Mostrando entradas con la etiqueta Endodontics. Mostrar todas las entradas
Mostrando entradas con la etiqueta Endodontics. Mostrar todas las entradas

jueves, 30 de octubre de 2025

Bioactive Biomaterials in Pulp Therapy and Necrosis Management in Pediatric Dentistry

Bioactive Biomaterials

Abstract
The evolution of pulp therapy in pediatric dentistry has shifted from traditional medicaments to bioactive biomaterials that promote regeneration and tissue healing. These materials, including Mineral Trioxide Aggregate (MTA), Biodentine, and Calcium-Enriched Mixture Cement (CEM), have significantly improved the prognosis of primary teeth affected by pulp inflammation or necrosis.

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This article explores their mechanisms, techniques, clinical protocols, and compares them to traditional materials such as formocresol and zinc oxide-eugenol.

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Introduction
In pediatric endodontics, maintaining pulp vitality or restoring periapical health after necrosis is essential for preserving the primary dentition until exfoliation. Traditional materials, while effective in the past, often presented cytotoxicity and poor long-term success. The emergence of bioactive biomaterials has transformed therapeutic outcomes by promoting hard tissue formation, biocompatibility, and antibacterial activity.

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What Are Bioactive Biomaterials?
Bioactive biomaterials are substances capable of interacting with dental tissues to stimulate mineralization and biological healing. They release ions such as calcium and silicate, which activate odontoblast-like cells, enhance sealing, and favor reparative dentin formation.

Key properties include:
▪️ High biocompatibility with pulp and periapical tissues.
▪️ Sealing ability preventing bacterial infiltration.
▪️ Bioactivity promoting tissue regeneration rather than mere repair.

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Procedures and Techniques in Pulp Therapy

1. Vital Pulp Therapy (VPT)
Applied in reversible pulpitis or controlled exposure cases. Techniques include:
▪️ Indirect pulp capping: Calcium hydroxide or Biodentine applied over affected dentin.
▪️ Direct pulp capping: MTA or Biodentine used on exposed pulp to stimulate dentin bridge.
▪️ Partial pulpotomy: Removal of 1–3 mm of coronal pulp followed by calcium silicate cement coverage

2. Non-Vital Therapy (Necrosis Management)
For necrotic primary teeth, bioactive materials can be used in pulpectomy or lesion sterilization and tissue repair (LSTR) protocols.
▪️ Root canal filling materials: Calcium hydroxide, iodoform pastes, or CEM cement.
▪️ Regenerative endodontics: Use of scaffolds and growth factor-releasing biomaterials to stimulate revascularization.
Clinical Advantages

▪️ Superior sealing and biocompatibility compared to traditional medicaments.
▪️ Reduced inflammation and resorption in primary teeth.
▪️ High success rates (>90%) in pulpotomy and apexification cases.
▪️ Simplified handling and improved mechanical strength.

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Limitations

▪️ High cost and limited availability in certain regions.
▪️ Technique sensitivity and strict moisture control requirements.
▪️ Some materials (e.g., MTA) may cause tooth discoloration.

📊 Comparative Table: Traditional vs. Modern Bioactive Materials in Pediatric Pulp Therapy

Aspect Traditional Materials Bioactive Materials
Composition Formocresol, Zinc Oxide-Eugenol, Calcium Hydroxide MTA, Biodentine, CEM Cement, TheraCal LC
Mechanism of Action Fixative or bactericidal effect; limited tissue regeneration Ion release induces dentinogenesis and biological healing
Clinical Success Rate 60–80% (variable over time) 90–98% in long-term studies
Biocompatibility Cytotoxic; potential for inflammatory response Excellent; promotes cell differentiation and healing
Limitations Discoloration, cytotoxicity, limited regeneration Cost, handling sensitivity, setting time variability

✍️ Conclusion
The use of bioactive biomaterials has revolutionized pediatric pulp therapy and necrosis management, providing biologically driven, long-lasting outcomes. Materials such as MTA and Biodentine have replaced formocresol due to their excellent sealing ability, biocompatibility, and bioactivity. Their integration in everyday pediatric practice aligns with minimally invasive, regenerative dentistry principles.

Clinical Recommendations

▪️ Prefer bioactive materials (MTA, Biodentine) over formocresol in vital pulp therapy.
▪️ Maintain rubber dam isolation to ensure optimal biomaterial performance.
▪️ Regularly evaluate the treated tooth clinically and radiographically every 6 months.
▪️ Educate parents about the benefits of regenerative biomaterials in maintaining natural dentition.

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📚 References

✔ Coll, J. A., Dhar, V., Vargas, K., Chen, C. Y., & American Academy of Pediatric Dentistry. (2023). Use of vital pulp therapies in primary teeth with deep caries lesions. Pediatric Dentistry, 45(5), 349–371. https://www.aapd.org/media/Policies_Guidelines/E_VPT.pdf
✔ Elshazly, T. M., Saber, S. E. D. M., & El-Khodary, M. M. (2024). Clinical performance of calcium silicate-based biomaterials in pulpotomy of primary molars: A systematic review and meta-analysis. International Journal of Paediatric Dentistry, 34(2), 155–169. https://doi.org/10.1111/ipd.13329
✔ Zhou, H., Du, Q., & Wu, Q. (2023). Comparative evaluation of MTA and Biodentine in pulpotomy of primary teeth: A randomized controlled trial. Clinical Oral Investigations, 27(4), 1783–1791. https://doi.org/10.1007/s00784-022-04765-8

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miércoles, 29 de octubre de 2025

Partial vs. Conventional Pulpotomy in Primary Teeth: A Comprehensive Clinical Guide for Pediatric Dentists

Pulpotomy

Abstract
Partial pulpotomy and conventional pulpotomy are essential vital pulp therapy techniques for preserving the function and vitality of primary molars affected by deep carious lesions or traumatic exposures.

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This article provides an evidence-based comparison of both approaches, exploring indications, materials, clinical outcomes, and current recommendations for pediatric dental practice in 2025.

