Regenerative Pulp Therapy in Pediatric Dentistry: When Is It Truly Indicated?

Regenerative pulp therapy is increasingly discussed in pediatric dentistry, but its clinical indication is narrower than the term may suggest.

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In current clinical practice, regenerative endodontic procedures (REPs) are primarily considered for immature permanent teeth with pulp necrosis, particularly when continued root development would provide a biological advantage.

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This distinction is important because regenerative endodontics should not be confused with vital pulp therapy, such as indirect pulp treatment or pulpotomy.
In a vital immature permanent tooth, preservation of the existing pulp is generally the preferred biological strategy; regeneration is primarily considered when the pulp is already necrotic and conventional treatment would leave a tooth with thin dentinal walls and an open apex.
The current AAPD guidance specifically identifies regenerative endodontics as an option for immature permanent teeth with necrotic pulp and apical periodontitis.

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✅ What Is Regenerative Endodontic Therapy?
Regenerative endodontic procedures (REPs) are biologically based treatments designed to disinfect the canal while creating conditions that may permit tissue ingrowth and continued development of an immature permanent root.

Unlike conventional root canal treatment, which removes the infected pulp and obturates the canal, REPs aim to preserve the potential for:
▪️ Continued root lengthening ▪️ Thickening of dentinal walls ▪️ Apical maturation ▪️ Resolution of periapical inflammation or apical periodontitis

Importantly, radiographic evidence of continued root development does not necessarily demonstrate regeneration of a normal pulp-dentin complex. Current literature emphasizes that clinical success and tooth survival are more predictable than true pulp regeneration or recovery of normal pulp function.

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✅ When Is Regenerative Therapy Actually Indicated?
The strongest clinical indication is an immature permanent tooth with necrotic pulp and an open apex, especially when the tooth is restorable and preservation of further root development is desirable.

Typical candidates include:
▪️ Immature permanent tooth
▪️ Necrotic pulp
▪️ Open or incompletely developed apex
▪️ Apical periodontitis or a periapical lesion may be present
▪️ Adequate tooth structure for restoration
▪️ A patient and family able to comply with follow-up
▪️ No contraindication to the required intracanal medicaments

The AAE's clinical considerations similarly identify a necrotic immature permanent tooth as the fundamental case-selection criterion and emphasize patient compliance, restorability, and appropriate informed consent.

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✅ Clinical Indication: At a Glance

Clinical Indications for Regenerative Endodontic Procedures

Clinical Factor	Typical Finding	Clinical Significance
Tooth type	Immature permanent tooth	Root development remains incomplete.
Pulp status	Necrotic pulp	Vital pulp therapy is no longer the appropriate biological objective.
Apical development	Open or immature apex	Provides access to the apical tissues involved in the regenerative process.
Periapical status	Apical periodontitis may be present	Periapical disease does not automatically exclude regenerative treatment.
Restorability	Adequate remaining tooth structure	A durable coronal seal is essential for long-term success.

✅ When Regenerative Therapy Is Not the First Choice
Regenerative endodontics is not a substitute for vital pulp therapy.
For an immature permanent tooth with a vital pulp or reversible pulpitis, preservation of the existing pulp through appropriate vital pulp therapy should generally be considered first. The AAPD includes indirect pulp treatment, direct pulp capping, partial pulpotomy, and complete pulpotomy among the vital pulp therapies applicable to immature permanent teeth.
Similarly, primary teeth are not the principal indication for regenerative endodontic procedures. Current AAPD recommendations address primary teeth using vital pulp therapies when the pulp is vital and pulpectomy or other nonvital approaches when necrosis or irreversible disease is present.

Therefore, the following situations should prompt consideration of another treatment strategy:

Clinical Situation	More Appropriate Approach
Vital immature permanent tooth	Vital pulp therapy
Reversible pulpitis	Vital pulp therapy
Necrotic mature permanent tooth	Conventional endodontic treatment is generally established
Necrotic immature permanent tooth with open apex	Regenerative endodontic procedure may be considered
Non-restorable tooth	Extraction or other appropriate treatment

✅ Biological Rationale
The principal advantage of regenerative treatment in the immature permanent tooth is not simply elimination of infection. It is the possibility of preserving or enhancing root development after pulpal necrosis.
A conventional apexification procedure can establish an apical barrier and facilitate canal obturation, but it does not reliably reproduce continued physiological root maturation. REPs, in contrast, are intended to create an environment that can support continued deposition of hard tissue along the canal walls and further root development.
This distinction is particularly relevant in young permanent teeth because thin dentinal walls increase susceptibility to cervical or root fracture. Consequently, maintaining or increasing root wall thickness may have important long-term biological implications.

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✅ Key Clinical Considerations
A regenerative procedure is highly dependent on case selection, infection control, and coronal sealing.
The contemporary AAE protocol emphasizes conservative canal disinfection, avoidance of unnecessary mechanical instrumentation of fragile immature roots, and careful control of irrigant extrusion. Calcium hydroxide or an appropriately prepared antibiotic formulation may be used as an intracanal medicament, followed by induction of intracanal bleeding or another scaffold strategy according to the selected protocol.
However, protocols continue to evolve. A 2024 systematic review and network meta-analysis found favorable clinical and radiographic outcomes with several scaffold approaches, but the certainty of evidence varied from low to very low, particularly for comparisons among different regenerative scaffolds.
Recent evidence also supports caution when interpreting radiographic "regeneration." A 2026 systematic review found high pooled clinical success and tooth survival across different degrees of root maturity, while complete apical closure and recovery of pulp vitality were considerably more variable. The authors specifically emphasized that clinical success does not necessarily demonstrate true pulp-dentin regeneration.

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💬 Discussion
The most important clinical question is not whether regenerative endodontics is possible, but whether it provides a meaningful biological advantage for the specific tooth.
For a necrotic immature permanent tooth, regenerative therapy can be attractive because conventional treatment may leave a tooth with compromised root dimensions. Evidence from systematic reviews indicates that REPs can produce high rates of clinical healing and tooth survival, while also providing greater potential for root lengthening and dentinal wall thickening than procedures designed solely to create an apical barrier.
Nevertheless, the evidence does not justify interpreting every increase in root dimensions as genuine regeneration of functional pulp tissue. Furthermore, treatment protocols remain heterogeneous, long-term randomized evidence is limited, and complications such as crown discoloration can occur, particularly with some antibiotic-based protocols.
Thus, regenerative endodontics should be regarded as a selective biological treatment for appropriately chosen immature permanent teeth, rather than a routine alternative to vital pulp therapy or conventional root canal treatment.

