Removable Inclined Plane for Anterior Crossbite

Anterior crossbite in the primary or mixed dentition is frequently associated with a dental or functional discrepancy rather than a true skeletal Class III relationship.

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When appropriately diagnosed, early interception can eliminate the anterior occlusal interference, improve incisor relationship, and establish a more favorable occlusal environment.

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The removable inclined plane is a simple interceptive appliance designed primarily to correct anterior dental crossbite by using the occlusal forces generated during mandibular closure. Its clinical value is greatest in selected patients with limited dental displacement, adequate space for correction, and sufficient overbite to allow the appliance to function effectively.
Current evidence supports intraoral appliances for dental and functional anterior crossbites, although the certainty of evidence varies and treatment selection should be based on the underlying etiology.

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🔹 What Is a Removable Inclined Plane?
A removable inclined plane is an acrylic orthodontic appliance that incorporates an inclined surface designed to contact the mandibular incisors during closure.
The appliance changes the direction of the occlusal force applied to the involved incisors. Instead of allowing the mandibular incisors to maintain a locked relationship behind the maxillary incisors, the inclined surface facilitates labial movement of the maxillary incisors and/or correction of the anterior crossbite.
The appliance is commonly considered when the crossbite is primarily dental or functional and does not require substantial skeletal modification.

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🔹 How Does the Inclined Plane Correct Anterior Crossbite?
The mechanism is predominantly dentoalveolar and mechanical.
During mandibular closure, the lower incisors contact the inclined acrylic surface. The resulting force redirects the mandibular closing movement and assists the maxillary incisors in moving toward a normal overjet relationship.

The clinical objective is to:
▪️ Eliminate the anterior occlusal interference.
▪️ Establish positive overjet.
▪️ Correct the abnormal incisor relationship.
▪️ Permit normal mandibular closure after correction.
▪️ Reduce the risk of maintaining a functional anterior displacement.

Because the appliance primarily produces dental movement, it should not be considered a substitute for orthopedic treatment in patients with a significant skeletal Class III discrepancy.

Indications
The removable inclined plane is most appropriate when the clinical examination demonstrates a relatively localized anterior dental problem.

Potential indications include:
▪️ Anterior crossbite involving one or several incisors.
▪️ Dental or functional anterior crossbite.
▪️ Mild anterior displacement without significant skeletal discrepancy.
▪️ Mixed dentition patients with adequate eruption of the involved incisors.
▪️ Sufficient overbite to permit contact with the inclined surface.
▪️ Patients capable of maintaining adequate appliance compliance.

A systematic review of removable appliances found that removable and fixed appliances can both effectively correct nonskeletal anterior crossbite, although the evidence quality was generally low.

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🔹 When Is It Not the Best Option?
The appliance should be selected cautiously when the anterior crossbite is associated with a substantial skeletal discrepancy.

It is generally inappropriate as the sole treatment when there is:
▪️ Significant skeletal Class III malocclusion.
▪️ Marked maxillary deficiency.
▪️ Excessive mandibular prognathism.
▪️ Severe crowding preventing the required tooth movement.
▪️ Insufficient overbite for appliance retention or function.
▪️ Poor expected compliance.
▪️ Multiple occlusal problems requiring comprehensive orthodontic mechanics.

In these circumstances, treatment may require other approaches, including maxillary expansion, facemask therapy, fixed appliances, or comprehensive Class III orthopedic/orthodontic treatment, depending on the diagnosis.

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🔹 Clinical Assessment Before Treatment
Correct diagnosis is more important than appliance selection. Before prescribing an inclined plane, the clinician should determine whether the crossbite is dental, functional, or skeletal.

The assessment should include:
1. Overjet and overbite
2. Incisor inclination and position
3. Presence of a functional mandibular shift
4. Facial profile and skeletal relationships
5. Available space for incisor correction
6. Occlusal interferences
7. Periodontal status of the involved teeth
8. Patient compliance potential

A functional shift should be identified by comparing the mandibular position in habitual occlusion with the position obtained when the patient is guided into a more favorable relationship.

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🔹 Clinical Effectiveness
Evidence from clinical studies indicates that inclined planes can produce rapid correction in appropriately selected dental anterior crossbites.
An early clinical study using a composite inclined plane for a single-incisor anterior crossbite reported correction in 33 of 35 children within one week. The authors emphasized that the technique was particularly useful for a localized crossbite.
More recent evidence also supports the effectiveness of removable inclined planes. A randomized clinical trial involving children aged 8–12 years with functional anterior crossbite found that both removable inclined planes and clear aligners were effective after four months, although the clear-aligner group demonstrated greater changes in some measurements.
These findings support the use of an inclined plane as a simple interceptive option, but they do not establish it as universally superior to other appliances.

📊 Removable Inclined Plane vs. Other Appliances

📊 Removable Inclined Plane vs. Other Appliances

Appliance	Primary Action	Typical Indication	Main Consideration
Removable inclined plane	Occlusally guided dental correction	Localized dental or functional crossbite	Requires adequate compliance and suitable overbite
Fixed 2×4 appliance	Controlled incisor movement	Dental crossbite with reduced compliance	Greater appliance complexity
Composite inclined plane	Occlusal guidance	Single or very localized incisor crossbite	Limited to carefully selected cases
Facemask ± expansion	Orthopedic maxillary protraction	Skeletal Class III with maxillary deficiency	Not indicated for an isolated dental crossbite

🔹 Advantages and Limitations
The principal advantage of the removable inclined plane is its simplicity. It can provide an effective interceptive approach without brackets, archwires, or complex mechanics.

Other potential advantages include:
▪️ Simple fabrication.
▪️ Limited treatment mechanics.
▪️ Low appliance complexity.
▪️ Potentially short active correction in selected cases.
▪️ Easy removal for hygiene.

However, removable appliances depend substantially on patient compliance. They may also be unsuitable when precise three-dimensional tooth movement is required.
A systematic review comparing removable and fixed appliances found that both approaches can be effective for nonskeletal anterior crossbite, while fixed appliances may provide advantages in treatment time and cost in some circumstances.

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💬 Discussion
The removable inclined plane should be regarded as an interceptive appliance for selected dental or functional anterior crossbites rather than a general treatment for all Class III presentations.
The distinction between a dental crossbite and a skeletal Class III discrepancy is fundamental. Recent evidence continues to support intraoral appliances for dental and functional crossbites, whereas significant skeletal discrepancies may require orthopedic approaches.
The available literature also has important limitations. Systematic reviews have reported low or very low certainty of evidence, methodological heterogeneity, and relatively limited high-quality randomized trials.
Therefore, the appliance should be selected according to the etiology, severity, location of the crossbite, overbite, eruption status, and expected compliance, rather than simply according to chronological age.

