Odontogenic Infection Protocol: Clinical & Pharmacological Guide

Odontogenic infections are bacterial infections that begin in or around a tooth, usually because of untreated dental caries, pulp necrosis, or periodontal disease.

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If managed early, most infections can be treated successfully without serious complications. However, delayed treatment may allow the infection to spread into the facial spaces, increasing the risk of hospitalization or even airway obstruction.

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This guide summarizes the current evidence-based clinical and pharmacological protocol recommended by international dental organizations, using clear language while maintaining scientific accuracy.

✅ Clinical Assessment
Before prescribing any medication, identify the source and severity of the infection.

Evaluate:
▪️ Medical history and allergies.
▪️ Presence of pain, swelling, fever, or difficulty swallowing.
▪️ Facial asymmetry or cellulitis.
▪️ Tooth vitality and periodontal status.
▪️ Radiographic examination (periapical or panoramic radiograph when indicated).
Patients should be classified into one of three categories:

1. Localized Infection
▪️ Pain localized to one tooth.
▪️ Small abscess or sinus tract.
▪️ No fever or facial swelling.

2. Spreading Infection
▪️ Diffuse facial swelling.
▪️ Cellulitis.
▪️ Trismus.
▪️ Enlarged lymph nodes.

3. Severe Infection
▪️ Fever.
▪️ Difficulty swallowing or breathing.
▪️ Rapidly progressing swelling.
▪️ Signs of systemic illness.
These patients require urgent referral and possible hospital management.

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✅ Clinical Management Protocol

Step 1 – Eliminate the Source of Infection
The defensive treatment is always dental treatment, not antibiotics alone.
Depending on the diagnosis:
▪️ Drain the abscess when fluctuation is present.
▪️ Perform root canal treatment if the tooth is restorable.
▪️ Extract teeth with poor prognosis.
▪️ Debride infected tissues when necessary.
Removing the infection source is the most effective way to stop disease progression.

Step 2 – Pain Management
Pain control improves patient comfort and quality of life.
First-line analgesics include:
▪️ Ibuprofen (when not contraindicated)
▪️ Acetaminophen (Paracetamol)
The combination of ibuprofen and acetaminophen has shown superior analgesic effects compared with opioid-containing medications for most dental pain.

Step 3 – Pharmacological Management
When Are Antibiotics Indicated?
Antibiotics should NOT be prescribed for:
▪️ Reversible pulpitis
▪️ Irreversible pulpitis
▪️ Localized periapical abscess that can be drained
▪️ Localized odontogenic infection without systemic involvement
Instead, provide definitive dental treatment.
Antibiotics ARE Indicated When There Is:
▪️ Fever
▪️ Cellulitis
▪️ Diffuse facial swelling
▪️ Progressive infection
▪️ Trismus
▪️ Immunocompromised patients
▪️ Regional lymphadenopathy associated with spreading infection

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✅ First-Line Antibiotics

Amoxicillin
The preferred first-line antibiotic for most odontogenic infections.
Typical adult dosage:
▪️ 500 mg every 8 hours
▪️ Duration: 3–7 days, depending on clinical response.

Amoxicillin + Clavulanic Acid
Recommended when:
▪️ Infection is severe.
▪️ β-lactamase-producing bacteria are suspected.
▪️ Initial treatment fails.
Typical adult dosage:
▪️ 875/125 mg every 12 hours

Penicillin Allergy
Recommended alternatives include:
▪️ Azithromycin
▪️ Clindamycin (use cautiously due to increased risk of Clostridioides difficile infection and follow current antimicrobial stewardship recommendations.)

Metronidazole
Useful as an adjunct in infections with significant anaerobic involvement. It is generally combined with amoxicillin, rather than used alone.

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✅ Clinical Follow-Up
Patients should be reassessed within 48–72 hours.
Evaluate:
▪️ Pain reduction.
▪️ Decreased swelling.
▪️ Improved mouth opening.
▪️ Resolution of fever.
▪️ Adequate drainage.
If symptoms worsen despite treatment, reassess the diagnosis, obtain additional imaging if necessary, and consider referral to an oral and maxillofacial surgeon.

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💬 Discussion
Current evidence shows that the success of odontogenic infection management depends primarily on eliminating the source of infection, while antibiotics serve as an adjunct only when systemic involvement or spreading infection is present. Excessive antibiotic prescribing contributes to antimicrobial resistance, making careful patient selection essential. Modern clinical guidelines therefore emphasize early diagnosis, prompt dental intervention, and responsible antibiotic stewardship.

🎯 Recommendations
▪️ Treat the source of infection first, whenever possible.
▪️ Do not prescribe antibiotics routinely for localized dental infections.
▪️ Drain abscesses whenever indicated.
▪️ Review patients within 48–72 hours.
▪️ Educate patients to seek care early to prevent complications.
▪️ Follow evidence-based antimicrobial stewardship principles to reduce unnecessary antibiotic use.

✍️ Conclusion
Early diagnosis, prompt dental treatment, and appropriate antibiotic use are the foundations of successful odontogenic infection management. Most localized infections can be resolved through definitive dental procedures alone, while antibiotics should be reserved for patients with systemic involvement or spreading infections. Following evidence-based clinical protocols improves patient outcomes, reduces complications, and supports global efforts against antimicrobial resistance.

📚 References

✔ American Academy of Pediatric Dentistry. (2024). Use of antibiotic therapy for pediatric dental patients. The Reference Manual of Pediatric Dentistry. American Academy of Pediatric Dentistry.
✔ American Dental Association. (2019). Evidence-based clinical practice guideline on antibiotic use for the urgent management of pulpal- and periapical-related dental pain and intra-oral swelling. Journal of the American Dental Association, 150(11), 906–921.e12. https://doi.org/10.1016/j.adaj.2019.08.020
✔ Flynn, T. R. (2011). Principles and surgical management of head and neck infections. Oral and Maxillofacial Surgery Clinics of North America, 23(3), 437–449. https://doi.org/10.1016/j.coms.2011.04.001
✔ Robertson, D., & Smith, A. J. (2009). The microbiology of the acute dental abscess. Journal of Medical Microbiology, 58(2), 155–162. https://doi.org/10.1099/jmm.0.003517-0
✔ World Health Organization. (2023). WHO AWaRe (Access, Watch, Reserve) antibiotic book. World Health Organization.

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Restorative Options After Abscess Drainage in Primary Teeth: When to Preserve and When to Extract

A dental abscess in a primary tooth is usually caused by deep tooth decay that reaches the dental pulp and surrounding tissues.