🎯 Clinical Recommendations
▪️ Confirm pulpal and periapical diagnosis carefully before considering a regenerative procedure; case selection is more important than the regenerative protocol itself.
▪️ Prioritize vital pulp therapy when the pulp remains viable, particularly in an immature permanent tooth where apexogenesis can still occur.
▪️ Consider REP primarily when there is a necrotic immature permanent tooth with an open apex and preservation of further root development is clinically desirable.
▪️ Establish effective infection control and a durable coronal seal; these remain fundamental determinants of treatment success.
▪️ Discuss with parents and patients that the objective includes healing and continued root development, not a guaranteed recreation of a normal pulp-dentin complex.
▪️ Maintain long-term clinical and radiographic follow-up, because radiographic maturation and pulp sensibility responses can be variable.

✍️ Conclusion
Regenerative endodontic procedures have their clearest role in immature permanent teeth with pulp necrosis and an open apex. Their principal biological rationale is the possibility of continued root maturation and reinforcement of thin dentinal walls.
They should not replace vital pulp therapy when a healthy or reparable pulp remains, nor should they be routinely extrapolated to primary teeth. Current evidence supports favorable healing and survival outcomes, but the terminology of "regeneration" should be interpreted cautiously because true functional pulp regeneration remains less predictable than clinical resolution and radiographic root development.

📚 References

✔ American Academy of Pediatric Dentistry. (2025). Pulp therapy for primary and immature permanent teeth: Indications and objectives. In The Reference Manual of Pediatric Dentistry (pp. 487–496). American Academy of Pediatric Dentistry.
✔ American Association of Endodontists. (2022). AAE clinical considerations for a regenerative procedure: Revised November 2022. American Association of Endodontists.
✔ Coll, J. A., Dhar, V., Chen, C.-Y., Crystal, Y. O., Guelmann, M., Marghalani, A. A., AlShamali, S., Xu, Z., Glickman, G. N., & Wedeward, R. (2024). Use of vital pulp therapies in primary teeth 2024. Pediatric Dentistry, 46(1), 13–26.
✔ Galler, K. M., Krastl, G., Simon, S., Van Gorp, G., Meschi, N., Vahedi, B., & Lambrechts, P. (2016). European Society of Endodontology position statement: Revitalization procedures. International Endodontic Journal, 49(8), 717–723. https://doi.org/10.1111/iej.12629
✔ Sabeti, M., Ghobrial, D., Zanjir, M., da Costa, B. R., Young, Y., & Azarpazhooh, A. (2024). Treatment outcomes of regenerative endodontic therapy in immature permanent teeth with pulpal necrosis: A systematic review and network meta-analysis. International Endodontic Journal, 57(3), 238–255. https://doi.org/10.1111/iej.13999
✔ Tewari, N., Devi, P., Sampath, S., Mathur, V. P., Tsilingaridis, G., Wikström, A., Rahul, M., & Bansal, K. (2025). Comparative effectiveness of regenerative endodontic treatment versus apexification for necrotic immature permanent teeth with or without apical periodontitis: An umbrella review. Endodontic Therapy, 41(3), 263–282. https://doi.org/10.1111/edt.13028

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Severe Toothache: When Is It an Emergency?

Severe toothache is a common reason for urgent dental consultation and may result from pulpal inflammation, pulpal necrosis, apical periodontitis, dental abscess, trauma, or extensive tooth destruction.

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Although intense pain does not necessarily indicate a life-threatening condition, certain clinical findings suggest the progression of an odontogenic infection and require immediate assessment.

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The critical distinction is between pain that requires urgent dental treatment and symptoms indicating possible extension into deeper facial or cervical spaces, which may require emergency medical evaluation. Current evidence emphasizes definitive dental treatment for the underlying cause rather than relying solely on analgesics or antibiotics.

✅ What Can Cause Severe Toothache?
Severe dental pain may be associated with several conditions:

▪️ Symptomatic irreversible pulpitis: often produces spontaneous, persistent, or poorly localized pain, frequently aggravated by thermal stimuli.
▪️ Symptomatic apical periodontitis: pain is commonly elicited by biting or percussion.
▪️ Acute apical abscess: may present with localized pain, swelling, tenderness, and purulent drainage.
▪️ Dental trauma or tooth fracture: can produce acute pain and pulpal or periodontal complications.
▪️ Advanced dental caries: extensive carious lesions may result in pulpal inflammation or necrosis.
▪️ Periodontal or pericoronal infections: particularly when localized swelling and tissue inflammation are present.

Clinical diagnosis should be based on the history, clinical examination, pulp sensibility testing when appropriate, periodontal assessment, and radiographic findings rather than pain intensity alone.

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✅ When Is Severe Toothache a Dental Emergency?
Severe toothache should generally receive prompt dental assessment, particularly when the pain is persistent, spontaneous, interferes with normal function, or does not respond adequately to appropriate analgesia. Toothache lasting more than two days, pain associated with biting, fever, unpleasant taste, gingival inflammation, or facial swelling warrants dental evaluation.

The following findings increase the likelihood that urgent dental treatment is required:

Clinical finding	Possible significance	Recommended action
Severe spontaneous pain	Possible symptomatic irreversible pulpitis	Urgent dental assessment and definitive treatment
Pain on biting or percussion	Possible symptomatic apical periodontitis	Prompt endodontic or restorative evaluation
Localized swelling or purulence	Possible acute apical abscess	Urgent source control and drainage when indicated
Fever or malaise	Possible systemic involvement	Urgent dental evaluation; assess need for systemic antibiotics
Progressive facial swelling	Potential spreading odontogenic infection	Urgent clinical assessment

✅ When Does Toothache Require Emergency Medical Care?
The most important emergency warning signs are those suggesting airway compromise, deep-space infection, or extension beyond the localized dental tissues.