🎯 Clinical Recommendations
▪️ Use a removable inclined plane primarily for dental or functional anterior crossbite, not as the principal treatment for a significant skeletal Class III discrepancy.
▪️ Confirm that sufficient overbite and incisor eruption are present to allow the appliance to function effectively.
▪️ Evaluate the mandibular path of closure before treatment to identify a functional shift.
▪️ Establish adequate space for the intended incisor correction before relying on occlusal guidance.
▪️ Monitor the involved incisors and periodontal tissues during active correction.
▪️ Reassess the occlusion after crossbite correction to confirm a stable positive overjet rather than stopping treatment immediately after the initial tooth movement.
▪️ Consider fixed or orthopedic mechanics when the required movement exceeds the predictable capabilities of an inclined plane.

✍️ Conclusion
The removable inclined plane is a useful interceptive appliance for selected anterior dental and functional crossbites in growing patients. Its principal mechanism is occlusally guided dentoalveolar correction rather than skeletal modification.
Its effectiveness depends on accurate diagnosis, adequate overbite, sufficient space, appropriate case selection, and patient compliance. Current evidence supports its use as a simple treatment option, while recognizing that the overall evidence base remains limited and that skeletal Class III cases require a different therapeutic strategy.

📚 References

✔ Jorge, J. O., Corradi-Dias, L., Flores-Mir, C., Pordeus, I. A., Paiva, S. M., & Abreu, L. G. (2020). Comparison between removable and fixed devices for nonskeletal anterior crossbite correction in children and adolescents: A systematic review. The Journal of Evidence-Based Dental Practice, 20(3), 101423. https://doi.org/10.1016/j.jebdp.2020.101423
✔ Khalaf, K., & Mando, M. (2020). Removable appliances to correct anterior crossbites in the mixed dentition: A systematic review. Acta Odontologica Scandinavica, 78(2), 118–125. https://doi.org/10.1080/00016357.2019.1657178
✔ Kourbaj, A., et al. (2026). Effectiveness of treatment modalities for the correction of anterior crossbite in children: A systematic review and meta-analysis of randomized controlled trials. [Journal publication indexed in PubMed].
✔ Salem, A. S., Albelasy, N. F., & El-Bialy, A. E. (2025). Effectiveness of clear aligner versus removable inclined plane in treatment of anterior crossbite in mixed dentition: A randomized clinical trial. Journal of the World Federation of Orthodontists, 14(3), 125–130. https://doi.org/10.1016/j.ejwf.2024.11.001
✔ Salem, A. S., Albelasy, N. F., & El-Bialy, A. E. (2026). Dento-facial changes and oral health-related quality of life assessment in management of anterior crossbite in mixed dentition: A randomized clinical trial. The Angle Orthodontist, 96(2), 206–214. https://doi.org/10.2319/020325-109.1
✔ Smahel, Z., & Faltin, K. (2011). Early correction of anterior crossbites: A systematic review. European Journal of Orthodontics.
✔ Almeida, M. R., et al. (2001). Correction of anterior dental crossbite with composite as an inclined plane. International Journal of Paediatric Dentistry. https://doi.org/10.1046/j.1365-263x.2001.00256.x

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Childhood Bruxism Causes: What Are the Main Triggers?

Childhood bruxism is a repetitive activity of the masticatory muscles that may involve tooth grinding, clenching, mandibular bracing, or jaw movements. It can occur during sleep (sleep bruxism) or while the child is awake (awake bruxism).

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Current evidence indicates that bruxism should not be viewed as having a single cause; rather, it is a multifactorial behavior influenced by sleep, respiratory, psychosocial, genetic, and behavioral factors.

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The identification of potential contributing factors is clinically important because bruxism may coexist with sleep disturbances, headaches, muscle discomfort, abnormal tooth wear, or other oral and systemic findings. However, the presence of bruxism does not necessarily indicate disease or require treatment in every child.

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✅ What Causes Bruxism in Children?
The causes of childhood bruxism are multifactorial, and the strength of evidence varies considerably among proposed factors.

1. Sleep Disturbances
Sleep-related factors are among the most consistently reported associations with sleep bruxism in children. Insufficient sleep, restless sleep, and other alterations in sleep behavior have been associated with increased likelihood of bruxism.
A systematic review and meta-analysis found associations between childhood bruxism and snoring, restless sleep, inadequate sleep duration, mouth breathing, and other sleep-related behaviors.
Therefore, the clinical history should include questions about sleep quality, duration, snoring, restless sleep, and unusual nocturnal behaviors.

2. Sleep-Disordered Breathing
Sleep-disordered breathing (SDB), including conditions associated with obstructive breathing during sleep, has been repeatedly associated with sleep bruxism.
A systematic review involving children and adolescents found a relationship between sleep bruxism and sleep respiratory disorders, although the authors emphasized that the available evidence does not establish a definitive causal relationship.
Persistent snoring, mouth breathing, witnessed pauses in breathing, restless sleep, or excessive daytime sleepiness should therefore prompt appropriate medical or sleep evaluation rather than assuming that bruxism is an isolated dental problem.

3. Psychological and Psychosocial Factors
Stress, anxiety, and other psychosocial factors may contribute to bruxism, particularly in older children and adolescents.
Evidence suggests that the association is age-dependent. A systematic review found no convincing evidence of an association between psychosocial factors and sleep bruxism in children younger than five years, whereas an association was observed in children aged 6–11 years and adolescents.
Consequently, psychosocial factors should be considered as possible contributors rather than automatically identifying stress or anxiety as the primary cause.

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4. Genetic and Familial Factors
Family history may also play a role. Recent evidence has identified an association between sleep bruxism in children and bruxism in their parents or guardians.
A 2025 systematic review and meta-analysis reported that children whose parents or guardians had sleep bruxism were more likely to exhibit sleep bruxism themselves. However, the certainty of evidence was rated very low, meaning that these findings should be interpreted cautiously and should not be considered proof of a direct genetic cause.

5. Behavioral and Parafunctional Factors
Some children exhibit repetitive oral behaviors or parafunctional activities that may coexist with bruxism. These behaviors can include persistent clenching, chewing habits, or other repetitive mandibular activities.
A systematic review identified parafunctional behaviors as a moderately associated factor, although the evidence remains heterogeneous.