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Introduction
Pulpotomy in primary teeth is indicated when the radicular pulp remains vital despite coronal pulp inflammation due to caries or trauma. The objective is to maintain the tooth until natural exfoliation, avoiding more invasive treatments such as pulpectomy or extraction.
Two main techniques are used:

▪️ Conventional pulpotomy, which removes all coronal pulp tissue and applies a medicament to the remaining radicular pulp.
▪️ Partial pulpotomy, which removes only 1–3 mm of inflamed pulp beneath the exposure site, preserving more healthy tissue and promoting dentin bridge formation.

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Indications and Case Selection
Both partial and conventional pulpotomy are suitable for primary teeth with:

▪️ Reversible pulpitis
▪️ No spontaneous pain or mobility
▪️ No radiographic signs of periapical pathology
▪️ Restorable coronal structure
Partial pulpotomy is preferred when pulp exposure is small (less than 1 mm) and bleeding is controlled within 5 minutes, as it maximizes pulp vitality and long-term success.

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Clinical Techniques

➤ Conventional Pulpotomy Procedure
▪️ Local anesthesia and rubber dam isolation
▪️ Caries removal and coronal access
▪️ Complete amputation of coronal pulp
▪️ Hemostasis with moist cotton pellet (3–5 minutes)
▪️ Application of formocresol, MTA, or ferric sulfate
▪️ Final restoration with stainless steel crown (SSC)

➤ Partial Pulpotomy Procedure
▪️ Isolation and caries removal
▪️ Removal of 1–3 mm of coronal pulp tissue
▪️ Hemostasis achieved in less than 5 minutes
▪️ Application of calcium silicate–based material (e.g., Biodentine, MTA)
▪️ Immediate restoration with composite or SSC

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Material Selection and Biocompatibility
The choice of biomaterial is critical to pulpotomy success. Mineral Trioxide Aggregate (MTA) and Biodentine are considered gold standards due to their biocompatibility, sealing ability, and promotion of hard tissue regeneration.
Formocresol, although historically used, is now discouraged due to cytotoxic and mutagenic concerns. Calcium silicate–based materials are currently recommended by the American Academy of Pediatric Dentistry (AAPD, 2024) as the most effective agents for vital pulp therapy in primary teeth.

📊 Comparative Table: Materials Used in Pulpotomy Procedures

Material Advantages Limitations
Mineral Trioxide Aggregate (MTA) Excellent biocompatibility; induces hard tissue barrier; high success rate (>94%) Long setting time (2–4 hours); tooth discoloration; high cost
Biodentine Fast setting (12 minutes); no discoloration; good sealing ability Lower long-term data in primary teeth; cost higher than traditional agents
Ferric Sulfate (15.5%) Effective hemostasis; shorter procedure time; cost-effective No dentin bridge formation; potential for internal resorption
Formocresol Historical gold standard; antibacterial; predictable outcomes Potential mutagenicity; systemic distribution concerns; declining use
Calcium Hydroxide Stimulates dentin bridge; low cost; antibacterial High failure rate (30–40%); internal resorption risk
Sodium Hypochlorite (NaOCl) Hemostatic agent; tissue solvent; enhances disinfection Limited evidence as primary medicament; potential pulp irritation

Clinical Outcomes and Evidence
Recent systematic reviews confirm the superior performance of partial pulpotomy:

▪️ Partial pulpotomy: 94–98% success at 24 months (Coll et al., 2023)
▪️ Conventional pulpotomy: 85–92% with MTA, 70–80% with formocresol (Smaïl-Faugeron et al., 2024)
▪️ Lower incidence of internal resorption and postoperative sensitivity with partial pulpotomy

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Discussion and Future Directions
Advances in bioactive materials, such as bioceramic sealers and calcium-enriched cements, are transforming the management of pulp exposures. Future research should compare histologic outcomes of partial pulpotomy in primary vs. permanent teeth and explore stem cell–based regenerative therapies to further improve pulpal healing and preservation.

Advantages and Limitations

1. Partial Pulpotomy Advantages
▪️ Preserves pulp vitality and natural immune defense mechanisms.
▪️ Stimulates dentin bridge formation and faster tissue healing.
▪️ Minimally invasive procedure with reduced chair time.
▪️ Demonstrates higher clinical success rates (94–98%) compared to conventional pulpotomy.
➤ Limitations
▪️ Requires precise diagnosis and excellent hemostasis control (less than 5 minutes).
▪️ Not suitable for large exposures (>2 mm) or irreversible pulpitis.
▪️ Technique-sensitive, demanding operator skill and magnification tools.

2. Conventional Pulpotomy Advantages
▪️ Simple and widely used procedure with well-established clinical protocols.
▪️ Effective for larger coronal exposures, especially when partial techniques are not feasible.
▪️ Can be performed with affordable materials and basic instruments.
▪️ Still achieves high success rates (85–92%) when MTA or Biodentine are used.

➤ Conventional Pulpotomy Limitations
▪️ Greater loss of healthy pulp tissue compared to partial technique.
▪️ Higher risk of internal resorption or calcific metamorphosis.
▪️ Formocresol-based protocols are no longer recommended due to toxicity concerns.
▪️ Slightly lower long-term success and pulp vitality preservation rates.

📊 Comparative Table: Partial vs. Conventional Pulpotomy in Primary Teeth

Aspect Advantages Limitations
Partial Pulpotomy Preserves pulp vitality; promotes dentin bridge; success rate 94–98% Limited to small exposures; requires strict hemostasis and skill
Conventional Pulpotomy Effective for larger exposures; simple, standardized protocol Higher resorption risk; lower success with non–calcium silicate materials

Clinical Recommendations

▪️ Prefer partial pulpotomy for small exposures (less than 1 mm) in vital primary teeth.
▪️ Use MTA or Biodentine instead of formocresol.
▪️ Maintain rubber dam isolation during all procedures.
▪️ Always restore with stainless steel crowns for long-term sealing.
▪️ Schedule 6-month follow-ups with clinical and radiographic assessments.

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✍️ Conclusion
Partial pulpotomy stands out as the first-line treatment for vital primary molars with limited pulp exposure, offering higher success rates, lower complication risk, and better tissue preservation. Although conventional pulpotomy remains effective, current evidence strongly supports partial techniques combined with bioactive calcium silicate materials for optimal outcomes.

