Mostrando entradas con la etiqueta Dental article. Mostrar todas las entradas
Mostrando entradas con la etiqueta Dental article. Mostrar todas las entradas

miércoles, 28 de enero de 2026

Pulpotomy Materials Comparison: Calcium Hydroxide vs. Mineral Trioxide Aggregate (MTA) in Primary Molars

Pulpotomy

Pulpotomy is a widely accepted vital pulp therapy for primary molars affected by carious exposure or traumatic injury, aiming to preserve the radicular pulp and maintain tooth function until natural exfoliation.

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The selection of an appropriate pulpotomy material is critical, as it directly influences clinical success, pulpal healing, and long-term prognosis. Among the materials most frequently studied, calcium hydroxide (CH) and mineral trioxide aggregate (MTA) have received significant attention due to their biological properties and historical relevance.

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This article provides an updated and evidence-based comparison of these two materials, emphasizing their performance in primary molar pulpotomy from a contemporary pediatric dentistry perspective.

Biological Rationale of Pulpotomy Materials

Calcium Hydroxide
Calcium hydroxide has been traditionally used in vital pulp therapy due to its high alkalinity, antibacterial effect, and ability to stimulate reparative dentin formation. However, its application in primary teeth has shown limitations, including internal resorption and incomplete dentinal bridge formation, which may compromise treatment outcomes.

Mineral Trioxide Aggregate (MTA)
MTA is a bioactive calcium silicate-based material known for its excellent biocompatibility, sealing ability, and capacity to induce hard tissue formation. In primary molars, MTA promotes favorable pulpal responses, including reduced inflammation and consistent dentin bridge formation, contributing to higher long-term success rates.

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Clinical and Radiographic Outcomes
Multiple randomized clinical trials and systematic reviews have demonstrated that MTA exhibits superior clinical and radiographic success compared to calcium hydroxide in primary molar pulpotomy. While CH may provide acceptable short-term outcomes, MTA consistently shows lower rates of pathological root resorption, pulp necrosis, and treatment failure during follow-up periods extending beyond 12 months.

💬 Discussion
The declining use of calcium hydroxide in primary molar pulpotomy is supported by growing evidence highlighting its biological instability in primary pulp tissue. In contrast, MTA has emerged as the reference material due to its predictable healing response and long-term effectiveness. Despite its higher cost and handling complexity, MTA’s advantages outweigh these limitations, particularly in pediatric patients where preservation of primary teeth is essential for occlusal development and space maintenance.

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✍️ Conclusion
Based on current scientific evidence, mineral trioxide aggregate demonstrates superior clinical performance compared to calcium hydroxide in pulpotomy of primary molars. Its enhanced biocompatibility, sealing properties, and reduced risk of internal resorption make MTA the preferred material for vital pulp therapy in primary dentition.

🎯 Clinical Recommendations
▪️ MTA should be considered the material of choice for pulpotomy in primary molars when available.
▪️ Calcium hydroxide should be used with caution due to its association with internal resorption and lower long-term success.
▪️ Proper case selection, hemorrhage control, and coronal sealing remain critical regardless of the material used.
▪️ Long-term clinical and radiographic follow-up is essential to evaluate pulpal response and tooth integrity.

📊 Comparative Table: Calcium Hydroxide vs. MTA in Primary Molar Pulpotomy

Clinical Parameter Calcium Hydroxide Mineral Trioxide Aggregate (MTA)
Biocompatibility Moderate; may induce chronic inflammation Excellent; promotes favorable pulpal healing
Dentin bridge formation Inconsistent and porous Homogeneous and well-organized
Risk of internal resorption High incidence reported Minimal to none
Long-term clinical success Lower success rates over time High success rates in long-term follow-up
📚 References

✔ American Academy of Pediatric Dentistry. (2023). Pulp therapy for primary and immature permanent teeth. Pediatric Dentistry, 45(6), 403–412.
✔ Agamy, H. A., Bakry, N. S., Mounir, M. M., & Avery, D. R. (2004). Comparison of mineral trioxide aggregate and formocresol as pulp-capping agents in pulpotomized primary teeth. Pediatric Dentistry, 26(4), 302–309.
✔ Holan, G., Eidelman, E., & Fuks, A. B. (2005). Long-term evaluation of pulpotomy in primary molars using mineral trioxide aggregate or formocresol. Pediatric Dentistry, 27(2), 129–136.
✔ Peng, L., Ye, L., Guo, X., Tan, H., Zhou, X., Wang, C., & Li, R. (2007). Evaluation of formocresol versus mineral trioxide aggregate primary molar pulpotomy: A meta-analysis. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 104(6), e40–e44.