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After the infection is controlled through abscess drainage, the next decision is whether the tooth should be preserved with restorative treatment or extracted.

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This choice depends on the severity of the infection, the condition of the tooth, and the child's stage of dental development.

✅ Introduction
The primary goal after treating a dental abscess is to eliminate infection, relieve pain, and maintain normal oral development whenever possible. Saving a primary tooth is often beneficial because these teeth help with chewing, speech, and guiding permanent teeth into their correct positions. However, preserving the tooth is only appropriate when long-term success is likely.

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✅ When Should a Primary Tooth Be Preserved?
A primary tooth can usually be preserved when:

▪️ The infection is well controlled after drainage.
▪️ Most of the tooth structure remains intact.
▪️ There is no excessive mobility.
▪️ Root resorption is within the normal stage for the child's age.
▪️ The permanent successor is not at immediate risk.
▪️ The child can attend follow-up appointments.

Common Restorative Options
▪️ Stainless steel crown (SSC): preferred for extensively damaged primary molars because it provides excellent durability.
▪️ Composite resin restoration: suitable for teeth with moderate loss of structure.
▪️ Glass ionomer cement: useful as an interim restoration or when moisture control is difficult.
▪️ Pulp therapy (pulpectomy): may be indicated if the root canals remain treatable after infection control.

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✅ When Is Extraction the Better Option?
Extraction is generally recommended when:

▪️ The tooth cannot be restored adequately.
▪️ There is severe root destruction or advanced pathological root resorption.
▪️ The infection persists despite treatment.
▪️ The permanent tooth germ is threatened.
▪️ The tooth has excessive mobility unrelated to normal exfoliation.
▪️ There is extensive bone loss or a vertical root fracture.
After extraction, space maintenance should be considered if premature tooth loss may affect the eruption of permanent teeth.

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✅ Factors That Influence Clinical Decision-Making
The decision should be individualized by considering:

Factor	Clinical Importance
Child's age	Determines the remaining lifespan of the primary tooth and influences treatment planning.
Tooth restorability	Adequate remaining tooth structure favors preservation with restorative treatment.
Infection severity	Persistent or extensive infection often indicates a poor prognosis and may require extraction.
Root resorption	Advanced pathological root resorption significantly reduces the likelihood of successful preservation.
Permanent successor	Treatment should protect the developing permanent tooth from infection or damage.
Patient cooperation	Good cooperation and regular follow-up improve long-term treatment success.

✅ Benefits of Preserving the Tooth
Whenever appropriate, preserving the tooth offers several advantages:

▪️ Maintains chewing efficiency.
▪️ Supports normal speech development.
▪️ Preserves arch length.
▪️ Guides eruption of permanent teeth.
▪️ Reduces the need for future orthodontic treatment.

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💬 Discussion
Current pediatric dental guidelines emphasize that treatment decisions should prioritize both infection control and long-term oral health. Simply draining an abscess is not considered definitive treatment. The infected tooth must either receive appropriate restorative and pulp therapy or be extracted if its prognosis is poor.
Recent evidence supports the use of stainless steel crowns following successful pulp therapy for severely damaged primary molars because they provide excellent longevity and reduce the risk of restoration failure. Conversely, retaining teeth with extensive infection or poor structural integrity may increase the risk of recurrent abscesses and damage to developing permanent teeth.
Therefore, clinicians should evaluate clinical findings, radiographic evidence, restorability, and the child's overall dental development before selecting the most appropriate treatment.

✍️ Conclusion
Abscess drainage is only the first step in managing infected primary teeth. The final treatment should be based on the tooth's restorability, infection control, and expected long-term prognosis. Preserving the tooth is preferred whenever predictable success can be achieved, while extraction remains the safest option for teeth with poor prognosis or persistent infection. An individualized treatment plan helps protect both the child's primary and permanent dentition.

🎯 Clinical Recommendations
▪️ Always perform a complete clinical and radiographic evaluation after abscess drainage.
▪️ Preserve primary teeth whenever restorability and prognosis are favorable.
▪️ Use stainless steel crowns for extensively restored primary molars whenever indicated.
▪️ Extract teeth with severe structural damage, persistent infection, or poor prognosis.
▪️ Consider space maintainers after premature extraction when clinically indicated.
▪️ Schedule regular follow-up visits to monitor healing and eruption of permanent teeth.

📚 References

✔ American Academy of Pediatric Dentistry. (2024). Use of vital pulp therapies in primary teeth with deep caries lesions. The Reference Manual of Pediatric Dentistry. Chicago, IL: American Academy of Pediatric Dentistry.
✔ American Academy of Pediatric Dentistry. (2024). Pulp therapy for primary and immature permanent teeth. The Reference Manual of Pediatric Dentistry. Chicago, IL: American Academy of Pediatric Dentistry.
✔ American Academy of Pediatric Dentistry. (2024). Guideline on management considerations for pediatric oral surgery and oral pathology. The Reference Manual of Pediatric Dentistry. Chicago, IL: American Academy of Pediatric Dentistry.
✔ Innes, N. P. T., Ricketts, D., Chong, L. Y., Keightley, A. J., Lamont, T., & Santamaria, R. M. (2015). Preformed crowns for decayed primary molar teeth. Cochrane Database of Systematic Reviews, 2015(12), CD005512. https://doi.org/10.1002/14651858.CD005512.pub3
✔ Coll, J. A., Dhar, V., Vargas, K., Chen, C. Y., Crystal, Y. O., & Alikhani, M. (2020). Use of non-vital pulp therapies in primary teeth. Pediatric Dentistry, 42(6), 337–349.

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Management of Severe Oral Infections in Children: From Cellulitis to Ludwig’s Angina

Severe oral infections in children are uncommon but can become medical emergencies if they spread beyond the teeth and gums.

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Most begin as untreated dental infections and may rapidly involve the facial spaces of the head and neck. Early recognition and prompt treatment greatly reduce the risk of serious complications.

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This guide explains the most important forms of severe oral infection, their warning signs, treatment options, and when urgent medical attention is required.

✅ What Are Severe Oral Infections?
A severe oral infection occurs when bacteria spread from an infected tooth or surrounding tissues into the deeper spaces of the face, jaw, or neck.

The most important conditions include:
▪️ Odontogenic cellulitis
▪️ Deep facial space infections
▪️ Ludwig's angina
▪️ Dental abscesses with systemic involvement
Although these infections are primarily caused by bacteria commonly found in the mouth, delayed treatment allows them to spread rapidly.