Immediate emergency evaluation is indicated when dental infection is accompanied by:
▪️ Difficulty breathing
▪️ Difficulty swallowing
▪️ Difficulty speaking
▪️ Marked swelling of the mouth, face, or neck
▪️ Progressive neck swelling
▪️ Periorbital swelling or ocular symptoms
▪️ Significant limitation of mouth opening (trismus) associated with spreading infection

These findings can indicate extension of an odontogenic infection into anatomical spaces where airway obstruction or other serious complications may develop. Emergency medical services or an emergency department should be considered when airway or swallowing function is compromised.

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✅ Does Severe Toothache Always Require Antibiotics?
Severe dental pain does not automatically indicate the need for antibiotics.
The American Dental Association guideline recommends prioritizing definitive conservative dental treatment for most pulpal and periapical conditions, including procedures such as pulpotomy, pulpectomy, nonsurgical root canal treatment, or incision and drainage when clinically indicated. Antibiotics are generally not recommended when infection remains localized and there is no systemic involvement.
Antibiotic therapy becomes more relevant when there is evidence of systemic involvement, such as fever or malaise, or when the infection demonstrates progression or poses concern for deeper-space involvement. Definitive dental treatment should not be unnecessarily delayed because antibiotics alone do not eliminate the underlying source of most odontogenic infections.

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✅ Pain Management While Definitive Treatment Is Pending
When immediate definitive treatment is temporarily unavailable, current ADA recommendations support non-opioid analgesics as first-line therapy for acute dental pain.
Nonsteroidal anti-inflammatory drugs (NSAIDs), alone or combined with acetaminophen, generally provide effective pain control and have a more favorable risk-benefit profile than opioids for most patients without contraindications.
Analgesic selection should consider contraindications, drug interactions, renal and gastrointestinal risk, anticoagulant therapy, pregnancy status, allergy history, and other relevant patient factors. Analgesics should be regarded as temporary symptom management, not definitive treatment of the dental cause.

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✅ Clinical Assessment of Severe Toothache
A systematic emergency assessment should establish:

1. Pain characteristics: onset, duration, spontaneous versus provoked pain, thermal sensitivity, and pain on biting.
2. Extraoral findings: facial asymmetry, swelling, lymphadenopathy, skin changes, and extension toward the neck or orbit.
3. Intraoral findings: caries, fractures, swelling, sinus tract, periodontal involvement, and purulent drainage.
4. Pulpal and periapical status: sensibility testing, percussion, palpation, and mobility as clinically indicated.
5. Airway-related symptoms: dysphagia, dyspnea, dysphonia, and progressive swelling.
6. Systemic status: temperature, malaise, and relevant medical conditions.
7. Radiographic assessment: when indicated to identify periapical pathology, extensive caries, fractures, or other sources of infection.

The presence of airway symptoms or rapidly progressive swelling should take precedence over routine dental diagnostic procedures.

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💬 Discussion
The clinical significance of severe toothache depends less on the numerical intensity of pain than on its etiology, associated findings, and progression. Symptomatic irreversible pulpitis can cause extremely severe pain without systemic infection, whereas a relatively localized dental infection may subsequently develop into a more serious spreading infection.
This distinction is particularly important for antibiotic stewardship. Current evidence supports source control and definitive dental treatment rather than antibiotic therapy for uncomplicated pulpal and localized periapical conditions. When systemic involvement occurs, antibiotics may become appropriate as an adjunct to definitive treatment.
Emergency medical referral is primarily determined by signs suggesting airway compromise, deep-space involvement, or significant spreading infection, rather than by pain severity alone. Difficulty breathing or swallowing, marked facial or neck swelling, ocular involvement, and significant trismus should therefore be considered high-priority findings.

🎯 Clinical Recommendations
▪️ Prioritize definitive dental treatment when severe toothache is caused by pulpal or periapical disease.
▪️ Do not use pain intensity alone to determine whether systemic antibiotics are indicated.
▪️ Assess systematically for fever, malaise, progressive swelling, trismus, dysphagia, and dyspnea.
▪️ Treat airway or swallowing compromise as a medical emergency, requiring immediate escalation of care.
▪️ Use NSAIDs, with or without acetaminophen when appropriate, as first-line pharmacologic management of acute dental pain.
▪️ Consider the patient's medical history and contraindications before prescribing analgesics or antibiotics.
▪️ When antibiotics are indicated, use them as an adjunct to source control, not as a substitute for definitive dental treatment.
▪️ Reassess patients with progressive symptoms promptly because the clinical status of odontogenic infections can change rapidly.

✍️ Conclusion
Severe toothache requires prompt evaluation, but not every episode represents a life-threatening emergency. Pulpal and periapical diseases commonly require urgent dental treatment, while fever, progressive swelling, trismus, dysphagia, dyspnea, and cervical or periorbital involvement indicate a higher level of concern.
The appropriate clinical approach is to identify the underlying dental cause, provide evidence-based analgesia, perform definitive source control when indicated, and recognize early signs of spreading odontogenic infection or airway compromise. Current guidelines support minimizing unnecessary antibiotic use while maintaining a low threshold for emergency escalation when systemic or deep-space involvement is suspected.

📚 References

✔ American Dental Association. (2019). Evidence-based clinical practice guideline on antibiotic use for the urgent management of pulpal- and periapical-related dental pain and intraoral swelling: A report from the American Dental Association. Journal of the American Dental Association, 150(11), 906–921. https://doi.org/10.1016/j.adaj.2019.08.020
✔ Carrasco-Labra, A., Polk, D. E., Urquhart, O., Aghaloo, T., Claytor, J. W., Jr., Dhar, V., Dionne, R. A., Espinoza, L., Gordon, S. M., Hersh, E. V., Law, A. S., Li, B. S.-K., Schwartz, P. J., Suda, K. J., Turturro, M. A., Wright, M. L., Dawson, T., Miroshnychenko, A., Pahlke, S., Pilcher, L., Shirey, M., Tampi, M., & Moore, P. A. (2024). Evidence-based clinical practice guideline for the pharmacologic management of acute dental pain in adolescents, adults, and older adults: A report from the American Dental Association Science and Research Institute, the University of Pittsburgh, and the University of Pennsylvania. Journal of the American Dental Association, 155(2), 102–117.e9. https://doi.org/10.1016/j.adaj.2023.10.009
✔ Green, V. G., Polk, D. E., Turturro, M. A., Moore, P. A., & Carrasco-Labra, A. (2025). Evidence-based clinical practice guidelines for the management of acute dental pain. American Journal of Emergency Medicine, 89, 247–253. https://doi.org/10.1016/j.ajem.2024.12.054
✔ National Health Service. (2026). Toothache. NHS.
✔ National Health Service. (2026). Dental abscess. NHS.