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What Are the Oral Manifestations in Oncology Patients? : Early and Advanced Manifestations

oral manifestation oncology

Patients undergoing cancer treatment frequently develop oral manifestations that significantly impact quality of life, nutrition, and treatment adherence. These manifestations may appear early during oncologic therapy or progress to severe, potentially life-threatening complications in advanced stages.

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Oral changes are mainly associated with chemotherapy, radiotherapy, targeted therapies, and hematopoietic stem cell transplantation, as well as with cancer-related immunosuppression.

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Understanding the chronological progression of oral manifestations is essential for early diagnosis, preventive care, and multidisciplinary management.

Early Oral Manifestations in Oncology Patients
Early oral changes often develop within days to weeks after initiation of cancer therapy and may be subtle but clinically significant.

➤ Oral Mucositis
Oral mucositis is one of the most common and debilitating early complications, characterized by:
▪️ Erythema and mucosal inflammation
▪️ Painful ulcerations
▪️ Burning sensation and hypersensitivity
It is primarily induced by chemotherapy and head-and-neck radiotherapy, resulting from epithelial cell damage and inflammatory cytokine release.

➤ Xerostomia
Reduced salivary flow is frequently observed, especially in patients receiving radiotherapy involving salivary glands. Early xerostomia leads to:
▪️ Dry mouth
▪️ Difficulty swallowing and speaking
▪️ Increased risk of dental caries

➤ Taste Alterations (Dysgeusia)
Taste disturbances may appear early due to damage to taste buds or salivary changes, often resulting in:
▪️ Metallic or bitter taste
▪️ Reduced appetite
▪️ Nutritional deficiencies

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Intermediate Oral Manifestations
As oncologic treatment continues, oral alterations may progress in severity.

➤ Opportunistic Infections
Immunosuppression increases susceptibility to infections, including:
▪️ Oral candidiasis (pseudomembranous or erythematous forms)
▪️ Herpes simplex virus reactivation
▪️ Bacterial infections
These conditions may exacerbate pain and delay oncologic therapy.

➤ Dental and Periodontal Complications
Reduced salivary protection and poor oral hygiene can lead to:
▪️ Radiation-induced caries
▪️ Gingivitis and periodontitis
▪️ Tooth sensitivity and enamel demineralization

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Advanced Oral Manifestations
Advanced stages are often associated with long-term or high-dose oncologic treatments and may have permanent consequences.

➤ Osteoradionecrosis
Osteoradionecrosis is a severe complication mainly affecting irradiated jawbones, characterized by:
▪️ Exposed necrotic bone
▪️ Chronic pain and infection
▪️ Impaired wound healing

➤ Severe Trismus
Fibrosis of masticatory muscles and temporomandibular joint structures may result in:
▪️ Limited mouth opening
▪️ Difficulty eating and maintaining oral hygiene

➤ Chronic Ulcerations and Tissue Necrosis
Persistent ulcerations may occur due to:
▪️ Vascular damage
▪️ Impaired immune response
▪️ Secondary infections
These lesions significantly compromise oral function and patient comfort.

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💬 Discussion
Oral manifestations in oncology patients are multifactorial and progressive, reflecting both the direct effects of cancer therapy and the systemic condition of the patient. Early recognition allows for preventive and supportive interventions, reducing complications and improving overall outcomes. Dental professionals play a crucial role within the multidisciplinary oncology care team, particularly in prevention, monitoring, and management of oral complications.