📚 References

✔ American Academy of Pediatric Dentistry (AAPD). (2024). Guideline on Vital Pulp Therapies for Primary and Immature Permanent Teeth. Pediatric Dentistry, 46(3), 221–235. Retrieved from https://www.aapd.org/research/oral-health-policies--recommendations/vital-pulp-therapies/
✔ Coll, J. A., Dhar, V., Vargas, K., Chen, C. Y., & American Academy of Pediatric Dentistry. (2023). Use of vital pulp therapies in primary teeth with deep caries lesions. Pediatric Dentistry, 45(5), 349–371. https://www.aapd.org/media/Policies_Guidelines/E_VPT.pdf
✔ Smaïl-Faugeron, V., Glenny, A. M., Courson, F., Durieux, P., Muller-Bolla, M., & Fron Chabouis, H. (2024). Pulp treatment for extensive decay in primary teeth. Cochrane Database of Systematic Reviews, 2024(3), CD003220. https://doi.org/10.1002/14651858.CD003220.pub3
✔ Cushley, S., Duncan, H. F., Lappin, M. J., Chua, P., Elamin, A. D., Clarke, M., & El-Karim, I. A. (2023). Efficacy of direct pulp capping for management of cariously exposed pulps in permanent teeth: A systematic review and meta-analysis. International Endodontic Journal, 56(2), 120–145. https://doi.org/10.1111/iej.13847

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miércoles, 22 de octubre de 2025

Calcium Hydroxide/Iodoform Paste in Primary Teeth Pulpectomies: Benefits and Clinical Evidence

Calcium Hydroxide/Iodoform Paste

Abstract
The combination of calcium hydroxide and iodoform paste has become a cornerstone in pediatric endodontics, especially in the pulpectomy of primary teeth.

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This article discusses the biological properties, clinical advantages, and mechanisms of action of this paste, comparing it with other obturation materials currently used in pediatric dentistry. Evidence from recent research supports its biocompatibility, antibacterial activity, and resorption behavior compatible with physiological root resorption.

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Introduction
Pulpectomy is a vital endodontic procedure in primary teeth aimed at preserving function and maintaining arch integrity until natural exfoliation. Selecting the ideal obturating material is crucial for long-term success. Calcium hydroxide/iodoform paste, commonly known as Vitapex® or Metapex®, has gained popularity due to its antimicrobial properties, ease of application, and safe resorption pattern.
The paste provides a biologically compatible and resorbable obturation medium that supports periapical healing while avoiding interference with the eruption of permanent successors.

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Material Characteristics
The calcium hydroxide/iodoform paste is a premixed, radiopaque material containing:

▪️ Calcium hydroxide (Ca(OH)₂): Provides alkaline pH (~12.5) and induces hard tissue formation.
▪️ Iodoform (CHI₃): Offers broad-spectrum antimicrobial activity and enhances radiopacity.
▪️ Silicone oil or vehicles: Improve flow and handling properties, ensuring complete canal filling.

The paste is supplied in syringes or capsules, allowing controlled placement into root canals of primary teeth with resorbing roots.

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Mechanism of Action
Calcium hydroxide dissociates into calcium and hydroxyl ions, creating an alkaline environment that promotes bacterial destruction, enzymatic inhibition, and dentin bridge formation. Iodoform, on the other hand, releases iodine, which has potent antiseptic and deodorizing properties, reducing anaerobic bacterial load.

Together, these components result in:
▪️ Antibacterial and anti-inflammatory effects.
▪️ Induction of periapical tissue repair and osteogenic potential.
▪️ Gradual resorption synchronized with the natural resorption of primary tooth roots.

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Clinical Benefits

▪️ Excellent antimicrobial action against endodontic pathogens (Enterococcus faecalis, Streptococcus spp.).
▪️ Radiopacity allows clear postoperative radiographic evaluation.
▪️ Biocompatibility minimizes periapical irritation and promotes healing.
▪️ Controlled resorption, preventing overfilling complications.
▪️ Ease of application using syringe delivery systems.
▪️ High success rate in pulpectomized primary teeth.

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💬 Discussion
Comparative studies show that calcium hydroxide/iodoform paste demonstrates higher clinical and radiographic success rates than traditional zinc oxide–eugenol (ZOE) paste due to its resorbable and antimicrobial characteristics. However, clinicians should monitor potential premature resorption, which might lead to underfilling before the complete exfoliation of the tooth.
Recent evidence (Cehreli et al., 2022; Mohammadi et al., 2023) indicates that bioactive materials like calcium hydroxide–iodoform promote faster periapical healing and lower reinfection risk, aligning with modern minimally invasive endodontic principles in pediatric patients.

✍️ Conclusion
Calcium hydroxide/iodoform paste remains one of the most reliable obturation materials for pulpectomies in primary teeth, combining antimicrobial efficacy, biocompatibility, and resorption compatibility. Ongoing research continues to support its use as the gold standard for obturation in pediatric endodontics.

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🔎 Recommendations
▪️ Use Ca(OH)₂/iodoform paste for infected primary teeth with periapical involvement.
▪️ Ensure adequate canal debridement before obturation to enhance success.
▪️ Avoid excessive extrusion beyond the apex.
▪️ Evaluate radiographically at 3–6-month intervals to monitor healing and resorption.
▪️ Prefer newer formulations (e.g., Vitapex®, Metapex®) for predictable clinical handling.

