Peri-implantitis is an inflammatory disease that affects the tissues surrounding a dental implant. Unlike peri-implant mucositis, which is limited to inflammation of the soft tissues, peri-implantitis is associated with progressive loss of the bone supporting the implant.
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✅ What Is Peri-Implantitis?
Peri-implantitis is a plaque-associated inflammatory disease characterized by inflammation of the tissues around a dental implant and progressive loss of supporting bone.
It should be distinguished from peri-implant mucositis:
| Condition | Main feature | Bone loss |
|---|---|---|
| Peri-implant health | No clinical signs of inflammation | No progressive bone loss |
| Peri-implant mucositis | Inflammation and bleeding around the implant | No progressive bone loss |
| Peri-implantitis | Inflammation with bleeding and/or suppuration | Progressive supporting bone loss |
✅ How Does Peri-Implantitis Develop?
The process usually begins with the accumulation of bacterial biofilm around the implant. This can trigger inflammation in the surrounding soft tissues.
If the inflammatory process persists, it may extend deeper and contribute to loss of the bone supporting the implant.
However, plaque is not the only consideration. Current evidence indicates that peri-implantitis results from the interaction of biofilm, patient susceptibility, implant characteristics, and local conditions.
Important Risk Factors
Recent AO/AAP evidence identifies several factors that may increase the risk of peri-implant diseases:
▪️ Previous periodontitis
▪️ Smoking
▪️ Poor plaque control
▪️ Uncontrolled diabetes
▪️ Obesity
▪️ Poorly positioned implants
▪️ Prosthetic factors that make cleaning difficult
▪️ Certain unfavorable peri-implant soft-tissue conditions
Among these, a history of periodontitis and cigarette smoking have particularly strong evidence as risk factors for peri-implantitis.
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Peri-implantitis may not always cause pain, so patients can have disease progression without obvious symptoms.
Possible warning signs include:
▪️ Bleeding when brushing or during professional probing
▪️ Redness or swelling around the implant
▪️ Suppuration or pus
▪️ Increasing probing depth
▪️ Gum recession around the implant
▪️ Unpleasant taste or odor in some cases
▪️ Progressive radiographic bone loss
▪️ Mobility of the implant in advanced cases
A particularly important point is that implant mobility is generally a late finding. An implant that becomes mobile may already have experienced substantial loss of supporting bone.
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Diagnosis requires more than simply observing redness around an implant.
The clinician evaluates the peri-implant tissues through:
1. Clinical examination
2. Gentle periodontal probing
3. Assessment of bleeding and/or suppuration
4. Comparison of probing depths with previous records
5. Radiographic evaluation of bone levels
6. Evaluation of prosthetic and implant-related factors
Whenever possible, baseline probing and radiographic measurements should be recorded after completion of the implant-supported restoration. These measurements make future changes easier to identify.
When previous records are unavailable, the 2017 classification proposed the combination of bleeding and/or suppuration, probing depths of ≥6 mm, and bone levels ≥3 mm apical to the most coronal portion of the intraosseous implant as criteria consistent with peri-implantitis.
These numerical criteria should not, however, replace clinical judgment and comparison with previous examinations.
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The main concern is progressive loss of the bone that supports the implant.
As bone is lost, the implant may become increasingly exposed and its long-term stability can be compromised. Advanced disease may also create deeper areas that are more difficult for the patient to clean, potentially sustaining the inflammatory process.
The clinical consequence can therefore be summarized as:
Biofilm accumulation → inflammation → progressive bone loss → reduced implant support → possible implant failure.
Importantly, peri-implantitis does not automatically mean that an implant must be removed. Treatment depends on disease severity, bone defects, implant position, prosthetic design, patient risk factors, and the response to treatment. Current consensus recommendations emphasize individualized management rather than a single treatment protocol for every case.
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Treatment aims to control inflammation, reduce bacterial contamination, manage contributing risk factors, and preserve or restore peri-implant tissues when possible.
1. Non-Surgical Management
Initial treatment may include:
Professional mechanical debridement
Improvement of the patient's oral hygiene
Management of modifiable risk factors
Correction of local factors that interfere with plaque control
A personalized supportive maintenance program
For some patients, nonsurgical therapy can reduce inflammation, but established peri-implantitis may require additional treatment when inflammation and bone loss persist.
2. Surgical Management
More advanced cases may require surgical treatment to obtain access to the affected implant surface and manage the bone defect.