6. Other Associated Factors
The pediatric literature has also investigated factors such as screen exposure, dietary patterns, family characteristics, personality traits, and environmental influences. Some studies have reported associations, but these findings are not sufficiently consistent to establish them as independent causes.
Current evidence therefore supports a multifactorial model of childhood bruxism, rather than a single etiological mechanism.

📊 Main Factors Associated With Childhood Bruxism

Factor	Examples	Clinical Relevance
Sleep disturbances	Restless sleep, insufficient sleep, altered sleep patterns	Frequently associated with sleep bruxism
Sleep-disordered breathing	Snoring, mouth breathing, obstructive breathing	Important association requiring appropriate evaluation
Psychosocial factors	Stress, anxiety, emotional difficulties	More relevant in older children and adolescents
Familial factors	Parental or familial history of bruxism	Association reported, but causality remains uncertain
Parafunctional behaviors	Clenching and repetitive oral behaviors	May coexist with or contribute to bruxism

✅ Is Tooth Wear Evidence of Bruxism?
Tooth wear may be observed in children with bruxism, but it should not be considered diagnostic by itself. Pediatric tooth wear may have multiple causes, and recent evidence indicates that tooth wear is not necessarily a major or specific indicator of sleep bruxism in children.
The diagnosis should therefore integrate the child's history, parental observations, clinical examination, and, when clinically indicated, additional assessment.

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💬 Discussion
The current understanding of childhood bruxism causes has shifted from a predominantly mechanical or occlusal explanation toward a broader biopsychosocial and sleep-related model. Sleep disturbances and respiratory changes appear particularly relevant, while psychosocial, behavioral, and familial factors may contribute in selected patients.
Importantly, most available pediatric studies are observational, use heterogeneous diagnostic methods, and frequently rely on parental reports. Consequently, associations should not automatically be interpreted as causal relationships.
The contemporary consensus also emphasizes that bruxism represents a type of masticatory muscle activity and should not automatically be classified as a disorder. Its clinical significance depends on the individual patient's symptoms, associated conditions, and potential consequences.

🎯 Clinical Recommendations
▪️ Assess sleep history in children with suspected sleep bruxism, particularly snoring, mouth breathing, restless sleep, and inadequate sleep duration.
▪️ Screen for sleep-disordered breathing when respiratory symptoms accompany nocturnal bruxism.
▪️ Consider psychosocial factors in school-aged children and adolescents, without assuming that stress is the sole cause.
▪️ Ask about familial history of bruxism, recognizing that current evidence demonstrates association rather than definitive genetic causation.
▪️ Do not diagnose bruxism solely from tooth wear; combine history, clinical findings, and relevant symptoms.
▪️ Avoid unnecessary irreversible dental treatment when the child has asymptomatic bruxism without significant clinical consequences.
▪️ Refer for medical, sleep, or psychological assessment when the clinical history suggests a relevant underlying condition.

✍️ Conclusion
Childhood bruxism is multifactorial and cannot generally be attributed to a single cause. Sleep disturbances, sleep-disordered breathing, psychosocial factors, familial influences, and parafunctional behaviors are among the factors most frequently associated with pediatric bruxism.
For dental clinicians, identifying potentially modifiable or clinically significant associated factors is more useful than attempting to identify a single cause. A comprehensive clinical assessment allows children who require further evaluation to be distinguished from those in whom observation and periodic follow-up are appropriate.

📚 References

✔ Lobbezoo, F., Ahlberg, J., Glaros, A. G., Kato, T., Koyano, K., Lavigne, G. J., de Leeuw, R., Manfredini, D., Svensson, P., & Winocur, E. (2013). Bruxism defined and graded: An international consensus. Journal of Oral Rehabilitation, 40(1), 2–4. https://doi.org/10.1111/joor.12011
✔ Lobbezoo, F., Ahlberg, J., Raphael, K. G., Wetselaar, P., Glaros, A. G., Kato, T., Santiago, V., Winocur, E., De Laat, A., De Leeuw, R., Koyano, K., Lavigne, G. J., Svensson, P., & Manfredini, D. (2018). International consensus on the assessment of bruxism: Report of a work in progress. Journal of Oral Rehabilitation, 45(11), 837–844. https://doi.org/10.1111/joor.12663
✔ Leung, A. K. C., Wong, A. H. C., Lam, J. M., & Hon, K. L. (2024). Sleep bruxism in children: A narrative review. Current Pediatric Reviews, 20(2), 139–148. https://doi.org/10.2174/1573396320666230915103716
✔ Melo, G., Dutra, K., Rodrigues, R., Machado, L., & Porporatti, A. L. (2017). Association between children's sleep bruxism and sleep behaviors: A systematic review and meta-analysis. Journal of Dentistry, 66, 12–18.
✔ Serra-Negra, J. M., Paiva, S. M., Flores-Mendoza, C. E., Ramos-Jorge, M. L., & Pordeus, I. A. (2015). Risk factors related to sleep bruxism in children: A systematic literature review. Journal of Indian Society of Pedodontics and Preventive Dentistry, 33(4), 303–306.
✔ Manfredini, D., et al. (2023). Sleep bruxism in children, from evidence to the clinic: A systematic review. Journal of Clinical Medicine, 12, 3660.
✔ Carra, M. C., et al. (2023). Sleep bruxism and sleep respiratory disorders in children and adolescents: A systematic review. Oral Diseases.
✔ Minervini, G., Franco, R., Marrapodi, M. M., Crimi, S., Fiorillo, L., Cervino, G., Bianchi, A., & Cicciù, M. (2024). Sleep bruxism in children main methods of treatment: A systematic review with meta-analysis. Journal of Clinical Pediatric Dentistry, 48(5), 41–50. https://doi.org/10.22514/jocpd.2024.102
✔ Medeiros, L. F., et al. (2025). Association between children's sleep bruxism with that of their parents/guardians: A systematic review and meta-analysis. Sleep Medicine.
✔ Manfredini, D., et al. (2025). Updating the bruxism definitions: Report of an international consensus meeting. Journal of Oral Rehabilitation.

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How to Calculate Pediatric Drug Doses in Dentistry?

Pediatric drug dosing requires greater precision than simply reducing an adult dose according to the child's age. In dentistry, medications such as analgesics, antibiotics, and local anesthetics are frequently prescribed according to body weight, clinical indication, age, and the specific characteristics of the medication.

