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domingo, 1 de febrero de 2026

Pain Management in Pediatric Pulp Therapy: Best Anesthetics and Clinical Techniques

pulp therapy - dental anesthesia

Pain control is a critical determinant of success in pediatric pulp therapy, directly influencing treatment outcomes, child cooperation, and future dental attitudes. Inadequate anesthesia may result in procedural discomfort, heightened anxiety, and long-term dental fear.

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Therefore, effective pain management in children undergoing pulp therapy requires a comprehensive understanding of anesthetic agents, injection techniques, and child-specific anatomical and psychological considerations. This article reviews the best anesthetics and evidence-based techniques currently recommended for pediatric pulp treatments.

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Anesthetic Agents Commonly Used in Pediatric Dentistry

Lidocaine (2% with epinephrine 1:100,000)
Lidocaine remains the gold standard local anesthetic in pediatric dentistry due to its rapid onset, adequate depth of anesthesia, and well-documented safety profile.

Articaine (4% with epinephrine 1:100,000)
Articaine provides enhanced bone penetration, making it effective for infiltration anesthesia in mandibular primary molars. However, its use in young children must be carefully dosed.

Mepivacaine (3% plain)
Indicated when vasoconstrictors are contraindicated, mepivacaine offers moderate duration anesthesia but reduced hemostasis.

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Anesthetic Techniques for Pulp Therapy in Children

Infiltration Anesthesia
Preferred for maxillary teeth and increasingly effective in mandibular primary molars due to thinner cortical bone.

Inferior Alveolar Nerve Block
Indicated for extensive mandibular pulp therapy but associated with higher failure rates and postoperative soft tissue trauma.

Supplemental Techniques
▪️ Intraligamentary anesthesia
▪️ Intrapulpal anesthesia (used only when other techniques fail)
These approaches enhance pain control during inflamed pulpal procedures.

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Pain Modulation Strategies Beyond Anesthesia
Adjunctive methods such as behavior guidance techniques, topical anesthetics, slow injection rates, and age-appropriate communication significantly improve perceived pain control. The combination of pharmacological and psychological strategies is essential for optimal pediatric pain management.

💬 Discussion
Despite advances in anesthetic pharmacology, pain during pediatric pulp therapy remains a clinical challenge, particularly in teeth with irreversible pulp inflammation. Studies demonstrate that articaine infiltration may outperform traditional nerve blocks in primary mandibular molars, reducing discomfort and soft tissue injury. However, technique sensitivity, dosage accuracy, and patient behavior remain critical variables influencing anesthetic success.

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🎯 Recommendations
▪️ Select anesthetic agents based on patient age, medical history, and procedure type
▪️ Prefer infiltration techniques whenever clinically feasible
▪️ Use supplemental anesthesia when conventional methods are insufficient
▪️ Combine anesthesia with non-pharmacological behavior management

✍️ Conclusion
Effective pain management in pediatric pulp therapy relies on appropriate anesthetic selection, precise technique, and child-centered care. Evidence supports the use of modern local anesthetics and minimally invasive approaches to enhance comfort and cooperation. When applied correctly, these strategies improve clinical outcomes and foster positive long-term dental experiences in children.

📊 Comparative Table: Common Pulp Therapy Treatments in Pediatric Dentistry

Pulp Therapy Procedure Clinical Indications Key Considerations
Indirect pulp treatment Deep caries without pulp exposure Requires accurate caries removal and sealing
Direct pulp capping Small mechanical or traumatic exposure Limited indication in primary teeth
Pulpotomy Vital pulp with coronal inflammation Adequate anesthesia essential for success
Pulpectomy Necrotic or irreversibly inflamed pulp More complex and time-consuming procedure
📚 References

✔ American Academy of Pediatric Dentistry. (2023). Guideline on pulp therapy for primary and immature permanent teeth. Pediatric Dentistry, 45(6), 343–351.
✔ Arrow, P. (2018). Pain management for pulp therapy in primary molar teeth. Australian Dental Journal, 63(2), 203–210. https://doi.org/10.1111/adj.12594
✔ Malamed, S. F. (2020). Handbook of local anesthesia (7th ed.). St. Louis, MO: Elsevier.
✔ Wright, G. Z., Kupietzky, A., & Martinez Mier, E. A. (2014). Behavior management in dentistry for children (2nd ed.). Ames, IA: Wiley-Blackwell.

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Pharmacological Behavior Management in Pediatric Dentistry: Drugs, Dosage, and Clinical Safety

 Behavior Management

Behavior management is a cornerstone of pediatric dentistry, particularly when non-pharmacological techniques fail to achieve adequate cooperation. Pharmacological behavior management in pediatric dentistry aims to reduce anxiety, fear, and disruptive behavior while ensuring patient safety and treatment efficacy.