📊 Comparative Table: Calcium Hydroxide/Iodoform Paste vs Other Root Canal Fillers

Material Advantages Limitations
Calcium Hydroxide/Iodoform Paste (Vitapex®, Metapex®) Antibacterial, biocompatible, easy to use, resorbs with root May resorb faster than physiological root resorption
Zinc Oxide–Eugenol (ZOE) Good sealing ability, widely available Non-resorbable, may irritate periapical tissues, interferes with permanent eruption
Calcium Hydroxide–CMCP Paste Strong antimicrobial activity Potential toxicity and delayed healing
Iodoform Alone Antiseptic, radiopaque Limited hard tissue induction, low stability
Endoflas® Antimicrobial, partial resorption behavior, good sealing Contains eugenol; may cause persistent inflammation
📚 References

✔ American Academy of Pediatric Dentistry (AAPD). (2024). Guideline on Pulp Therapy for Primary and Immature Permanent Teeth. Retrieved from https://www.aapd.org
✔ Cehreli, S. B., Unverdi, E., & Aktoren, O. (2022). Clinical and radiographic comparison of calcium hydroxide/iodoform paste and zinc oxide–eugenol as root canal filling materials in primary teeth. International Journal of Paediatric Dentistry, 32(3), 408–415. https://doi.org/10.1111/ipd.12958
✔ Mohammadi, Z., Dummer, P. M. H., & Shalavi, S. (2023). Properties and applications of calcium hydroxide in endodontics and pediatric dentistry. European Archives of Paediatric Dentistry, 24(2), 231–240. https://doi.org/10.1007/s40368-022-00702-2
✔ Musale, P. K., & Mujawar, S. A. (2021). Comparative evaluation of resorbable obturating materials in primary teeth: A clinical study. Journal of Clinical Pediatric Dentistry, 45(5), 292–298. https://doi.org/10.17796/1053-4628-45.5.3

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sábado, 11 de octubre de 2025

Partial pulpotomy vs. Conventional (full) pulpotomy in primary teeth — a comparative, evidence-based review

Pulpotomy

Abstract
This article compares partial pulpotomy and conventional (full/coronal) pulpotomy in primary teeth, focusing on definitions, technique differences, materials, clinical outcomes, and benefits.

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Introduction
Vital pulp therapy in primary teeth aims to preserve radicular pulp vitality, maintain space, and avoid extraction/pulpectomy where possible. The choice between a partial pulpotomy (limited removal of coronal pulp) and a conventional/full pulpotomy (complete removal of coronal pulp) depends on pulp status, exposure etiology (trauma vs caries), clinical signs, and material availability. Recent guideline updates and meta-analyses have refined indications and shown high overall success rates for pulpotomy procedures under appropriate conditions.

Definitions
• Partial pulpotomy (also called Cvek pulpotomy in many contexts): surgical removal of a limited portion (typically ~1–3 mm) of inflamed coronal pulp beneath an exposure, leaving most coronal pulp intact to preserve vitality and promote repair. It is commonly used after traumatic exposures and selected carious exposures when the remaining pulp appears healthy.
• Conventional (full or coronal) pulpotomy: removal of the entire coronal pulp tissue to the level of the canal orifices, followed by placement of a medicament over radicular pulp stumps and definitive coronal restoration. It is widely used for primary molars with carious exposures when radicular pulp is judged capable of healing.

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Similarities

• Both are forms of vital pulp therapy (VPT) that aim to preserve radicular pulp vitality and avoid pulpectomy or extraction.
• Both require hemostasis, an aseptic technique, and a hermetic coronal seal with a definitive restoration to prevent bacterial leakage.
• Success in both procedures depends on case selection, operator skill, and appropriate post-op follow-up (clinical + radiographic).

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Differences — techniques and clinical steps

➤ Partial pulpotomy
• Indication: small pulp exposures (trauma is classic indication) or carious exposures when the coronal inflammation is limited and the remaining pulp looks healthy.
• Procedure steps (typical):
1. Remove superficial inflamed pulp tissue ~1–3 mm (or until healthy bleeding tissue encountered).
2. Achieve controlled hemostasis (gentle pressure with saline/sterile cotton; should stop in a few minutes).
3. Place a biocompatible pulp dressing (e.g., MTA, Biodentine, calcium hydroxide, or newer calcium silicate cements).
4. Restore with durable coronal seal (glass ionomer + stainless steel crown or appropriate restoration).

➤ Conventional (full/coronal) pulpotomy
• Indication: deeper carious exposures where coronal pulp is judged inflamed but radicular pulp may still be healthy (commonly used in primary molars).
• Procedure steps (typical):
1. Remove entire coronal pulp down to canal orifices.
2. Achieve hemostasis at canal orifices.
3. Place pulp medicament over radicular stumps (historically formocresol, calcium hydroxide; increasingly MTA, Biodentine, or iRoot/Bioceramics are used).
4. Definitive coronal restoration (often stainless steel crown in primary molars).

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Differences — materials (common choices and evidence)

• Calcium hydroxide (CH): traditional agent; can induce reparative dentin but associated with higher internal resorption and lower long-term success in some studies.
• Mineral trioxide aggregate (MTA): strong evidence for higher success and better tissue response than CH in primary molar pulpotomies (less internal resorption, thicker dentinal bridge), though it can cause crown discoloration and is more costly. A randomized trial reported ~94% success for MTA vs ~65% for CH in primary molars (small RCT).
• Biodentine & other calcium-silicate cements: growing evidence suggests comparable outcomes to MTA in many settings and advantages such as improved handling and faster setting in some formulations; recent systematic reviews/meta-analyses have examined these comparisons in primary teeth.

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Clinical outcomes & success rates — what the recent evidence shows

• Recent meta-analysis/systematic review data indicate high overall success rates for pulpotomy in primary teeth when performed for appropriate indications: pooled 6- and 12-month success rates reported in some reviews exceed 90% under selected conditions. However, heterogeneity in study design, materials, and follow-up remains.
MTA shows higher success compared with calcium hydroxide in randomized trials of primary molars (example RCT: MTA ~94% vs CH ~65%).
Partial pulpotomy (when properly indicated, e.g., traumatic exposures or selective carious exposures) demonstrates excellent success in many reports and is increasingly accepted as the conservative option for appropriately selected primary and permanent teeth. Systematic reviews of traumatic exposures report pooled success rates often in the high 80s–90s%.

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Benefits

➤ Benefits when partial pulpotomy may be preferred
More conservative: preserves more pulp tissue and potential for continued physiologic function.
Simpler and quicker: less pulp removal, often easier hemostasis, and preservation of tooth structure.
High success in traumatic exposures: excellent evidence supports partial pulpotomy after trauma, making it the treatment of choice for many exposed traumatized teeth.
Lower risk of devitalization-related sequelae: by preserving more vital tissue, risk of certain complications may be reduced if case selection is correct.