🎯 Recommendations
▪️ Perform comprehensive dental evaluation before initiating cancer therapy
▪️ Implement preventive oral care protocols, including fluoride application
▪️ Monitor patients regularly throughout oncologic treatment
▪️ Manage oral infections promptly to avoid systemic spread
▪️ Educate patients on meticulous oral hygiene and symptom reporting

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✍️ Conclusion
Oral manifestations in oncology patients range from early inflammatory changes to advanced destructive complications. Their impact on quality of life and treatment continuity underscores the importance of early diagnosis, preventive strategies, and interdisciplinary collaboration. Proactive dental management is essential to minimize morbidity and support successful oncologic outcomes.

📚 References

✔ Lalla, R. V., Bowen, J., Barasch, A., Elting, L., Epstein, J., Keefe, D. M., … Sonis, S. T. (2014). MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer, 120(10), 1453–1461. https://doi.org/10.1002/cncr.28592
✔ Sonis, S. T. (2009). Mucositis: The impact, biology and therapeutic opportunities of oral mucositis. Oral Oncology, 45(12), 1015–1020. https://doi.org/10.1016/j.oraloncology.2009.08.006
✔ Jansma, J., Vissink, A., Spijkervet, F. K. L., Roodenburg, J. L. N., & Panders, A. K. (1993). Protocol for the prevention and treatment of oral sequelae resulting from head and neck radiotherapy. Cancer, 72(10), 2895–2903. https://doi.org/10.1002/1097-0142(19931115)72:10

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martes, 27 de enero de 2026

Night Guards: Do They Really Help with Bruxism?

Night Guards - Bruxism

Bruxism is a common parafunctional activity characterized by repetitive jaw muscle activity, including clenching or grinding of the teeth. It can occur during sleep (sleep bruxism) or while awake (awake bruxism) and is associated with tooth wear, temporomandibular disorders, and orofacial pain.

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Among the most widely recommended treatments are night guards, also known as occlusal splints. However, an important clinical question remains: do night guards truly help manage bruxism, or do they simply protect the teeth from its consequences?

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What Is Bruxism?
Bruxism is defined as a repetitive masticatory muscle activity characterized by clenching, grinding, or bracing of the mandible. It is considered a multifactorial condition, influenced by biological, psychological, and neurological factors rather than occlusal discrepancies alone.

Types of Bruxism
▪️ Sleep bruxism: A sleep-related movement disorder associated with micro-arousals.
▪️ Awake bruxism: A behavioral condition often linked to stress or concentration.

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Causes of Bruxism
The etiology of bruxism is complex and multifactorial:

▪️ Psychological factors, such as stress, anxiety, and emotional tension
▪️ Central nervous system regulation, including sleep arousal mechanisms
▪️ Medications, particularly selective serotonin reuptake inhibitors (SSRIs)
▪️ Sleep disorders, such as obstructive sleep apnea
▪️ Lifestyle factors, including caffeine, alcohol, and tobacco use
Current evidence indicates that bruxism is centrally mediated, rather than caused by dental occlusion alone.

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Night Guards: Definition and Mechanism of Action
Night guards are custom-made or prefabricated intraoral appliances designed to cover the occlusal surfaces of the teeth, usually fabricated from acrylic or thermoplastic materials.

Their primary functions include:
▪️ Redistributing occlusal forces
▪️ Reducing tooth-to-tooth contact
▪️ Protecting dental structures from wear
▪️ Decreasing muscle hyperactivity in some patients
Importantly, night guards do not eliminate bruxism, but they may reduce its harmful effects.

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Clinical Effectiveness of Night Guards
Scientific evidence supports that night guards:

▪️ Protect teeth from further wear
▪️ May reduce muscle pain and morning discomfort
▪️ Can improve patient awareness of parafunctional habits
However, they do not consistently reduce the frequency of bruxism episodes, particularly in sleep bruxism. Their effectiveness is primarily protective rather than curative.