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Most pediatric doses are expressed as mg/kg/dose or mg/kg/day. Correct interpretation of these units is essential because confusing a dose per administration with a total daily dose can result in clinically significant medication errors.

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Pediatric dosing must also respect the recommended maximum single dose and maximum daily dose for the specific drug. The following approach provides a practical framework for calculating pediatric doses in dental practice.

1. Obtain the Child's Current Weight
The first step is to determine the child's current body weight in kilograms (kg).

If weight is provided in pounds:
Weight (kg) = Weight (lb) ÷ 2.2

Whenever possible, the child's measured current weight should be used rather than an estimated weight.
The medication reference should then be consulted to determine whether dosing is based on actual body weight, age, body surface area, or another parameter. Pediatric pharmacokinetics are not simply a scaled-down version of adult pharmacology.

2. Identify How the Dose Is Expressed
The prescription information must be carefully interpreted before performing the calculation.

Dosing Expression	Meaning	Calculation
mg/kg/dose	Amount administered at each administration	Weight × recommended mg/kg
mg/kg/day	Total amount allowed during 24 hours	Weight × recommended mg/kg/day
mg/kg/day divided doses	Total daily dose divided according to the prescribed frequency	(Weight × mg/kg/day) ÷ number of doses
mg/m²	Dose based on body surface area	Requires height and weight

The distinction between mg/kg/dose and mg/kg/day is particularly important. A value expressed as mg/kg/day should not be administered as though it were the dose for each individual administration.

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3. Basic Formula for Weight-Based Dosing
When a medication is prescribed in mg/kg/dose, the calculation is:
Dose (mg) = Body weight (kg) × Recommended dose (mg/kg/dose)

Example
Consider a hypothetical medication with a recommended dose of 10 mg/kg/dose for a child weighing 20 kg:
20 kg × 10 mg/kg/dose = 200 mg/dose

Therefore, the calculated dose is 200 mg per administration, provided that this does not exceed the medication's specified maximum dose.
This example illustrates the calculation method and is not a recommendation to prescribe a particular medication.

4. Calculating a Daily Dose
When the reference specifies mg/kg/day, the calculation is different.

For example, if a hypothetical drug has a recommended dosage of 30 mg/kg/day for a child weighing 20 kg:
20 kg × 30 mg/kg/day = 600 mg/day

If the prescribed regimen is divided into three equal administrations:
600 mg/day ÷ 3 = 200 mg/dose

Thus, the child would receive 200 mg per administration, three times daily, assuming that regimen is appropriate for the specific medication and clinical indication.

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5. Converting Milligrams to Milliliters
Liquid pediatric medications are commonly supplied as oral suspensions. The concentration must therefore be checked before converting the calculated dose from milligrams to milliliters.

The general formula is:
Volume (mL) = Required dose (mg) ÷ Concentration (mg/mL)
If the label expresses concentration as 160 mg/5 mL:
160 mg ÷ 5 mL = 32 mg/mL
If the calculated dose were 160 mg:
160 mg ÷ 32 mg/mL = 5 mL
The final volume should be measured using an appropriate oral dosing syringe or other calibrated device rather than a household spoon.

6. Always Check the Maximum Dose
A weight-based calculation does not automatically mean that the resulting dose is appropriate.

Before prescribing, the clinician should verify:
▪️ Maximum single dose
▪️ Maximum daily dose
▪️ Recommended dosing interval
▪️ Minimum and maximum treatment duration when applicable
▪️ Age restrictions
▪️ Renal or hepatic considerations
▪️ Drug allergies and contraindications
▪️ Drug interactions
▪️ Available formulation and concentration

The American Academy of Pediatric Dentistry specifically notes that pediatric dosage should not exceed the adult dosage for the medications listed in its pediatric dentistry reference.

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7. Example Relevant to Pediatric Dentistry
The AAPD lists acetaminophen for children younger than 12 years at 10–15 mg/kg/dose every 4–6 hours as needed, with a stated maximum daily dose of 75 mg/kg, subject to an absolute maximum of 4,000 mg per 24 hours.

For illustration, consider a child weighing 20 kg:
20 kg × 10 mg/kg = 200 mg/dose
At the upper end:
20 kg × 15 mg/kg = 300 mg/dose

The clinician must then verify the appropriate formulation, dosing interval, maximum daily exposure, and the possibility that the child is receiving acetaminophen from another medication.
This demonstrates why weight-based calculation alone is insufficient; the complete dosing instructions and maximum limits must also be checked.

8. Antibiotic Dose Calculation in Pediatric Dentistry
When an antibiotic is indicated, the calculation should follow the drug-specific pediatric dosing recommendation rather than a generic mg/kg formula.
The clinician should first establish whether the selected antibiotic is appropriate for the infection and whether antibiotic therapy is actually indicated. The AAPD emphasizes antibiotic stewardship and recommends judicious use in pediatric dental patients.

Once the appropriate drug and regimen have been selected, the calculation follows the same principles:
Weight × prescribed mg/kg/dose = mg per administration
or:
Weight × prescribed mg/kg/day = total mg/day

The resulting amount must then be compared with the drug-specific maximum dose and converted into the appropriate formulation.

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9. Local Anesthetics Require an Additional Safety Check
Local anesthetic dosing in children requires particular attention because systemic toxicity can occur when the maximum recommended dose is exceeded.
The AAPD recommends considering the patient's age, weight, medical history, developmental status, planned procedure, anesthetic selection, and maximum recommended dose when administering local anesthesia to pediatric dental patients. Documentation should include the anesthetic used and the dose administered.
For local anesthetics, the clinician should calculate the total amount of drug administered in mg, not simply count cartridges.

For example:
Total dose (mg) = concentration (mg/mL) × volume administered (mL)

The total calculated dose should then be compared with the applicable maximum recommended dose.

10. Common Pediatric Dose-Calculation Errors

Error	Potential Problem	Safer Approach
Using an outdated weight	Incorrect dose calculation	Obtain current measured weight
Confusing mg/kg/day with mg/kg/dose	Excessive daily exposure	Identify the dosing unit before calculating
Ignoring the maximum dose	Dose may exceed recommended exposure	Check the drug reference after calculation
Converting mg to mL incorrectly	Incorrect volume administered	Calculate the concentration in mg/mL
Using household spoons	Inaccurate volume measurement	Use a calibrated oral syringe
Ignoring combination products	Unintentional duplicate dosing	Review all current medications
Assuming all pediatric drugs use weight alone	Some drugs require other dosing parameters	Follow the product-specific reference
Automatically reducing an adult dose	Pediatric pharmacology differs from adults	Use an evidence-based pediatric regimen

The FDA notes that pediatric dosing is commonly based on mg/kg body weight, but also emphasizes that children have pharmacokinetic characteristics that can differ from adults. Consequently, simple dose scaling is not universally appropriate.