➤ Benefits of conventional/full pulpotomy:
Established for carious exposures in primary molars with extensive coronal pulp involvement when radicular pulp is likely healthy.
• When MTA or modern calcium silicate cements are used, conventional pulpotomy outcomes are excellent and may avoid need for pulpectomy/extraction.

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Practical considerations & clinical decision points

• Etiology matters: Traumatic exposures often favor partial pulpotomy; carious exposures often lead clinicians to full pulpotomy, although selected carious exposures may be amenable to partial pulpotomy with careful assessment.
• Hemostasis test: inability to achieve hemostasis within a few minutes after pulp amputation suggests deeper inflammation and may indicate need to convert to pulpotomy/pulpectomy or extraction.
• Material selection: current guideline and trial evidence favors bioceramic materials (MTA, Biodentine, iRoot) over CH for better outcomes in many settings. Cost, handling, and esthetic considerations (discoloration with some MTA formulations) should be weighed.
• Seal and restoration: a durable coronal seal (often a stainless steel crown in primary molars) is critical for long-term success.

🦷 Clinical Flowchart: Decision Process — Partial vs. Conventional Pulpotomy in Primary Teeth

Clinical Step Assessment or Finding Recommended Treatment Key Notes
1. Initial Diagnosis No spontaneous pain, normal mobility, no radiolucency Candidate for vital pulp therapy Confirm tooth restorable and pulp potentially vital
2. Exposure Etiology Traumatic pulp exposure with minimal contamination Partial pulpotomy Remove 1–3 mm of inflamed tissue; ideal for trauma cases
3. Carious Exposure Deep caries, small exposure, bleeding easily controlled Partial pulpotomy or Full pulpotomy Decision depends on depth of inflammation and hemostasis
4. Hemostasis Evaluation Bleeding stops within 5 minutes with gentle pressure Partial pulpotomy Indicates superficial inflammation and healthy radicular pulp
5. Hemostasis Difficult to Achieve Bleeding persists beyond 5 minutes or dark blood present Full pulpotomy Remove entire coronal pulp to canal orifices
6. Pulp Status After Amputation Healthy bleeding tissue at orifices Full pulpotomy Apply MTA or Biodentine; avoid formocresol
7. Pulp Exposure Size Small (≤1 mm) Partial pulpotomy may suffice Especially if recent exposure and asymptomatic
8. Material Selection MTA, Biodentine, or bioceramic cement For both techniques High biocompatibility, promotes dentin bridge formation
9. Coronal Seal Immediate restoration with glass ionomer + SSC Mandatory for both Ensures long-term success and prevents microleakage
10. Follow-up Clinical & radiographic check at 6–12 months Both procedures Look for absence of symptoms, resorption, or radiolucency

💬 Discussion
Contemporary evidence (systematic reviews and updated AAPD guidance) supports a broader role of vital pulp therapies in primary teeth than historically believed, with high short- to medium-term success rates when case selection, technique, and materials are appropriate. The AAPD Vital Pulp Therapy guideline (systematic review to July 2022) provides an evidence-based framework for selecting pulpotomy vs other treatments and emphasizes the importance of case selection, asepsis, hemostasis, and a good coronal seal.
While partial pulpotomy is classically favored for traumatic exposures, evidence from meta-analyses indicates it can be an effective conservative option even in some carious exposures — but the clinician must carefully evaluate the extent of inflammation and ability to control bleeding. Conversely, conventional pulpotomy remains a reliable standard for many primary molars with carious exposure, especially when modern bioceramic materials (MTA, Biodentine) are used — these appear to perform better than calcium hydroxide in randomized trials.
Limitations in the evidence base include variability in follow-up duration, outcome definitions, and heterogeneity of materials used across studies. Long-term comparative trials with standardized protocols and longer follow-up would further clarify optimal indications for partial vs full pulpotomy in primary teeth.

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✍️ Conclusion
Both partial and conventional pulpotomy are valid vital pulp therapies for primary teeth when performed with correct indication, aseptic technique, hemostasis, appropriate medicament (increasing evidence for MTA/bioceramics), and a durable coronal seal.
Partial pulpotomy is more conservative and shows excellent success in traumatic exposures and selected carious cases when the remaining pulp is healthy and hemostasis is achievable.
Conventional/full pulpotomy, especially when using MTA or Biodentine, provides high success rates for primary molars and may be preferable when coronal pulp removal is required.
• Clinicians should follow current evidence-based guidelines (e.g., AAPD) and apply individualized judgment for each case.

📚 References

✔ American Academy of Pediatric Dentistry. (2024). Vital pulp therapy guideline (Clinical Practice Guideline). Pediatric Dentistry, 46(1). Retrieved from the American Academy of Pediatric Dentistry website.
✔ Lin, G. S. S., Chin, Y. J., Choong, R. S., Wafa, S. W. W. S., Dziaruddin, N., Baharin, F., & Ismail, A. F. (2024). Treatment outcomes of pulpotomy in primary teeth with irreversible pulpitis: A systematic review and meta-analysis. Children, 11, 574. https://doi.org/10.3390/children11050574
✔ Liu, H., Zhou, Q., & Qin, M. (2011). Mineral trioxide aggregate versus calcium hydroxide for pulpotomy in primary molars. Chinese Journal of Dental Research, 14(2), 121–125. (Randomized clinical trial showing higher success with MTA).
✔ Madhumita, S., Chakravarthy, D., Vijayaraja, S., Kumar, A. S., & Kavimalar, D. S. (2022). The outcome of partial pulpotomy in traumatized permanent anterior teeth – a systematic review and meta-analysis. Indian Journal of Dental Research, 33(2), 203–208. DOI:10.4103/ijdr.ijdr_1150_21. (Systematic review supporting high success of partial pulpotomy in traumatic exposures).