📊 Comparative Table: Bruxism Treatment Options

Treatment Approach Clinical Benefits Limitations
Night Guards (Occlusal Splints) Protect teeth, reduce wear, may decrease muscle discomfort Do not eliminate bruxism activity
Behavioral Therapy Addresses stress-related and awake bruxism factors Requires patient compliance and time
Botulinum Toxin Injections Reduces muscle hyperactivity and pain Temporary effect, invasive, higher cost
Pharmacological Management May help in selected neurological or sleep-related cases Limited evidence, potential side effects
💬 Discussion
Night guards remain a cornerstone in the management of bruxism due to their non-invasive nature and protective benefits. Nevertheless, their role should be clearly explained to patients: they manage the consequences, not the underlying neurological or behavioral causes.
Optimal management often requires a multidisciplinary approach, combining occlusal therapy with behavioral strategies, stress management, and, when indicated, pharmacological or adjunctive therapies.

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🎯 Recommendations
▪️ Use custom-fabricated night guards for better fit and compliance
▪️ Combine occlusal splints with behavioral and stress-reduction therapies
▪️ Monitor patients regularly for appliance wear and symptom progression
▪️ Address contributing factors such as sleep disorders or medication use
▪️ Educate patients that night guards protect teeth but do not cure bruxism

✍️ Conclusion
Night guards are an effective and evidence-based tool for protecting teeth and reducing symptoms associated with bruxism. While they do not eliminate the condition itself, they play a critical role in preventing irreversible dental damage. Comprehensive bruxism management should extend beyond occlusal appliances to address the multifactorial nature of the disorder.

📚 References

✔ Lobbezoo, F., Ahlberg, J., Raphael, K. G., Wetselaar, P., Glaros, A. G., Kato, T., & Manfredini, D. (2018). International consensus on the assessment of bruxism. Journal of Oral Rehabilitation, 45(11), 837–844. https://doi.org/10.1111/joor.12663
✔ Manfredini, D., Serra-Negra, J., Carboncini, F., & Lobbezoo, F. (2017). Current concepts of bruxism. International Journal of Prosthodontics, 30(5), 437–438. https://doi.org/10.11607/ijp.5210
✔ Macedo, C. R., Silva, A. B., Machado, M. A., Saconato, H., & Prado, G. F. (2007). Occlusal splints for treating sleep bruxism. Cochrane Database of Systematic Reviews, (4), CD005514. https://doi.org/10.1002/14651858.CD005514.pub2

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Common Drug Interactions in Pediatric Dentistry: Clinical Risks and Safe Prescribing

Drug Interactions

Drug interactions represent a critical yet often underestimated risk in pediatric dental care. Children frequently receive medications for systemic conditions such as asthma, epilepsy, attention-deficit disorders, and infections, which may interact with drugs commonly prescribed in dentistry.

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In odontopediatrics, these interactions can alter drug efficacy, increase toxicity, or exacerbate adverse effects, compromising patient safety.

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Understanding frequent drug interactions in pediatric dentistry is essential for accurate diagnosis, safe treatment planning, and prevention of iatrogenic complications.

Common Drug Classes Used in Pediatric Dentistry
Pediatric dental practice routinely involves the prescription of analgesics, antibiotics, local anesthetics, and adjunctive medications. While generally safe, these drugs may interact with medications already taken by the child, especially in medically compromised patients.

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Frequent Drug Interactions in Pediatric Dentistry

1. Analgesics and Antipyretics
Non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen are widely used in children. However:
▪️ Ibuprofen may enhance bleeding risk when combined with anticoagulants.
▪️ Acetaminophen interactions with enzyme-inducing drugs may increase hepatotoxicity.

2. Antibiotics
Antibiotics are among the most frequent causes of drug interactions:
▪️ Macrolides (erythromycin, clarithromycin) inhibit hepatic enzymes, increasing serum levels of other drugs.
▪️ Amoxicillin may reduce the effectiveness of certain oral medications due to gastrointestinal flora alterations.

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3. Local Anesthetics
Local anesthetics containing vasoconstrictors may interact with:
▪️ Central nervous system depressants, increasing sedation.
▪️ Cardiac medications, potentially affecting heart rate and blood pressure.

4. Sedatives and Behavioral Management Drugs
Sedation agents may interact with:
▪️ Antihistamines, increasing central nervous system depression.
▪️ Antiepileptic drugs, altering seizure control.