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✅ Common Causes
The most frequent causes include:

▪️ Untreated dental caries
▪️ Dental abscesses
▪️ Advanced pulp infections
▪️ Dental trauma with pulp necrosis
▪️ Delayed dental treatment
▪️ Poor oral hygiene
Children with weakened immune systems may be at higher risk of developing severe infections.

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✅ Warning Signs
Parents should seek immediate dental or medical evaluation if a child develops:

▪️ Rapid facial swelling
▪️ Severe toothache
▪️ Fever
▪️ Difficulty swallowing
▪️ Difficulty opening the mouth (trismus)
▪️ Difficulty breathing
▪️ Neck swelling
▪️ Fatigue or lethargy
Breathing difficulty is always an emergency.

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✅ From Cellulitis to Ludwig's Angina

Cellulitis
Cellulitis is a diffuse bacterial infection that spreads through the soft tissues instead of remaining localized like an abscess.
Typical signs include:
▪️ Painful swelling
▪️ Redness
▪️ Warm skin
▪️ Fever
▪️ Rapid progression
Without treatment, cellulitis may spread into deeper facial spaces.

Ludwig's Angina
Ludwig's angina is one of the most dangerous odontogenic infections.
It is characterized by:
▪️ Rapid bilateral swelling beneath the jaw
▪️ Elevation of the tongue
▪️ Difficulty swallowing
▪️ Drooling
▪️ Muffled voice
▪️ Airway obstruction
Because the airway may become blocked, Ludwig's angina requires immediate hospital treatment.

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✅ Diagnosis
Diagnosis is based on:

▪️ Complete medical and dental history
▪️ Clinical examination
▪️ Evaluation of airway involvement
▪️ Dental radiographs when appropriate
▪️ Contrast-enhanced CT imaging for suspected deep neck infections
Blood tests may be requested in severe systemic infections.

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✅ Treatment
Management depends on the severity of infection.

Localized infections
▪️ Drainage of the abscess when indicated
▪️ Removal of the infection source
▪️ Appropriate antibiotics
▪️ Pain control

Severe infections
Children with facial cellulitis or suspected deep space infection often require:
▪️ Hospital admission
▪️ Intravenous antibiotics
▪️ Airway monitoring
▪️ Surgical drainage if necessary
▪️ Treatment of the infected tooth after stabilization
Early intervention significantly improves outcomes.

📊 Pharmacological Management of Severe Oral Infections in Children

Medication	Clinical Use	Important Considerations
Amoxicillin	First-line oral antibiotic for mild to moderate odontogenic infections without systemic involvement.	Not appropriate for severe facial cellulitis requiring hospitalization. Dose should be adjusted according to the child's weight.
Amoxicillin–Clavulanate	Preferred for moderate to severe odontogenic infections when broader antibacterial coverage is needed.	Provides activity against beta-lactamase-producing bacteria. Gastrointestinal upset may occur.
Clindamycin	Alternative for children allergic to penicillins and effective against anaerobic bacteria.	Associated with an increased risk of Clostridioides difficile infection. Use only when clinically indicated.
Ampicillin–Sulbactam (IV)	Recommended for hospitalized children with facial cellulitis or deep odontogenic infections.	Requires intravenous administration and close hospital monitoring.
Ceftriaxone (IV)	May be used in selected hospitalized patients, often combined with anaerobic coverage.	Should be prescribed according to local antimicrobial guidelines and infection severity.
Metronidazole	Adjunctive therapy when enhanced anaerobic coverage is required.	Usually combined with another antibiotic rather than used alone for odontogenic infections.
Acetaminophen (Paracetamol)	First-choice analgesic and antipyretic for pain and fever control.	Does not treat the infection. Maximum daily dose should not be exceeded.
Ibuprofen	Provides analgesic, antipyretic, and anti-inflammatory effects in children without contraindications.	Use cautiously in dehydrated children or those with renal disease or gastrointestinal disorders.

✅ Possible Complications
Without prompt treatment, severe infections may lead to:

▪️ Deep neck infections
▪️ Airway obstruction
▪️ Sepsis
▪️ Mediastinitis
▪️ Osteomyelitis
▪️ Hospitalization
▪️ Rarely, death
Fortunately, these complications are uncommon when treatment begins early.

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✅ Prevention
The best prevention strategies include:

▪️ Regular dental check-ups
▪️ Early treatment of cavities
▪️ Daily tooth brushing with fluoride toothpaste
▪️ Healthy diet with limited sugar intake
▪️ Immediate evaluation of facial swelling or dental pain
Preventive dental care remains the most effective way to avoid severe odontogenic infections.

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💬 Discussion
Most severe oral infections in children originate from preventable dental disease. Although antibiotics are essential in selected cases, they do not replace definitive dental treatment, such as drainage or removal of the infection source.
The greatest clinical concern is recognizing signs of airway compromise, particularly in children with rapidly progressing swelling or suspected Ludwig's angina. Close collaboration between pediatric dentists, oral and maxillofacial surgeons, pediatricians, and emergency physicians is often necessary to ensure safe and effective care.

🎯 Recommendations

▪️ Never ignore facial swelling associated with tooth pain.
▪️ Seek emergency care immediately if breathing or swallowing becomes difficult.
▪️ Complete the full course of prescribed antibiotics.
▪️ Attend regular dental examinations.
▪️ Treat dental decay before complications develop.
▪️ Educate parents about the warning signs of spreading dental infections.

✍️ Conclusion
Severe oral infections in children can progress quickly from localized cellulitis to life-threatening conditions such as Ludwig's angina. Early diagnosis, prompt dental intervention, appropriate antibiotic therapy, and timely hospital management are essential for preventing serious complications. Maintaining good oral hygiene and treating dental disease early remain the most effective preventive measures.

📚 References

✔ American Academy of Pediatric Dentistry. (2024). Use of antibiotic therapy for pediatric dental patients. The Reference Manual of Pediatric Dentistry. Chicago, IL: American Academy of Pediatric Dentistry.
✔ American Association of Endodontists. (2021). AAE guidance on the use of systemic antibiotics in endodontics. Chicago, IL: American Association of Endodontists.
✔ Flynn, T. R.. (2011). Severe odontogenic infections. Oral and Maxillofacial Surgery Clinics of North America, 23(3), 401–413. https://doi.org/10.1016/j.coms.2011.04.001
✔ National Institute for Health and Care Excellence. (2020). Dental abscess: antimicrobial prescribing (NG187).