Depending on the defect and clinical situation, treatment may involve:
▪️ Access-flap surgery
▪️ Resective procedures
▪️ Regenerative procedures
▪️ Soft-tissue augmentation when indicated
▪️ Implant removal in selected cases where the implant cannot be predictably maintained
The 2025 AO/AAP consensus emphasizes that treatment should be individualized according to disease severity and patient- and site-specific factors, followed by supportive peri-implant maintenance.
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Peri-implantitis is one of the most important biological complications associated with long-term implant therapy. Current evidence supports viewing it as a multifactorial inflammatory disease, rather than simply an infection caused by poor oral hygiene.
Its clinical importance lies in the potential for progressive bone destruction around an otherwise functional implant. Prevention and early detection are therefore essential.
Recent AO/AAP evidence estimated patient-level prevalence of peri-implantitis at approximately 21%, although prevalence varies substantially according to diagnostic criteria, study populations, and follow-up periods.
The most important practical message is that implant therapy does not end when the prosthesis is delivered. Long-term maintenance, plaque control, management of risk factors, and periodic clinical and radiographic monitoring are essential components of implant care.
✍️ Conclusion
Peri-implantitis is a plaque-associated inflammatory disease that causes progressive loss of bone around a dental implant. It differs from peri-implant mucositis because bone destruction is a defining feature.
Although peri-implantitis can threaten the long-term stability of an implant, early diagnosis and appropriate management can help control disease progression. Patients with a history of periodontitis, smokers, and individuals with inadequate plaque control or other risk factors require particular attention.
Successful implant therapy therefore depends not only on implant placement and restoration, but also on lifelong peri-implant maintenance and risk-factor management.
🎯 Clinical Recommendations
▪️ Establish baseline probing and radiographic records after implant restoration whenever possible.
▪️ Do not wait for pain or implant mobility before investigating suspicious peri-implant changes.
▪️ Bleeding on probing should be taken seriously, particularly when it is persistent or accompanied by increasing probing depths.
▪️ Identify and manage modifiable risk factors, especially smoking, poor plaque control, and uncontrolled diabetes.
▪️ Assess whether the prosthesis or implant position makes effective plaque removal difficult.
▪️ Treat peri-implant mucositis early to reduce the risk of progression.
▪️ For established peri-implantitis, use a severity- and defect-specific treatment plan and maintain the patient in supportive peri-implant care.
📚 References
✔ Berglundh, T., Armitage, G., Araujo, M. G., Avila-Ortiz, G., Blanco, J., Camargo, P. M., Chen, S., Cochran, D., Derks, J., Figuero, E., Hämmerle, C. H. F., Heitz-Mayfield, L. J. A., Huynh-Ba, G., Iacono, V., Koo, K.-T., Lambert, F., McCauley, L., Quirynen, M., Renvert, S., Salvi, G. E., Schwarz, F., Tarnow, D., Tomasi, C., Wang, H.-L., & Zitzmann, N. (2018). Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. Journal of Periodontology, 89(Suppl. 1), S313–S318. https://doi.org/10.1002/JPER.17-0739
✔ Fiorellini, J. P., Mojaver, S., Sarmiento, H., & Aghaloo, T. (2025). Clinical translation of the 2024 AO/AAP consensus on prevention and management of peri-implant diseases and conditions. The International Journal of Periodontics & Restorative Dentistry, 45(4), 1–30. https://doi.org/10.11607/prd.7658
✔ Galarraga-Vinueza, M. E., Pagni, S., Finkelman, M., Schoenbaum, T., & Chambrone, L. (2025). Prevalence, incidence, systemic, behavioral, and patient-related risk factors and indicators for peri-implant diseases: An AO/AAP systematic review and meta-analysis. Journal of Periodontology, 96(6), 587–633. https://doi.org/10.1002/JPER.24-0154
✔ Renvert, S., Persson, G. R., Pirih, F. Q., & Camargo, P. M. (2018). Peri-implant health, peri-implant mucositis, and peri-implantitis: Case definitions and diagnostic considerations. Journal of Periodontology, 89(Suppl. 1), S304–S312. https://doi.org/10.1002/JPER.17-0588
✔ Wang, H.-L., Avila-Ortiz, G., Monje, A., Kumar, P., Calatrava, J., Aghaloo, T., Barootchi, S., Fiorellini, J. P., Galarraga-Vinueza, M. E., Kan, J., Lin, G.-H., Ravida, A., Saleh, M. H. A., Tavelli, L., & Rosen, P. S. (2025). AO/AAP consensus on prevention and management of peri-implant diseases and conditions: Summary report. Journal of Periodontology, 96(6), 519–541. https://doi.org/10.1002/JPER.25-0270
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