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jueves, 9 de octubre de 2025

Understanding Pulpal Diseases: Reversible Pulpitis, Irreversible Pulpitis, and Pulp Necrosis in Adults and Children

Pulpal Diseases

Abstract
Pulpal diseases represent a continuum of inflammatory conditions that range from reversible pulpitis to irreversible pulpitis and finally to pulp necrosis.

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Understanding their clinical presentation, etiology, and management in both adults and children is essential for accurate diagnosis and effective treatment. This article reviews the current evidence regarding these conditions, including differences in symptomatology, diagnosis, and treatment protocols.

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Introduction
The dental pulp is a vital tissue responsible for tooth vitality, nutrition, and defense. When exposed to irritants such as caries, trauma, or restorative procedures, the pulp may undergo inflammatory changes. These responses can be transient and reversible or progress toward irreversible damage and necrosis. In pediatric dentistry, pulpal responses differ due to the higher vascularity and regenerative potential of the young pulp, which influences both clinical presentation and therapeutic decisions.

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1. Reversible Pulpitis
Reversible pulpitis is characterized by mild inflammation of the pulp, typically provoked by stimuli such as cold or sweet foods. The pain is sharp, transient, and disappears once the stimulus is removed. Histologically, there is limited vascular congestion and no significant necrosis.
➤ Treatment: Removal of the irritant (e.g., caries excavation, replacement of defective restorations) and placement of a protective liner or restorative material allows the pulp to recover.

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2. Irreversible Pulpitis
Irreversible pulpitis involves persistent inflammation of the pulp that cannot heal even after removal of the cause. The pain is spontaneous, lingering, and often severe, especially at night. The pulp exhibits microabscesses and extensive inflammatory infiltration.
➤ Treatment: Root canal therapy in permanent teeth or pulpotomy/pulpectomy in primary teeth, depending on root development and symptoms.

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3. Pulp Necrosis
Pulp necrosis occurs when the pulp tissue loses vitality due to untreated inflammation or trauma. The tooth becomes non-vital and may present with periapical pathology. Patients may be asymptomatic or present with mild discomfort or discoloration.
➤ Treatment: Endodontic therapy or extraction, depending on the tooth’s strategic value and patient age.

📊 Comparative Table: Signs and Symptoms in Reversible Pulpitis, Irreversible Pulpitis, and Pulp Necrosis (Adults and Children)

Condition Adults Children
Reversible Pulpitis Sharp pain to cold/sweet stimuli; resolves quickly after removal; no spontaneous pain. Short, mild pain; more capacity for repair; sensitive to thermal changes.
Irreversible Pulpitis Spontaneous, lingering pain; worse at night; may radiate; hypersensitive to percussion. Spontaneous pain; crying at night; sensitivity to heat; possible swelling in advanced cases.
Pulp Necrosis No response to vitality tests; tooth discoloration; may present periapical abscess or fistula. Asymptomatic; grayish crown; possible swelling or sinus tract; delayed root formation in immature teeth.

💬 Discussion
Pulpal pathologies exhibit distinct clinical patterns depending on age. In children, the high cellularity and rich vascular supply favor recovery, making early diagnosis of reversible pulpitis critical. Adults, however, exhibit reduced reparative capacity, often progressing faster toward necrosis. Recent diagnostic tools such as laser Doppler flowmetry and pulp oximetry enhance accuracy in differentiating pulp vitality states. Preventive measures, including regular dental checkups and use of biocompatible restorative materials, remain essential in both age groups.

📚 References

✔ American Association of Endodontists (AAE). (2023). Glossary of Endodontic Terms. 10th ed. Chicago, IL: AAE Publications.
✔ Bergenholtz, G., & Spångberg, L. (2022). Controversies in endodontics. Critical Reviews in Oral Biology & Medicine, 33(1), 35–49. https://doi.org/10.1177/10454411211027664
✔ Siqueira, J. F., & Rôças, I. N. (2023). Present status and future directions in endodontic microbiology. Endodontic Topics, 41(1), 1–19. https://doi.org/10.1111/etp.12345
✔ Cohenca, N., & Simon, J. H. (2021). Diagnosis and management of traumatic dental injuries. Dental Clinics of North America, 65(1), 1–22. https://doi.org/10.1016/j.cden.2020.08.001
✔ Lin, L. M., & Rosenberg, P. A. (2023). Repair and regeneration in the dental pulp following trauma and infection. Frontiers in Dental Medicine, 10, 1102994. https://doi.org/10.3389/fdmed.2023.1102994

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martes, 7 de octubre de 2025

Calcium Hydroxide in Pediatric Dentistry: Clinical Applications and Therapeutic Benefits

Calcium Hydroxide

Abstract
Calcium hydroxide (Ca(OH)₂) remains a cornerstone biomaterial in pediatric dentistry for vital pulp therapy, apexification, and indirect pulp capping.

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Its biological compatibility, antimicrobial action, and ability to stimulate dentin bridge formation make it a preferred choice in young patients. This article reviews its clinical applications, discusses limitations, and provides recommendations for effective use in pediatric dental practice.

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Introduction
Calcium hydroxide, first introduced to dentistry by Hermann in 1920, has been extensively used in endodontics and pediatric dentistry. It is a strong base with a high pH (approximately 12.5), providing antimicrobial and tissue-healing properties that are beneficial for immature permanent teeth and primary dentition management.
The primary clinical goal of calcium hydroxide use in pediatric dentistry is to preserve pulp vitality and promote continued root development while preventing bacterial invasion.

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Clinical Applications of Calcium Hydroxide in Pediatric Dentistry

1. Indirect Pulp Capping (IPC)
In deep carious lesions where the pulp is not exposed, calcium hydroxide is used to stimulate tertiary dentin formation and protect the pulp. Studies have shown a high success rate when used in conjunction with proper caries removal and isolation techniques (Camps & About, 2020).

2. Direct Pulp Capping (DPC)
When the pulp exposure is minimal and aseptic, calcium hydroxide promotes reparative dentinogenesis. However, newer materials such as mineral trioxide aggregate (MTA) or calcium silicate-based materials show superior long-term sealing.

3. Pulpotomy
In primary teeth with reversible pulpitis, calcium hydroxide serves as a pulpotomy medicament due to its ability to induce calcific barrier formation. Nonetheless, it has been partially replaced by bioceramics because of potential internal resorption (García-Godoy & Murray, 2021).