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Managing Odontogenic Infections in Adults

Odontogenic infections remain among the most common infectious diseases encountered in dental practice. These infections originate from dental or periodontal tissues and can range from localized abscesses to severe deep fascial space infections with potentially life-threatening complications.

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Effective management requires accurate diagnosis, elimination of the source of infection, appropriate surgical intervention, and judicious use of antimicrobial therapy. This article reviews the current evidence regarding the diagnosis, classification, treatment, and prevention of odontogenic infections in adult patients.

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✅ Introduction
Odontogenic infections arise primarily from dental caries, pulpal necrosis, periodontal disease, pericoronitis, or traumatic injuries. Although advances in preventive dentistry have reduced their prevalence in some populations, odontogenic infections continue to represent a significant cause of emergency dental visits worldwide.
Most odontogenic infections are polymicrobial, involving a combination of aerobic and anaerobic bacteria. If left untreated, these infections may spread into adjacent tissues and fascial spaces, potentially resulting in serious complications such as osteomyelitis, airway compromise, mediastinitis, sepsis, and intracranial infections.
Therefore, prompt diagnosis and evidence-based management are essential to minimize morbidity and prevent systemic dissemination.

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✅ Etiology and Microbiology
The microbial flora associated with odontogenic infections is typically polymicrobial. Common pathogens include:
▪️ Streptococcus viridans group
▪️ Streptococcus anginosus group
▪️ Prevotella species
▪️ Porphyromonas species
▪️ Fusobacterium species
▪️ Peptostreptococcus species
Anaerobic bacteria often predominate as the infection progresses and oxygen tension decreases within affected tissues.

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✅ Classification of Odontogenic Infections
Odontogenic infections can be classified according to their origin and anatomical spread:

Periapical Infections
These infections develop secondary to pulpal necrosis and bacterial invasion of periapical tissues.

Periodontal Infections
Periodontal abscesses originate from periodontal pockets and supporting tissues.

Pericoronal Infections
Pericoronitis commonly affects partially erupted mandibular third molars and may progress to fascial space involvement.

Fascial Space Infections
Advanced infections may extend into:
▪️ Buccal space
▪️ Submandibular space
▪️ Sublingual space
▪️ Submental space
▪️ Masticator space
▪️ Parapharyngeal space
These infections require immediate evaluation because of the potential risk of airway obstruction.

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✅ Clinical Assessment
Accurate diagnosis requires a comprehensive clinical examination.

Local Signs and Symptoms
Common findings include:
▪️ Dental pain
▪️ Swelling
▪️ Erythema
▪️ Fluctuance
▪️ Purulent drainage
▪️ Tooth mobility
▪️ Trismus

Systemic Signs
The presence of systemic involvement may indicate severe infection:
▪️ Fever
▪️ Malaise
▪️ Tachycardia
▪️ Dysphagia
▪️ Odynophagia
▪️ Lymphadenopathy

Radiographic Evaluation
Diagnostic imaging may include:
▪️ Periapical radiographs
▪️ Panoramic radiographs
▪️ Cone-beam computed tomography (CBCT)
▪️ Contrast-enhanced computed tomography (CT) in severe cases
CBCT and CT imaging are particularly valuable when evaluating deep space infections and determining the extent of disease spread.

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✅ Principles of Management

Elimination of the Source
Definitive treatment of the infection source is the cornerstone of management.
Options include:
▪️ Root canal treatment
▪️ Tooth extraction
▪️ Periodontal therapy
▪️ Operculectomy when indicated
Failure to eliminate the source frequently results in recurrence.

Surgical Drainage
Incision and drainage remain essential components of treatment for abscesses.
Benefits include:
▪️ Reduction of bacterial load
▪️ Decreased tissue pressure
▪️ Improved vascular perfusion
▪️ Enhanced antibiotic penetration
Drainage should be performed whenever a fluctuant collection is present.

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✅ Antibiotic Therapy
Antibiotics should be considered adjunctive rather than primary therapy.
Current evidence indicates that localized odontogenic infections without systemic involvement often respond adequately to definitive dental treatment alone.

Antibiotics are generally indicated when:
▪️ Systemic signs are present
▪️ Cellulitis is evident
▪️ Fascial spaces are involved
▪️ The patient is immunocompromised
▪️ Infection is rapidly spreading

Common antibiotic regimens include:
First-Line Therapy
▪️ Amoxicillin
▪️ Amoxicillin-clavulanate

Penicillin Allergy
▪️ Clindamycin (when appropriate and after risk assessment)
▪️ Azithromycin
The increasing prevalence of antimicrobial resistance highlights the importance of antibiotic stewardship in dental practice.

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✅ Supportive Care
Additional management measures include:
▪️ Adequate hydration
▪️ Analgesic therapy
▪️ Monitoring of airway status
▪️ Nutritional support when necessary

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✅ Complications
Untreated odontogenic infections may result in severe complications:
▪️ Deep neck space infections
▪️ Ludwig's angina
▪️ Osteomyelitis
▪️ Cavernous sinus thrombosis
▪️ Mediastinitis
▪️ Sepsis
Early identification of high-risk patients is critical to prevent adverse outcomes.

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💬 Discussion
The management of odontogenic infections has evolved significantly with the increasing emphasis on evidence-based dentistry and antimicrobial stewardship. Contemporary guidelines recommend prioritizing source control through endodontic treatment, extraction, or drainage rather than relying solely on antibiotics.
Several studies have demonstrated that unnecessary antibiotic prescribing remains common in dental settings. This practice contributes to the global emergence of antimicrobial resistance and may expose patients to adverse drug reactions.
Recent evidence supports a patient-centered approach in which treatment decisions are guided by infection severity, systemic involvement, host immune status, and anatomical location. Advanced infections involving fascial spaces require multidisciplinary management and, in some cases, hospitalization.
The growing availability of CBCT imaging has improved diagnostic accuracy and treatment planning, particularly in complex infections involving deep anatomical structures.

🎯 Recommendations
1. Establish an accurate diagnosis before prescribing antibiotics.
2. Prioritize elimination of the infectious source.
3. Perform incision and drainage whenever clinically indicated.
4. Reserve antibiotics for cases with systemic involvement or spreading infection.
5. Monitor patients with deep space infections closely for airway compromise.
6. Promote antibiotic stewardship to minimize resistance development.
7. Educate patients regarding oral hygiene and regular dental care.
8. Consider referral to oral and maxillofacial surgery for severe infections.

