Tongue cancer—primarily squamous cell carcinoma (SCC)—represents a significant portion of head and neck malignancies. Although relatively rare (less than 1 % of new cancer cases), its incidence is rising among younger, non‑smoking populations .
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✅ Risk Factors
° Tobacco smoking and smokeless tobacco: Primary risk factor; smoking increases risk 3–6× and smokeless forms similarly elevate risk.
° Alcohol consumption: Heavy alcohol use independently increases risk (~20 % of oral cancers), synergizes with tobacco to cause ~72 % of head and neck cancers.
° HPV infection: High-risk strains (HPV‑16/18) are strongly linked to base‑of‑tongue SCC; rising HPV-driven oropharyngeal cancers.
° Betel nut and paan chewing: Doubles oral cancer risk even without tobacco, contributing up to 40 % of cases in endemic regions.
° Chronic inflammation and oral dysbiosis: Emerging research links chronic oral irritation/infections with oxidative stress and carcinogenesis.
° Non-modifiable factors: Includes age (≥ 40), male sex (2× risk), race (higher in African‑American men), family or personal cancer history.
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° Non-healing ulcers or sores, red/white patches (erythroplakia, leukoplakia).
° Lumps or thickening on tongue; easy bleeding.
° Pain, burning, numbness, or discomfort in mouth/jaw .
° Functional issues: difficulty chewing, swallowing, speaking; ear, throat, or jaw pain; loose teeth .
° Late-stage signs: neck lymphadenopathy, weight loss, bleeding, voice changes.
✅ Diagnosis
° Clinical exam: Visual and manual inspection, mirror or endoscopic (nasendoscopy) evaluation.
° Biopsy & histopathology: Essential for definitive diagnosis. HPV testing often included.
° Imaging: CT, MRI, ultrasound, PET‑CT to assess tumor extent and lymph node involvement.
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° Surgery: Primary for early-stage disease; transoral resections for oral tongue; neck dissection as needed.
° Radiation therapy: Often adjuvant post-surgery or primary modality for advanced/inoperable cases.
° Chemotherapy & chemoradiation: Platinum-based regimens, especially for HPV-negative or bulky disease .
° Targeted therapies & immunotherapy: Emerging modalities; microenvironment-targeted immunotherapy under study.
° Supportive care: Speech/swallow rehabilitation, nutritional support to manage side effects.
✅ Prevention
° Smoking cessation and reduced alcohol intake are the most effective strategies.
° HPV vaccination (recommended through age 45) may reduce HPV-driven tongue cancer.
° Avoid betel nut/paan; improve oral hygiene and diet (fruit/vegetable intake).
° Regular dental/oral screenings with prompt evaluation of lesions persisting >2–3 weeks .
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Recent epidemiological trends indicate an increase in tongue cancer among young, non-smoking individuals, highlighting the growing importance of HPV and alternative risk factors. Concurrently, advancements in diagnostic imaging, minimally invasive surgical techniques, and immunotherapies offer improved outcomes and functional preservation. However, challenges persist: late-stage presentation, therapy-related toxicity, and disparities in access to HPV vaccination and specialist care.
💡 Conclusion
Tongue cancer is a multifactorial disease shaped by lifestyle, viral, environmental, and biological determinants. Contemporary understanding underscores the interplay of traditional risks—tobacco and alcohol—with newer drivers like HPV, chronic inflammation, and betel nut use. Early detection and a multidisciplinary treatment approach remain paramount. Preventive measures, especially smoking cessation, alcohol reduction, and HPV vaccination, are critical for reducing incidence.
📚 References
✔ American Cancer Society. (2021). Risk Factors for Oral Cavity and Oropharyngeal Cancers. Retrieved from American Cancer Society website.
✔ Cleveland Clinic. (2023). Tongue cancer: symptoms, causes & treatment. Cleveland Clinic.
✔ Mayo Clinic Staff. (2025, November). Tongue cancer: symptoms and causes. Mayo Clinic.
✔ Current trends on prevalence, risk factors and prevention of oral... Frontiers in Oral Health, 2024.
✔ Exploration Pub. (2024). Risk factors, prevention, diagnosis, and immunotherapy’s role in oral cancer.
✔ Verywell Health. (2024, April 22). Tongue Cancer: Everything You Need to Know.
✔ New York Post. (2025, May). Top Chef alum Shirley Chung cancer update.
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