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Metal Braces Benefits: Why Are They Still Used?

Metal braces, particularly conventional stainless-steel brackets, remain one of the most widely used fixed orthodontic appliances.

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Their continued clinical use is related to their mechanical properties, versatility, durability, and ability to provide precise three-dimensional control of tooth movement.

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Although newer orthodontic systems, including ceramic brackets, self-ligating brackets, and clear aligners, offer alternative treatment approaches, conventional metal brackets continue to have an important role in comprehensive orthodontic therapy.
Current evidence indicates that the choice of appliance should be based on the patient's malocclusion, treatment objectives, biomechanics, esthetic preferences, and clinical circumstances rather than on the bracket material alone.

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🔹 What Are the Main Benefits of Metal Braces?

1. High Mechanical Strength and Durability
Stainless-steel brackets have high resistance to deformation and fracture under normal clinical conditions. This mechanical stability is particularly useful when orthodontic treatment requires substantial wire engagement, torque expression, or complex biomechanics.
Their durability also makes them suitable for prolonged fixed-appliance treatment.

2. Precise Control of Tooth Movement
One of the principal advantages of fixed metal appliances is their ability to maintain continuous mechanical control over individual teeth.
The bracket slot–archwire relationship permits the clinician to control:
▪️ Angulation
▪️ Inclination and torque
▪️ Rotation
▪️ Mesiodistal positioning
▪️ Vertical tooth position
The degree of torque expression depends on factors such as bracket slot dimensions, archwire size, material, and bracket–wire interaction. Therefore, the presence of a metal bracket alone does not guarantee a specific treatment effect.

3. Versatility in Orthodontic Mechanics
Metal brackets are compatible with a wide range of orthodontic mechanics, including:
▪️ Elastic chains
▪️ Intermaxillary elastics
▪️ Closing loops
▪️ Open and closed coil springs
▪️ Auxiliary wires
▪️ Temporary anchorage device–supported mechanics
This versatility is particularly relevant in complex malocclusions, extraction cases, space closure, and three-dimensional tooth-position correction.

4. Effective Treatment of Complex Malocclusions
Fixed appliances provide continuous force application and allow the orthodontist to control individual teeth throughout treatment. This can be particularly useful when substantial changes in tooth position or occlusal relationships are required.
Systematic reviews confirm that fixed appliances can produce substantial improvements in occlusal outcomes, although treatment effectiveness is influenced by the initial malocclusion and treatment protocol rather than by the bracket type alone.

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5. Predictable Integration With Different Archwires
Metal brackets can be used throughout the different stages of fixed orthodontic treatment, from initial alignment to finishing.
A typical treatment sequence may incorporate nickel-titanium archwires during alignment and leveling, followed by progressively more rigid wires for space control, torque expression, and finishing.
This allows the clinician to modify the biomechanics according to the treatment phase.

6. Resistance to Clinical Wear
The oral environment exposes orthodontic materials to mechanical forces, moisture, temperature fluctuations, plaque, and chemical changes. Although bracket surfaces can undergo clinical changes and friction may increase after intraoral aging, stainless-steel brackets remain mechanically suitable for long-term orthodontic use.

7. Established Clinical Evidence
Conventional fixed appliances have been investigated extensively in clinical orthodontics. Systematic reviews have reported average comprehensive fixed-appliance treatment durations of approximately 20–25 months, although considerable variation exists between patients and treatment protocols.
Importantly, current evidence does not support attributing treatment duration or final occlusal quality exclusively to bracket material. Patient characteristics, malocclusion severity, extraction requirements, biomechanics, and treatment objectives can substantially influence outcomes.

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🔹 Metal Braces: Key Benefits at a Glance

Benefit	Clinical Relevance
Durability	Resistant to deformation and suitable for prolonged fixed treatment.
Three-dimensional control	Allows control of angulation, torque, rotation, and tooth position.
Biomechanical versatility	Compatible with elastics, springs, loops, chains, and auxiliary mechanics.
Complex case management	Useful when extensive tooth movement and detailed occlusal correction are required.
Archwire compatibility	Supports different archwire materials and dimensions throughout treatment.

💬 Discussion
The main advantage of metal orthodontic brackets is not simply their material composition but the combination of mechanical strength, fixed tooth control, and biomechanical versatility. These characteristics make them applicable to a broad spectrum of orthodontic treatments.
However, the evidence does not demonstrate that metal brackets inherently produce superior treatment outcomes compared with every alternative appliance. Recent systematic evidence indicates that differences between bracket designs may have limited influence on overall treatment duration or occlusal outcome.
Bracket selection should therefore be incorporated into a broader treatment strategy that considers malocclusion severity, anchorage requirements, desired tooth movements, patient factors, esthetics, and clinician-controlled biomechanics.

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✍️ Conclusion
Metal braces remain a reliable and versatile option for fixed orthodontic treatment. Their principal advantages include durability, precise tooth control, compatibility with diverse biomechanical systems, and extensive clinical experience.
Rather than considering metal brackets inherently superior, their value should be understood in relation to the specific treatment objectives and biomechanical requirements of each patient.

🎯 Clinical Recommendations
▪️ Select metal brackets when precise fixed-appliance control and broad biomechanical versatility are required.
▪️ Match bracket slot, prescription, and archwire dimensions to the intended tooth movements rather than relying solely on bracket material.
▪️ Consider the entire biomechanical system—including ligation, archwire properties, anchorage, and auxiliaries—when planning treatment.
▪️ Avoid promising shorter treatment solely because metal brackets are being used; treatment duration is multifactorial.