✍️ Conclusion
Managing odontogenic infections in adults requires a systematic and evidence-based approach focused on source control, surgical intervention when necessary, and appropriate antibiotic use. While most infections can be successfully treated in the dental office, severe infections involving fascial spaces may progress rapidly and require urgent multidisciplinary care. Early diagnosis, prompt treatment, and adherence to antimicrobial stewardship principles remain essential for achieving optimal clinical outcomes and reducing the risk of complications.

📚 References

✔ American Association of Endodontists. (2021). AAE guidance on the use of systemic antibiotics in endodontics. Journal of Endodontics, 47(9), 1405–1414. https://doi.org/10.1016/j.joen.2021.06.014
✔ Flynn, T. R. (2011). Principles and surgical management of head and neck infections. Oral and Maxillofacial Surgery Clinics of North America, 23(3), 437–449. https://doi.org/10.1016/j.coms.2011.04.002
✔ Robertson, D., & Smith, A. J. (2009). The microbiology of the acute dental abscess. Journal of Medical Microbiology, 58(2), 155–162. https://doi.org/10.1099/jmm.0.003517-0
✔ Segura-Egea, J. J., Gould, K., Şen, B. H., Jonasson, P., Cotti, E., Mazzoni, A., Sunay, H., Tjäderhane, L., Dummer, P. M. H., & European Society of Endodontology. (2018). Antibiotics in Endodontics: A review. International Endodontic Journal, 51(1), 20–25. https://doi.org/10.1111/iej.12741
✔ Sweeney, L. C., Dave, J., Chambers, P. A., & Heritage, J. (2004). Antibiotic resistance in general dental practice—a cause for concern? Journal of Antimicrobial Chemotherapy, 53(4), 567–576. https://doi.org/10.1093/jac/dkh137

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What Is Facial Cellulitis? Signs, Symptoms and Treatment

Facial cellulitis is an acute, diffuse infection of the soft tissues of the face, most commonly originating from untreated dental infections such as periapical abscesses, periodontal infections, or pericoronitis.

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It is characterized by rapid spread through fascial planes, causing swelling, pain, erythema, and systemic symptoms such as fever and malaise. Early recognition and prompt treatment are essential to prevent severe complications, including airway compromise, orbital cellulitis, cavernous sinus thrombosis, and sepsis.

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Management involves elimination of the odontogenic source, appropriate antibiotic therapy, and surgical drainage when purulence or deep space involvement is present.

✅ Introduction
Facial cellulitis is a potentially life-threatening complication of odontogenic infections. Unlike localized abscesses, cellulitis is a diffuse inflammatory process without a well-defined collection of pus during the initial stages. The infection spreads rapidly through connective tissue and facial spaces, causing extensive swelling and systemic manifestations.
Dental practitioners must identify the signs and symptoms promptly and initiate evidence-based treatment to reduce morbidity and prevent hospitalization.

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✅ What Is Facial Cellulitis?
Facial cellulitis is a diffuse bacterial infection involving the subcutaneous tissues and fascial planes of the face. The most common cause is spread of microorganisms from necrotic teeth, periodontal pockets, or partially erupted third molars.

Common Odontogenic Causes
▪️ Untreated dental caries with pulp necrosis
▪️ Acute apical abscess
▪️ Severe periodontitis
▪️ Pericoronitis of impacted third molars
▪️ Post-extraction infections
▪️ Trauma-associated dental infections

Main Causative Microorganisms
Odontogenic cellulitis is usually polymicrobial and includes:
▪️ Streptococcus viridans group
▪️ Peptostreptococcus species
▪️ Prevotella species
▪️ Fusobacterium nucleatum

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✅ Signs and Symptoms of Facial Cellulitis

Local Signs
▪️ Diffuse facial swelling
▪️ Pain and tenderness
▪️ Erythema and increased temperature
▪️ Firm, indurated tissues
▪️ Trismus
▪️ Dysphagia
▪️ Regional lymphadenopathy
▪️ Fluctuation in advanced stages

Systemic Symptoms
▪️ Fever
▪️ Malaise
▪️ Fatigue
▪️ Tachycardia
▪️ Leukocytosis

Warning Signs Requiring Emergency Referral
▪️ Dyspnea
▪️ Stridor
▪️ Difficulty swallowing saliva
▪️ Bilateral submandibular swelling
▪️ Altered mental status
▪️ Rapid progression of edema

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✅ Diagnosis
Diagnosis is based on history, clinical examination, and radiographic imaging.

Clinical Evaluation
▪️ Identification of the source tooth
▪️ Assessment of swelling extent
▪️ Measurement of mouth opening
▪️ Evaluation of airway patency

Imaging Studies
▪️ Periapical radiographs
▪️ Panoramic radiography
▪️ Contrast-enhanced computed tomography (CT) for deep space infections

Laboratory Tests
▪️ Complete blood count
▪️ C-reactive protein
▪️ Blood cultures in severe cases

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✅ Pharmacological Treatment

First-Line Antibiotics

Amoxicillin-Clavulanate
▪️ Adults: 875/125 mg every 12 hours
▪️ Duration: 5–7 days
Penicillin Allergy
▪️ Clindamycin 300 mg every 6–8 hours
Severe Infections
▪️ Intravenous ampicillin-sulbactam
▪️ Intravenous clindamycin with metronidazole when indicated

Adjunctive Medications
▪️ Ibuprofen 400–600 mg every 6–8 hours
▪️ Acetaminophen for pain and fever control
▪️ Adequate hydration

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✅ Surgical Treatment
Antibiotics alone are insufficient if the source of infection is not eliminated.