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This approach is especially indicated in children with severe dental anxiety, odontophobia, extensive treatment needs, or special health care requirements. The present article reviews the most commonly used pharmacological agents, including commercial names, dosages, pre- and post-administration care, and current clinical recommendations based on scientific evidence.

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Common Pharmacological Agents in Pediatric Dentistry

Midazolam
▪️ Drug class: Benzodiazepine
▪️ Commercial names: Versed®, Buccolam®
▪️ Dosage (oral): 0.3–0.5 mg/kg (maximum 10 mg)
▪️ Dosage (intranasal): 0.2–0.3 mg/kg
Midazolam provides anxiolysis, sedation, and anterograde amnesia, making it one of the most widely used agents for conscious sedation in children.

Nitrous Oxide–Oxygen Sedation
▪️ Commercial systems: Porter®, Matrx®
▪️ Concentration: 30–50% nitrous oxide, titrated individually
Nitrous oxide offers minimal sedation with rapid onset and recovery, preserving protective reflexes and allowing communication with the patient.

Hydroxyzine
▪️ Drug class: Antihistamine with sedative properties
▪️ Commercial names: Atarax®, Vistaril®
▪️ Dosage: 0.6–1 mg/kg, administered orally
Hydroxyzine is frequently used as an adjunct sedative, especially in mildly anxious pediatric patients.

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Mechanism of Action
Pharmacological agents used in behavior management act primarily by modulating the central nervous system, reducing anxiety and motor activity. Benzodiazepines enhance GABAergic inhibition, while nitrous oxide exerts anxiolytic effects through NMDA receptor modulation and endogenous opioid release.

Pre-Administration Care

▪️ Comprehensive medical and dental history evaluation
▪️ Assessment of ASA physical status
▪️ Strict adherence to fasting (NPO) guidelines
▪️ Informed consent from parents or legal guardians
▪️ Baseline recording of vital signs

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Post-Administration Care

▪️ Continuous monitoring until full recovery of consciousness
▪️ Discharge only after meeting standard recovery criteria
▪️ Clear written and verbal post-sedation instructions
▪️ Avoid physical activity for 24 hours when oral sedatives are used

💬 Discussion
While pharmacological behavior management can significantly improve treatment outcomes, it requires proper training, patient selection, and emergency preparedness. The indiscriminate use of sedatives may increase the risk of adverse events, particularly respiratory depression. Therefore, pharmacological techniques must be integrated within a comprehensive behavior management framework, emphasizing safety and ethical responsibility.

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🎯 Recommendations
▪️ Reserve pharmacological methods for clearly indicated cases
▪️ Use the lowest effective dose
▪️ Ensure availability of emergency equipment and trained personnel
▪️ Combine pharmacological and non-pharmacological behavior guidance techniques

✍️ Conclusion
Pharmacological management of behavior in pediatric dentistry is a valuable clinical tool when used judiciously. Evidence supports its effectiveness in reducing anxiety and improving cooperation, provided that strict protocols, accurate dosing, and vigilant monitoring are followed. When integrated responsibly, pharmacological behavior management enhances both patient experience and clinical success.

📊 Comparative Table: Clinical Characteristics of Odontophobia

Clinical Aspect Behavioral Manifestations Clinical Impact
Intense dental fear Crying, avoidance, panic reactions Delayed or avoided dental treatment
Physiological response Increased heart rate, sweating, nausea Difficulty performing routine procedures
Negative past experiences Anticipatory anxiety before appointments Reduced cooperation during treatment
Cognitive distress Catastrophic thoughts about pain Need for advanced behavior management
📚 References

✔ American Academy of Pediatric Dentistry. (2023). Guideline on behavior guidance for the pediatric dental patient. Pediatric Dentistry, 45(6), 292–310.
✔ Coté, C. J., Wilson, S., & American Academy of Pediatrics. (2019). Guidelines for monitoring and management of pediatric patients before, during, and after sedation. Pediatrics, 143(6), e20191000. https://doi.org/10.1542/peds.2019-1000
✔ Wilson, S. (2016). Pharmacologic behavior management for pediatric dental treatment. Pediatric Clinics of North America, 63(5), 965–981. https://doi.org/10.1016/j.pcl.2016.06.009
✔ Malamed, S. F. (2020). Sedation: A guide to patient management (6th ed.). St. Louis, MO: Elsevier.

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CTZ vs. Guedes-Pinto Paste in Necrotic Teeth: Which Endodontic Material Performs Better?