📚 References

✔ Abbing, A., Koretsi, V., Eliades, T., & Papageorgiou, S. N. (2020). Duration of orthodontic treatment with fixed appliances in adolescents and adults: A systematic review with meta-analysis. Progress in Orthodontics, 21, 37. https://doi.org/10.1186/s40510-020-00334-4
✔ Papageorgiou, S. N., Höchli, D., & Eliades, T. (2017). Outcomes of comprehensive fixed appliance orthodontic treatment: A systematic review with meta-analysis and methodological overview. Korean Journal of Orthodontics, 47(6), 401–413. https://doi.org/10.4041/kjod.2017.47.6.401
✔ Tsichlaki, A., Chin, S. Y., Pandis, N., & Fleming, P. S. (2016). How long does treatment with fixed orthodontic appliances last? A systematic review. American Journal of Orthodontics and Dentofacial Orthopedics, 149(3), 308–318. https://doi.org/10.1016/j.ajodo.2015.09.020
✔ Wazwaz, F., Seehra, J., Carpenter, G. H., Ireland, A. J., Papageorgiou, S. N., & Cobourne, M. T. (2022). Duration of tooth alignment with fixed appliances: A systematic review and meta-analysis. American Journal of Orthodontics and Dentofacial Orthopedics, 161(1), 20–36. https://doi.org/10.1016/j.ajodo.2021.06.016

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Bionator Technique: Clinical Guide for Class II

The Bionator technique is a removable functional orthodontic appliance approach primarily used for the treatment of growing patients with Class II malocclusion, particularly when mandibular retrusion contributes substantially to the sagittal discrepancy.

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Developed within the functional orthopedic philosophy associated with Balters, the Bionator is designed to influence mandibular posture, neuromuscular function, and dentoalveolar relationships through controlled mandibular advancement.

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Its clinical effects are not exclusively skeletal: contemporary evidence indicates that dentoalveolar changes frequently represent a substantial component of Class II correction, while skeletal effects may occur in appropriately growing patients.

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🔹 What Is the Bionator Technique?
The Bionator is a relatively lightweight, removable functional appliance that positions the mandible anteriorly and modifies the relationship between the upper and lower dental arches.

Its design generally incorporates:
▪️ An acrylic functional body.
▪️ A lingual acrylic component that guides mandibular posture.
▪️ Upper and lower incisor elements adapted according to the treatment objective.
▪️ A labial bow for anterior control.
▪️ Posterior acrylic areas that establish the desired occlusal relationship.
▪️ Selective acrylic trimming to facilitate tooth eruption and dentoalveolar adaptation.


The exact design should be individualized according to the skeletal pattern, vertical dimension, incisor position, overjet, eruption stage, and treatment objectives.

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🔹 Main Indications
The Bionator is most commonly considered when the following characteristics are present:

▪️ Growing patient with Class II malocclusion.
▪️ Mandibular retrognathia or retrusion contributing to the sagittal discrepancy.
▪️ Increased overjet.
▪️ Favorable growth potential.
▪️ Sufficient patient cooperation for removable-appliance therapy.
▪️ A treatment objective that includes mandibular advancement and dentoalveolar correction.

Clinical studies have demonstrated that Bionator treatment can improve molar relationships, overjet, and sagittal skeletal relationships in appropriately selected growing patients.

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🔹 Construction Bite and Mandibular Advancement
The construction bite is one of the most important components of the Bionator technique because it determines the mandibular position incorporated into the appliance.

Mandibular advancement should be established according to the individual patient's:
▪️ Initial overjet.
▪️ Sagittal discrepancy.
▪️ Incisor inclination.
▪️ Vertical facial pattern.
▪️ Temporomandibular joint status.
▪️ Tolerance to mandibular advancement.
▪️ Treatment objectives.

The available evidence does not establish a universally superior advancement protocol for all functional appliances. A systematic review found that incremental advancement may produce somewhat greater short-term mandibular skeletal changes than maximal advancement, but the certainty of evidence was low to very low, and long-term clinical conclusions remain limited.
Therefore, mandibular advancement should be considered an individualized biomechanical prescription rather than a fixed numerical protocol.

🔹 Clinical Effects of the Bionator
The therapeutic response can involve several components:

Component	Potential Clinical Effect
Skeletal	Improvement in the sagittal mandibular relationship during growth.
Dentoalveolar	Correction of the molar relationship and reduction of overjet.
Maxillary dentition	Possible posterior movement or restraint of forward dental displacement.
Mandibular incisors	Possible proclination depending on appliance design and treatment mechanics.
Vertical dimension	Changes influenced by acrylic design, eruption, and individual growth pattern.
Soft tissues	Improvement in the sagittal facial profile may accompany skeletal and dental correction.

Clinical trials have shown that Bionator therapy can produce mandibular growth and anterior mandibular displacement; however, comparative studies indicate that dentoalveolar effects frequently account for a considerable proportion of the overall correction.

🔹 Bionator Technique: Key Clinical Parameters

Parameter	Clinical Consideration
Growth status	Treatment is primarily considered in actively growing patients.
Mandibular position	The construction bite should establish a clinically appropriate advanced mandibular position.
Vertical control	Acrylic design and selective trimming should be adapted to the patient's vertical pattern.
Incisor control	The appliance should account for existing incisor inclination and the desired dentoalveolar response.
Patient cooperation	Treatment effectiveness depends substantially on adequate appliance wear and follow-up.

🔹 Treatment Timing
The growth phase is an important consideration when using the Bionator. Early treatment studies have demonstrated measurable improvements in Class II relationships with Bionator therapy compared with observation, although treatment response varies considerably between individuals. Compliance and initial malocclusion severity have also been associated with treatment effectiveness.
Importantly, early functional treatment should not be interpreted as producing permanent skeletal correction in every patient. Long-term evidence indicates that functional appliances can produce skeletal and dentoalveolar effects, but the magnitude and clinical relevance of skeletal changes are variable.