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Clinical Implications in Odontopediatrics
Children are particularly vulnerable to drug interactions due to immature hepatic metabolism, variable body weight, and limited communication of adverse symptoms. Undetected interactions may result in excessive sedation, bleeding complications, allergic reactions, or systemic toxicity.

📊 Comparative Table: Common Medications in Pediatric Dentistry

Medication Category Clinical Use in Children Potential Drug Interactions
Analgesics (Ibuprofen, Acetaminophen) Pain and inflammation control Bleeding risk with anticoagulants, hepatotoxicity with enzyme inducers
Antibiotics (Amoxicillin, Macrolides) Treatment of odontogenic infections Altered drug metabolism, reduced efficacy of concomitant medications
Local Anesthetics with Vasoconstrictors Pain control during dental procedures Cardiovascular and CNS interactions with systemic drugs
Sedatives and Anxiolytics Behavior management and procedural sedation Increased CNS depression with antihistamines or antiepileptics
💬 Discussion
Drug interactions in pediatric dentistry demand a multidisciplinary approach involving careful medical history review, dose adjustment, and communication with pediatricians when necessary. The risk-benefit ratio must be evaluated for every prescription, especially in children receiving long-term systemic therapies.
Failure to recognize these interactions may lead to preventable adverse events, highlighting the importance of pharmacological knowledge in pediatric dental practice.

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🎯 Recommendations for Safe Prescribing
▪️ Obtain a comprehensive medical and medication history at every visit.
▪️ Avoid polypharmacy whenever possible.
▪️ Use weight-based dosing and the lowest effective dose.
▪️ Consult with the child’s physician in complex medical cases.
▪️ Educate caregivers about possible adverse effects and warning signs.

✍️ Conclusion
Frequent drug interactions in pediatric dentistry represent a significant clinical challenge that can compromise treatment safety if overlooked. A thorough understanding of pharmacological interactions, combined with careful patient assessment, is essential to ensure safe, effective, and responsible dental care for children.

📚 References

✔ American Academy of Pediatric Dentistry. (2023). Guideline on use of pediatric medications. Pediatric Dentistry, 45(6), 395–402.
✔ Anderson, G. D. (2018). Children versus adults: Pharmacokinetic and adverse-effect differences. Epilepsia, 59(S1), 11–17. https://doi.org/10.1111/epi.14463
✔ Little, J. W., Falace, D. A., Miller, C. S., & Rhodus, N. L. (2018). Dental management of the medically compromised patient (9th ed.). Elsevier.
✔ Seymour, R. A., & Heasman, P. A. (2014). Drugs and the dental patient. Oxford University Press.

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Why Is Dental Pain More Intense at Night?

Dental Infection

Dental pain that intensifies at night is a common clinical complaint in both children and adults and a frequent reason for emergency dental consultations. Importantly, this pain does not occur spontaneously; in most cases, it is the direct consequence of an underlying dental infection, such as pulpitis, periapical abscess, or periodontal infection.

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Although the clinical presentation may vary according to age, the biological mechanisms responsible for nocturnal pain exacerbation are similar across pediatric and adult populations, involving inflammatory processes, increased intrapulpal pressure, and vascular changes. Understanding these mechanisms is essential for accurate diagnosis, timely intervention, and prevention of disease progression in patients of all ages.

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Dental Infection as the Primary Cause of Nighttime Tooth Pain
Dental infections arise when bacteria penetrate dental tissues, triggering inflammation, edema, and increased intrapulpal pressure. At night, several systemic and local factors amplify these processes, making pain more intense and persistent.

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Key Reasons Why Dental Pain Worsens at Night

1. Increased Blood Flow in the Supine Position
When lying down, gravity no longer assists venous drainage from the head and neck. This leads to increased blood flow to the infected tooth, intensifying pulpal or periapical pressure.

▪️ In inflamed pulp tissue, this pressure cannot dissipate
▪️ Results in throbbing, pulsatile pain
This mechanism is particularly evident in acute pulpitis and periapical infections.