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💬 Discussion
Pediatric pharmacological dosing in dentistry is fundamentally a process of translating an evidence-based drug regimen into an accurate patient-specific dose. The mathematical calculation is relatively simple; the greater clinical challenge is selecting the correct dosing parameter and interpreting the medication reference correctly.
The distinction between mg/kg/dose and mg/kg/day is particularly important because both expressions can appear in pediatric prescribing information. Confusion between them can produce substantial dosing errors. The FDA has specifically recognized inconsistent presentation of these dosing approaches as a potential source of medication confusion and recommends clear standardization of pediatric dosing instructions.
For dental practitioners, the calculation should therefore be viewed as a multi-step safety process: confirm the indication, obtain the current weight, identify the drug-specific pediatric regimen, calculate the dose, verify maximum limits, convert the dose to the available formulation, and document the medication administered or prescribed.

🎯 Clinical Recommendations
1. Use the child's current measured weight in kilograms whenever weight-based dosing is indicated.
2. Determine whether the reference specifies mg/kg/dose or mg/kg/day before performing any calculation.
3. Verify the maximum single and daily doses after calculating the weight-based dose.
4. For liquid medications, convert the concentration to mg/mL before calculating the required volume.
5. For local anesthetics, calculate the total milligrams administered, considering the concentration and volume of every cartridge used.
6. Check for duplicate active ingredients, allergies, contraindications, interactions, and organ-function considerations before prescribing.
7. Use current pediatric and dental prescribing references rather than extrapolating adult doses without supporting evidence.
8. Document the patient's weight, medication, dose, concentration, route, frequency, and total quantity whenever clinically appropriate.

✍️ Conclusion
Accurate pediatric drug dose calculation requires more than multiplying body weight by a numerical factor. Safe prescribing depends on correctly interpreting the dosing unit, verifying maximum exposure, accounting for the formulation concentration, and considering the child's clinical characteristics.
In pediatric dentistry, this systematic approach is particularly important for analgesics, antibiotics, and local anesthetics, where dosing errors can result in inadequate treatment or medication toxicity. A standardized calculation process, supported by current evidence-based references, improves prescribing accuracy and contributes to safer pediatric dental care.

📚 References

✔ American Academy of Pediatric Dentistry. (2025). Useful medications for oral conditions. In The Reference Manual of Pediatric Dentistry (pp. 669–677). American Academy of Pediatric Dentistry.
✔ American Academy of Pediatric Dentistry. (2026). Use of antibiotic therapy for pediatric dental patients. In The Reference Manual of Pediatric Dentistry. American Academy of Pediatric Dentistry.
✔ American Academy of Pediatric Dentistry. (2023). Use of local anesthesia for pediatric dental patients. In The Reference Manual of Pediatric Dentistry. American Academy of Pediatric Dentistry.
✔ American Academy of Pediatric Dentistry. (2026). Acute pain management for pediatric dental patients. In The Reference Manual of Pediatric Dentistry. American Academy of Pediatric Dentistry.
✔ U.S. Food and Drug Administration. (2003). General clinical pharmacology considerations for pediatric studies for drugs and biological products. U.S. Department of Health and Human Services.
✔ U.S. Food and Drug Administration. (2023). Dosage and administration section of labeling: Part 1 of 2. U.S. Department of Health and Human Services.
✔ U.S. Food and Drug Administration. (2025). Got a sick kid? Don't guess. Read the label. U.S. Department of Health and Human Services.

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Pediatric Dentistry Treatment Planning: Key Clinical Steps

Pediatric dentistry treatment planning is a structured process that integrates the child's oral and systemic health, developmental stage, disease risk, behavior, family circumstances, and long-term dental needs.

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Unlike an isolated procedure-based approach, comprehensive planning establishes priorities and determines the appropriate sequence, timing, and intensity of dental care.

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The American Academy of Pediatric Dentistry (AAPD) emphasizes individualized care, early professional intervention, continuity of care, and risk-based decision-making throughout childhood. Current recommendations address examination, caries-risk assessment, prevention, restorative care, pulp therapy, behavior guidance, developing dentition, and transition toward adult dental care.

✅ Objectives of Pediatric Dental Treatment Planning
The principal objectives are to:

▪️ Establish an accurate diagnosis and risk profile.
▪️ Control active oral disease and eliminate pain or infection.
▪️ Preserve primary and permanent teeth whenever appropriate.
▪️ Maintain oral function and support normal growth and development.
▪️ Prevent new disease through individualized preventive strategies.
▪️ Monitor the developing dentition and occlusion.
▪️ Establish an appropriate recall and maintenance schedule.
▪️ Address behavioral, medical, developmental, and psychosocial factors that may influence treatment.
▪️ Coordinate referral when the child's needs exceed the clinician's scope of practice.

AAPD guidance considers comprehensive pediatric oral care an ongoing process rather than a single treatment episode.

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✅ Phases of Pediatric Dentistry Treatment Planning

Phase 1: Comprehensive Assessment and Diagnosis
The first phase establishes the child's baseline oral and general health status.

Clinical activities include:
▪️ Medical and dental history.
▪️ Review of medications, allergies, and relevant medical conditions.
▪️ Assessment of growth and development.
▪️ Extraoral and intraoral examination.
▪️ Dental charting.
▪️ Caries-risk assessment.
▪️ Periodontal assessment when indicated.
▪️ Occlusal and eruption assessment.
▪️ Evaluation of oral habits.
▪️ Assessment of behavior and anxiety.
▪️ Radiographic examination when clinically justified.
▪️ Identification of urgent conditions such as pain, infection, trauma, or rapidly progressing disease.

Radiographs should be prescribed according to the patient's clinical circumstances rather than according to an indiscriminate routine schedule. AAPD periodicity recommendations also emphasize individualized examination, diagnostic testing, prevention, counseling, treatment, and periodic reevaluation.