Indications for Surgical Intervention
▪️ Presence of abscess
▪️ Fluctuant swelling
▪️ Failure of antibiotic therapy
▪️ Deep fascial space involvement
▪️ Airway compromise

Surgical Procedures
▪️ Incision and drainage
▪️ Root canal treatment
▪️ Tooth extraction
▪️ Placement of drains when necessary

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✅ Hospitalization Criteria
Patients should be admitted when any of the following are present:

▪️ Airway compromise
▪️ Deep neck space infection
▪️ Immunosuppression
▪️ Uncontrolled diabetes
▪️ High fever with systemic toxicity
▪️ Inability to tolerate oral medications

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✅ Potential Complications
Untreated facial cellulitis may progress to:
▪️ Ludwig's angina
▪️ Orbital cellulitis
▪️ Osteomyelitis
▪️ Cavernous sinus thrombosis
▪️ Mediastinitis
▪️ Sepsis

📊 Summary Table: Differential Diagnosis of Facial Cellulitis

Condition	Key Clinical Features	Distinguishing Characteristics
Facial Cellulitis	Diffuse, firm, painful swelling with erythema and fever	Rapid spread through fascial planes; may compromise the airway
Odontogenic Abscess	Localized fluctuant swelling with purulent collection	Well-circumscribed lesion; drainage yields pus
Ludwig's Angina	Bilateral submandibular swelling, tongue elevation, dysphagia	Medical emergency with high risk of airway obstruction
Pericoronitis	Localized inflammation around a partially erupted third molar	Usually confined to soft tissue overlying the tooth crown
Necrotizing Periodontal Disease	Interdental papilla necrosis, bleeding, severe pain, halitosis	Predominantly affects gingival tissues rather than facial spaces
Orbital Cellulitis	Periorbital edema, pain, proptosis, restricted eye movement	Visual symptoms and ophthalmologic involvement are prominent
Sialadenitis	Painful swelling of salivary glands, reduced salivary flow	Often associated with meals and gland duct obstruction
Allergic Angioedema	Sudden, non-erythematous swelling with itching or urticaria	Usually painless and not associated with odontogenic infection

💬 Discussion
Facial cellulitis remains one of the most important emergencies in dental practice. Although antibiotics are essential, the cornerstone of treatment is prompt elimination of the infection source. Delayed intervention may result in rapid spread to critical anatomical spaces and systemic deterioration.
Current evidence emphasizes conservative antibiotic stewardship, recommending narrow-spectrum agents when possible and limiting treatment duration to the shortest effective course. Surgical drainage significantly reduces bacterial load and accelerates recovery.

🎯 Recommendations
▪️ Perform an immediate clinical assessment to determine severity.
▪️ Identify and remove the odontogenic source as early as possible.
▪️ Prescribe antibiotics according to current evidence-based guidelines.
▪️ Refer urgently if airway compromise is suspected.
▪️ Monitor patients within 24–48 hours.
▪️ Educate patients about the importance of early treatment of dental infections.

✍️ Conclusion
Facial cellulitis is a serious odontogenic infection that requires urgent diagnosis and comprehensive management. Successful treatment depends on early recognition, targeted antibiotic therapy, and elimination of the dental source through endodontic treatment, extraction, or surgical drainage. Dentists play a crucial role in preventing life-threatening complications by acting promptly and appropriately.

📚 References

✔ Flynn, T. R. (2011). Severe odontogenic infections, part 1: Prospective report. Journal of Oral and Maxillofacial Surgery, 69(7), 1726–1733. https://doi.org/10.1016/j.joms.2011.02.090
✔ Hupp, J. R., Ellis, E., & Tucker, M. R. (2019). Contemporary oral and maxillofacial surgery (7th ed.). Elsevier.
✔ Robertson, D., & Smith, A. J. (2009). The microbiology of the acute dental abscess. Journal of Medical Microbiology, 58(2), 155–162. https://doi.org/10.1099/jmm.0.003517-0

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How to Choose the Right Antibiotic for Pediatric Dental Infections?

Choosing the right antibiotic for pediatric dental infections requires a structured clinical assessment rather than reliance on a single “best” drug.

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The decision depends on the extent of infection, systemic involvement, allergy history, medical conditions, and anticipated microbial profile. Most odontogenic infections in children are polymicrobial and dominated by viridans group streptococci and anaerobic bacteria.

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According to the American Academy of Pediatric Dentistry and American Dental Association, definitive dental treatment is the primary intervention, and systemic antibiotics should be prescribed only when there is evidence of spreading infection or systemic compromise. This review explains the evidence-based criteria used by pediatric dentists to select the most appropriate antibiotic while promoting antimicrobial stewardship.

✅ Introduction
Pediatric dental infections are common sequelae of untreated caries, pulp necrosis, traumatic injuries, and periodontal conditions. Although antibiotics are frequently prescribed, inappropriate use increases the risk of antimicrobial resistance, adverse drug reactions, and disruption of the developing intestinal and oral microbiome.

The clinical objective is to eliminate the infectious source through:
▪️ Pulpotomy or pulpectomy
▪️ Incision and drainage
▪️ Tooth extraction
▪️ Removal of necrotic tissue
Antibiotic selection should be individualized and based on objective clinical findings.

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✅ Microbiology of Pediatric Odontogenic Infections
The microbial composition of pediatric dental infections typically includes:

▪️ Viridans group streptococci
▪️ Prevotella species
▪️ Fusobacterium nucleatum
▪️ Peptostreptococcus species
▪️ Streptococcus mutans
This polymicrobial pattern explains why beta-lactam antibiotics remain effective in many clinical situations.

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✅ When Are Antibiotics Indicated?

Antibiotics Are Recommended When the Child Presents With
▪️ Facial cellulitis
▪️ Diffuse swelling
▪️ Fever greater than 38°C
▪️ Trismus
▪️ Regional lymphadenopathy
▪️ Malaise
▪️ Rapid progression
▪️ Immunocompromised status

Antibiotics Are Usually Not Required For
▪️ Localized abscess with spontaneous drainage
▪️ Reversible pulpitis
▪️ Irreversible pulpitis
▪️ Localized sinus tract without systemic symptoms

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✅ Clinical Criteria for Choosing the Right Antibiotic

1. Extent and Severity of Infection
The presence of diffuse swelling, cellulitis, or systemic symptoms indicates the need for systemic therapy. Localized infections often resolve after operative treatment alone.

2. Allergy History
A detailed history is necessary to distinguish true IgE-mediated hypersensitivity from non-allergic gastrointestinal intolerance.

3. Child’s Age and Body Weight
All pediatric prescriptions must be weight-based and should not exceed established maximum daily doses.

4. Medical Status
Children with immunodeficiency, oncologic treatment, congenital heart disease, or other significant conditions may require modified antibiotic selection and interdisciplinary consultation.

5. Likely Bacterial Susceptibility
Knowledge of common oral pathogens and regional resistance patterns improves therapeutic precision.

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✅ Preferred Antibiotic Selection Strategies

1.Amoxicillin
Amoxicillin is the preferred first-line option for most pediatric odontogenic infections requiring systemic therapy.

