://doi.org/10.1016/j.clindermatol.2019.10.004
✔ Reid, C., & Powell, F. C. (2018). Perioral dermatitis: A review. Journal of the European Academy of Dermatology and Venereology, 32(10), 1682–1689. https://doi.org/10.1111/jdv.15011
✔ Tan, E., Martinka, M., & Crawford, R. I. (2022). Clinical pitfalls in the management of perioral dermatitis. Journal of Cutaneous Medicine and Surgery, 26(1), 41–47. https://doi.org/10.1177/12034754211031234
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