CTZ-Guedes-Pinto Paste

The management of necrotic teeth, particularly in pediatric and mixed dentition, remains a clinical challenge due to the presence of polymicrobial infection, periapical inflammation, and complex root canal anatomy. Intracanal medicaments and obturation pastes play a critical role in controlling infection and promoting periapical healing.

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Among the materials most frequently discussed in Latin American pediatric dentistry are CTZ paste and Guedes-Pinto paste, both widely used as alternatives to conventional endodontic protocols. This article provides an evidence-based comparison of their composition, mechanisms of action, clinical performance, and limitations in the treatment of necrotic teeth.

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Composition of CTZ Paste
CTZ paste is composed of:

▪️ Chloramphenicol
▪️ Tetracycline
▪️ Zinc oxide–eugenol
This combination offers broad-spectrum antimicrobial activity, targeting aerobic and anaerobic bacteria commonly associated with endodontic necrosis. Zinc oxide–eugenol serves as a vehicle and obturation medium, providing sealing ability and mild anti-inflammatory effects.

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Composition of Guedes-Pinto Paste
Guedes-Pinto paste consists of:

▪️ Rifampicin
▪️ Prednisolone
▪️ Camphorated paramonochlorophenol (CMCP)
This formulation combines antimicrobial, anti-inflammatory, and analgesic properties, making it particularly suitable for infected primary teeth. The corticosteroid component helps reduce periapical inflammation, while CMCP enhances antibacterial efficacy.

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Mechanisms of Action

CTZ Paste
▪️ Inhibits bacterial protein synthesis via tetracycline and chloramphenicol
▪️ Provides chemical disinfection without mechanical instrumentation
▪️ Acts as a long-term antimicrobial obturating material

Guedes-Pinto Paste
▪️ Disrupts bacterial cell metabolism through rifampicin and CMCP
▪️ Reduces inflammatory response via prednisolone
▪️ Promotes symptom relief and periapical tissue recovery

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Clinical Performance in Necrotic Teeth
Clinical studies indicate that both materials demonstrate high success rates in necrotic primary teeth when properly indicated. CTZ paste is often associated with simplified single-visit protocols, while Guedes-Pinto paste shows favorable outcomes in cases with acute inflammation and pain. However, neither material should be considered a substitute for adequate diagnosis and case selection.

💬 Discussion
The choice between CTZ and Guedes-Pinto paste should be guided by clinical presentation, patient age, systemic considerations, and operator experience. CTZ paste offers prolonged antimicrobial action but raises concerns regarding antibiotic resistance and tooth discoloration. Guedes-Pinto paste provides strong anti-inflammatory effects but may present higher cytotoxic potential due to CMCP. Current evidence supports their use mainly in primary teeth, with limited indication in permanent dentition.

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🎯 Recommendations
▪️ Use CTZ paste in necrotic primary teeth requiring simplified endodontic protocols
▪️ Consider Guedes-Pinto paste in cases with acute inflammation or symptomatic necrosis
▪️ Avoid indiscriminate use due to antibiotic stewardship concerns
▪️ Always perform radiographic and clinical follow-up

✍️ Conclusion
Both CTZ and Guedes-Pinto pastes are effective materials for managing necrotic teeth, particularly in pediatric dentistry. Their success depends on appropriate case selection, understanding of their pharmacological properties, and adherence to evidence-based protocols. Neither material replaces conventional endodontic principles, but both remain valuable tools when used judiciously.

📊 Comparative Table: Clinical Characteristics of a Necrotic Tooth

Clinical Feature Diagnostic Indicators Clinical Implications
Loss of pulp vitality Negative thermal and electric pulp tests Indicates irreversible pulp damage
Periapical radiolucency Radiographic evidence of bone loss Suggests chronic periapical infection
Tooth discoloration Gray or dark crown appearance Common in long-standing necrosis
Possible fistula or abscess Clinical drainage or swelling Requires immediate infection control
📚 References

✔ Guedes-Pinto, A. C., Paiva, J. G., & Bozzola, J. R. (1981). Endodontic treatment of primary teeth with a paste containing antibiotics and corticosteroids. Journal of Dentistry for Children, 48(2), 144–147.
✔ Rifkin, A. (1980). A simple, effective endodontic technique for primary teeth. Journal of Dentistry for Children, 47(6), 435–441.
✔ Santos, P. S., & de Araujo, F. B. (2009). Antimicrobial activity of CTZ paste in primary teeth. International Journal of Paediatric Dentistry, 19(6), 397–401. https://doi.org/10.1111/j.1365-263X.2009.01007.x
✔ Leonardo, M. R., & Silva, L. A. B. (2008). Endodontia: Tratamento de canais radiculares. São Paulo: Artes Médicas.