Phase 2: Risk Assessment and Disease Control
Once the diagnosis is established, the clinician determines the patient's principal risk factors and establishes treatment priorities.

Caries-risk assessment is particularly important because treatment should not be based solely on the number of existing lesions. AAPD recommendations incorporate social/behavioral/medical factors, clinical factors, protective factors, and disease indicators to classify children into low-, moderate-, or high-risk categories.
Initial disease-control activities may include:
▪️ Oral hygiene instruction.
▪️ Fluoride therapy.
▪️ Dietary counseling.
▪️ Professional preventive care.
▪️ Sealants when indicated.
▪️ Nonrestorative caries management.
▪️ Management of active carious lesions.
▪️ Treatment of acute infection and pain.
▪️ Interim therapeutic restorations when appropriate.

An important contemporary principle is that restoring a carious lesion alone does not control the underlying disease process. Risk assessment and preventive management should accompany restorative treatment.

Phase 3: Definitive Treatment
After disease control and stabilization, definitive treatment is performed according to diagnosis, prognosis, age, developmental stage, and treatment feasibility.

Possible procedures include:
▪️ Restorative treatment.
▪️ Pulp therapy.
▪️ Stainless steel crowns or other full-coverage restorations when indicated.
▪️ Extractions when teeth have an unfavorable prognosis or cannot be appropriately maintained.
▪️ Space maintenance following premature tooth loss when indicated.
▪️ Management of developmental abnormalities.
▪️ Treatment of traumatic dental injuries.
▪️ Surgical procedures when necessary.

For deep carious lesions in primary teeth, contemporary AAPD guidance includes evidence-based approaches such as indirect pulp treatment, direct pulp capping, and pulpotomy, selected according to the clinical diagnosis and circumstances.

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Phase 4: Developing Dentition and Interceptive Care
Treatment planning in children must consider not only existing disease but also the future development of the dentition.

Clinical assessment should identify:
▪️ Premature loss of primary teeth.
▪️ Space loss or arch-length deficiency.
▪️ Ectopic eruption.
▪️ Crossbite.
▪️ Crowding.
▪️ Abnormal eruption patterns.
▪️ Oral habits.
▪️ Missing or supernumerary teeth.
▪️ Ankylosis or primary failure of eruption.
▪️ Developing Class II or Class III relationships.

AAPD guidance emphasizes that the diagnostic summary should help determine treatment priorities, timing, sequence, and appropriateness of intervention. Management should be adapted to the stage of dentition rather than applying an identical protocol to every child.

Phase 5: Maintenance and Periodic Reevaluation
Pediatric treatment planning does not end when active treatment is completed.

Maintenance includes:
▪️ Periodic clinical examinations.
▪️ Reassessment of caries risk.
▪️ Reinforcement of oral hygiene.
▪️ Fluoride and preventive interventions according to risk.
▪️ Monitoring of eruption and occlusal development.
▪️ Evaluation of restorations and pulp-treated teeth.
▪️ Review of oral habits.
▪️ Assessment of treatment outcomes.
▪️ Modification of the recall interval according to individual risk.

AAPD recommendations emphasize continuity of care based on the individual needs of the child rather than a rigid schedule applied universally.

📊 Pediatric Treatment Planning: Phases and Clinical Activities

Phase	Main Objective	Key Clinical Activities
1. Assessment	Establish diagnosis and risk profile	History, examination, charting, risk assessment, radiographs when indicated
2. Disease Control	Control active disease and urgent problems	Pain and infection management, fluoride, hygiene, diet counseling, caries control
3. Definitive Treatment	Restore function and preserve oral structures	Restorations, pulp therapy, crowns, extractions, trauma and surgical care
4. Interceptive Care	Guide dentofacial development	Eruption monitoring, space management, habit intervention and early orthodontic referral
5. Maintenance	Maintain oral health and monitor development	Periodic examinations, risk reassessment, prevention and eruption monitoring

✅ Methods Used in Pediatric Treatment Planning
Several clinical approaches can be incorporated into an individualized treatment plan.

Risk-Based Caries Management
The AAPD caries-risk assessment and management pathway is a practical method for integrating disease indicators, clinical factors, protective factors, and social or behavioral factors into treatment decisions. Management is then adjusted according to low, moderate, or high risk.

Minimal and Nonrestorative Caries Management
Not every caries lesion requires immediate conventional restoration. Depending on lesion activity, cavitation, location, progression, and patient risk, treatment may involve active surveillance, fluoride, sealants, nonrestorative management, resin infiltration in selected situations, or restorative treatment.

Interim Therapeutic Restoration
Interim therapeutic restoration (ITR) can be considered for caries control when definitive conventional treatment is temporarily impractical, including selected young or uncooperative patients and children with special health care needs. It may also serve as an initial disease-control measure before definitive restoration.

Behavior Guidance
Behavior guidance should be incorporated into the treatment plan rather than treated as an independent issue. Current AAPD guidance recommends individualized selection of behavioral techniques according to the child's needs, treatment requirements, previous behavior, medical history, and family preferences. Options range from basic communication and behavioral techniques to pharmacological methods when indicated.

📊 Treatment Prioritization
A practical sequence should prioritize conditions according to urgency, disease activity, risk of progression, pain, infection, functional impact, and developmental consequences.

Priority	Clinical Situation	General Approach
1. Urgent	Pain, acute infection, trauma or rapidly progressing disease	Immediate assessment and appropriate emergency or disease-control treatment
2. Disease Control	Active caries and significant risk factors	Risk-based preventive, nonrestorative and restorative interventions
3. Definitive	Teeth requiring definitive restoration or pulp treatment	Complete indicated restorative, pulp or surgical treatment
4. Developmental	Eruption, space, occlusal or developmental abnormalities	Monitor, intercept, maintain space or refer according to diagnosis
5. Maintenance	Stable oral health following active care	Individualized recall, prevention and developmental monitoring

💬 Discussion
An effective pediatric dental treatment plan should not be constructed as a list of procedures alone. The diagnosis must determine the objectives, and the objectives should determine the sequence of interventions.
A major contemporary change is the increasing emphasis on risk-based and minimally invasive care. For dental caries, the presence of a lesion does not automatically indicate conventional operative treatment; disease activity, progression risk, lesion characteristics, patient age, cooperation, and feasibility should influence management.
Treatment planning must also incorporate the developing dentition. Eruption disturbances, premature tooth loss, space problems, crossbites, and skeletal or dental discrepancies may require observation, interceptive treatment, space management, or referral. The appropriate timing depends on the developmental stage and the specific abnormality.
Behavior guidance is another integral component. The child's behavioral needs, anxiety, developmental level, previous dental experiences, and family preferences can influence the feasibility and safety of treatment. Current evidence supports individualized selection of behavior-guidance strategies rather than a universal technique for every patient.

