The trigeminal nerve (cranial nerve V) is the primary sensory nerve of the face and oral cavity and a key motor nerve for mastication.
📌 Recommended Article :
Video 🔽 Muscles of Mastication in 3D - Origin, insertion and functions ... The masticatory muscles insert into the mandible, and together with the TMJ they create opening, closing, protruding, retracting, and lateral movements.A precise understanding of its origin, pathways, and terminal branches is essential for safe local anesthesia, accurate diagnosis of orofacial pain, and prevention of iatrogenic nerve injuries in dental practice. This guide provides a clear, structured, and clinically oriented overview of trigeminal nerve anatomy as a reference for daily dental use.
Advertisement
✅ General Overview of the Trigeminal Nerve
The trigeminal nerve is a mixed nerve with:
▪️ Sensory fibers supplying the face, oral mucosa, teeth, periodontium, nasal cavity, and anterior two-thirds of the tongue (general sensation)
▪️ Motor fibers innervating the muscles of mastication
It emerges from the pons, making it the largest cranial nerve.
📌 Recommended Article :
Video 🔽 Formation and development of the face and oral cavity (Orofacial Complex) ... The formation of the face starts from the five prominences (one frontonasal, two maxillary and two mandibular). The prominences develop giving rise to different regions of the face.✅ Origin and Trigeminal Ganglion
▪️ Brainstem origin: Pons
▪️ Sensory cell bodies: Trigeminal (Gasserian) ganglion, located in Meckel’s cave
▪️ From the ganglion arise three major divisions:
- Ophthalmic (V1) – sensory
- Maxillary (V2) – sensory
- Mandibular (V3) – sensory and motor
📌 Recommended Article :
Dental Article 🔽 Anatomical Landmarks in Dental Anesthetic Techniques: A Complete Clinical Review ... This article reviews the main anatomical references for each local anesthetic technique in both adult and pediatric patients, emphasizing clinical precision and anatomical variations.✅ Main Divisions and Dental Relevance
1. Ophthalmic Division (V1)
▪️ Purely sensory
▪️ Innervates: forehead, scalp, upper eyelid, cornea, dorsum of the nose
▪️ Dental relevance: Indirect; important in differential diagnosis of facial pain
2. Maxillary Division (V2)
▪️ Purely sensory
▪️ Passes through the foramen rotundum
▪️ Supplies:
- Maxillary teeth and periodontium
- Maxillary sinus
- Hard and soft palate
- Upper lip and cheek
Key dental branches:
▪️ Posterior superior alveolar nerve
▪️ Middle superior alveolar nerve
▪️ Anterior superior alveolar nerve
▪️ Greater and lesser palatine nerves
▪️ Nasopalatine nerve
3. Mandibular Division (V3)
▪️ Mixed sensory and motor
▪️ Passes through the foramen ovale
▪️ Sensory supply:
- Mandibular teeth and gingiva
-Lower lip and chin
-Anterior two-thirds of the tongue (general sensation)
▪️ Motor supply:
- Muscles of mastication
- Mylohyoid, anterior belly of digastric, tensor tympani, tensor veli palatini
Key dental branches:
▪️ Inferior alveolar nerve
▪️ Lingual nerve
▪️ Buccal nerve
▪️ Mental nerve
📌 Recommended Article :
Dental Article 🔽 Temporomandibular Joint (TMJ) Disorders: Structure, Symptoms, Causes, and Treatment ... The temporomandibular joint (TMJ) is a complex bilateral synovial articulation that connects the mandible to the temporal bone of the skull. It plays a vital role in essential functions such as mastication, speech, and swallowing.✅ Clinical Importance in Dentistry
Understanding trigeminal nerve anatomy is fundamental for:
▪️ Effective and safe local anesthesia
▪️ Interpretation of pain patterns
▪️ Avoidance of nerve injury during surgical procedures
▪️ Differential diagnosis between dental and neuropathic pain
⚠️ Trigeminal neuralgia and other neuropathic conditions are clinically relevant but are not explored in depth here, as they warrant dedicated evidence-based discussion.
📊 Comparative Table: Trigeminal Nerve Divisions and Dental Relevance
| Aspect | Advantages | Limitations |
|---|---|---|
| Ophthalmic (V1) | Helps differentiate dental vs. non-dental facial pain | No direct dental innervation |
| Maxillary (V2) | Primary sensory supply for maxillary teeth and palate | Complex branching may cause overlapping pain patterns |
| Mandibular (V3) | Essential for mandibular anesthesia and mastication | Higher risk of iatrogenic nerve injury |
The trigeminal nerve forms the anatomical and functional foundation of dental sensory and motor innervation. Mastery of its origin, pathways, and branches enhances diagnostic accuracy, improves anesthetic success, and reduces clinical complications. As a dental reference guide, this overview supports safe, informed, and evidence-based practice.
📚 References
✔ Standring, S. (2021). Gray’s Anatomy: The Anatomical Basis of Clinical Practice (42nd ed.). Elsevier.
✔ Netter, F. H. (2023). Atlas of Human Anatomy (8th ed.). Elsevier.
✔ Renton, T. (2019). Dental (odontogenic) pain. Reviews in Pain, 13(2), 1–9. https://doi.org/10.1177/2049463719864895
✔ Malamed, S. F. (2020). Handbook of Local Anesthesia (7th ed.). Elsevier.
📌 More Recommended Items
► Pink Tooth in Dentistry: Etiology, Diagnosis, Treatment, and Forensic Relevance
► Trigeminal Neuralgia: Clinical features and pharmacological and surgical treatment
► Webinar: Minor Oral Surgery in Pediatric Dentistry - Dr. Fawaz Siddiqui


.jpg)



