Cold Sores (Herpes Labialis): What You Need to Know in Dental Practice

Herpes labialis, commonly known as cold sores, is a highly prevalent viral infection affecting the perioral region. It is caused primarily by Herpes Simplex Virus type 1 (HSV-1) and represents a frequent finding in dental practice.

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This article reviews the etiology, clinical signs, symptoms, updated treatment options, and differential diagnosis of herpes labialis, with a focus on relevance for dental professionals.

✅ Etiology
Herpes labialis is caused by Herpes Simplex Virus type 1 (HSV-1), an enveloped double-stranded DNA virus from the Herpesviridae family. Primary infection usually occurs during childhood through direct contact with infected saliva or lesions.
After initial infection, the virus establishes latency in the trigeminal ganglion, where it remains dormant. Reactivation may occur due to several triggers, including:

▪️ Emotional or physical stress
▪️ Fever or systemic illness
▪️ Ultraviolet light exposure
▪️ Immunosuppression
▪️ Hormonal changes

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✅ Clinical Signs and Symptoms
Herpes labialis typically follows a predictable clinical course:

Prodromal Phase
▪️ Tingling, burning, or itching sensation
▪️ Mild erythema at the affected site

Vesicular Phase
▪️ Formation of clusters of small, fluid-filled vesicles
▪️ Lesions are usually painful and located on the vermilion border

Ulcerative and Crusting Phase
▪️ Vesicle rupture leading to shallow ulcers
▪️ Formation of a yellow-brown crust
▪️ Healing without scarring in immunocompetent patients
Systemic symptoms such as fever or lymphadenopathy may occur during primary infection but are uncommon in recurrent episodes.

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✅ Diagnosis
The diagnosis of herpes labialis is primarily clinical, based on lesion appearance and patient history. Laboratory tests are reserved for atypical or severe cases.

Diagnostic methods include:
▪️ Viral culture (limited sensitivity)
▪️ Polymerase chain reaction (PCR)
▪️ Direct fluorescent antibody testing
▪️ Serological testing (limited clinical utility)

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✅ Updated Treatment Options
There is no cure for HSV infection; therefore, treatment focuses on reducing symptom severity, lesion duration, and viral shedding.

Topical Antiviral Therapy
▪️ Acyclovir 5% cream
▪️ Penciclovir 1% cream
Most effective when applied during the prodromal phase.

Systemic Antiviral Therapy
▪️ Acyclovir
▪️ Valacyclovir
▪️ Famciclovir
Systemic therapy is indicated for:
▪️ Severe or frequent recurrences
▪️ Immunocompromised patients
▪️ Extensive lesions

Adjunctive Measures
▪️ Analgesics for pain control
▪️ Sun protection to prevent recurrence
▪️ Avoidance of lesion manipulation

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✅ Differential Diagnosis
Herpes labialis must be differentiated from other perioral and oral conditions with similar clinical appearance.

📊 Comparative Table: Differential Diagnosis of Herpes Labialis

Condition	Key Clinical Features	Diagnostic Considerations
Herpes labialis	Grouped vesicles, prodromal symptoms, recurrent pattern	Clinical diagnosis, PCR if atypical
Angular cheilitis	Erythema and fissuring at lip commissures	Often associated with Candida or bacterial infection
Aphthous ulcer	Painful ulcer without vesicular stage	Occurs on non-keratinized mucosa
Impetigo	Honey-colored crusts, common in children	Bacterial etiology, highly contagious

💬 Discussion
Herpes labialis remains a common and clinically significant condition in dentistry due to its high prevalence and risk of cross-infection. Dental professionals must recognize active lesions and postpone elective procedures when necessary. Advances in antiviral therapy have improved symptom control, but early intervention remains critical for optimal outcomes.

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🎯 Clinical Recommendations
▪️ Identify prodromal symptoms to initiate early treatment
▪️ Avoid elective dental procedures during active outbreaks
▪️ Educate patients about triggers and recurrence prevention
▪️ Use appropriate infection control measures in clinical settings
▪️ Consider systemic antiviral therapy for high-risk patients

✍️ Conclusion
Herpes labialis is a recurrent viral condition with important implications in dental practice. Accurate diagnosis, patient education, and timely antiviral therapy are essential to minimize discomfort, prevent transmission, and ensure safe dental care. A structured clinical approach allows effective management while maintaining professional and ethical standards.