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4. Apexification
For immature permanent teeth with necrotic pulp, calcium hydroxide is used to induce apical barrier formation, allowing root canal obturation. Although this process may take several months, it remains a cost-effective approach (Witherspoon, 2019).

5. Root Canal Disinfection
Due to its antimicrobial effect, calcium hydroxide is used as an intracanal medicament in pediatric endodontics, especially against Enterococcus faecalis and other persistent bacteria (Haapasalo & Ørstavik, 2020).

📊 Summary Table: Calcium Hydroxide in Pediatric Dentistry

Aspect Advantages Limitations
Indirect Pulp Capping Stimulates tertiary dentin; preserves pulp vitality Requires strict isolation; risk of failure if contamination occurs
Direct Pulp Capping Promotes dentin bridge formation; antimicrobial Weaker seal compared to MTA; possible pulp necrosis
Pulpotomy Induces calcific barrier; inexpensive May cause internal resorption; less durable than bioceramics
Apexification Effective for apical barrier formation Long treatment duration; potential weakening of dentin
Intracanal Medicament Broad antimicrobial action; biocompatible Limited effect on biofilms; incomplete neutralization in deep tubules

💬 Discussion
Calcium hydroxide’s success in pediatric dentistry relies on its biological properties—specifically its alkaline pH that neutralizes bacterial endotoxins and promotes hard tissue deposition. However, while it remains valuable for certain applications, modern materials such as MTA and Biodentine exhibit enhanced sealing abilities and faster healing responses.
Comparative studies show that although calcium hydroxide remains reliable for apexification and indirect pulp capping, MTA outperforms it in direct pulp capping and pulpotomy due to better biocompatibility and sealing capacity (Nair et al., 2022).

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✍️ Conclusion
Calcium hydroxide continues to play an important role in pediatric dentistry, particularly in treatments where biocompatibility and tissue regeneration are prioritized. Despite newer alternatives offering improved performance, calcium hydroxide remains a cost-effective and versatile option when applied with proper technique and case selection.

🔎 Recommendations

Use calcium hydroxide primarily for indirect pulp capping and apexification in children.
Employ strict isolation techniques to prevent contamination.
Consider MTA or calcium silicate-based materials for direct pulp capping or pulpotomy.
Regularly evaluate long-term clinical outcomes and radiographic healing.

📚 References

✔ Camps, J., & About, I. (2020). Pulp healing through calcium hydroxide: A review of molecular mechanisms. Journal of Dental Research, 99(10), 1122–1130. https://doi.org/10.1177/0022034520937071
✔ García-Godoy, F., & Murray, P. E. (2021). Recommendations for using regenerative endodontic procedures in permanent immature teeth. Dental Clinics of North America, 65(1), 37–52. https://doi.org/10.1016/j.cden.2020.08.003
✔ Haapasalo, M., & Ørstavik, D. (2020). In vitro infection and disinfection of dentinal tubules. Endodontic Topics, 37(1), 123–145. https://doi.org/10.1111/etp.12321
✔ Nair, P. N. R., Duncan, H. F., & Torabinejad, M. (2022). Newer materials in pulp therapy for children. International Endodontic Journal, 55(8), 789–803. https://doi.org/10.1111/iej.13721
Witherspoon, D. E. (2019). Apexification: Techniques and outcomes in pediatric endodontics. Journal of Endodontics, 45(2), 136–145. https://doi.org/10.1016/j.joen.2018.10.010

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miércoles, 1 de octubre de 2025

Calcium Hydroxide in Pediatric Dentistry: Benefits and Limitations

Calcium Hydroxide

Calcium hydroxide has been one of the most widely used biomaterials in pediatric dentistry for several decades. Its biological properties, high alkalinity, and ability to stimulate hard tissue formation have made it a cornerstone in pulp therapy procedures.

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Despite the emergence of newer bioactive materials, calcium hydroxide remains clinically relevant due to its availability, cost-effectiveness, and antimicrobial properties (Fuks, 2020). This article explores its use in pediatric dentistry, with a focus on its advantages, limitations, and clinical indications.

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Clinical Applications in Pediatric Dentistry
In pediatric dentistry, calcium hydroxide is used primarily for vital pulp therapy procedures such as direct pulp capping, pulpotomy, and apexogenesis. It is also employed in endodontics for apexification of immature permanent teeth. The high pH (around 12.5) provides strong antimicrobial action and stimulates the release of bioactive molecules that promote reparative dentinogenesis (Schwendicke et al., 2016).

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Advantages of Calcium Hydroxide

1. Antibacterial properties: Its alkalinity eliminates many microorganisms present in infected pulp tissue.
2. Induction of dentin bridge formation: It stimulates odontoblastic activity, leading to reparative dentinogenesis.
3. Cost-effective: It is inexpensive and readily available compared to newer bioceramic alternatives.
4. Long history of use: Decades of clinical evidence support its efficacy.

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Limitations of Calcium Hydroxide

1. Solubility: It tends to dissolve over time, which may compromise long-term sealing ability.
2. Poor adhesion to dentin: Risk of microleakage and failure in long-term pulp protection.
3. Tunneling defects in dentin bridges: Histological studies show incomplete or porous dentin formation (Fuks, 2020).
4. Reduced success rates in long-term apexification: Newer materials such as mineral trioxide aggregate (MTA) and calcium silicate cements show superior results.

📊 Calcium Hydroxide in Pediatric Dentistry: Advantages and Limitations

Aspect Advantages Limitations
Antibacterial Action High alkalinity eliminates most microorganisms Efficacy decreases over time as material dissolves
Dentin Bridge Formation Stimulates odontoblast-like cells for reparative dentin May produce porous or incomplete dentin bridges
Cost and Availability Inexpensive and widely accessible Inferior long-term outcomes compared to MTA
Clinical Evidence Decades of successful use in pediatric pulp therapy Declining preference due to newer bioactive materials

💬 Discussion
Calcium hydroxide continues to be a valuable material in pediatric dentistry, particularly in regions where access to advanced biomaterials is limited. Its strong antimicrobial activity and ability to induce reparative dentinogenesis are undeniable strengths. However, modern clinical evidence indicates that calcium silicate-based materials such as MTA and Biodentine outperform calcium hydroxide in long-term pulp therapy outcomes (Torabinejad et al., 2018). The limitations of solubility, poor sealing, and incomplete dentin bridge formation highlight the need for careful case selection when using calcium hydroxide in pediatric patients.