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sábado, 31 de enero de 2026

Recognizing Life-Threatening Odontogenic Infections: Emergency Protocols for Dentists

Odontogenic Infections

Odontogenic infections are common in dental practice; however, under certain conditions, they may progress rapidly and become life-threatening medical emergencies. Failure to recognize early warning signs can result in severe complications such as airway obstruction, sepsis, mediastinitis, or intracranial spread.

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Dentists play a crucial role in the early identification, risk stratification, and timely referral of these infections. This article reviews the clinical characteristics of severe odontogenic infections, outlines emergency management protocols, and emphasizes the importance of prompt intervention.

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Pathophysiology of Life-Threatening Odontogenic Infections
Most severe odontogenic infections originate from:

▪️ Untreated dental caries
▪️ Pulpal necrosis
▪️ Periodontal infections
▪️ Pericoronitis of third molars
The spread occurs through fascial spaces of the head and neck, facilitated by anatomical pathways and virulent polymicrobial flora dominated by anaerobic bacteria. Once deep cervical spaces are involved, the risk of systemic dissemination and airway compromise increases significantly.

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Clinical Warning Signs and Red Flags
Dentists must recognize early indicators of severe infection, including:
▪️ Rapidly progressing facial or cervical swelling
▪️ Trismus (limited mouth opening)
▪️ Dysphagia or odynophagia
▪️ Voice changes or drooling
▪️ Fever with systemic toxicity
▪️ Dyspnea or stridor
▪️ Elevated heart rate and hypotension
These findings may indicate involvement of critical spaces such as the submandibular, sublingual, parapharyngeal, or retropharyngeal spaces, commonly associated with Ludwig’s angina and other deep neck infections.

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Emergency Protocols for Dentists
When a life-threatening odontogenic infection is suspected, the following steps are essential:

1. Do not delay referral for imaging or outpatient antibiotic trials.
2. Assess airway patency immediately.
3. Initiate urgent referral to a hospital setting with maxillofacial and medical support.
4. Avoid definitive dental procedures in unstable patients.
5. Communicate clearly with emergency physicians regarding the odontogenic source.
6. Document all clinical findings thoroughly.
Antibiotic therapy alone is insufficient in advanced cases; surgical drainage and airway management are often required.

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💬 Discussion
Despite advances in dentistry, severe odontogenic infections remain a significant clinical challenge. Delayed diagnosis, inappropriate antibiotic use, and underestimation of severity contribute to poor outcomes. Dentists must maintain a high index of suspicion, particularly in patients with systemic diseases, immunosuppression, or limited access to care. Early recognition and interdisciplinary collaboration are critical to reducing morbidity and mortality.

✍️ Conclusion
Life-threatening odontogenic infections require immediate recognition and decisive action. Dentists are often the first healthcare providers to encounter these patients and must be prepared to identify danger signs, initiate emergency protocols, and ensure timely referral. Adhering to evidence-based clinical criteria can be lifesaving.

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🎯 Clinical Recommendations
▪️ Always assess systemic symptoms in patients with odontogenic infections.
▪️ Consider deep space involvement when swelling extends beyond the alveolar process.
▪️ Do not rely solely on oral antibiotics in severe cases.
▪️ Educate patients on the importance of early dental infection management.
▪️ Maintain updated emergency referral pathways.

📊 Comparative Table: Step-by-Step Oral Self-Examination

Step What to Observe Warning Signs
Lips and cheeks Color, symmetry, swelling Persistent swelling or asymmetry
Tongue Surface texture and mobility Restricted movement or painful enlargement
Floor of the mouth Firmness and tenderness Hard swelling or elevation of the tongue
Gingiva Redness, discharge, bleeding Suppuration or rapidly spreading inflammation
Neck region Palpable lymph nodes Painful, enlarging cervical masses
📚 References

✔ Flynn, T. R. (2011). Severe odontogenic infections, part 1: Prospective report. Journal of Oral and Maxillofacial Surgery, 69(11), 2715–2723. https://doi.org/10.1016/j.joms.2011.02.015
✔ Hupp, J. R., Ellis, E., & Tucker, M. R. (2019). Contemporary oral and maxillofacial surgery (7th ed.). Elsevier.
✔ Marioni, G., Rinaldi, R., Staffieri, C., Marchese-Ragona, R., & Staffieri, A. (2008). Deep neck infection with dental origin: Analysis of 85 consecutive cases. Acta Oto-Laryngologica, 128(2), 201–206. https://doi.org/10.1080/00016480701488511
✔ Wang, L. F., Kuo, W. R., Tsai, S. M., & Huang, K. J. (2003). Characterizations of life-threatening deep cervical space infections. Journal of Otolaryngology, 32(6), 400–404.