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🔹 Bionator and Mandibular Growth
One of the principal objectives of the Bionator technique is to take advantage of active mandibular growth.
Research using longitudinal and implant-based methodologies has documented adaptive condylar growth and mandibular remodeling during Bionator therapy.
However, the clinical interpretation should remain cautious. Functional appliance therapy does not simply "create" mandibular growth independently of the patient's biological growth potential. The observed correction represents an interaction between growth modification, mandibular positioning, dentoalveolar adaptation, and appliance-related mechanics.

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🔹 Limitations and Clinical Considerations
Several factors can limit the predictability of Bionator treatment:

▪️ Poor compliance with appliance wear.
▪️ Advanced skeletal maturity or limited remaining growth.
▪️ Severe skeletal Class II discrepancies.
▪️ Excessive mandibular incisor proclination.
▪️ Unfavorable vertical growth pattern.
▪️ Inadequate construction bite.
▪️ Insufficient retention or stabilization after active correction.

The distinction between skeletal and dental correction is particularly important when evaluating treatment outcomes. In controlled clinical research, Bionator therapy has repeatedly demonstrated improvement in Class II relationships, but a substantial proportion of the correction may arise from dentoalveolar adaptation rather than mandibular skeletal advancement alone.

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💬 Discussion
The Bionator technique remains a relevant option for selected growing patients with Class II malocclusion, particularly when mandibular retrusion is an important component of the sagittal discrepancy.
The available evidence supports its ability to improve overjet and molar relationships and to produce measurable skeletal effects during growth. Nevertheless, these effects should not be characterized as exclusively orthopedic. Comparative clinical studies and systematic reviews indicate that dentoalveolar changes are often a major, and sometimes predominant, contributor to Class II correction.
Current evidence also emphasizes the importance of treatment timing, patient cooperation, initial severity, and appliance design. Consequently, treatment planning should be based on the complete dentofacial diagnosis rather than on the assumption that mandibular advancement will produce a predictable amount of additional mandibular growth.

✍️ Conclusion
The Bionator technique is a removable functional approach primarily indicated for growing patients with selected Class II malocclusions. Its therapeutic effects involve a combination of skeletal, dentoalveolar, and soft-tissue adaptations.
Successful clinical application requires appropriate patient selection, individualized mandibular advancement, control of vertical and incisor effects, and adequate patient cooperation. The evidence supports its effectiveness for improving Class II relationships, while also indicating that the magnitude of skeletal correction is variable and should not be overestimated.

💡 Clinical Pearls
▪️ Select patients according to growth potential and skeletal diagnosis, not solely by overjet or molar relationship.
▪️ Individualize the construction bite according to sagittal and vertical objectives rather than applying a universal advancement value.
▪️ Monitor mandibular incisor inclination, because dentoalveolar compensation can contribute substantially to Class II correction.
▪️ Assess treatment response periodically and distinguish skeletal changes from dental compensation when evaluating progress.
▪️ Plan the subsequent orthodontic phase and retention from the beginning, particularly when early functional treatment is used as an initial stage of comprehensive treatment.

📚 References

✔ Almeida, M. R., Henriques, J. F. C., & Ursi, W. (2002). Comparative study of the Fränkel (FR-2) and bionator appliances in the treatment of Class II malocclusion. American Journal of Orthodontics and Dentofacial Orthopedics, 121(5), 458–466. https://doi.org/10.1067/mod.2002.123037
✔ Araujo, A. M., Buschang, P. H., & Melo, A. C. M. (2004). Adaptive condylar growth and mandibular remodelling changes with bionator therapy—an implant study. European Journal of Orthodontics, 26(5), 515–522. https://doi.org/10.1093/ejo/26.5.515
✔ Keeling, S. D., Wheeler, T. T., King, G. J., Garvan, C. W., & McGorray, S. (1998). Anteroposterior skeletal and dental changes after early Class II treatment with bionators and headgear. American Journal of Orthodontics and Dentofacial Orthopedics, 113(1), 40–50. https://doi.org/10.1016/S0889-5406(98)70275-6
✔ O'Brien, K., Wright, J., Conboy, F., Appelbe, P., Davies, L., Connolly, I., Houston, F., & Mandall, N. (2003). Early treatment for Class II Division 1 malocclusion with the Twin-block appliance: A multicenter, randomized, controlled trial. American Journal of Orthodontics and Dentofacial Orthopedics, 124(3), 234–243. [Reference included for broader functional-appliance evidence.]
✔ Santana, L. G., Avelar, K., Flores-Mir, C., & Marques, L. S. (2020). Incremental or maximal mandibular advancement in the treatment of class II malocclusion through functional appliances: A systematic review with meta-analysis. Orthodontics & Craniofacial Research, 23(4), 371–384. https://doi.org/10.1111/ocr.12388
✔ Vig, P. S., Orth, D., & Ellis, J. (2002). Effectiveness of early treatment of Class II malocclusion. American Journal of Orthodontics and Dentofacial Orthopedics, 121(1), 9–17. https://doi.org/10.1067/mod.2002.120159

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5 Common Oral Infections in Dentistry: Signs and Treatment

Oral infections encompass a heterogeneous group of bacterial, fungal, and viral diseases affecting the teeth, periodontal tissues, oral mucosa, and surrounding structures.

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Their clinical presentation ranges from localized inflammation to infections capable of spreading into deep facial and cervical spaces.

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Accurate diagnosis is essential because treatment depends on the etiology, anatomical site, severity, and systemic involvement. In odontogenic bacterial infections, definitive dental treatment and elimination of the source should generally take priority over systemic antibiotics.
The following five conditions represent clinically important infections frequently encountered in dental practice.

1. Periodontitis
Definition
Periodontitis is a chronic inflammatory disease associated with dysbiotic subgingival biofilms that results in progressive destruction of the tooth-supporting tissues. Clinical features include periodontal pocketing, clinical attachment loss, and alveolar bone loss.

Signs
▪️ Gingival inflammation and bleeding on probing
▪️ Periodontal pockets
▪️ Clinical attachment loss
▪️ Gingival recession
▪️ Tooth mobility in advanced disease
▪️ Radiographic alveolar bone loss
▪️ Tooth migration in severe cases

Symptoms
Patients may be asymptomatic during the early stages. Advanced disease may produce gingival bleeding, halitosis, discomfort during mastication, tooth mobility, or sensitivity.