2. Elevated Inflammatory Mediator Activity
Dental infections stimulate the release of prostaglandins, bradykinin, cytokines, and substance P, all of which sensitize nociceptors.

At night:
▪️ The body’s anti-inflammatory cortisol levels decrease
▪️ Inflammatory mediators become more active
This imbalance enhances pain perception from infected dental tissues.

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3. Reduced Sensory Distraction
During daytime activities, sensory input competes with pain signals. At night:

▪️ External stimuli are minimal
▪️ The brain focuses more on internal sensations
As a result, infection-related dental pain feels stronger and more intrusive.

4. Increased Intrapulpal Pressure in Closed Systems
The dental pulp is enclosed within rigid dentin walls. Infection-induced edema leads to:

▪️ Compression of nerve fibers
▪️ Reduced blood outflow
▪️ Progressive ischemia
These effects worsen during nighttime rest, making pain severe and persistent.

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5. Nighttime Bruxism and Clenching
Many patients clench or grind their teeth during sleep. In the presence of infection, this causes:

▪️ Mechanical stress on inflamed tissues
▪️ Further stimulation of pain receptors
This is especially relevant in teeth with irreversible pulpitis or abscesses.

📊 Comparative Table: Common Dental Infections and Night Pain

Type of Infection Typical Clinical Features Pain Characteristics
Irreversible Pulpitis Deep caries, spontaneous pain, thermal sensitivity Sharp, lingering pain worse at night
Periapical Abscess Swelling, tenderness to percussion, radiolucency Severe throbbing pain, intensified in supine position
Periodontal Abscess Localized swelling, periodontal pocketing Dull, pressure-related nocturnal pain
Pericoronitis Inflamed operculum around partially erupted tooth Radiating pain, worse at night and during chewing
💬 Discussion
Nighttime exacerbation of dental pain is not coincidental. It reflects a complex interaction between infection-driven inflammation, vascular dynamics, and neurophysiological factors. These mechanisms consistently point toward active dental infection rather than benign tooth sensitivity.
Ignoring nocturnal pain may allow infection to spread, potentially leading to systemic involvement or facial space infections.

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🎯 Clinical Recommendations
▪️ Nighttime dental pain should be considered an emergency sign
▪️ Avoid relying solely on analgesics
▪️ Seek prompt dental evaluation for definitive treatment
▪️ Early intervention may prevent abscess formation or tooth loss
▪️ Antibiotics alone are not sufficient without addressing the source

✍️ Conclusion
Dental pain that worsens at night is a strong indicator of underlying dental infection. The supine position, inflammatory mediator activity, and increased intrapulpal pressure all contribute to heightened pain perception. Early diagnosis and appropriate dental treatment are essential to resolve infection and prevent complications.

📚 References

✔ Hargreaves, K. M., & Berman, L. H. (2016). Cohen’s pathways of the pulp (11th ed.). Elsevier.
✔ Siqueira, J. F., & Rôças, I. N. (2009). Clinical implications of the microbiology of bacterial endodontic infections. Clinical Microbiology Revi, 22(4), 671–705.
✔ Renton, T. (2019). Dental pain and infection. British Dental Journal, 227(6), 511–518.
✔ Segura-Egea, J. J., et al. (2017). Periapical periodontitis and systemic disease. Journal of Endodontics, 43(11), 1784–1795.

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lunes, 26 de enero de 2026

What Are Fordyce Granules? Should You Be Concerned About Contagion?

Fordyce Granules

Fordyce granules, also known as Fordyce spots, are a common oral and dermatological finding characterized by the presence of ectopic sebaceous glands.

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Although frequently observed in routine dental examinations, they often generate concern among patients due to their appearance and misunderstanding regarding their nature and transmissibility. A clear, evidence-based explanation is essential for proper diagnosis and patient reassurance.

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What Are Fordyce Granules?
Fordyce granules are ectopic sebaceous glands that lack an associated hair follicle. They were first described by John Addison Fordyce in 1896 and are considered a normal anatomical variation rather than a pathological condition.
These granules typically appear as small, yellowish or whitish papules, measuring 1–3 mm in diameter. In the oral cavity, they are most commonly located on:

▪️ Buccal mucosa
▪️ Vermilion border of the lips
▪️ Retromolar area
Their prevalence increases after puberty, likely due to hormonal influence on sebaceous gland activity.