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Silver Diamine Fluoride in Pediatric Dentistry: Evidence-Based Clinical Protocols

Silver Diamine Fluoride

Silver diamine fluoride (SDF) has gained strong scientific support as a minimally invasive and cost-effective agent for managing dental caries in pediatric patients.

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Its use aligns with contemporary preventive dentistry and caries management philosophies, particularly in children with high caries risk, limited cooperation, or restricted access to conventional restorative care. This guide presents evidence-based protocols, clinical indications, and the mechanism of action of SDF, supported by current literature.

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What Is Silver Diamine Fluoride?
Silver diamine fluoride is a topical cariostatic agent composed of silver, fluoride, and ammonia. The most widely studied and clinically used formulation is 38% SDF, which contains approximately 44,800 ppm fluoride.

SDF is primarily indicated for:
▪️ Arresting active dentinal caries
▪️ Managing caries in primary teeth
▪️ Treating children with special health care needs
▪️ Reducing the need for invasive procedures

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Mechanism of Action
The therapeutic effect of silver diamine fluoride is based on a dual antimicrobial and remineralizing mechanism:

▪️ Silver ions exert a potent antibacterial effect by disrupting bacterial cell walls, inhibiting enzymes, and interfering with DNA replication.
▪️ Fluoride ions promote remineralization by forming fluorapatite, increasing enamel and dentin resistance to acid attacks.
▪️ The alkaline environment created by ammonia enhances the stability of the solution and prolongs its antimicrobial activity.
▪️ SDF also inhibits collagen degradation within dentin, slowing lesion progression.
Together, these actions lead to caries arrest and lesion hardening, which is clinically observable.

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Evidence-Based Clinical Protocols
Current clinical guidelines support the following protocol for pediatric use:

1. Diagnosis of active cavitated caries
2. Isolation and drying of the tooth
3. Application of a small amount of 38% SDF using a microbrush
4. Allowing contact for at least one minute
5. Avoiding rinsing immediately after application
6. Reapplication every 6–12 months, depending on caries risk
The black staining of arrested lesions should be discussed with parents prior to treatment.

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💬 Discussion
The growing body of evidence supports SDF as a safe and effective caries management tool in pediatric dentistry. Its ability to arrest caries without anesthesia or tooth preparation makes it particularly valuable in young or anxious children. However, esthetic concerns related to permanent dark staining remain a limitation. Ethical practice requires informed consent and proper case selection.

✍️ Conclusion
Silver diamine fluoride is a scientifically validated, minimally invasive option for arresting dental caries in children. When applied following evidence-based protocols, it significantly reduces disease progression and treatment burden. SDF should be considered an essential component of modern pediatric caries management.

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🎯 Clinical Recommendations
▪️ Use 38% SDF for caries arrest in primary teeth.
▪️ Obtain informed parental consent, especially regarding discoloration.
▪️ Reassess lesions periodically to confirm arrest.
▪️ Combine SDF with preventive education and fluoride exposure.
▪️ Integrate SDF within a comprehensive caries management plan.

📊 Comparative Table: Clinical Uses of Silver Diamine Fluoride in Pediatric Dentistry

Clinical Indication Primary Benefit Main Limitation
Active dentinal caries Effective caries arrest without drilling Permanent black staining
Uncooperative pediatric patients Non-invasive and quick application Limited esthetic acceptance
Children with special health care needs Reduces need for general anesthesia Does not restore tooth anatomy
High caries risk populations Cost-effective disease control Requires periodic reapplication
📚 References

✔ American Academy of Pediatric Dentistry. (2023). Use of silver diamine fluoride for dental caries management in children. The Reference Manual of Pediatric Dentistry, 410–416.
✔ Horst, J. A., Ellenikiotis, H., & Milgrom, P. M. (2016). UCSF protocol for caries arrest using silver diamine fluoride. Journal of the California Dental Association, 44(1), 16–28.
✔ Rosenblatt, A., Stamford, T. C., & Niederman, R. (2009). Silver diamine fluoride: A caries “silver-fluoride bullet”. Journal of Dental Research, 88(2), 116–125. https://doi.org/10.1177/0022034508329406
✔ Zhi, Q. H., Lo, E. C. M., & Lin, H. C. (2012). Randomized clinical trial on effectiveness of silver diamine fluoride and glass ionomer in arresting dentine caries. Journal of Dentistry, 40(11), 962–967. https://doi.org/10.1016/j.jdent.2012.08.002

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