Advantages
▪️ Effective against common oral streptococci and anaerobes
▪️ Excellent oral bioavailability
▪️ Favorable taste and adherence
▪️ Low incidence of gastrointestinal adverse effects
Limitations
▪️ Ineffective against some beta-lactamase-producing organisms
▪️ Contraindicated in true penicillin allergy

2. Amoxicillin-Clavulanate
Selected when:
▪️ The infection is severe
▪️ Initial therapy is unsuccessful
▪️ Beta-lactamase-producing organisms are suspected

3. Azithromycin
Useful for children with immediate hypersensitivity to penicillins.

4. Clindamycin
Reserved for selected cases because of the increased risk of Clostridioides difficile infection.

5. Metronidazole
Commonly used as an adjunct to enhance anaerobic coverage in refractory infections.

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✅ Antimicrobial Stewardship Principles
Antibiotic stewardship in pediatric dentistry involves:

▪️ Prescribing only when clinically justified
▪️ Choosing the narrowest effective spectrum
▪️ Using the shortest effective duration
▪️ Monitoring clinical response within 48–72 hours
▪️ Educating caregivers regarding adherence

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✅ Recommended Duration of Therapy
Most pediatric dental infections requiring antibiotics are treated for 3 to 7 days, with duration adjusted according to clinical improvement and definitive treatment timing.

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💬 Discussion
The question is not simply which antibiotic is “best,” but how clinicians determine the most appropriate antibiotic for each child. The decision integrates infection severity, systemic manifestations, allergy profile, host factors, and expected microbiology. In uncomplicated cases, amoxicillin remains the preferred first-line agent because of its efficacy and safety. Broader-spectrum agents should be reserved for severe infections or treatment failures, while alternatives such as azithromycin are appropriate in penicillin-allergic patients. This individualized approach aligns with modern antimicrobial stewardship.

✍️ Conclusion
Choosing the right antibiotic for pediatric dental infections requires a methodical clinical approach. Dentists must first determine whether antibiotics are indicated and then select the narrowest effective agent based on the child’s clinical condition and medical history. In most children, amoxicillin is the preferred first-line option, while alternative agents are selected only when justified by allergy, severity, or treatment response.

🎯 Clinical Recommendations
1. Prioritize definitive dental treatment over empiric antibiotic use.
2. Prescribe systemic antibiotics only when systemic or spreading infection is present.
3. Use amoxicillin as the initial option in children without penicillin allergy.
4. Reserve broader-spectrum agents for severe or refractory infections.
5. Apply weight-based dosing and reassess within 48–72 hours.
6. Promote antimicrobial stewardship in every prescription decision.

📊 Summary Table: Antibiotic Selection in Pediatric Dental Infections

Clinical Scenario	Recommended Option	Selection Criteria
Localized abscess without systemic signs	No antibiotic usually required	Definitive dental treatment is generally sufficient.
Facial cellulitis or fever	Amoxicillin	Preferred first-line option in children without penicillin allergy.
Severe or nonresponsive infection	Amoxicillin-Clavulanate	Provides broader coverage against beta-lactamase producers.
Immediate penicillin allergy	Azithromycin	Useful alternative with convenient once-daily dosing.
Selected severe allergy cases	Clindamycin	Reserved because of C. difficile risk.
Predominantly anaerobic infection	Metronidazole (adjunct)	Usually combined with amoxicillin rather than used alone.

📚 References

✔ American Academy of Pediatric Dentistry. (2024). Use of antibiotic therapy for pediatric dental patients. In The Reference Manual of Pediatric Dentistry (2024–2025 ed., pp. 503–510). American Academy of Pediatric Dentistry.
✔ Lockhart, P. B., Tampi, M. P., Abt, E., et al. (2019). Evidence-based clinical practice guideline on antibiotic use for the urgent management of pulpal- and periapical-related dental pain and intra-oral swelling. The Journal of the American Dental Association, 150(11), 906–921.e12. https://doi.org/10.1016/j.adaj.2019.08.020
✔ Roberts, R. M., Bartoces, M., Thompson, S. E., Hicks, L. A., & Fleming-Dutra, K. E. (2017). Antibiotic prescribing by general dentists in the United States, 2013. Journal of the American Dental Association, 148(3), 172–178.e1. https://doi.org/10.1016/j.adaj.2016.12.020

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Safe Drug Prescribing for Pediatric Dental Infections: A Practical Clinical Guide

Safe drug prescribing for pediatric dental infections requires a comprehensive understanding of infection severity, patient age, body weight, medical history, and evidence-based pharmacologic principles.

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Most odontogenic infections in children are effectively managed through definitive dental treatment, while systemic medications are reserved for selected cases involving spreading infection, systemic signs, or significant discomfort.

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This practical clinical guide reviews current recommendations for antibiotics, analgesics, contraindications, and prescribing precautions based on guidelines from the American Academy of Pediatric Dentistry and the American Dental Association.

✅ Introduction
Odontogenic infections are among the most common causes of pain and emergency visits in pediatric dentistry. Appropriate pharmacologic management must balance therapeutic efficacy with patient safety. Injudicious antibiotic prescribing contributes to antimicrobial resistance, adverse drug reactions, and microbiome disruption.
Children differ substantially from adults in drug metabolism, organ maturation, and dosing requirements. Consequently, all medications should be prescribed according to body weight (mg/kg) and adjusted to the child’s clinical status.
The core principle in pediatric dental infections is that operative treatment is the primary therapy, while medications serve as adjunctive measures.

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✅ Principles of Safe Prescribing

1. Establish an Accurate Diagnosis
Drug therapy should be based on a definitive diagnosis, such as:
▪️ Localized dentoalveolar abscess
▪️ Acute apical periodontitis
▪️ Cellulitis
▪️ Pericoronitis
▪️ Necrotizing periodontal disease
▪️ Postoperative infection

2. Determine the Need for Systemic Medication
Antibiotics are indicated when infection presents with:
▪️ Facial swelling
▪️ Diffuse cellulitis
▪️ Fever
▪️ Lymphadenopathy
▪️ Trismus
▪️ Malaise
▪️ Difficulty swallowing
▪️ Immunocompromised status

Antibiotics are generally not indicated for:
▪️ Reversible pulpitis
▪️ Irreversible pulpitis without swelling
▪️ Localized abscess with immediate drainage
▪️ Chronic sinus tract without systemic signs

3. Calculate Weight-Based Doses
Prescriptions should include:
▪️ Child’s weight in kilograms
▪️ Dose in mg/kg
▪️ Frequency
▪️ Maximum daily dose
▪️ Treatment duration

4. Review Medical History
Evaluate for:
▪️ Drug allergies
▪️ Renal or hepatic disease
▪️ Cardiac conditions
▪️ Immunodeficiency
▪️ Current medications
▪️ Previous adverse reactions