📚 References

✔ Arduino, P. G., & Porter, S. R. (2008). Herpes simplex virus type 1 infection: Overview on relevant clinico-pathological features. Journal of Oral Pathology & Medicine, 37(2), 107–121. https://doi.org/10.1111/j.1600-0714.2007.00586.x
✔ Fatahzadeh, M., & Schwartz, R. A. (2007). Human herpes simplex virus infections: Epidemiology, pathogenesis, symptomatology, diagnosis, and management. Journal of the American Academy of Dermatology, 57(5), 737–763. https://doi.org/10.1016/j.jaad.2007.06.027
✔ Spruance, S. L., & Kriesel, J. D. (2002). Treatment of herpes simplex labialis. Herpes, 9(3), 64–69.
✔ UpToDate. (2024). Treatment and prevention of herpes simplex virus type 1 in immunocompetent adults. Wolters Kluwer.

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Cold Sore, Canker Sore, and Oral Thrush: Key Differences You Should Know

Cold sores, canker sores, and oral thrush are among the most frequent oral lesions, often mistaken for one another.

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This article explains their main features, clinical presentation, diagnosis, and treatment in both children and adults, providing practical keys for differentiation.

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✅ Introduction
Oral lesions are common in dentistry and general practice. Cold sores (herpes labialis), canker sores (recurrent aphthous stomatitis), and oral thrush (candidiasis) are frequent conditions, but they differ in etiology: viral, inflammatory, and fungal, respectively. Correct identification is essential for adequate management, prevention, and recurrence control.

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1. Cold Sore (Herpes Labialis)

➤ Etiology
Caused by herpes simplex virus type 1 (HSV-1).
➤ Signs and Symptoms
° Prodromal stage: tingling, itching, or burning on the lip.
° Lesion: grouped vesicles on the vermilion border that ulcerate and form crusts.
➤ Diagnosis
Mainly clinical; PCR or serology can be used in atypical cases.
➤ Treatment
° Adults: oral or topical antivirals (acyclovir, valacyclovir).
° Children: symptomatic management; antivirals in severe cases.

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2. Canker Sore (Recurrent Aphthous Stomatitis)

➤ Etiology
Multifactorial: genetic predisposition, nutritional deficiencies (iron, folic acid, vitamin B12), trauma, or stress.
➤ Signs and Symptoms
° Round, painful ulcers with a white-yellow base and red halo.
° Pain can impair eating and speaking.
➤ Diagnosis
Clinical, based on ulcer morphology and absence of vesicular stage.
➤ Treatment
° Adults and children: antiseptic rinses (chlorhexidine), topical anesthetics (lidocaine), and topical corticosteroids for severe episodes.

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3. Oral Thrush (Oral Candidiasis)

➤ Etiology
Fungal infection caused by Candida albicans. Risk factors: immunosuppression, antibiotic use, inhaled corticosteroids, dentures.
➤ Signs and Symptoms
° Forms:

• Pseudomembranous: removable white plaques with red underlying mucosa.
• Atrophic: painful red mucosa.
• Hyperplastic: non-removable white lesions.

° Burning sensation, dysphagia, taste disturbances.
➤ Diagnosis
Mainly clinical; confirmed with exfoliative cytology or fungal culture.
➤ Treatment
° Adults: topical antifungals (nystatin, miconazole) or systemic antifungals (fluconazole) in resistant cases.
° Children: oral suspension of nystatin.

📊 Comparative Table: Cold Sore, Canker Sore, and Oral Thrush

💬 Discussion
Although similar in appearance, these conditions can be clearly distinguished through careful clinical evaluation. Cold sores show a vesicular stage and recurrence, canker sores are isolated painful ulcers without vesicles, and oral thrush presents as persistent plaques or erythematous mucosa. Treatment differs according to etiology, highlighting the need for precise diagnosis and tailored therapy in both children and adults.

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✍️ Conclusion
Recognizing the differences between cold sores, canker sores, and oral thrush ensures appropriate treatment and reduces recurrence or complications. Patient education, preventive measures, and early evaluation remain key in managing these frequent oral conditions.

📚 References

✔ Arduino, P. G., & Porter, S. R. (2008). Herpes Simplex Virus Type 1 infection: overview on relevant clinico-pathological features. Journal of Oral Pathology & Medicine, 37(2), 107-121. https://doi.org/10.1111/j.1600-0714.2007.00586.x
✔ Belenguer-Guallar, I., Jiménez-Soriano, Y., & Claramunt-Lozano, A. (2014). Treatment of recurrent aphthous stomatitis. A literature review. Journal of Clinical and Experimental Dentistry, 6(2), e168–e174. https://doi.org/10.4317/jced.51402
✔ Scully, C., & Porter, S. (2008). Oral candidosis: current concepts in pathogenesis and therapy. Dental Update, 35(9), 606-612. https://doi.org/10.12968/denu.2008.35.9.606

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