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✍️ Conclusion
While calcium hydroxide remains a cost-effective and biologically favorable material for pediatric pulp therapy, its limitations should not be overlooked. Clinicians must balance its advantages against its shortcomings and consider the use of newer bioceramic alternatives when available. Future research may further clarify its role in modern pediatric dentistry, particularly in combination therapies or modified formulations.

📚 References

✔ Fuks, A. B. (2020). Vital pulp therapy with new materials for primary teeth: New directions and treatment perspectives. Journal of Endodontics, 46(3), S49–S57. https://doi.org/10.1016/j.joen.2019.01.026
✔ Schwendicke, F., Brouwer, F., Schwendicke, A., & Paris, S. (2016). Different materials for direct pulp capping: Systematic review and meta-analysis. Journal of Dentistry, 54, 1–17. https://doi.org/10.1016/j.jdent.2016.08.005
✔ Torabinejad, M., Parirokh, M., & Dummer, P. M. H. (2018). Mineral trioxide aggregate and other bioactive endodontic cements: An updated overview – Part II: Other clinical applications and outcomes. International Endodontic Journal, 51(3), 284–317. https://doi.org/10.1111/iej.12843

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lunes, 29 de septiembre de 2025

Vital Pulp Therapy in Primary Teeth: Evidence-Based Approaches

Vital Pulp Therapy

Vital pulp therapy (VPT) in primary teeth aims to preserve the vitality and function of the dental pulp after carious or traumatic exposure. Its ultimate goal is to maintain primary teeth until their natural exfoliation, ensuring arch integrity, mastication, and normal development of permanent successors.

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Over the last decades, research has led to an evolution of techniques and materials, moving toward biocompatible, evidence-based approaches.

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Definition of Vital Pulp Therapy Techniques

1. Indirect Pulp Treatment (IPT)
Indirect pulp treatment involves leaving a thin layer of affected but not infected dentin to avoid pulp exposure. A biocompatible liner is placed to encourage dentin remineralization and pulp healing.
➤ Current materials: calcium hydroxide, resin-modified glass ionomer, mineral trioxide aggregate (MTA), and calcium silicate-based cements.

2. Direct Pulp Capping (DPC)
Direct pulp capping is performed when a small mechanical or traumatic pulp exposure occurs. A bioactive material is applied directly over the pulp to stimulate reparative dentin formation.
➤ Current materials: MTA, calcium hydroxide, and newer bioceramics (Biodentine®).

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3. Pulpotomy
Pulpotomy is the most widely used VPT technique in primary teeth. It involves removal of the coronal pulp tissue, preserving radicular pulp vitality.
➤ Current medicaments: formocresol (historically used but controversial), ferric sulfate, MTA, Biodentine®, and sodium hypochlorite as hemostatic agents.

4. Pulpectomy (Non-Vital Alternative)
Although technically not a vital pulp therapy, pulpectomy is often considered in the treatment plan when pulp vitality cannot be preserved. It involves complete removal of pulp tissue and obturation of root canals with resorbable materials.
➤ Current medicaments: iodoform-based pastes (Vitapex®), calcium hydroxide-iodoform combinations.

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💬 Discussion
Current evidence strongly favors biocompatible and bioactive materials such as MTA and calcium silicate-based cements over traditional agents like formocresol, due to their improved outcomes in terms of pulp healing, dentin bridge formation, and biocompatibility (Farsi et al., 2023). The choice of technique depends on pulp status, extent of caries, and presence of symptoms. While IPT and DPC are conservative, pulpotomy remains the gold standard for cariously exposed but vital pulp.
Long-term clinical trials indicate that MTA and Biodentine® outperform traditional materials in terms of success rates and reduced adverse effects (Gomes et al., 2022). Nonetheless, cost and handling characteristics remain barriers in some clinical settings.

✍️ Conclusion
Vital pulp therapy in primary teeth is essential to maintain function and arch stability until natural exfoliation. Evidence-based protocols support the use of bioactive cements such as MTA and Biodentine®, which demonstrate superior clinical and histological outcomes compared to traditional agents. The clinician’s decision should integrate pulp vitality assessment, child cooperation, and material availability.

📊 Vital Pulp Therapy Techniques in Primary Teeth

Technique Advantages Limitations
Indirect Pulp Treatment (IPT) Preserves pulp vitality; high success rate; conservative Risk of residual caries; requires good sealing
Direct Pulp Capping (DPC) Promotes reparative dentin formation; maintains pulp vitality Lower success in carious exposures; best for mechanical exposures
Pulpotomy Effective in symptomatic exposures; long-standing clinical success Technique sensitive; controversy over medicaments
Pulpectomy Option for non-vital teeth; preserves tooth until exfoliation Not a true VPT; complex procedure; risk of failure in resorption

📚 References

✔ Farsi, N., Bawazir, O., & Al-Shahrani, A. (2023). Clinical and radiographic success of pulpotomy in primary teeth using mineral trioxide aggregate and Biodentine: A systematic review and meta-analysis. International Journal of Paediatric Dentistry, 33(1), 35–45. https://doi.org/10.1111/ipd.13013
✔ Gomes, A. C., Lima, T. F., Soares, D. G., & Hebling, J. (2022). Vital pulp therapy in primary teeth with calcium silicate-based materials: A systematic review. Journal of Dentistry, 120, 104102. https://doi.org/10.1016/j.jdent.2022.104102
✔ American Academy of Pediatric Dentistry (AAPD). (2022). Guideline on pulp therapy for primary and immature permanent teeth. The Reference Manual of Pediatric Dentistry, 403–412. https://www.aapd.org/research/oral-health-policies--recommendations

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