🎯 Clinical Recommendations
1. Build the treatment plan from diagnosis and risk assessment, not from the number of procedures required.
2. Establish a clear distinction between urgent care, disease control, definitive treatment, developmental management, and maintenance.
3. Use a caries-risk-based management pathway to determine preventive, nonrestorative, and restorative interventions.
4. Consider the stage of dentition and anticipated eruption pattern before extracting primary teeth or initiating space-related interventions.
5. Incorporate behavior guidance into the treatment plan from the first visit, particularly when extensive treatment is anticipated.
6. Reassess the child after disease-control interventions and modify the definitive treatment plan when the clinical condition changes.
7. Establish an individualized recall and preventive program based on disease risk rather than applying the same interval to every child.
8. Refer complex orthodontic, surgical, medical, developmental, or behavioral conditions when they exceed the clinician's scope of practice.

✍️ Conclusion
Pediatric dentistry treatment planning is a dynamic, individualized process that integrates diagnosis, risk assessment, prevention, disease control, definitive treatment, developmental management, behavior guidance, and long-term maintenance.
The most effective plans establish priorities before procedures, consider the child's developmental stage, and adapt treatment intensity to disease risk and clinical circumstances. Current AAPD recommendations support early intervention, continuity of care, individualized risk assessment, evidence-based treatment selection, and periodic reevaluation as fundamental components of comprehensive pediatric dental care.

📚 References

✔ American Academy of Pediatric Dentistry. (2024). Behavior guidance for the pediatric dental patient. In The Reference Manual of Pediatric Dentistry (pp. 379–399). American Academy of Pediatric Dentistry.
✔ American Academy of Pediatric Dentistry. (2024). Management of the developing dentition and occlusion in pediatric dentistry. In The Reference Manual of Pediatric Dentistry (pp. 497–515). American Academy of Pediatric Dentistry.
✔ American Academy of Pediatric Dentistry. (2022). Caries-risk assessment and management for infants, children, and adolescents. In The Reference Manual of Pediatric Dentistry (pp. 325–331). American Academy of Pediatric Dentistry.
✔ American Academy of Pediatric Dentistry. (2022). Pediatric restorative dentistry. In The Reference Manual of Pediatric Dentistry (pp. 473–486). American Academy of Pediatric Dentistry.
✔ American Academy of Pediatric Dentistry. (2022). Periodicity of examination, preventive dental services, anticipatory guidance/counseling, and oral treatment for infants, children, and adolescents. In The Reference Manual of Pediatric Dentistry (pp. 312–324). American Academy of Pediatric Dentistry.
✔ Dhar, V., Gosnell, E., Jayaraman, J., et al. (2023). Nonpharmacological behavior guidance for the pediatric dental patient. Pediatric Dentistry, 45(5), 385–410.
✔ American Academy of Pediatric Dentistry. (2024). Use of vital pulp therapies in primary teeth 2024. Pediatric Dentistry, 46(1), 13–26.

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How Poor Patient Cooperation Affects Orthodontic Treatment

Patient compliance in orthodontics is an important component of successful treatment. Orthodontic therapy requires more than biomechanical control by the clinician; patients must also participate through adequate oral hygiene, attendance at appointments, prescribed appliance wear, elastics use, and adherence to post-treatment retention protocols.

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The term irresponsibility is clinically imprecise because inadequate adherence may result from multiple factors, including insufficient understanding, motivation, treatment burden, discomfort, forgetfulness, family circumstances, or difficulties following prescribed instructions. Contemporary literature therefore favors the terms patient adherence, compliance, and cooperation when describing these behaviors.

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🔹 What Does Poor Orthodontic Compliance Mean?
Poor orthodontic compliance refers to inadequate adherence to treatment-related recommendations. It may involve one or several behaviors:

▪️ Missing or repeatedly rescheduling orthodontic appointments.
▪️ Inadequate oral hygiene during treatment.
▪️ Failure to wear removable appliances for the prescribed duration.
▪️ Inconsistent use of intermaxillary elastics.
▪️ Repeated appliance breakage associated with inappropriate habits or failure to follow instructions.
▪️ Failure to follow dietary recommendations with fixed appliances.
▪️ Inadequate use of retainers after active treatment.

Importantly, adherence is multidimensional. A patient may attend appointments consistently but demonstrate inadequate appliance wear or oral hygiene. Consequently, compliance should not be assessed using a single behavior or isolated clinical observation.

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🔹 Why Does Patient Adherence Matter?
Orthodontic treatment is based on a combination of professional management and patient participation. Poor adherence can interfere with treatment progression, particularly when treatment depends on removable appliances, elastics, or other patient-controlled components.
A systematic review and meta-analysis found that compliance with removable orthodontic appliances and adjuncts was generally suboptimal, while patients frequently overestimated their actual appliance wear time when compared with objective measurements.
Similarly, adherence to appointments and oral hygiene represents an important component of treatment management. A systematic review of randomized controlled trials found that reminder interventions reduced missed appointments and improved oral-hygiene-related outcomes in orthodontic patients.

📊 Common Clinical Consequences

Compliance Problem	Potential Clinical Consequence
Poor appliance wear	Reduced effectiveness of removable appliances
Inconsistent elastic use	Slower or less predictable correction of the targeted discrepancy
Missed appointments	Delayed monitoring and treatment adjustments
Poor oral hygiene	Increased risk of plaque accumulation and white spot lesions
Repeated bracket breakage	Additional appointments and interruptions in treatment
Poor retainer adherence	Increased risk of post-treatment tooth movement

🔹 Factors Associated With Poor Compliance
Patient adherence should not be interpreted simply as a matter of willingness or discipline. The 2024 scoping review of orthodontic adherence identified a broad and heterogeneous literature and concluded that there is no conclusive evidence for a single set of factors that consistently determines adherence.
Relevant factors may include:

1. Understanding of the Treatment
Patients who do not clearly understand the purpose of an appliance, elastic, or hygiene recommendation may have difficulty maintaining the required behavior.

2. Treatment Burden
Long treatment periods, discomfort, frequent instructions, and removable appliances can increase the practical burden of treatment.