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✅ Antibiotic Therapy

1. First-Line Antibiotic: Amoxicillin
Amoxicillin remains the preferred first-line antibiotic due to:
▪️ Broad activity against oral streptococci and anaerobes
▪️ Favorable safety profile
▪️ Good gastrointestinal tolerance
▪️ Palatable pediatric formulations

Recommended Dose
▪️ 20–40 mg/kg/day, divided every 8 hours, or
▪️ 25–45 mg/kg/day, divided every 12 hours
▪️ Maximum: 875 mg per dose

Typical Duration
▪️ 3–7 days, with reassessment within 48–72 hours

2. Alternative for Penicillin Allergy

Azithromycin
Used in children with immediate hypersensitivity to penicillins.
▪️ Day 1: 10–12 mg/kg
▪️ Days 2–5: 5–6 mg/kg once daily
▪️ Maximum: 500 mg on day 1

Cephalexin
May be used when allergy is non-anaphylactic.
▪️ 25–50 mg/kg/day divided every 6–8 hours

3. Severe or Refractory Infections

Amoxicillin/clavulanate
Provides enhanced anaerobic coverage.
▪️ 25–45 mg/kg/day (based on amoxicillin component) divided every 12 hours

Metronidazole
Useful as adjunct therapy for anaerobic infections.
▪️ 20–30 mg/kg/day divided every 8 hours

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✅ Analgesic Therapy

Ibuprofen
Preferred for mild to moderate dental pain and inflammation.
▪️ 4–10 mg/kg/dose every 6–8 hours
▪️ Maximum: 400 mg per dose

Acetaminophen
Alternative when NSAIDs are contraindicated.
▪️ 10–15 mg/kg/dose every 4–6 hours
▪️ Maximum: 75 mg/kg/day
Combined Use
Alternating or combining ibuprofen and acetaminophen may provide superior analgesia in moderate to severe pain.

Table 1. Common Pediatric Drug Prescriptions for Dental Infections

Medication	Usual Dose	Interval	Main Indication
Amoxicillin	20–40 mg/kg/day	Every 8 h	First-line odontogenic infection
Azithromycin	10–12 mg/kg day 1	Once daily	Penicillin allergy
Amoxicillin/Clavulanate	25–45 mg/kg/day	Every 12 h	Severe infection
Metronidazole	20–30 mg/kg/day	Every 8 h	Anaerobic infection
Ibuprofen	4–10 mg/kg/dose	Every 6–8 h	Pain and inflammation
Acetaminophen	10–15 mg/kg/dose	Every 4–6 h	Pain or fever

✅ Contraindications and Precautions

Antibiotic-Associated Risks
▪️ Diarrhea
▪️ Rash
▪️ Hypersensitivity reactions
▪️ Opportunistic infections
▪️ Selection of resistant organisms

NSAID Precautions
Avoid ibuprofen in children with:
▪️ Dehydration
▪️ Renal impairment
▪️ Peptic ulcer disease
▪️ NSAID hypersensitivity

Acetaminophen Toxicity
Overdose may result in severe hepatic injury. Caregivers should be instructed to avoid duplicate formulations.

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✅ Clinical Red Flags Requiring Urgent Referral
Immediate hospital referral is warranted if the child develops:
▪️ Rapidly increasing facial swelling
▪️ Periorbital involvement
▪️ Dysphagia
▪️ Respiratory difficulty
▪️ Fever > 38.5°C
▪️ Dehydration
▪️ Toxic appearance

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Dental Article 🔽 Amoxicillin–Clavulanic Acid in Pediatric Dentistry: Current Indications and Optimal Dosing ... Amoxicillin–clavulanic acid remains one of the most frequently prescribed antibiotics in pediatric dentistry, particularly for odontogenic infections with suspected beta-lactamase–producing bacteria.

💬 Discussion
Current evidence confirms that source control through pulpotomy, pulpectomy, extraction, or incision and drainage is the cornerstone of treatment. Antibiotics alone do not eliminate odontogenic infections when the infectious focus remains untreated.
The American Dental Association strongly discourages unnecessary antibiotic use, emphasizing that overprescribing contributes to global antimicrobial resistance. Similarly, the American Academy of Pediatric Dentistry advocates for individualized, weight-based prescribing and careful reassessment.
Recent literature also supports the preferential use of non-opioid analgesics, particularly ibuprofen and acetaminophen, which provide effective pain control with an excellent safety profile when dosed correctly.

🎯 Clinical Recommendations
1. Prioritize definitive dental treatment over empiric medication use.
2. Prescribe antibiotics only when systemic involvement or spreading infection is present.
3. Use body weight in kilograms to calculate all pediatric doses.
4. Reassess the patient within 48–72 hours.
5. Educate caregivers regarding dosage accuracy and adherence.
6. Avoid unnecessary prolonged antibiotic courses.
7. Document indication, dose, and follow-up plan.

✍️ Conclusion
Safe prescribing for pediatric dental infections requires diagnostic precision, strict weight-based dosing, and adherence to antimicrobial stewardship principles. Amoxicillin remains the preferred first-line antibiotic when indicated, while Ibuprofen and Acetaminophen are the foundation of pain management. Clinicians who combine accurate diagnosis with evidence-based prescribing can maximize therapeutic success and minimize adverse outcomes.

📚 References

✔ American Academy of Pediatric Dentistry. (2024). Use of antibiotic therapy for pediatric dental patients. In The Reference Manual of Pediatric Dentistry (2024–2025 ed.). Chicago, IL: American Academy of Pediatric Dentistry. https://www.aapd.org/research/oral-health-policies--recommendations/use-of-antibiotic-therapy-for-pediatric-dental-patients/
✔ American Academy of Pediatric Dentistry. (2024). Pain management in infants, children, adolescents, and individuals with special health care needs. In The Reference Manual of Pediatric Dentistry (2024–2025 ed.). Chicago, IL: American Academy of Pediatric Dentistry. https://www.aapd.org/research/oral-health-policies--recommendations/pain-management-in-infants-children-adolescents-and-individuals-with-special-health-care-needs/
✔ American Dental Association. (2019). Antibiotics for dental pain and swelling guideline. Journal of the American Dental Association, 150(11), 906–921.e12. https://doi.org/10.1016/j.adaj.2019.08.020
✔ World Health Organization. (2023). Antimicrobial resistance. Geneva, Switzerland: World Health Organization. https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance

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