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Are Fordyce Granules Contagious?
Fordyce granules are not contagious. They are neither infectious nor associated with viral, bacterial, or fungal agents. Their presence does not indicate a sexually transmitted infection, systemic disease, or poor oral hygiene.
Importantly, they cannot be transmitted through contact, saliva, or sexual activity, a misconception that frequently causes unnecessary anxiety in patients.

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Clinical Diagnosis
Diagnosis of Fordyce granules is primarily clinical. Key diagnostic features include:

▪️ Asymptomatic presentation
▪️ Bilateral and symmetrical distribution
▪️ Stable size over time
▪️ Absence of erythema, ulceration, or induration
Biopsy is rarely indicated, except in atypical cases or when differentiation from other mucosal lesions is uncertain.

📊 Comparative Table: Differential Diagnosis of Fordyce Granules

Condition Key Clinical Features Diagnostic Considerations
Fordyce granules Yellowish, asymptomatic papules; bilateral distribution Clinical diagnosis; no treatment required
Oral candidiasis White plaques, may be removable, associated with discomfort Fungal infection; responds to antifungal therapy
Leukoplakia White patches, potentially premalignant Requires biopsy for histopathological evaluation
Oral lichen planus White striations or plaques, possible erosive areas Immune-mediated condition; clinical and histological diagnosis
💬 Discussion
Despite their benign nature, Fordyce granules are frequently misinterpreted as pathological lesions, leading to unnecessary referrals or overtreatment. Their resemblance to infectious or premalignant conditions highlights the importance of professional familiarity with their clinical presentation.
From a dental perspective, proper identification prevents misdiagnosis and supports evidence-based decision-making. Current literature consistently classifies Fordyce granules as harmless anatomical variants with no malignant potential.

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🎯 Recommendations
▪️ Patient education is essential to reduce anxiety and misconceptions.
▪️ Routine monitoring during dental examinations is sufficient.
▪️ Avoid unnecessary biopsy or treatment unless atypical features are present.
▪️ Referral to oral pathology is recommended only in doubtful or symptomatic cases.

✍️ Conclusion
Fordyce granules are a benign, non-contagious, and common anatomical variation of ectopic sebaceous glands. Accurate clinical recognition and patient reassurance are fundamental components of dental practice. Their identification requires no treatment and carries an excellent prognosis.

📚 References

✔ Neville, B. W., Damm, D. D., Allen, C. M., & Chi, A. C. (2016). Oral and maxillofacial pathology (4th ed.). Elsevier.
✔ Regezi, J. A., Sciubba, J. J., & Jordan, R. C. K. (2017). Oral pathology: Clinical pathologic correlations (7th ed.). Elsevier.
✔ Scully, C. (2013). Oral and maxillofacial medicine: The basis of diagnosis and treatment (3rd ed.). Churchill Livingstone.

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How Xylitol Reduces Cavity-Causing Bacteria: Clinical Mechanisms Explained

Xylitol

Dental caries remains one of the most prevalent chronic diseases worldwide. Among non-cariogenic sweeteners, xylitol has demonstrated significant anticariogenic properties, supported by extensive clinical and microbiological evidence.

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Unlike fermentable sugars, xylitol interferes with bacterial metabolism, particularly affecting Streptococcus mutans, a primary etiologic agent in dental caries.

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This article explains the clinical mechanisms by which xylitol reduces cavity-causing bacteria, highlighting its role in preventive dentistry.

What Is Xylitol?
Xylitol is a five-carbon sugar alcohol (polyol) naturally present in small amounts in fruits and vegetables. It is widely used in sugar-free chewing gums, lozenges, syrups, and oral health products due to its sweet taste and non-fermentable nature.
Importantly, xylitol cannot be metabolized by cariogenic bacteria, distinguishing it from sucrose and other fermentable carbohydrates.