3. Motivation and Expectations
Patient expectations can influence cooperation, satisfaction, and treatment-related behaviors. A systematic review has identified expectations as a potentially relevant patient-centered factor in orthodontic treatment.

4. Forgetfulness and Daily Routine
Some adherence problems are behavioral rather than intentional. Appointment reminders and digital communication can therefore provide useful support. Evidence from systematic reviews indicates that reminder systems can improve appointment attendance and oral-hygiene behaviors.

5. Family and Social Factors
For younger patients, adherence may depend partly on parental or caregiver involvement. Recent evidence suggests that parental attitudes and reasonable patient motivation can be relevant patient-centered factors associated with orthodontic treatment success.

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🔹 How Should the Orthodontist Assess Compliance?
Assessment should be objective, continuous, and nonjudgmental. Useful indicators include:

▪️ Appointment attendance.
▪️ Appliance wear when objectively measurable.
▪️ Elastic compliance.
▪️ Oral-hygiene status.
▪️ Frequency of bracket or appliance breakage.
▪️ Retainer use during the retention phase.
▪️ Patient and caregiver understanding of instructions.

Self-reported compliance should be interpreted cautiously because studies have demonstrated discrepancies between reported and objectively measured appliance wear.

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🔹 Orthodontic Compliance: Clinical Assessment

📊 Orthodontic Compliance: Clinical Assessment

Parameter	What to Assess	Clinical Action
Appointments	Attendance, cancellations, and repeated delays	Identify barriers and reinforce scheduling support
Appliance wear	Prescribed versus actual wear when measurable	Review instructions and consider objective monitoring
Elastics	Frequency and consistency of use	Clarify wear schedule and demonstrate placement
Oral hygiene	Plaque accumulation and gingival condition	Provide targeted hygiene instruction and reinforcement
Appliance integrity	Bracket failures, appliance damage, or loss	Identify behavioral or practical causes and modify instructions
Retention	Retainer wear and maintenance	Reinforce long-term retention requirements

🔹 Improving Patient Adherence
Evidence does not support a single universal strategy for improving orthodontic compliance. Instead, interventions should be individualized according to the specific barrier identified.

Effective clinical approaches may include:
▪️ Clear and repeated instructions about what the patient must do and why it matters.
▪️ Demonstration of appliances and elastics rather than relying exclusively on verbal instructions.
▪️ Written or digital instructions that the patient can review later.
▪️ Appointment reminders through digital communication.
▪️ Regular reinforcement of oral-hygiene behaviors.
▪️ Early identification of repeated non-adherence.
▪️ Involving parents or caregivers when appropriate.
▪️ Objective monitoring when appliance wear is clinically important.

Digital communication and remote monitoring technologies have shown potential for improving appointment adherence and oral-hygiene behaviors, although evidence for individual technologies and protocols remains heterogeneous.

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💬 Discussion
The concept of patient compliance in orthodontics should be approached as a clinical variable rather than a moral judgment. Labeling a patient as “irresponsible” may obscure the underlying reason for inadequate adherence and does not provide a mechanism for improving treatment behavior.
Current evidence indicates that adherence is influenced by multiple interacting factors, and there is insufficient evidence to identify one universally effective intervention.
The distinction between reported and actual compliance is also clinically relevant. Objective monitoring studies demonstrate that patients may overestimate appliance wear, emphasizing the limitations of relying exclusively on self-reporting.
Therefore, the orthodontist should identify specific adherence problems, determine their likely barriers, provide targeted interventions, and reassess the response throughout treatment.

🎯 Clinical Recommendations
1. Assess adherence from the beginning of treatment, particularly when therapy depends heavily on patient-controlled appliances or elastics.
2. Replace generalized instructions with specific behavioral instructions that define what the patient should do, when, and for how long.
3. Use reminders for appointments and other recurring treatment tasks when appropriate; evidence supports their usefulness for improving attendance and some oral-hygiene outcomes.
4. Do not rely exclusively on self-reported appliance wear when objective monitoring is available and clinically justified.
5. Investigate the cause of non-adherence before modifying treatment, distinguishing knowledge gaps, practical barriers, discomfort, motivation, and family-related factors.
6. Document repeated adherence problems objectively and reassess the patient's ability to follow the prescribed treatment protocol.
7. Use individualized reinforcement rather than punitive communication, particularly in adolescent patients.

✍️ Conclusion
Orthodontic patient compliance is an important component of treatment management, but poor adherence should not automatically be interpreted as patient irresponsibility. It is a multidimensional behavior influenced by treatment demands, understanding, motivation, routine, communication, and social factors.
A structured approach based on early identification, objective assessment, clear communication, reminders, and individualized intervention can help clinicians address adherence problems while maintaining a professional and patient-centered treatment relationship. Current evidence supports these strategies, although additional high-quality research is still needed to establish which interventions are most effective across different orthodontic populations.

📚 References

✔ Aljabaa, A., McDonald, F., & Newton, J. T. (2015). A systematic review of randomized controlled trials of interventions to improve adherence among orthodontic patients aged 12 to 18. The Angle Orthodontist, 85(2), 305–313. https://doi.org/10.2319/031214-184.1
✔ Al-Moghrabi, D., Salazar, F. C., Pandis, N., & Fleming, P. S. (2017). Compliance with removable orthodontic appliances and adjuncts: A systematic review and meta-analysis. American Journal of Orthodontics and Dentofacial Orthopedics, 152(1), 17–32. https://doi.org/10.1016/j.ajodo.2017.03.019
✔ Mohammed, H., Rizk, M. Z., Wafaie, K., Ulhaq, A., & Almuzian, M. (2019). Reminders improve oral hygiene and adherence to appointments in orthodontic patients: A systematic review and meta-analysis. European Journal of Orthodontics, 41(2), 204–213. https://doi.org/10.1093/ejo/cjy045
✔ van der Bie, R. M., Bos, A., Bruers, J. J. M., & Jonkman, R. E. G. (2024). Patient adherence in orthodontics: A scoping review. BDJ Open, 10, 58. https://doi.org/10.1038/s41405-024-00235-2
✔ Wafaie, K., Rizk, M. Z., Basyouni, M. E., Daniel, B., & Mohammed, H. (2023). Tele-orthodontics and sensor-based technologies: A systematic review of interventions that monitor and improve compliance of orthodontic patients. European Journal of Orthodontics, 45(3), 245–255. https://doi.org/10.1093/ejo/cjad004

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