Treatment
Treatment is based on disease stage and risk profile. It generally includes:
▪️ Patient education and oral-hygiene optimization
▪️ Supragingival and subgingival biofilm control
▪️ Professional periodontal instrumentation
▪️ Risk-factor control
▪️ Periodontal surgery when indicated
▪️ Long-term supportive periodontal care
Systemic antibiotics are not routinely indicated for conventional periodontitis and should be reserved for selected clinical situations.

Prevention
▪️ Maintain effective daily plaque control with toothbrushing and interdental cleaning.
▪️ Undergo regular periodontal assessment based on individual risk.
▪️ Avoid tobacco use and address modifiable periodontal risk factors.
▪️ Maintain appropriate supportive periodontal care after active treatment.

2. Odontogenic Abscess
Definition
An odontogenic abscess is a localized collection of purulent material resulting from a bacterial infection originating from the dental pulp, periapical tissues, or periodontal structures.

Signs
▪️ Localized swelling
▪️ Fluctuance or purulent drainage
▪️ Tenderness to percussion
▪️ Intraoral or extraoral edema
▪️ Local lymphadenopathy in some cases
▪️ Tooth discoloration or extensive caries when pulpal necrosis is present

Symptoms
Common symptoms include spontaneous dental pain, pain on biting, swelling, tenderness, and a sensation of pressure. Fever, malaise, and regional lymphadenopathy may indicate systemic involvement.

Treatment
Management should focus on eliminating the source of infection and establishing drainage when indicated. Depending on the diagnosis, treatment may include:
▪️ Pulpotomy or pulpectomy in appropriate cases
▪️ Nonsurgical root canal treatment
▪️ Tooth extraction when the tooth cannot be predictably restored
▪️ Incision and drainage when clinically indicated
▪️ Analgesics for pain control
Systemic antibiotics are generally unnecessary for localized infections in immunocompetent patients when definitive dental treatment is available.Antibiotics become appropriate when systemic involvement or significant spreading infection is present.

Prevention
▪️ Maintain effective oral hygiene and plaque control.
▪️ Prevent and treat dental caries at an early stage.
▪️ Attend regular dental examinations to identify caries, pulpal disease, and defective restorations.
▪️ Complete indicated restorative or endodontic treatment before infection progresses.

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3. Periodontal Abscess
Definition
A periodontal abscess is an acute localized accumulation of pus within the periodontal tissues, commonly associated with a periodontal pocket and rapid localized tissue destruction.

Signs
▪️ Localized gingival swelling
▪️ Purulent exudate
▪️ Deep periodontal pocket
▪️ Tooth mobility
▪️ Gingival erythema
▪️ Localized elevation of the gingival margin

Symptoms
Patients may report localized pain, tenderness during biting, a feeling of tooth elevation, and discomfort during chewing.

Treatment
Treatment generally involves:
▪️ Drainage through the periodontal pocket or incision when necessary
▪️ Thorough periodontal debridement
▪️ Removal of local contributing factors
▪️ Occlusal assessment when indicated
▪️ Periodontal therapy after the acute phase
Systemic antibiotics should not replace local treatment and are generally reserved for systemic manifestations, spreading infection, or specific medically compromised situations.

Prevention
▪️ Maintain adequate periodontal biofilm control.
▪️ Treat periodontal pockets and active periodontal disease appropriately.
▪️ Attend supportive periodontal therapy at intervals determined by individual risk.
▪️ Monitor sites with previous periodontal abscesses for recurrent inflammation or pocketing.

4. Pericoronitis
Definition
Pericoronitis is an inflammatory and infectious condition of the soft tissues surrounding the crown of a partially erupted tooth, most frequently associated with mandibular third molars.

Signs
▪️ Inflamed operculum
▪️ Localized edema and erythema
▪️ Purulent discharge
▪️ Food accumulation beneath the operculum
▪️ Tender regional lymph nodes in some cases
▪️ Limited mouth opening in more severe infections

Symptoms
Typical symptoms include localized pain, swelling, unpleasant taste or odor, difficulty chewing, and sometimes trismus or dysphagia.

Treatment
Initial management focuses on controlling the local infection:
▪️ Irrigation and debridement of the affected area
▪️ Removal of local irritants and impacted debris
▪️ Appropriate analgesia
▪️ Antiseptic therapy when indicated
▪️ Evaluation for extraction or other definitive management of the associated tooth
Systemic antibiotics should be considered primarily when there is spreading infection, systemic involvement, or significant trismus rather than uncomplicated localized inflammation.

Prevention
▪️ Maintain meticulous oral hygiene around partially erupted third molars.
▪️ Remove food debris and plaque from the operculum region.
▪️ Monitor partially erupted third molars clinically and radiographically when indicated.
▪️ Consider definitive management when recurrent pericoronitis is associated with a tooth with poor eruption potential.

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5. Oral Candidiasis
Definition
Oral candidiasis is a fungal infection of the oral mucosa, most commonly associated with Candida albicans. Predisposing factors include immunosuppression, antibiotic exposure, corticosteroid use, xerostomia, and poorly controlled systemic disease.

Signs
▪️ Removable white plaques in pseudomembranous candidiasis
▪️ Erythematous mucosa after plaque removal
▪️ Atrophic or erythematous lesions
▪️ Angular involvement in some patients
▪️ Chronic mucosal changes in persistent disease

Symptoms
Patients may experience oral burning, soreness, altered taste, taste loss, or discomfort when eating spicy or acidic foods. Some cases are asymptomatic.

Treatment
Management includes:
▪️ Identification and correction of predisposing factors
▪️ Improved oral hygiene and denture hygiene
▪️ Topical antifungal therapy for mild disease
▪️ Systemic antifungal therapy for moderate-to-severe disease or selected refractory cases
Persistent or recurrent candidiasis should prompt evaluation for underlying predisposing conditions.

Prevention
▪️ Maintain good oral and denture hygiene.
▪️ Remove and clean dentures regularly; avoid wearing them continuously, particularly during sleep.
▪️ Rinse the mouth after using inhaled corticosteroids.
▪️ Minimize unnecessary antibiotic exposure when clinically appropriate.
▪️ Address xerostomia and other predisposing factors when identified.