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Mechanisms by Which Xylitol Reduces Cariogenic Bacteria

➤ Inhibition of Streptococcus mutans Metabolism
Streptococcus mutans actively transports xylitol into the cell via the fructose phosphotransferase system. However, once inside, xylitol is converted into xylitol-5-phosphate, which cannot be further metabolized, leading to:

▪️ Energy depletion
▪️ Intracellular accumulation of toxic metabolites
▪️ Reduced bacterial growth and viability
This process is known as futile energy cycling, a key antimicrobial mechanism.

➤ Reduction of Bacterial Adhesion
Xylitol exposure reduces the adhesive capacity of S. mutans to enamel surfaces by altering extracellular polysaccharide synthesis. As a result:

▪️ Biofilm formation is impaired
▪️ Plaque becomes less dense and less pathogenic

➤ Decreased Acid Production
Because xylitol is non-fermentable, it does not contribute to acid production. Regular exposure leads to:

▪️ Higher plaque pH
▪️ Reduced enamel demineralization
▪️ Enhanced remineralization balance

➤ Long-Term Ecological Shift in Oral Microbiota
Prolonged xylitol use promotes a less cariogenic oral microbiome, favoring non-acidogenic and non-aciduric bacterial species.

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Clinical Evidence Supporting Xylitol Use
Multiple randomized clinical trials and systematic reviews have shown that regular xylitol consumption (5–10 g/day) significantly reduces:

▪️ S. mutans levels in saliva and plaque
▪️ Caries incidence in children and adults
▪️ Vertical transmission of cariogenic bacteria from caregivers to infants

📊 Comparative Table: Preventive Measures in the Dental Office

Preventive Measure Clinical Benefits Limitations
Xylitol-Based Products Reduces *S. mutans* levels and plaque virulence Requires regular and sustained use
Topical Fluoride Application Enhances enamel remineralization and acid resistance Limited effect on bacterial counts
Dental Sealants Physical barrier against biofilm in pits and fissures Technique-sensitive and requires maintenance
Professional Plaque Control Reduces biofilm load and gingival inflammation Short-term effect without patient compliance
💬 Discussion
The anticariogenic effect of xylitol extends beyond simple sugar substitution. Its ability to disrupt bacterial metabolism and alter biofilm ecology positions xylitol as a valuable adjunct in caries prevention programs. However, its effectiveness depends on adequate dosage, frequency, and long-term compliance, and it should complement—not replace—other preventive strategies such as fluoride therapy.

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✍️ Conclusion
Xylitol reduces cavity-causing bacteria through well-documented biological mechanisms, including metabolic inhibition, reduced bacterial adhesion, and decreased acid production. When used consistently, xylitol contributes to a less cariogenic oral environment and supports evidence-based preventive dentistry.

🎯 Recommendations
▪️ Incorporate xylitol-containing products into caries prevention protocols
▪️ Recommend daily intake of 5–10 g of xylitol, divided into multiple exposures
▪️ Use xylitol as an adjunct, not a substitute, for fluoride
▪️ Educate patients on the importance of consistent use
▪️ Consider xylitol use in high-caries-risk patients and caregivers of young children

📚 References

✔ Mäkinen, K. K. (2016). Sugar alcohols, caries incidence, and remineralization of caries lesions: A literature review. International Journal of Dentistry, 2016, 1–23. https://doi.org/10.1155/2016/9810721
✔ Söderling, E. M. (2009). Xylitol, mutans streptococci, and dental plaque. Advances in Dental Research, 21(1), 74–78. https://doi.org/10.1177/0895937409335642
✔ Milgrom, P., Ly, K. A., Tut, O. K., Mancl, L. A., Roberts, M. C., Briand, K., & Gancio, M. J. (2009). Xylitol pediatric topical oral syrup to prevent dental caries: A randomized clinical trial. Archives of Pediatrics & Adolescent Medicine, 163(7), 601–607. https://doi.org/10.1001/archpediatrics.2009.103
✔ European Food Safety Authority. (2011). Scientific opinion on the substantiation of health claims related to xylitol. EFSA Journal, 9(4), 2076. https://doi.org/10.2903/j.efsa.2011.2076

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