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✅ Clinical Comparison

Infection	Primary Cause	Key Signs	Main Treatment
Periodontitis	Dysbiotic periodontal biofilm and host inflammatory response	Pocketing, bleeding, attachment and bone loss	Periodontal therapy and supportive care
Odontogenic Abscess	Bacterial infection of pulpal/periapical tissues	Pain, swelling, tenderness, purulence	Drainage and definitive dental treatment
Periodontal Abscess	Infection associated with periodontal pocketing	Localized swelling, pus, deep pocket, pain	Drainage and periodontal debridement
Pericoronitis	Infection/inflammation around a partially erupted tooth	Operculum inflammation, pain, swelling, possible trismus	Local debridement and definitive tooth management
Oral Candidiasis	Overgrowth of Candida species	White plaques, erythema, burning, altered taste	Antifungal therapy and correction of predisposing factors

✅ Prevention of Common Oral Infections
Preventive strategies should focus on biofilm control, early detection, management of predisposing factors, and regular dental care. Prevention differs according to the infectious process and should be individualized according to the patient's oral and systemic risk profile.

Infection	Key Preventive Measures
Periodontitis	Daily plaque control, interdental cleaning, periodontal monitoring, tobacco cessation, and supportive periodontal care.
Odontogenic Abscess	Caries prevention, early restorative care, regular examinations, and timely endodontic treatment when indicated.
Periodontal Abscess	Periodontal disease control, biofilm management, pocket monitoring, and maintenance therapy.
Pericoronitis	Oral hygiene around partially erupted teeth, debris removal, clinical monitoring, and definitive management when recurrent.
Oral Candidiasis	Denture hygiene, appropriate corticosteroid use, avoidance of unnecessary antibiotics, and management of predisposing factors.

💬 Discussion
Although these conditions are grouped under the broad concept of oral infection, their biological mechanisms and therapeutic approaches differ substantially. Periodontitis is a chronic biofilm-associated inflammatory disease, whereas odontogenic and periodontal abscesses are typically acute bacterial infections requiring control of the local source.
A clinically important principle is that antimicrobial therapy should not substitute for definitive dental treatment. For localized pulpal and periapical infections, current evidence-based guidance emphasizes procedures such as root canal treatment, extraction, or drainage rather than routine antibiotic prescribing. Antibiotics are principally indicated when systemic involvement or clinically significant spread is present.
Fungal and viral infections require a different therapeutic approach. Oral candidiasis is managed with antifungal therapy and correction of predisposing factors, whereas herpes labialis, when treated, responds to antiviral therapy initiated early in the course of recurrence.
Therefore, diagnosis should integrate clinical examination, periodontal assessment, pulpal and periapical testing, radiographic findings, and evaluation for systemic involvement rather than relying exclusively on the presence of pain or swelling.

✍️ Conclusion
The five conditions reviewed—periodontitis, odontogenic abscess, periodontal abscess, pericoronitis, and oral candidiasis—represent important infectious or infection-associated conditions encountered in dental practice. Their management requires accurate diagnosis, control of the underlying cause, and treatment according to the specific pathology.
Prevention remains fundamental and relies on effective oral-hygiene measures, early detection and treatment of dental and periodontal disease, appropriate management of predisposing factors, and regular professional follow-up. In acute infections, source control should remain the primary therapeutic objective, while systemic antimicrobial therapy should be reserved for appropriate clinical indications.

🎯 Clinical Recommendations
▪️ Establish the anatomical and etiological source of infection before prescribing antimicrobial therapy.
▪️ Prioritize source control, including drainage, periodontal debridement, endodontic treatment, or extraction when indicated.
▪️ Assess every acute infection for fever, malaise, facial/cervical swelling, dysphagia, dyspnea, or progressive trismus.
▪️ Avoid routine systemic antibiotics for localized odontogenic infections when adequate definitive dental treatment can be provided.
▪️ Reassess patients with persistent, recurrent, or atypical oral infections for underlying systemic, immunological, medication-related, or local predisposing factors.
▪️ Refer urgently when infection threatens the airway, extends into deep facial or cervical spaces, or is associated with systemic deterioration.

📚 References

✔ Sanz, M., Herrera, D., Kebschull, M., Chapple, I., Jepsen, S., Beglundh, T., Sculean, A., Tonetti, M. S., & EFP Workshop Participants and Methodological Consultants. (2020). Treatment of stage I–III periodontitis—The EFP S3 level clinical practice guideline. *Journal of Clinical Periodontology, 47*(Suppl. 22), 4–60. https://doi.org/10.1111/jcpe.13290
✔ Jevon, P., Abdelrahman, A., & Pigadas, N. (2020). Management of odontogenic infections and sepsis: An update. *British Dental Journal, 229*(6), 363–370. https://doi.org/10.1038/s41415-020-2114-5
✔ Pappas, P. G., Kauffman, C. A., Andes, D. R., Clancy, C. J., Marr, K. A., Ostrosky-Zeichner, L., Reboli, A. C., Schuster, M. G., Vazquez, J. A., Walsh, T. J., Zaoutis, T. E., & Sobel, J. D. (2016). Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America. *Clinical Infectious Diseases, 62*(4), e1–e50. https://doi.org/10.1093/cid/civ933
✔ Du, R., Ba, K., Yang, Y., Zhao, Y., & Lin, Y. (2024). Efficacy of ornidazole for pericoronitis: A meta-analysis and systematic review. *Archives of Medical Science*. https://doi.org/10.5114/aoms/171907
✔ Chen, F., Xu, H., Liu, J., Cui, Y., Luo, X., Zhou, Y., Chen, Q., & Jiang, L. (2017). Efficacy and safety of nucleoside antiviral drugs for treatment of recurrent herpes labialis: A systematic review and meta-analysis. *Journal of Oral Pathology & Medicine, 46*(8), 561–568. https://doi.org/10.1111/jop.12534
✔ American Dental Association. (2019). *Antibiotics for dental pain and swelling guideline*. American Dental Association.

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